Monitoring the Accumulation of Fluorescently Labeled Phospholipids in Cell Cultures Provides an Accurate Screen for Drugs that Induce Phospholipidosis

REFERENCES

• N. Anderson, and J. Borlak. (2006). Drug-induced phospholipidosis. FEBS Lett. 580:5533–5540.
   PubMed Web of Science ®Google Scholar
• F. Atienzar, H. Gerets, S. Dufrane, K. Tilmant, M. Cornet, S. Dhalluin, B. Ruty, G. Rose, and M. Canning. (2007). Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol. Sci. 96:101–114.
   PubMed Web of Science ®Google Scholar
• I. L. Chen, and R. D. Yates. (1967). An ultrastructural study of opague cytoplasmic inclusions induced by triparanol treatment. Am. J. Anat. 121:705–725.
   PubMedGoogle Scholar
• M. E. De Broe, G. J. Paulus, G. A. Verpooten, F. Roels, N. Buyssens, R. Wedeen, F. Van Hoof, and P. M. Tulkens. (1984). Early effects of gentamicin, tobramycin, and amikacin on the human kidney. Kidney Int. 25:643–652.
   PubMed Web of Science ®Google Scholar
• S. E. Dietert, and T. J. Scallen. (1969). An ultrastructural and biochemical study of the effects of three inhibitors of cholesterol biosynthesis upon murine adrenal gland and testis. Histochemical evidence for a lysosome response. J. Cell Biol. 40:44–60.
   PubMed Web of Science ®Google Scholar
• M. N. Diez-Blanco, J. Sanchez-Yague, J. A. Cabezas, and M. Llanillo. (1987). Isolation, characterization, and phospholipid composition of lamellar bodies and subcellular fractions from dog lung. Int. J. Biochem. 19:693–698.
   PubMedGoogle Scholar
• M. El Mouedden, G. Laurent, M. P. Mingeot-Leclercq, H. S. Taper, J. Cumps, and P. M. Tulkens. (2000). Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides. Antimicrob. Agents Chemother. 44:665–675.
   PubMed Web of Science ®Google Scholar
• J. E. Gray, A. Purmalis, B. Purmalis, and J. Mathews. (1971). Ultrastructural studies of the hepatic changes brought about by clindamycin and erythromycin in animals. Toxicol. Appl. Pharmacol. 19:217–233.
   PubMed Web of Science ®Google Scholar
• Z. Hruban, A. Slesers, and E. Hopkins. (1972). Drug-induced and naturally occurring myeloid bodies. Lab. Invest. 27:62–70.
   PubMed Web of Science ®Google Scholar
• G. J. Kaloyanides, and E. Pastoriza-Munoz. (1980). Aminoglycoside nephrotoxicity. Kidney Int. 18:571–582.
   PubMed Web of Science ®Google Scholar
• T. Kasahara, K. Tomita, H. Murano, T. Harada, K. Tsubakimoto, T. Ogihara, S. Ohnishi, and C. Kakinuma. (2006). Establishment of an in vitro high-throughput screening assay for detecting phospholipidosis-inducing potential. Toxicol. Sci. 90:133–141.
   PubMed Web of Science ®Google Scholar
• Y. Kikkawa, and E. K. Motoyama. (1973). Effect of AY-9944, a cholesterol biosynthesis inhibitor, on fetal lung development and on the development of type ii alveolar epithelial cells. Lab. Invest. 28:48–54.
   PubMed Web of Science ®Google Scholar
• Y. Kikkawa, and K. Suzuki. (1972). Alteration of cellular and acellular alveolar and bronchiolar walls produced by hypocholesteremic drug AY9944. Lab. Invest. 26:441–447.
   PubMed Web of Science ®Google Scholar
• J. C. Kosek, R. I. Mazze, and M. J. Cousins. (1974). Nephrotoxicity of gentamicin. Lab. Invest. 30:48–57.
   PubMed Web of Science ®Google Scholar
• G. Laurent, B. K. Kishore, and P. M. Tulkens. (1990). Aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem. Pharmacol. 40:2383–2392.
   PubMed Web of Science ®Google Scholar
• G. A. Leeson, S. A. Biedenbach, K. Y. Chan, J. P. Gibson, and G. J. Wright. (1976). Decrease in the activity of the drug-metabolizing enzymes of rat liver following the administration of tilorone hydrochloride. Drug Metab. Dispos. 4:232–238.
   PubMed Web of Science ®Google Scholar
• F. C. Luft, M. N. Yum, P. D. Walker, and S. A. Kleit. (1977). Gentamicin gradient patterns and morphological changes in human kidneys. Nephron 18:167–174.
   PubMed Web of Science ®Google Scholar
• M. M. McGovern, A. Aron, S. E. Brodie, R. J. Desnick, and M. P. Wasserstein. (2006). Natural history of Type A Niemann-Pick disease: possible endpoints for therapeutic trials. Neurology 66:228–232.
   PubMed Web of Science ®Google Scholar
• P. Nioi, B. K. Perry, E. J. Wang, Y. Z. Gu, and R. D. Snyder. (2007). In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol. Sci. 99:162–173.
   PubMed Web of Science ®Google Scholar
• D. J. Pelletier, D. Gehlhaar, A. Tilloy-Ellul, T. O. Johnson, and N. Greene. (2007). Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. J. Chem. Inf. Mod. 47:1196–1205.
   PubMed Web of Science ®Google Scholar
• J. R. Piccotti, M. S. LaGattuta, S. A. Knight, A. J. Gonzales, and M. R. Bleavins. (2005). Induction of apoptosis by cationic amphiphilic drugs amiodarone and imipramine. Drug Chem. Toxicol 28:117–133.
   PubMed Web of Science ®Google Scholar
• J. P. Ploemen, J. Kelder, T. Hafmans, H. van de Sandt, J. A. van Burgsteden, P. J. Saleminki, and E. van Esch. (2004). Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines. Exp. Toxicol. Pathol. 55:347–355.
   PubMed Web of Science ®Google Scholar
• F. A. Rawlins, and B. G. Uzman. (1970). Effect of AY-9944, a cholesterol biosynthesis inhibitor, on peripheral nerve myelination. Lab. Invest. 23:184–189.
   PubMed Web of Science ®Google Scholar
• M. J. Reasor, K. L. Hastings, and R. G. Ulrich. (2006). Drug-induced phospholipidosis: issues and future directions. Exp. Opin. Drug Saf. 5:567–583.
   PubMed Web of Science ®Google Scholar
• H. Sawada, K. Takami, and S. Asahi. (2005). A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol. Sci. 83:282–292.
   PubMed Web of Science ®Google Scholar
• W. L. Spangler, R. D. Adelman, G. M. ConzelmanJr., and G. Ishizaki. (1980). Gentamicin nephrotoxicity in the dog: sequential light and electron microscopy. Vet. Pathol. 17:206–217.
   PubMed Web of Science ®Google Scholar
• G. Toubeau, P. Maldague, G. Laurent, C. A. Vaamonde, P. M. Tulkens, and J. A. Heuson Stiennon. (1986). Morphological alterations in distal and collecting tubules of the rat renal cortex after aminoglycoside administration at low doses. Virchows Arch. B: Cell Pathol. Incl. Mol. Pathol. 51:475–485.
   PubMedGoogle Scholar
• J. N. Weiss, R. S. Weinberg, and W. Regelson. (1980). Keratopathy after oral administration of tilorone hydrochloride. Am. J. Ophthalmol. 89:46–53.
   PubMed Web of Science ®Google Scholar