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Drug and Chemical Toxicology Volume 32, 2009 - Issue 3
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Research Article

A 90-day subchronic toxicity study of beta-calcium pyrophosphate in rat

Jae Hyup LeeDepartment of Orthopedic Surgery, Seoul National University, College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea
,
Bong-Soon ChangDepartment of Orthopedic Surgery, Seoul National University, College of Medicine, Seoul National University Hospital, Seoul, Korea
,
Hyun-Seung RyuResearch Center, Bioalpha, Sung-Nam, Korea
&
Choon-Ki LeeDepartment of Orthopedic Surgery, Seoul National University, College of Medicine, Seoul National University Hospital, Seoul, KoreaCorrespondence[email protected]
Pages 277-282 | Received 01 Jan 2009, Accepted 10 Mar 2009, Published online: 19 Jun 2009

References

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  • Lee, J.H., Lee, D.H., Ryu, H.S., Chang, B.S., Hong, K.S., Lee, C.K. (2003). Porous beta-calcium pyrophosphate as a bone graft substitute in a canine bone defect model. Key Eng Mater 240–242:399–402.
  • Lee, J.H., Ryu, H.S., Lee, D.S., Hong, K.S., Chang, B.S., Lee, C.K. (2005). Biomechanical and histomorphometric study on the bone-screw interface of bioactive ceramic-coated titanium screws. Biomaterials 26:3249–3257.
  • Rosenthal, A.K. (2000). Formation of calcium pyrophosphate crystal: biologic implications. Curr Opin Rheumatol 12:219–222.
  • Silcox, D.C., McCarty, D.J. (1974). Elevated inorganic pyrophosphate concentration in synovial fluid in osteoarthritis and pseudogout. J Lab Clin Med 83:518–531.
  • Tancred, D.C., McCormack, B.A., Carr, A.J. (1998). A quantitative study of the sintering and mechanical properties of hydroxyapatite/phosphate glass composites. Biomaterials 19:1735–1743.
  • U.S. FDA. (2006). Part 182—substances generally recognized as safe. Section 182.8223-calcium pyrophosphate. In: Code of Federal Regulations (CFR) Title 21—Food and Drugs (U.S. Food and Drugs Administration) (p 478 ). Washington, DC: U.S. Government Printing Office (GPO).

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