In vitro cytogenetic evaluation of the particular combination of flurbiprofen and roxithromycin

References

• Barzilai A, Yamamoto K. (2004). DNA damage responses to oxidative stress. DNA Repair (Amst) 38:1109–1115
   Web of Science ®Google Scholar
• Battisti N. (1994). The evaluation of the analgesic and anti-inflammatory effects of flurbiprofen mouthwash and 100-mg tablets in oral medicine. Minerva Stomatol 43:141–144
   PubMedGoogle Scholar
• Bock JM, Menon SG, Goswami PC, et al. (2007). Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition. Mol Carcinog 46:857–864
   PubMed Web of Science ®Google Scholar
• Cabrespine A, Bay JO, Barthomeuf C, et al. (2005). In vitro assessment of cytotoxic agent combinations for hormone-refractory prostate cancer treatment. Anticancer Drugs 16:417–422
   PubMed Web of Science ®Google Scholar
• Carrano AV, Natarajan AT. (1988). International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques. Mutat Res 204:379–406
   PubMed Web of Science ®Google Scholar
• Costa D, Moutinho L, Lima JL, Fernandes E. (2006). Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol Pharm Bull 29:1659–1670
   PubMed Web of Science ®Google Scholar
• Dai YR, Wu HY, Wu LQ, et al. (2014). Roxithromycin reduces the viability of cultured airway smooth muscle cells from a rat model of asthma. Eur Rev Med Pharmacol Sci 18:3564–3572
   PubMed Web of Science ®Google Scholar
• Ekici A, Ekici M, Erdemoglu AK. (2002). Effect of azithromycin on the severity of bronchial hyperresponsiveness in patients with mild asthma. J Asthma 39:181–185
   PubMed Web of Science ®Google Scholar
• Erel O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277–285
   PubMed Web of Science ®Google Scholar
• Erel O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103–1111
   PubMed Web of Science ®Google Scholar
• Fang JY, Hwang TL, Fang CL, Chiu HC. (2003). In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int J Pharm 255:153–166
   PubMed Web of Science ®Google Scholar
• Fenech M. (2000). The in vitro micronucleus technique. Mutat Res 455:81–95
   PubMed Web of Science ®Google Scholar
• Fenech M, Kirsch-Volders M, Natarajan AT, et al. (2011). Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis 26:125–132
   PubMed Web of Science ®Google Scholar
• Fernandez LL, Montes-Bayon M, Gonzalez EB, et al. (2011). Initial studies on quantitative DNA induced oxidation by gel electrophoresis (GE)-ICP-MS. J Anal Atom Spectrom 26:195–200
   Web of Science ®Google Scholar
• Gao X, Ray R, Xiao Y, et al. (2007). Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells. BMC Cell Biol 8:17
   PubMed Web of Science ®Google Scholar
• Harma M, Harma M, Erel O. (2003). Increased oxidative stress in patients with hydatidiform mole. Swiss Med Wkly 133:563–566
   PubMed Web of Science ®Google Scholar
• Hodge S, Hodge G, Brozyna S, et al. (2006). Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages. Eur Respir J 28:486–495
   PubMed Web of Science ®Google Scholar
• Jaju M, Jaju M, Ahuja YR. (1984). Evaluation of genotoxicity of ampicillin and carbenicillin on human lymphocytes in vitro: chromosome aberrations, mitotic index, cell cycle kinetics, satellite associations of acrocentric chromosomes and sister chromatid exchanges. Hum Toxicol 33:173–191
   Google Scholar
• Jun YT, Kim HJ, Song MJ, et al. (2003). In vitro effects of ciprofloxacin and roxithromycin on apoptosis of jurkat T lymphocytes. Antimicrob Agents Chemother 47:1161–1164
   PubMed Web of Science ®Google Scholar
• Jurima-Romet M, Crawford K, Huang HS. (1994). Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes. Toxicol In Vitro 81:55–66
   Web of Science ®Google Scholar
• Kawadkar J, Pathak A, Kishore R, Chauhan MK. (2013). Formulation, characterization and in vitro-in vivo evaluation of flurbiprofen-loaded nanostructured lipid carriers for transdermal delivery. Drug Dev Ind Pharm 39:569–578
   PubMed Web of Science ®Google Scholar
• Kosecik M, Erel O, Sevinc E, Selek S. (2005). Increased oxidative stress in children exposed to passive smoking. Int J Cardiol 100:61–64
   PubMed Web of Science ®Google Scholar
• Kullich W, Klein G. (1986). Investigations of the influence of nonsteroidal antirheumatic drugs on the rates of sister-chromatid exchange. Mutat Res 174:131–134
   PubMed Web of Science ®Google Scholar
• Kusuhara H, Komatsu H, Sumichika H, Sugahara K. (1999). Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. Eur J Pharmacol 383:331–337
   PubMed Web of Science ®Google Scholar
• Labro MT. (1998). Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother 41:37–46
   PubMedGoogle Scholar
• Li J, Xue L, Hao H, et al. (2014). Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway. Tumor Biol 35:6467–6474
   PubMed Web of Science ®Google Scholar
• Masubuchi Y, Saito H, Horie T. (1998). Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther 287:208–213
   PubMed Web of Science ®Google Scholar
• Nakabeppu Y, Sakumi K, Sakamoto K, et al. (2006). Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids. Biol Chem 387:373–379
   PubMed Web of Science ®Google Scholar
• Nath N, Liu X, Jacobs L, Kashfi K. (2013). Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets beta-catenin. Drug Des Dev Ther 7:389–396
   PubMed Web of Science ®Google Scholar
• Niu G, Liao Z, Cai L, et al. (2008). The combined effects of celecoxib and minocycline hydrochloride on inhibiting the osseous metastasis of breast cancer in nude mice. Cancer Biother Radiopharm 23:469–476
   PubMed Web of Science ®Google Scholar
• Nivsarkar M, Banerjee A, Padh H. (2008). Cyclooxygenase inhibitors: a novel direction for Alzheimer's management. Pharmacol Rep 60:692–698
   PubMed Web of Science ®Google Scholar
• OECD. (1997). Test No. 473: in vitro mammalian chromosome aberration test. Amsterdam: OECD Publishing
   Google Scholar
• Rubin BK. (2004). Immunomodulatory properties of macrolides: overview and historical perspective. Am J Med 117:2S–4S
   PubMed Web of Science ®Google Scholar
• Simandan T, Sun J, Dix TA. (1998). Oxidation of DNA bases, deoxyribonucleosides and homopolymers by peroxyl radicals. Biochem J 335:233–240
   PubMed Web of Science ®Google Scholar
• Southern KW, Barker PM, Solis-Moya A, Patel L. (2012). Macrolide antibiotics for cystic fibrosis. Cochrane Database Syst Rev 11:CD002203
   PubMedGoogle Scholar
• Stadtman ER. (1992). Protein oxidation and aging. Science 257:1220–1224
   PubMed Web of Science ®Google Scholar
• Suksomtip M, Pongsamart S. (2008). Protective effect against oxidation of human low-density lipoprotein and plasmid DNA strand scission of Tamarind seed coat extract in vitro. LWT – Food Sci Technol 41:2002–2007
   Web of Science ®Google Scholar
• Tewari AK, Srivastava P, Singh VP, et al. (2010). Novel anti-inflammatory agents based on pyrazole based dimeric compounds; design, synthesis, docking and in vivo activity. Chem Pharm Bull (Tokyo) 58:634–638
   PubMed Web of Science ®Google Scholar
• Timocin T, Ila HB. (2015). Investigation of flurbiprofen genotoxicity and cytotoxicity in rat bone marrow cells. Drug Chem Toxicol 38:355–360
   PubMed Web of Science ®Google Scholar
• Timocin T, Ila HB, Dordu T, et al. (2016). Assessment of in vitro genotoxic and cytotoxic effects of flurbiprofen on human cultured lymphocytes. Drug Chem Toxicol 39:338–343
   PubMed Web of Science ®Google Scholar
• Ueno S, Aoki D, Kubo F, et al. (2005). Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Clin Cancer Res 11:5645–5650
   PubMed Web of Science ®Google Scholar
• Valko M, Izakovic M, Mazur M, et al. (2004). Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266:37–56
   PubMed Web of Science ®Google Scholar
• Watson N, Nimmo WS, Christian J, et al. (2000). Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 54:490–496
   PubMed Web of Science ®Google Scholar
• Yatsunami J, Fukuno Y, Nagata M, et al. (1999). Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells. Cancer Lett 147:17–24
   PubMed Web of Science ®Google Scholar
• Yavuz-Kocaman A, Rencuzogullari E, Ila HB, Topaktas M. (2008). The genotoxic effect of potassium metabisulfite using chromosome aberration, sister chromatid exchange, micronucleus tests in human lymphocytes and chromosome aberration test in bone marrow cells of rats. Environ Mol Mutagen 49:276–282
   PubMed Web of Science ®Google Scholar
• Yoshimura T, Kurita C, Yamazaki F, et al. (1995). Effects of roxithromycin on proliferation of peripheral blood mononuclear cells and production of lipopolysaccharide-induced cytokines. Biol Pharm Bull 18:876–881
   PubMed Web of Science ®Google Scholar
• Young RA, Gonzalez JP, Sorkin EM. (1989). Roxithromycin. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs 37:8–41
   PubMed Web of Science ®Google Scholar
• Yumru M, Savas HA, Kalenderoglu A, et al. (2009). Oxidative imbalance in bipolar disorder subtypes: a comparative study. Prog Neuropsychopharmacol Biol Psychiatry 33:1070–1074
   PubMed Web of Science ®Google Scholar
• Zielinska-Przyjemska M, Glowka FK, Klaczynska J. (2008). Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils. Chirality 202:159–165
   Web of Science ®Google Scholar