In vitro potential cytogenetic and oxidative stress effects of roxithromycin

References

• Aktan B, Taysi S, Gumustekin K, et al. (2003). Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion. Pol J Pharmacol 55:1105–1110
   PubMedGoogle Scholar
• Beausse J. (2004). Selected drugs in solid matrices: a review of environmental determination, occurrence and properties of principal substances. Trends Analyt Chem 23:753–761
   Web of Science ®Google Scholar
• Brutsch TM, Bucher P, Altmann KH. (2015). Total synthesis and biological assessment of mandelalide A. Chemistry 22:1292–1300
   PubMed Web of Science ®Google Scholar
• Choi Y, Koh SJ, Lee HS, et al. (2015). Roxithromycin inhibits nuclear factor kappaB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates experimental colitis in mice. Exp Biol Med (Maywood) 240:1664–1671
   PubMed Web of Science ®Google Scholar
• Dillehay LE, Thompson LH, Minkler JL, et al. (1983). The relationship between sister-chromatid exchange and perturbations in DNA replication in mutant EM9 and normal CHO cells. Mutat Res 109:283–296
   PubMed Web of Science ®Google Scholar
• el-Ashmawy IM, el-Nahas AF, Bayad AE. (2011). Teratogenic and cytogenetic effects of ivermectin and its interaction with P-glycoprotein inhibitor. Res Vet Sci 90:116–123
   PubMed Web of Science ®Google Scholar
• Erel O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277–285
   PubMed Web of Science ®Google Scholar
• Erel O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103–1111
   PubMed Web of Science ®Google Scholar
• Fenech M. (2000). The in vitro micronucleus technique. Mutat Res 455:81–95
   PubMed Web of Science ®Google Scholar
• Fenech M, Kirsch-Volders M, Natarajan AT, et al. (2011). Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. Mutagenesis 26:125–132
   PubMed Web of Science ®Google Scholar
• Gao X, Ray R, Xiao Y, et al. (2007). Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells. BMC Cell Biol 8:17
   PubMed Web of Science ®Google Scholar
• Harma M, Harma M, Erel O. (2003). Increased oxidative stress in patients with hydatidiform mole. Swiss Med Wkly 133:563–566
   PubMed Web of Science ®Google Scholar
• Hirano F, Takeda U. (1981). Evaluation of the mutagenicity of miokamycin (MOM), a new macrolide antibiotic in the Ames Salmonella test and the dominant lethal assay. J Antibiot (Tokyo) 34:443–446
   PubMed Web of Science ®Google Scholar
• Ila HB, Topaktas M. (1999). In vivo genotoxic effects of spiramycin in rat bone marrow cells. Cytologia 64:277–283
   Google Scholar
• Isidori M, Lavorgna M, Nardelli A, et al. (2005). Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci Total Environ 346:87–98
   PubMed Web of Science ®Google Scholar
• Jena G, Kaul C, Ramarao P. (2002). Genotoxicity testing, a regulatory requirement for drug discovery and development: impact of ICH guidelines. Indian J Pharmacol 34:86–99
   Google Scholar
• Kaufmann P, Haschke M, Torok M, et al. (2006). Mechanisms of venoocclusive disease resulting from the combination of cyclophosphamide and roxithromycin. Ther Drug Monit 28:766–774
   PubMed Web of Science ®Google Scholar
• Kayraldiz A, Donbak L, Yavuz Kocaman A, et al. (2015). Evaluation of possible genotoxic activity of dirithromycin in cultured human lymphocytes. J Toxicol 2015:535490
   PubMedGoogle Scholar
• Komatsu S, Miyazawa K, Moriya S, et al. (2012). Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. Int J Oncol 40:1029–1039
   PubMed Web of Science ®Google Scholar
• Kosecik M, Erel O, Sevinc E, et al. (2005). Increased oxidative stress in children exposed to passive smoking. Int J Cardiol 100:61–64
   PubMed Web of Science ®Google Scholar
• Lacaze E, Pedelucq J, Fortier M, et al. (2015). Genotoxic and immunotoxic potential effects of selected psychotropic drugs and antibiotics on blue mussel (Mytilus edulis) hemocytes. Environ Pollut 202:177–186
   PubMed Web of Science ®Google Scholar
• Mahmoodi M, Soleyman-Jahi S, Zendehdel K, et al. (2016). Chromosomal aberrations, sister chromatid exchanges, and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs. Drug Chem Toxicol [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Millrose M, Kruse M, Flick B, et al. (2009). Effects of macrolides on proinflammatory epitopes on endothelial cells in vitro. Arch Toxicol 83:469–476
   PubMed Web of Science ®Google Scholar
• Molinari G, Soloneski S, Reigosa MA, et al. (2009). In vitro genotoxic and cytotoxic effects of ivermectin and its formulation ivomec on Chinese hamster ovary (CHOK1) cells. J Hazard Mater 165:1074–1082
   PubMed Web of Science ®Google Scholar
• Nagai M, Yamada H, Nakada S, et al. (1995). A macrolide antibiotic, roxithromycin, inhibits the growth of human myeloid leukemia HL60 cells by producing multinucleate cells. Mol Cell Biochem 144:191–195
   PubMed Web of Science ®Google Scholar
• OECD Test No. 473. (1997) In vitro Mammalian Chromosome Aberration Test, OECD Publishing. Available from: http://www.oecd.org/chemicalsafety/testing/50108781.pdf [Accessed 8 March 2016]
   Google Scholar
• Qiu XH, Shao JJ, Mei JG, et al. (2016). Clarithromycin synergistically enhances thalidomide cytotoxicity in myeloma cells. Acta Haematol 135:103–109
   PubMed Web of Science ®Google Scholar
• Rocco L, Peluso C, Stingo V. (2012). Micronucleus test and comet assay for the evaluation of zebrafish genomic damage induced by erythromycin and lincomycin. Environ Toxicol 27:598–604
   PubMed Web of Science ®Google Scholar
• Rothfuss A, Schutz P, Bochum S, et al. (2000). Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60:390–394
   PubMed Web of Science ®Google Scholar
• Salvador-Reyes LA, Sneed J, Paul VJ, et al. (2015). Amantelides A and B, polyhydroxylated macrolides with differential broad-spectrum cytotoxicity from a Guamanian marine cyanobacterium. J Nat Prod 78:1957–1962
   PubMed Web of Science ®Google Scholar
• Schulz M, Hammerlein A, Hinkel U, et al. (2006). Safety and usage pattern of an over-the-counter ambroxol cough syrup: a community pharmacy-based cohort study. Int J Clin Pharmacol Ther 44:409–421
   PubMed Web of Science ®Google Scholar
• Sekeroglu V, Aksoy M, Atli Sekeroglu Z. (2016). Cytogenetic alterations in human lymphocyte cultures following exposure to ofloxacin. Drug Chem Toxicol [Epub ahead of print]
   Web of Science ®Google Scholar
• Singh P, Singh L, Mondal SC, et al. (2014). Erythromycin-induced genotoxicity and hepatotoxicity in mice pups treated during prenatal and postnatal period. Fundam Clin Pharmacol 28:519–529
   PubMed Web of Science ®Google Scholar
• Sono A, Oyaide K, Suzuki A, et al. (1989). [Mutagenicity studies of miporamicin]. Jpn J Antibiot 42:2506–2512
   PubMedGoogle Scholar
• Speit G, Haupter S. (1985). On the mechanism of differential Giemsa staining of bromodeoxyuridine-substituted chromosomes. II. Differences between the demonstration of sister chromatid differentiation and replication patterns. Hum Genet 70:126–129
   PubMed Web of Science ®Google Scholar
• Suke SG, Chahande AD, Kasliwal RH, et al. (2015). Roxithromycin potency quantification in pharmaceutical preparation by applying a validated bioassay method and comparison with HPLC analysis. Ann Pharm Fr 73:340–350
   PubMedGoogle Scholar
• Takahashi H, Hashimoto Y, Ishida-Yamamoto A, et al. (2005). Roxithromycin suppresses involucrin expression by modulation of activator protein-1 and nuclear factor-kappaB activities of keratinocytes. J Dermatol Sci 39:175–182
   PubMed Web of Science ®Google Scholar
• Timocin T, Ila HB, Dordu T, et al. (2016). Assessment of in vitro genotoxic and cytotoxic effects of flurbiprofen on human cultured lymphocytes. Drug Chem Toxicol 39:338–343
   PubMed Web of Science ®Google Scholar
• Tucker JD, Auletta A, Cimino MC, et al. (1993). Sister-chromatid exchange: second report of the Gene-Tox Program. Mutat Res 297:101–180
   PubMed Web of Science ®Google Scholar
• Ueno S, Aoki D, Kubo F, et al. (2005). Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Clin Cancer Res 11:5645–5650
   PubMed Web of Science ®Google Scholar
• Urasaki Y, Nori M, Iwata S, et al. (2005). Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages. J Rheumatol 32:1765–1774
   PubMed Web of Science ®Google Scholar
• Viluksela M, Vainio PJ, Tuominen RK. (1996). Cytotoxicity of macrolide antibiotics in a cultured human liver cell line. J Antimicrob Chemother 38:465–473
   PubMed Web of Science ®Google Scholar
• Wang P, Qi M, Jin X. (2005). Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectrometry. J Pharm Biomed Anal 39:618–623
   PubMed Web of Science ®Google Scholar
• Wilson DM, 3rd Thompson LH. (2007). Molecular mechanisms of sister-chromatid exchange. Mutat Res 616:11–23
   PubMed Web of Science ®Google Scholar
• Yatsunami J, Fukuno Y, Nagata M, et al. (1999). Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells. Cancer Lett 147:17–24
   PubMed Web of Science ®Google Scholar
• Young RA, Gonzalez JP, Sorkin EM. (1989). Roxithromycin. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs 37:8–41
   PubMed Web of Science ®Google Scholar
• Yumru M, Savas HA, Kalenderoglu A, et al. (2009). Oxidative imbalance in bipolar disorder subtypes: a comparative study. Prog Neuropsychopharmacol Biol Psychiatry 33:1070–1074
   PubMed Web of Science ®Google Scholar