In vitro genotoxic and cytotoxic effects of some paraben esters on human peripheral lymphocytes

References

• Al-Gubory, K.H., 2014. Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reproductive BioMedicine Online, 29, 17–31.
   PubMed Web of Science ®Google Scholar
• Alam, M.S., et al., 2014. Single administration of butylparaben induces spermatogenic cell apoptosis in prepubertal rats. Acta Histochemica, 116, 474–480.
   PubMed Web of Science ®Google Scholar
• Albertini, R.J., et al., 2000. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans International Programme on Chemical Safety. Mutation Research, 463, 111–172.
   PubMed Web of Science ®Google Scholar
• Andersen, F.A., 2008. Final amended report on the safety assessment of methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, and benzylparaben as used in cosmetic products. International Journal of Toxicology, 27 (4), 1–82.
   Google Scholar
• Barr, L., et al., 2012. Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum. Journal of Applied Toxicology, 32, 219–232.
   PubMed Web of Science ®Google Scholar
• Bledzka, D., Gromadzinska, J., and Wasowicz, W., 2014. Parabens. From environmental studies to human health. Environment International, 67, 27–42.
   PubMed Web of Science ®Google Scholar
• Byford, J.R., et al., 2002. Oestrogenic activity of parabens in MCF7 human breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology, 80, 49–60.
   PubMed Web of Science ®Google Scholar
• Boberg, J., et al., 2010. Possible endocrine disrupting effects of parabens and their metabolites. Reproductive Toxicology, 30, 301–312.
   PubMed Web of Science ®Google Scholar
• Boffetta, P., et al., 2007. Chromosomal aberrations andcancer risk: results of a cohort study from Central Europe. American Journal of Epidemiology, 165 (1), 36–43.
   PubMed Web of Science ®Google Scholar
• Bonassi, S., et al., 2010. Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis, 26, 93–100.
   Web of Science ®Google Scholar
• Braun, J.M., et al., 2014. Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. Journal of Exposure Science & Environmental Epidemiology, 24 (5), 459–466.
   PubMed Web of Science ®Google Scholar
• Chandirasekar, R., et al., 2014. Assessment of genotoxic and molecular mechanisms of cancer risk in smoking and smokeless tobacco users. Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 767, 21–27.
   PubMed Web of Science ®Google Scholar
• Charnock, C., and Finsrud, T., 2007. Combining esters of para-hydroxy benzoic acid (parabens) to achieve increased antimicrobial activity. Journal of Clinical Pharmacy and Therapeutics, 32, 567–572.
   PubMed Web of Science ®Google Scholar
• Charles, A.K., and Darbre, P.D., 2013. Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF-7 human breast cancer cells. Journal of Applied Toxicology, 33, 390–398.
   PubMed Web of Science ®Google Scholar
• Chen, J., et al., 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicology and Applied Pharmacology, 221, 278–284.
   PubMed Web of Science ®Google Scholar
• Chen, F.P., Chien, M.H., and Chern, I.Y., 2016. Impact of low concentrations of phthalates on the effects of 17β-estradiol in MCF-7 breast cancer cells. Taiwan Journal of Obstetrics and Gynecology, 55, 826–834.
   PubMed Web of Science ®Google Scholar
• Chianese, R., et al., 2016. Kisspeptins, estrogens and male fertility. Current Medicinal Chemistry, 23, 4070–4091.
   PubMed Web of Science ®Google Scholar
• Cosmetic Ingredient Review Expert Panel, 2008. Final amended report on the safety assessment of methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben and benzylparaben as used in cosmetic products. International Journal of Toxicology, 27, 1–82.
   Web of Science ®Google Scholar
• Danish MOE (Danish Ministry of the Environment), 2011. Statutory Order Amending the Statutory Order on Cosmetic Products (Amendment to Annex5). Danish Ministry of the Environment.
   Google Scholar
• Darbre, P.D., et al., 2004. Concentrations of parabens in human breast tumours. Journal of Applied Toxicology, 24, 5–13.
   PubMed Web of Science ®Google Scholar
• Darbre, P.D., et al., 2002. Oestrogenic activity of isobutylparaben in vitro and in vivo. Journal of Applied Toxicology, 22, 219–226.
   PubMed Web of Science ®Google Scholar
• Darbre, P.D., and Harvey, P.W., 2008. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Journal of Applied Toxicology, 28, 561–578.
   PubMed Web of Science ®Google Scholar
• European Commission, 2014. Commission regulation (EUa) no 358/2014 of 9 April 2014 amending annexes II and V to regulation (EC) No 1223/2009 of the European parliament and of the council on cosmetic products. Official Journal of the European Union, 107, 5–9.
   Google Scholar
• Evans, H. J., 1984. Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests. In: B.J. Kilbey, M. Legator, W. Nichols and C. Ramel, eds. Handbook of mutagenicity test procedures, 2nd ed. Amsterdam: Elsevier Sciences, 405–427.
   Google Scholar
• Fenech, M., 1993. The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environmental Health Perspectives Supplements, 3, 101–107.
   Google Scholar
• Fenech, M., 2000. The in vitro micronucleus technique. Mutation Research, 455, 81–95.
   PubMed Web of Science ®Google Scholar
• Fenech, M., et al., 2011. The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells–past, present and future. Mutagenesis, 26, 239–245.
   PubMed Web of Science ®Google Scholar
• Fenech, M., Nersesyan, A., and Knasmueller, S., 2016. Review A systematic review of the association between occupational exposure to formaldehyde and effects on chromosomal DNA damage measured using the cytokinesis-block micronucleus assay in lymphocytes. Mutation Research, 770, 46–57.
   PubMed Web of Science ®Google Scholar
• Food and drug administration (FDA) 2016. Parabens in Cosmetics.
   Google Scholar
• Frederiksen, H., et al., 2008. Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than inmaternal plasma after subcutaneous administration. Toxicological Sciences, 106, 376–383.
   PubMed Web of Science ®Google Scholar
• Frederiksen, H., Jørgensen, N., and Andersson, A.M., 2011. Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Journal of Exposure Science & Environmental Epidemiology, 21, 262–271.
   PubMed Web of Science ®Google Scholar
• Golden, R., Gandy, J., and Vollmer, G., 2005. A review of the endocrine activity of parabens and implications for potential risks to human health. Critical Reviews in Toxicology, 35, 435–458.
   PubMed Web of Science ®Google Scholar
• Grześkowiak, T., Czarczynska-Goslinska, B., and Zgoła-Grześkowiak, A., 2016. Current approaches in sample preparation for trace analysis of selected endocrine disrupting compounds: focus on polychlorinated biphenyls, alkylphenols, and parabens. TrAC Trends in Analytical Chemistry, 75, 209–226.
   Web of Science ®Google Scholar
• Güzel Bayülken, D., et al., 2017. Investigation of genotoxic effects of paraben in cultured human lymphocytes. Drug and Chemical Toxicology. DOI: 10.1080/01480545.2017.1414834
   PubMed Web of Science ®Google Scholar
• Güzel Bayülken, D., et al., 2018. Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates. Cytotechnology. https://doi.org/10.1007/s10616-018-0187-7
   PubMed Web of Science ®Google Scholar
• Hu, Y., et al., 2013. The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats. Food and Chemical Toxicology, 53, 69–74.
   PubMed Web of Science ®Google Scholar
• Jiménez-Díaz, I., et al., 2011. A new liquid chromatography–tandem mass spectrometry method for determination of parabens in human placental tissue samples. Talanta, 84, 02–09.
   Web of Science ®Google Scholar
• Kang, S., et al., 2013. Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers. Science of the Total Environment, 461–462, 214–221.
   PubMed Web of Science ®Google Scholar
• Karpuzoglu, E., Holladay, S.D., and Gogal, R.M., 2013. Parabens: potential impact of low affinity estrogen receptor binding chemicals on human health. Journal of Toxicology and Environmental Health B Critical Reviews, 16, 321–335.
   PubMed Web of Science ®Google Scholar
• Khanala, T., et al., 2012. Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures. Toxicology Letters, 213, 174–183.
   PubMed Web of Science ®Google Scholar
• Khanna, S., Dash, P.R., and Darbre, P.D., 2014. Exposure to parabens at the concentration of maximal proliferative response increases migratory and invasive activity of human breast cancer cells in vitro. Journal of Applied Toxicology, 34, 1051–1059.
   PubMed Web of Science ®Google Scholar
• Kim, M.J., et al., 2015. Toxicological evaluation of isopropylparaben and isobutylparaben mixture in Spraguee Dawley rats following 28 days of dermal exposure. Regulatory Toxicology and Pharmacology, 73, 544–551.
   PubMed Web of Science ®Google Scholar
• Kirchhof, M.G., and de Gannes, G.C., 2013. The health controversies of parabens. Skin Therapy Letter, 18, 5–7.
   PubMedGoogle Scholar
• Liou, S.H., et al., 2002. The association between frequencies of mitomycin C-induced sister-chromatid exchange and cancer risk in arseniasis. Toxicology Letters, 129, 237–243.
   PubMed Web of Science ®Google Scholar
• Meeker, J.D., et al., 2011. Urinary concentrations of parabens and serum hormone levels semen quality parameters, and sperm DNA damage. Environmental Health Perspectives, 119, 252–257.
   PubMed Web of Science ®Google Scholar
• Morisseau, C., and Hammock, B.D., 2013. Impact of soluble epoxide hydrolase andepoxyeicosanoids on human health. Annual Review of Pharmacology and Toxicology, 53, 37–58.
   PubMed Web of Science ®Google Scholar
• Nakagawa, Y., and Moldeus, P., 1998. Mechanism of p-hydroxybenzoate ester-induced mitochondrial dysfunction and cytotoxicity in isolated rat hepatocytes. Biochemical Pharmacology, 55, 1907–1914.
   PubMed Web of Science ®Google Scholar
• Nakagawa, Y., et al., 1999. p-Hydroxybenzoate alkyl esters cause cytotoxicity via mitochondrial dysfunction in isolated rat hepatocytes. Tokyo Toritsu Eisei Kenkyusho Kenkyu Nenpo, 49, 297–301.
   Google Scholar
• OECD 2014. OECD Guideline for the testing of chemicals. In vitro mammalian cell micronucleus test. TG 487, 26 September 2014.
   Google Scholar
• Perez Martin, J.M., et al., 2010. Oxidative DNA damage contributes to the toxic activity of propylparaben in mammalian cells. Mutation Research, 702, 86–91.
   PubMed Web of Science ®Google Scholar
• Perez Martin, J.M., et al., 2014. The antioxidant butylated hydroxyanisole potentiates the toxic effects of propylparaben in cultured mammalian cells. Food and Chemical Toxicology, 72, 195–203.
   PubMed Web of Science ®Google Scholar
• Perry, P. E., and Thompson, E. J., 1984. The methodology of sister chromatid exchanges. In: B.J. Kilbey, M. Legator, W. Nichols and C. Ramel, eds. Handbook of mutagenicity test procedures. 2nd ed. Amsterdam: Elsevier Sciences, 495–529.
   Google Scholar
• Rencüzoğulları, E., et al., 2004. Genotoxicity of aspartame. Drug Chemical Toxicology, 27, 257–268.
   PubMed Web of Science ®Google Scholar
• Roszak, J., et al., 2017. Genotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with aluminium chloride, butylparaben or di-n-butylphthalate. Toxicology in Vitro, 45, 181–193.
   PubMed Web of Science ®Google Scholar
• Russo, J., and Russo, I.H., 2006. The role of estrogen in the initiation of breast cancer. Journal of Steroid Biochemistry and Molecular Biology, 102, 89–96.
   PubMed Web of Science ®Google Scholar
• Sandanger, T.M., et al., 2011. Plasma concentrations of parabens in postmenopausal women and self-reported use of personal care products: the NOWAC postgenome study. Journal of Exposure Science & Environmental Epidemiology, 21, 595–600.
   PubMed Web of Science ®Google Scholar
• Santovito, A., Cervella, P., and Delpero, M., 2014. Increased frequency of chromosomal aberrations and sister chromatid exchanges in peripheral lymphocytes of radiology technicians chronically exposed to low levels of ionizing radiations. Environmental Toxicology and Pharmacology, 37, 396–403.
   PubMed Web of Science ®Google Scholar
• Satoh, K., et al., 2005. Androgenic and antiandrogenic effects of alkylphenols and parabens assessed using the reporter gene assay with stably transfected CHO-K1 cells (AR-Eco-Screen system). Journal of Health Science, 51, 557–568.
   Google Scholar
• Schlumpf, M., et al., 2010. Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics. Chemosphere, 81, 1171–1183.
   PubMed Web of Science ®Google Scholar
• Schulster, M., Bernie, A., and Ramasamy, R., 2016. The role of estradiol in male reproductive function. Asian Journal of Andrology, 18, 1–6.
   Web of Science ®Google Scholar
• SCCS, 2013. Scientific Committee on Consumer Safety. 2013. Opinion on Parabens. Updated Request for a Scientific Opinion on Propyl- and Butylparaben (Adopted by the SCCS by written procedure on 3 May 2013).
   Google Scholar
• Sebastia, N., et al., 2014. Sister chromatid exchange, (SCE), high-frequency cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers. Food and Chemical Toxicology, 66, 107–112.
   PubMed Web of Science ®Google Scholar
• SCCS, 2011. Scientific Committee on Consumer Safety Parabens Opinion on Parabens- SCCS/1348/10.
   Google Scholar
• Shen, H.Y., et al., 2007. Simultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC-DAD and GC–MS methods. Journal of Separation Science, 30, 48–54.
   PubMed Web of Science ®Google Scholar
• Soni, M., et al., 2001. Safety assessment of propyl paraben: a review of the published literature. Food and Chemical Toxicology, 39, 513–532.
   PubMed Web of Science ®Google Scholar
• Soni, M.G., Carabin, I.G., and Burdock, G.A., 2005. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43, 985–1015.
   PubMed Web of Science ®Google Scholar
• Speit, G., and Haupter, S., 1985. On the mechanisms of differential giemsa staining of bromodeoxyuridine-substituted chromosomes. II Differences between the demonstration of sister chromatid differentiation and replication patterns. Human Genetics, 70, 126–129.
   PubMed Web of Science ®Google Scholar
• Surralles, J., et al., 1995. The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair. Mutation Research, 342, 43–59.
   PubMed Web of Science ®Google Scholar
• Taxvig, C., et al., 2012. Differential effects of environmental chemicals and food contaminants on adipogenesis, biomarker release and PPAR gamma activation. Molecular and Cellular Endocrinology, 361, 106–115.
   PubMed Web of Science ®Google Scholar
• Tayama, S., Nakagawa, Y., and Tayama, K., 2008. Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells. Mutation Research, 649, 114–125.
   PubMed Web of Science ®Google Scholar
• Yılmaz, E.A., Ünal, F., and Yuzbasioglu, D., 2017. Evaluation of cytogenetic and DNA damage induced by the antidepressant drug-active ingredients, trazodone and milnacipran, in vitro. Drug Chemical Toxicology, 40, 57–66.
   PubMed Web of Science ®Google Scholar
• Yoon, K., et al., 2014. Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases. Journal of Toxicology and Environmental Health Critical Review, 17 (3), 127–174.
   PubMed Web of Science ®Google Scholar
• Wróbel, A.M., and Gregoraszczuk, E.L., 2014. Actions of methyl-, propyl- and butylparaben on estrogen receptor-a and -b and the progesterone receptor in MCF-7 cancer cells and non-cancerous MCF-10A cells. Toxicology Letters, 230, 375–381.
   PubMed Web of Science ®Google Scholar
• Zhang, Q.L., et al., 2005. High-performance liquid chromatographic assay of parabens in wash-off cosmetic products and foods using chemiluminescence detection. Analytica Chimica Acta, 537, 31–39.
   Web of Science ®Google Scholar