Analysis of bioactive components in Ghost chili (Capsicum chinense) for antioxidant, genotoxic, and apoptotic effects in mice

References

• Abraham, S.K. and Khandelwal, N., 2013. Ascorbic acid and dietary polyphenol combinations protect against genotoxic damage induced in mice by endogenous nitrosation. Mutation Research, 757 (2), 167–172.
   PubMed Web of Science ®Google Scholar
• Adams, J.M. and Cory, S., 2007. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 26 (9), 1324–1337.
   PubMed Web of Science ®Google Scholar
• Aebi, H., 1984. Catalase in vitro. In: S.P. Colowick, N.O. Kaplan, eds. Methods in enzymology. New York: Academic Press, Vol. 105, 121–126.
   Google Scholar
• Aguilera, Y., Martin-Cabrejas, M.A., and González de Mejia, E., 2016. Phenolic compounds in fruits and beverages consumed as part of the Mediterranean diet: their role in prevention of chronic diseases. Phytochemistry Reviews, 15 (3), 405–423.
   Web of Science ®Google Scholar
• Benzie, I.F. and Strain, J.J., 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power: the FRAP assay”. Analytical Biochemistry, 239 (1), 70–76.
   PubMed Web of Science ®Google Scholar
• Bertao, M.R., 2016. Cytotoxicity, genotoxicity and antioxidant activity of extracts from Capsicum spp. Research Journal of Medicinal Plants, 10 (4), 265–275.
   Google Scholar
• Blondet, N.M., et al., 2018. Mechanisms of hepatocyte detoxification. In Physiology of the Gastrointestinal Tract, 6th ed., 981–1001.
   Google Scholar
• Boeing, H., et al., 2012. Critical review: vegetables and fruit in the prevention of chronic diseases. European Journal of Nutrition, 51 (6), 637–663.
   PubMed Web of Science ®Google Scholar
• Bradford, M.M., 1976. A dye binding assay for protein. Analytical Biochemistry, 72 (1–2), 248–254.
   PubMed Web of Science ®Google Scholar
• Carlberg, I. and Mannervik, B., 1985. Glutathione reductase. Methods in enzymology, Academic Press, New York, Vol. 113, 484–490.
   Google Scholar
• Cho, S., Lee, H., and Choi, B.Y., 2017. An updated review on molecular mechanisms underlying the anticancer effects of capsaicin. Food Science and Biotechnology, 26 (1), 1–13.
   PubMed Web of Science ®Google Scholar
• Choi, C.H., Jung, Y.K., and Oh, S.H., 2010. Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis. Molecular Pharmacology, 78 (1), 114–125.
   PubMed Web of Science ®Google Scholar
• Dubey, R.K., et al., 2015. Assessment of phytochemical composition and antioxidant potential in some indigenous chilli genotypes from North East India. Food Chemistry, 188, 119–125.
   PubMed Web of Science ®Google Scholar
• Ertani, A., et al., 2014. Capsicum chinensis L. growth and nutraceutical properties are enhanced by biostimulants in a long-term period: chemical and metabolomic approaches. Frontiers in Plant Science, 5, 1–12.
   Web of Science ®Google Scholar
• Gajalakshmi, C.K. and Shanta, V., 1996. Lifestyle and risk of stomach cancer: a hospital-based case-control study. International Journal of Epidemiology, 25 (6), 1146–1153.
   PubMed Web of Science ®Google Scholar
• Golynski, M., et al., 2015. Systemic and local effects of intragastric administration of the Habanero fruit (Capsicum chinense Jacquin c.v.) in rats. Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society, 66 (2), 259–265.
   PubMed Web of Science ®Google Scholar
• Guertin, K.A., et al., 2014. Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations. The American Journal of Clinical Nutrition, 100 (1), 208–217.
   PubMed Web of Science ®Google Scholar
• Guinness Book of World Records 2006. Hottest Spice. www.guinnessworldrecords.com.
   Google Scholar
• Habig, W.H., Pabst, M.J., and Jacoby, W.B., 1974. Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249, 7129–7130.
   Web of Science ®Google Scholar
• Hanahan, D. and Weinberg, R.A., 2011. Hallmarks of cancer: the next generation. Cell, 144 (5), 646–674.
   PubMed Web of Science ®Google Scholar
• Kanki, K., et al., 2003. A 13-week subchronic toxicity study of paprika color in F344 rats. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 41 (10), 1337–1343.,
   PubMed Web of Science ®Google Scholar
• Kasibhatla, S., 2006. Acridine Orange/Ethidium Bromide (AO/EB) staining to detect apoptosis. Cold Spring Harbor Protocols, 2006 (21), 4493–4493.
   Google Scholar
• Kowalczyk, M.C., et al., 2010. Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice. Cancer Prevention Research, 3 (2), 170–178.
   PubMed Web of Science ®Google Scholar
• Lee, J.C., et al., 2002. Antioxidant property of an ethanol extract of the stem of Opuntia ficus-indica var. Journal of Agricultural and Food Chemistry, 50 (22), 6490–6496.
   PubMed Web of Science ®Google Scholar
• Lewinska, A., et al., 2015. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells. Mutation Research, 779, 23–34.
   Web of Science ®Google Scholar
• Livak, K.J. and Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, California), 25 (4), 402–408.
   PubMed Web of Science ®Google Scholar
• Marklund, S. and Marklund, G., 1974. Involvement of superoxide anion radical in autooxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47 (3), 469–474.
   PubMedGoogle Scholar
• Mayne, S.T., Playdon, M.C., and Rock, C.L., 2016. Diet, nutrition, and cancer: past, present and future. Nature Reviews. Clinical Oncology, 13 (8), 504–515.
   PubMed Web of Science ®Google Scholar
• Meghvansi, M.K., et al., 2010. Naga chilli: A potential source of capsaicinoids with broad-spectrum ethnopharmacological applications. Journal of Ethnopharmacology, 132 (1), 1–14.
   PubMed Web of Science ®Google Scholar
• Mihara, K. and Sato, R., 1972. Partial purification of NADH-cytochrome b 5 reductase from rabbit liver microsomes with detergents and its properties. Journal of Biochemistry, 71 (4), 725–735.
   PubMed Web of Science ®Google Scholar
• Moron, M., Depierre, J., and Mannervik, B., 1979. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochimica Et Biophysica Acta, 582 (1), 67–78.
   PubMed Web of Science ®Google Scholar
• Omura, T., and Takesue, S., 1970. A new method for simultaneous purification of cytochrome b5 and NADPH cytochrome c reductase from rat liver microsomes. The Journal of Biochemistry, 67 (2), 249–257.
   PubMed Web of Science ®Google Scholar
• Oren, M., 2003. Decision making by p53: life, death and cancer. Cell Death and Differentiation, 10 (4), 431–442.
   PubMed Web of Science ®Google Scholar
• Rossé, T., et al., 1998. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature, 391 (6666), 496–499.
   PubMed Web of Science ®Google Scholar
• Roy, A., 2016. Bhut Jolokia (Capsicum chinense Jaqc): a review. International Journal of Pharmaceutical Sciences and Research, 7, 882–889.
   Web of Science ®Google Scholar
• Sarpras, M., et al., 2016. Comparative analysis of fruit metabolites and pungency candidate genes expression between Bhut Jolokia and other Capsicum species. PLoS One, 11 (12), e0167791.
   PubMed Web of Science ®Google Scholar
• Saunders, F.R. and Wallace, H.M., 2010. On the natural chemoprevention of cancer. Plant Physiology and Biochemistry, 48 (7), 621–626.
   PubMed Web of Science ®Google Scholar
• Schauer, N., Zamir, D., and Fernie, A.R., 2004. Metabolic profiling of leaves and fruit of wild species tomato: a survey of the Solanum lycopersicum complex. Journal of Experimental Botany, 56 (410), 297–307.
   PubMed Web of Science ®Google Scholar
• Schmid, W., 1975. The micronucleus test. Mutation Research, 31 (1), 9–15.
   PubMed Web of Science ®Google Scholar
• Sora, G.T.S., et al., 2015. A comparative study of the capsaicinoid and phenolic contents and in vitro antioxidant activities of the peppers of the genus Capsicum: an application of chemometrics. Journal of Food Science and Technology, 52 (12), 8086–8094.
   PubMed Web of Science ®Google Scholar
• Srinivasan, K., 2016. Biological activities of red pepper (Capsicum annuum) and its pungent principle capsaicin: a review. Critical Reviews in Food Science and Nutrition, 56 (9), 1488–1500.
   PubMed Web of Science ®Google Scholar
• Surh, Y.J. and Lee, S.S., 1996. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 34 (3), 313–316.
   PubMed Web of Science ®Google Scholar
• Surh, Y.J., 2003. Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer, 3 (10), 768–780.
   PubMed Web of Science ®Google Scholar
• Varshney, R. and Kale, R.K., 1990. Effects of calmodulin antagonists on radiation induced lipid peroxidation in microsomes. International Journal of Radiation Biology, 58 (5), 733–743.
   PubMed Web of Science ®Google Scholar
• Wahyuni, Y., et al., 2013. Secondary metabolites of Capsicum species and their importance in the human diet. Journal of Natural Products, 76 (4), 783–793.
   PubMed Web of Science ®Google Scholar
• Zimmer, A.R., et al., 2012. Long-term oral administration of Capsicum baccatum extracts does not alter behavioral, hematological, and metabolic parameters in CF1 mice. Evidence-Based Complementary and Alternative Medicine, 2012, 1–9.
   Web of Science ®Google Scholar