249
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

An in vitro investigation of genotoxic effects of dexketoprofen trometamol on healthy human lymphocytes

&
Pages 174-181 | Received 12 Mar 2018, Accepted 22 May 2018, Published online: 27 Jul 2018

References

  • Albertini, R.J., et al., 2000. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. Mutation Research, 463 (2), 111–172.
  • Aykaç, E., 2010. Spinal Anestezi Altındaki Elektif Sezaryen Olgularında İv Deksketoprofen Trometamolün Postoperatif Analjezik Etkinliğinin Lornoksikam Ve Plasebo İle Karşılattırılması. Kırıkkale Üniversitesi Tıp Fakültesi Uzmanlık Tezi, Kırıkkale
  • Aykaç, E., et al., 2012. Sezaryen İle Doğum Sonrası Ağrıda Deksketoprofen Trometamolün Analjezik Etkisinin Lornoksikam Ve Plasebo İle Karşılaştırılması. Journal of Anesthesia, 20 (2), 80–85.
  • Barbanoj, M.J., Antonijoan, R.M., and Gich, I., 2001. Clinical pharmacokinetics of dexketoprofen. Clinical Pharmacokinetics, 40 (4), 245–262.
  • Botting, R., and Ayoub, S.S., 2005. COX-3 and the mechanism of action of paracetamol/acetaminophen. Prostaglandins, Leukotrienes, and Essential Fatty Acids , 72 (2), 85–87.
  • Dannhardt, G., and Kiefer, W., 2001. Cyclooxygenase inhibitors – current status and future prospects. European Journal of Medicinal Chemistry, 36 (2), 109–126.
  • Dannhardt, G., and Laufer, S., 2000. Structural approaches to explain the selectivity of COX-2 inhibitors: is there a common pharmacophore? Current Medicinal Chemistry, 7 (11), 1101–1112.
  • Dikici, S., et al., 2012. İlk Basamak Sağlık Merkezine Başvuran Hastalarda Baş Ağrısının Özellikleri Ve Etkili Olabilecek Etmenlerin Belirlenmesi. Dicle Tıp Dergisi, 39 (1), 35–41.
  • Fenech, M., 2000. The in vitro micronucleus technique. Mutation Research, 455 (1–2), 81–95.
  • Fenech, M., 2007. Cytokinesis-block micronucleus cytoma assay. Nature Protocols, 2 (5), 1084–1104.
  • Fenech, M., 1993. The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environmental Health Perspectives Supplements, 101, 101–107.
  • Flower, R.J., 2003. The development of COX2 inhibitors. Nature Reviews. Drug Discovery, 2 (3), 179–186.
  • Francis, B., 2004. COX-3: fact or fancy? Joint Bone Spine. Revue du Rhumatisme, 71 (6), 451–453.
  • Hacıbeyoğlu, G., 2013. Tavşan Diz Eklemine Enjekte Edilen Deksketoprofen Trometamolün Histopatolojik Ve Biyokimyasal Etkilerinin Araştırılması, Konya
  • Hanna, M.H., et al., 2003. Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen trometamol with ketoprofen or placebo after major orthopaedic surgery. British Journal of Clinical Pharmacology, 55 (2), 126–133.
  • İnan, N., et al., 2009. Total Kalça Protezi Operasyonlarında İki Multimodal Analjezi Yönteminin Etkinliği. Ağrı, 21 (2), 69–74.
  • Iohom, G., et al., 2002. Effect of perioperative administration of dexketoprofen on opioid requirements and inflammatory response following elective hip arthroplasty. British Journal of Anaesthesia, 88 (4), 520–526.
  • Jackson, I.D., et al., 2004. Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry . British Journal of Anaesthesia, 92 (5), 675–680.
  • Koç, E., 2010. Küçük Hücreli Olmayan Akciğer Kanserlerinde “Excısıon Repaır Cross-Complementıng Group 1” (Ercc1) Geni T19007c Ve C8092a Tek Nükleotid Polimorfizmlerinin Klinikopatolojik Parametrelerle İlişkilerinin Belirlenmesi, Pamukkale Üniversitesi Sağlık Bilimleri Enstitüsü Yüksek Lisans Tezi Tıbbi Biyoloji Anabilim Dalı, Denizli.
  • Leval, X., et al., 2002. New trends in dual 5-LOX/COX inhibition. Current Medicinal Chemistry, 9 (9), 941–962.
  • Mauleon, D., et al., 1996. Preclinical and clinical development of dexketoprofen. Drugs, 52 (Supplement 5), 24–46.
  • Meek, I.L., Mart, A.F., and Vonkeman, H.E., 2010. Non-steroidal antiinflammatory drugs: an overview of cardiovascular risks. Pharmaceuticals, 3, 2146–2162.
  • Moore, R.A., and Barden, J., 2008. Systematic review of dexketoprofen in acute and chronic pain. BMC Clinical Pharmacology, 8, 11.
  • Mpountoukas, P., et al., 2010. Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine. Food and Chemical Toxicology, 48 (10), 2934–2944.
  • Öner, S.F., 2010. Ortopedik Alt Ekstremite Cerrahisinde, Postoperatif Analjezi İçin İntravenöz Verilen Deksketoprofen Trometamol “Un Optimal Dozunun Araştırılması. Fırat Üniversitesi Tıp Fakültesi Anesteziyoloji Ve Reanimasyon Anabilim Dalı Uzmanlık Tezi, Elazığ
  • Ramírez, E., et al., 2013. Drug-induced life-threatening potassium disturbances detected by a pharmacovigilance program from laboratory signals. European Journal of Clinical Pharmacology, 69 (1), 97–110.
  • Sağir, Ö., et al., 2013. Evaluation of the effects of dexketoprofen trometamol on knee joınt: an in vivo & in vitro study, Balikesir, Turkey. Indian Journal of Medical Research, 138, 912–918.
  • Sancher, C.J., et al., 2007. Comparison of intravenous dexketoprofen and dipyrone in acute renal colic. European Journal of Clinical Pharmacology, 63, 751–760.
  • Sav, T., et al., 2012. Single-dose-dexketoprofen-induced acute kidney injury due to massive rhabdomyolysis. International Urology and Nephrology, 44 (5), 1581–1583.
  • Tuncer, S., et al., 2003. Adding ketoprofen to intravenous patient-controlled analgesia with tramadol after major gynecological cancer surgery: a double-blinded, randomized, placebo-controlled clinical trial . European Journal of Gynaecological Oncology, 24 (2), 181–184.
  • Turini, E.M., and Dubois, R.N., 2002. Cyclooxygenase-2: a therapeutic target. Annual Review of Medicine, 53, 35–57.
  • Vane, J.R., and Botting, R.M., 2003. The mechanism of action of aspirin. Thrombosis Research , 110 (5–6), 255–258.
  • Yentür, E.A., 2006. Nonsteroid antienflamatuar ilaçlar. I. Ağrı Bülten, 1, 1.
  • Zabala, S., et al., 2008. Neutropenia, thrombocytopenia and hepatic injury associated with dexketoprofen trometamol therapy in a previously healthy 35-year-old woman. Journal of Clinical Pharmacy and Therapeutics, 33 (1), 79–81.
  • Zegpi, C., et al., 2009. The effect of opioid antagonists on synergism between dexketoprofen and tramadol. Pharmacological Research, 60 (4), 291–295.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.