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Research Articles

Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model

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Pages 335-346 | Received 09 Feb 2018, Accepted 11 Jun 2018, Published online: 26 Sep 2018

References

  • Anderson, P.D., 2012. Emergency management of chemical weapons injuries. Journal of Pharmacy Practice, 25 (1), 61–68.
  • Anumolu, S.S., et al., 2011. Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. Biomaterials, 32 (4), 1204–1217.
  • Billack, B., et al., 2010. Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs in S. cerevisiae cultures. Journal of Enzyme Inhibition and Medicinal Chemistry, 25 (3), 312–317.
  • Brinkley, F. B., et al., 1989. The mouse ear model as an in vivo bioassay for the assessment of topical mustard (HD) injury. In Proceedings of the 1989 Medical Defense Review, 15–17 August 1989 US. Aberdeen Proving Ground: MD, 595–602.
  • Brodsky, B., et al., 2008. From topical antidote against skin irritants to a novel counter-irritating and anti-inflammatory peptide. Toxicology and Applied Pharmacology, 229 (3), 342–350.
  • Casillas, R.P., Mitcheltree, L.W., and Stemler, F.W., 1997. The mouse ear model of cutaneous sulfur mustard injury. Toxicology Mechanisms and Methods, 7 (4), 381–397.
  • Casillas, R.P., et al., 2000. Therapeutic approaches to dermatotoxicity by sulfur mustard I. modulation of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model. Journal of Applied Toxicology, 20, S145–S151.
  • Cassagnol, M., and McBride, A., 2009. Management of chemotherapy extravasations. U.S. Clinical Pharmacist, 34 (9), 3–11.
  • Chang, Y., et al., 2013. Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicology and Applied Pharmacology, 268 (2), 178–187.
  • Chang, Y.C., et al., 2014. Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicology and Applied Pharmacology, 280 (2), 236–244.
  • Composto, G.M., et al., 2016. Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Experimental and Molecular Pathology, 100 (3), 522–531.
  • Crater, J., and Kannan, S., 2007. Molecular mechanism of nitrogen mustard induced leukocyte(s) chemotaxis. Medical Hypotheses, 68 (2), 318–319.
  • Dachir, S., et al., 2002. Potential anti-inflammatory treatments against cutaneous sulfur mustard injury using the mouse ear vesicant model. Human and Experimental Toxicology, 21 (4), 197–203.
  • Debiak, M., Kehe, K., and Bürkle, A., 2009. Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity. Toxicology, 263 (1), 20–25.
  • Gordon, M.K., et al., 2016. The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies. Annals of the New York Academy of Sciences, 1378 (1), 158–165.
  • Goswami, D.G., et al., 2018. Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicology Letters, 293, 127–132.
  • Hollebeeck, S., et al., 2011. Dimethyl sulfoxide (DMSO) attenuates the inflammatory response in the in vitro intestinal caco-2 cell model. Toxicology Letters, 206 (3), 268–275.
  • Ishida, H., Ray, R., and Ray, P., 2008. Sulfur mustard downregulates iNOS expression to inhibit wound healing in a human keratinocyte model. Journal of Dermatological Science, 49 (3), 207–216.
  • Kehe, K., and Szinicz, L., 2005. Medical aspects of sulphur mustard poisoning. Toxicology, 214 (3), 198–209.
  • Kehe, K., et al., 2009. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology, 263 (1), 12–19.
  • Kenar, L., et al., 2005. Evaluation of protective ointments used against dermal effects of nitrogen mustard, a vesicant warfare agent. Military Medicine, 170 (1), 1–6.
  • Korkmaz, A., et al., 2006. Molecular targets against mustard toxicity: implication of cell surface receptors, peroxynitrite production, and PARP activation. Archives of Toxicology, 80 (10), 662–670.
  • Laskin, J.D., et al., 2010. Oxidants and antioxidants in sulfur mustard-induced injury. Annals of the New York Academy of Sciences, 1203, 92–100.
  • Lulla, A., et al., 2013. Ebselen reduces the toxicity of mechlorethamine in A-431 cells via inhibition of apoptosis. Journal of Biochemical and Molecular Toxicology, 27 (6), 313–322.
  • Lulla, A., et al., 2014. Use of the mouse ear vesicant model to evaluate the effectiveness of ebselen as a countermeasure to the nitrogen mustard mechlorethamine. Journal of Applied Toxicology, 34 (12), 1373–1378.
  • Malaviya, R., et al., 2010. Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicology and Applied Pharmacology, 248 (2), 89–99.
  • Minsavage, G.D., and Dillman, J.F., 2007. Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor κB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling. Journal of Pharmacology and Experimental Therapeutics, 321 (1), 202–212.
  • Młochowski, J., et al., 2007. Developments in the chemistry of selenaheterocyclic compounds of practical importance in synthesis and medicinal biology. ARKIVOC, vi, 14–46.
  • Paromov, V., et al., 2007. Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. Journal of Burns and Wounds, 7, e7.
  • Pino, M.A., Pietka-Ottlik, M., and Billack, B., 2014. Selected ebselen analogs reduce mechlorethamine toxicity in vitro. Cutaneous and Ocular Toxicology, 33 (1), 32–41.
  • Ricci, L., et al., 2009. Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage. European Journal of Pharmacology, 621 (1–3), 26–32.
  • Ries, C., et al., 2009. Matrix metalloproteinase-9 expression and release from skin fibroblasts interacting with keratinocytes: upregulation in response to sulphur mustard. Toxicology, 263 (1), 26–31.
  • Rock, K.L., and Kono, H., 2008. The inflammatory response to cell death. Annual Review of Pathology, 3, 99–126.
  • Rosenthal, D.S., et al., 1998. Sulfur mustard induces markers of terminal differentiation and apoptosis in keratinocytes via a Ca2+-calmodulin and caspase-dependent pathway. The Journal of Investigative Dermatology, 111 (1), 64–71.
  • Ruff, A.L., and Dillman, J.F., 2007. Signaling molecules in sulfur mustard-induced cutaneous injury. Eplasty, 8, e2.
  • Sakurai, T., et al., 2006. Ebselen, a seleno-organic antioxidant, as an electrophile. Chemical Research in Toxicology, 19 (9), 1196–1204.
  • Schwentker, A., et al., 2002. Nitric oxide and wound repair: role of cytokines? Nitric Oxide: Biology and Chemistry, 7 (1), 1–10.
  • Shakarjian, M.P., et al., 2006. Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure. Journal of Applied Toxicology, 26 (3), 239–246.
  • Shakarjian, M.P., et al., 2010. Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicological Sciences, 114 (1), 5–19.
  • Sies, H., 1993. Ebselen, a selenoorganic compound as glutathione peroxidase mimic. Free Radical Biology & Medicine, 14 (3), 313–323.
  • Singer, A.J., et al., 2018. The effects of topical nitric oxide on healing of partial thickness porcine burns. Burns: Journal of the International Society for Burn Injuries, 44 (2), 423–428.
  • Smith, K.J., et al., 1997. Histopathologic features seen with different animal models following cutaneous sulfur mustard exposure. Journal of Dermatological Science, 14 (2), 126–135.
  • Sunil, V.R., et al., 2011. Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. Toxicology and Applied Pharmacology, 250 (1), 10–18.
  • Wormser, U., et al., 2005. Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine. Archives of Toxicology, 79 (11), 660–670.
  • Zong, W.-X., et al., 2004. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes & Development, 18 (11), 1272–1282.

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