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Review Article

Health hazards of nanoparticles: understanding the toxicity mechanism of nanosized ZnO in cosmetic products

, , , , , , & ORCID Icon show all
Pages 84-93 | Received 23 Dec 2017, Accepted 17 Jun 2018, Published online: 13 Aug 2018

References

  • Agarwal, H., Kumar, S.V., and Rajeshkumar, S., 2017. A review on green synthesis of zinc oxide nanoparticles – an eco-friendly approach. Resource-Efficient Technologies, 3 (4), 406–413.
  • Akhtar, M.J., et al., 2012. Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species. International Journal of Nanomedicine, 7, 845–857.
  • Alarifi, S., et al., 2013. Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticles. International Journal of Nanomedicine, 8, 983–993.
  • Baek, M.K.K.M., et al., 2011. Factors influencing the cytotoxicity of zinc oxide nanoparticles: particle size and surface charge. Journal of Physics: Conference Series, 304, 012044.
  • Baveye, P., and Laba, M., 2008. Aggregation and toxicology of titanium dioxide nanoparticles. Environmental Health Perspectives, 116 (4), A152.
  • Bhattacharya, D., et al., 2014. Differential toxicity of rod and spherical zinc oxide nanoparticles on human peripheral blood mononuclear cells. Journal of Biomedical Nanotechnology, 10 (4), 707–716.
  • Brouwer, D.H., et al., 2016. Occupational dermal exposure to nanoparticles and nano-enabled products: part 2, exploration of exposure processes and methods of assessment. International Journal of Hygiene and Environmental Health, 219 (6), 503–512.
  • Buzea, C., Pacheco, I.I., and Robbie, K., 2007. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases, 2 (4), MR17–MR71.
  • Chang, X., et al., 2013. Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies. Nanoscale Research Letters, 8 (1), 51.
  • Crosera, M., et al., 2015. Titanium dioxide nanoparticle penetration into the skin and effects on HaCaT cells. International Journal of Environmental Research and Public Health, 12 (8), 9282–9297.
  • Deng, X., et al., 2009. Nanosized zinc oxide particles induce neural stem cell apoptosis. Nanotechnology, 20 (11), 115101.
  • Dietz, G.P., and Bähr, M., 2004. Delivery of bioactive molecules into the cell: the Trojan horse approach. Molecular and Cellular Neurosciences, 27 (2), 85–131.
  • Di Virgilio, A.L., Reigosa, M., Arnal, P.M., and De Mele, M.F.L., 2010. Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells. Journal of Hazardous Materials, 177 (1–3), 711.
  • Dufour, E.K., et al., 2006. Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutation Research, 607 (2), 215–224.
  • Duvall, M. N., 2012. FDA regulation of nanotechnology. Washington, DC: Beveridge & Diamond, PG.
  • Fu, J., Zeng, X., and He, N., 2017. Comparative cytotoxicity induced by zinc oxide nanoparticles in human prostate cells. Journal of Nanoscience and Nanotechnology, 17 (1), 196–202.
  • Fu, P.P., et al., 2014. Mechanisms of nanotoxicity: generation of reactive oxygen species. Journal of Food and Drug Analysis, 22 (1), 64–75.
  • Gatti, A.M., 2004. Biocompatibility of micro- and nano-particles in the colon. Part II. Biomaterials, 25 (3), 385–392.
  • Geiser, M., et al., 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environmental Health Perspectives, 113 (11), 1555.
  • Gosens, I., et al., 2015. Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice. PLoS One, 10 (5), e0126934
  • Gulson, B., et al., 2010. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicological Sciences, 118 (1), 140–149.
  • Gümüş, D., et al., 2014. In vitro genotoxic effects of ZnO nanomaterials in human peripheral lymphocytes. Cytotechnology, 66 (2), 317–325.
  • Hackenberg, S., et al., 2011. Repetitive exposure to zinc oxide nanoparticles induces DNA damage in human nasal mucosa mini organ cultures. Environmental and Molecular Mutagenesis, 52 (7), 582–589.
  • Hackenberg, S., et al., 2012. Antitumor activity of photo-stimulated zinc oxide nanoparticles combined with paclitaxel or cisplatin in HNSCC cell lines. Journal of Photochemistry and Photobiology B: Biology, 114, 87–93.
  • Han, Z., et al., 2016. Cytotoxic effects of ZnO nanoparticles on mouse testicular cells. International Journal of Nanomedicine, 11, 5187.
  • Hanley, C., et al., 2009. The influences of cell type and ZnO nanoparticle size on immune cell cytotoxicity and cytokine induction. Nanoscale Research Letters, 4 (12), 1409.
  • Heng, B.C., et al., 2011. Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles. Archives of Toxicology, 85 (12), 1517–1528.
  • Hillegass, J.M., et al., 2010. Assessing nanotoxicity in cells in vitro. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2 (3), 219–231.
  • Ho, M., et al., 2011. Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: mass and surface area as an exposure metric. Inhalation Toxicology, 23 (14), 947–956.
  • Hoet, P.H., Brüske-Hohlfeld, I., and Salata, O.V., 2004. Nanoparticles – known and unknown health risks. Journal of Nanobiotechnology, 2 (1), 12.
  • Howard, M. A., III., et al., 1999. Magnetically guided stereotaxis. In: E. Alexander III, R.J. Maciunas, eds. Advanced neurosurgical navigation. New York, NY: Thieme Medical Publishers, 549–563.
  • https://chemicalwatch.com/63613/cosmetics-producers-face-french-court-action-over-nano-labelling
  • https://pubchem.ncbi.nlm.nih.gov/compound/zinc_oxide#section=Top
  • Huang, C.C., et al., 2010. Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicology in Vitro, 24 (1), 45–55.
  • Ickrath, P., et al., 2017. Time-dependent toxic and genotoxic effects of zinc oxide nanoparticles after long-term and repetitive exposure to human mesenchymal stem cells. International Journal of Environmental Research and Public Health, 14 (12), 1590.
  • Ivask, A., et al., 2015. Toxicity of 11 metal oxide nanoparticles to three mammalian cell types in vitro. Current Topics in Medicinal Chemistry, 15 (18), 1914–1929.
  • Jeng, H.A., and Swanson, J., 2006. Toxicity of metal oxide nanoparticles in mammalian cells. Journal of Environmental Science and Health. Part A, Toxic/Hazardous Substances & Environmental Engineering, 41 (12), 2699–2711.
  • Kaur, I.P., et al., 2014. Issues and concerns in nanotech product development and its commercialization. Journal of Controlled Release: Official Journal of the Controlled Release Society, 193, 51–62.
  • Khan, M., Naqvi, A.H., and Ahmad, M., 2015. Comparative study of the cytotoxic and genotoxic potentials of zinc oxide and titanium dioxide nanoparticles. Toxicology Reports, 2, 765–774.
  • Khanna, P., et al., 2015a. Nanotoxicity: an interplay of oxidative stress, inflammation and cell death. Nanomaterials, 5 (3), 1163–1180.
  • Khanna, P., et al., 2015b. Comparative cytotoxicity of Al2O3, CeO2, TiO2 and ZnO nanoparticles to human lung cells. Journal of Nanoscience and Nanotechnology, 5 (3), 1163–3458.
  • Kim, I.S., Baek, M., and Choi, S.J., 2010. Comparative cytotoxicity of Al2O3, CeO2, TiO2 and ZnO nanoparticles to human lung cells. Jounal of Nanoscience Nanotechnology, 10, 3453.
  • Kocbek, P., et al., 2010. Toxicological aspects of long-term treatment of keratinocytes with ZnO and TiO2 nanoparticles . Small (Weinheim an Der Bergstrasse, Germany), 6 (17), 1908–1917.
  • Kononenko, V., et al., 2017. Comparative in vitro genotoxicity study of ZnO nanoparticles, ZnO macroparticles and ZnCl2 to MDCK kidney cells: size matters. Toxicology in Vitro: An International Journal Published in Association with Bibra, 40, 256–263.
  • Lewicka, Z.A., et al., 2013. Photochemical behavior of nanoscale TiO2 and ZnO sunscreen ingredients. Journal of Photochemistry and Photobiology A: Chemistry, 263, 24–33.
  • Lin, W., et al., 2009. Toxicity of nano-and micro-sized ZnO particles in human lung epithelial cells. Journal of Nanoparticle Research, 11 (1), 25–39.
  • Lozano, T., et al., 2011. Cytotoxicity effects of metal oxide nanoparticles in human tumor cell lines. Journal of Physics: Conference Series, 304, 012046.
  • Mansouri, E., et al., 2015. Dose-dependent hepatotoxicity effects of zinc oxide nanoparticles. Nanomedicine Journal, 2 (4), 273–282.
  • Melo, A., et al., 2015. The role of nanomaterials in cosmetics: national and international legislative aspects. Química Nova, 38 (4), 599–603.
  • Meng, H., et al., 2011. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. ACS nano, 5 (6), 4434.
  • Meyer, K., et al., 2011. ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways. Toxicology in Vitro, 25 (8), 1721–1726.
  • Monsé, C., et al., 2018. Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers. Particle and Fibre Toxicology, 15 (1), 8.
  • Moos, P.J., et al., 2010. ZnO particulate matter requires cell contact for toxicity in human colon cancer cells. Chemical Research in Toxicology, 23 (4), 733–739.
  • Moos, P.J., et al., 2011. Responses of human cells to ZnO nanoparticles: a gene transcription study. Metallomics: Integrated Biometal Science, 3 (11), 1199–1211.
  • Morimoto, Y., et al., 2016. Evaluation of pulmonary toxicity of zinc oxide nanoparticles following inhalation and intratracheal instillation. International Journal of Molecular Sciences, 17 (8), 1241.
  • Nagajyothi, P.C., et al., 2013. Green route biosynthesis: characterization and catalytic activity of ZnO nanoparticles. Materials Letters, 108, 160–163.
  • Nakane, H., 2012. Translocation of particles deposited in the respiratory system: a systematic review and statistical analysis. Environmental Health and Preventive Medicine, 17 (4), 263.
  • Nohynek, G.J., Dufour, E.K., and Roberts, M.S., 2008. Nanotechnology, cosmetics and the skin: is there a health risk? Skin Pharmacology and Physiology, 21 (3), 136–149.
  • Norval, M., et al., 2007. The effects on human health from stratospheric ozone depletion and its interactions with climate change. Photochemical & Photobiological Sciences, 6 (3), 232–251.
  • Norval, M., et al., 2011. The human health effects of ozone depletion and interactions with climate change. Photochemical & Photobiological Sciences, 10, 199.
  • Oberdörster, G., Oberdörster, E., and Oberdörster, J., 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives, 113 (7), 823.
  • Pandurangan, M., and Kim, D.H., 2015. ZnO nanoparticles augment ALT, AST, ALP and LDH expressions in C2C12 cells. Saudi Journal of Biological Sciences, 22 (6), 679–684.
  • Pandurangan, M., and Ravikumar, S., 2014. Impact of stress hormone on adipogenesis in the 3T3-L1 adipocytes. Cytotechnology, 66 (4), 619–624.
  • Park, J., et al., 2009. Exposure assessment of engineered nanomaterials in the workplace. Korean Journal of Chemical Engineering, 26 (6), 1630–1636.
  • Piccinno, F., et al., 2012. Industrial production quantities and uses of ten engineered nanomaterials in Europe and the world. Journal of Nanoparticle Research, 14 (9), 1109.
  • Raj, S., et al., 2012. Nanotechnology in cosmetics: opportunities and challenges. Journal of Pharmacy & Bioallied Sciences, 4 (3), 186.
  • Ray, P.C., Yu, H., and Fu, P.P., 2009. Toxicity and environmental risks of nanomaterials: challenges and future needs. Journal of Environmental Science and Health Part C, 27 (1), 1–35.
  • Rodriguez, J.A., 2002. Orbital-band interactions and the reactivity of molecules on oxide surfaces: from explanations to predictions. Theoretical Chemistry Accounts, 107 (3), 117–129.
  • Sahu, D., et al., 2013. Nanosized zinc oxide induces toxicity in human lung cells. ISRN Toxicology, 2013, 316075.
  • Saliani, M., Jalal, R., and Goharshadi, E.K., 2016. Mechanism of oxidative stress involved in the toxicity of ZnO nanoparticles against eukaryotic cells. Nanomedicine Journal, 3 (1), 1–14.
  • Savolainen, K., et al., 2010. Risk assessment of engineered nanomaterials and nanotechnologies – a review. Toxicology, 269 (2–3), 92–104.
  • Schieber, M., and Chandel, N.S., 2014. ROS function in redox signaling and oxidative stress. Current Biology, 24 (10), R453–R462.
  • Schneider, T., Westermann, M., and Glei, M., 2017. In vitro uptake and toxicity studies of metal nanoparticles and metal oxide nanoparticles in human HT29 cells. Archives of Toxicology, 91 (11), 3517–3527.
  • Schreiver, I., et al., 2017. Synchrotron-based ν-XRF mapping and μ-FTIR microscopy enable to look into the fate and effects of tattoo pigments in human skin. Scientific Reports, 7 (1), 11395.
  • Sha, B., et al., 2011. Cytotoxicity of titanium dioxide nanoparticles differs in four liver cells from human and rat. Composites Part B: Engineering, 42 (8), 2136.
  • Sharma, V., Anderson, D., and Dhawan, A., 2012. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2). Apoptosis, 17 (8), 852–870.
  • Sharma, V., et al., 2009. DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicology letters, 185 (3), 211.
  • Srivastava, V., Gusain, D., and Sharma, Y.C., 2015. Critical review on the toxicity of some widely used engineered nanoparticles. Industrial & Engineering Chemistry Research, 54 (24), 6209–6233.
  • Taatjes, D.J., Sobel, B.E., and Budd, R.C., 2008. Morphological and cytochemical determination of cell death by apoptosis. Histochemistry and Cell Biology, 129 (1), 33–43.
  • Titma, T., et al., 2016. Toxicity of antimony, copper, cobalt, manganese, titanium and zinc oxide nanoparticles for the alveolar and intestinal epithelial barrier cells in vitro. Cytotechnology, 68 (6), 2363–2377.
  • Vandebriel, R.J., and De Jong, W.H., 2012. A review of mammalian toxicity of ZnO nanoparticles. Nanotechnology, Science and Applications, 5, 61.
  • Vevers, W.F., and Jha, A.N., 2008. Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro. Ecotoxicology, 17 (5), 410.
  • Wang, C., et al., 2015. ZnO nanoparticles treatment induces apoptosis by increasing intracellular ROS levels in LTEP-a-2 cells. BioMed Research International, 2015, 1.
  • Wang, C., et al., 2016. Effects of long-term exposure to zinc oxide nanoparticles on development, zinc metabolism and biodistribution of minerals (Zn, Fe, Cu, Mn) in mice. PLoS One, 11 (10), e0164434.
  • Wang, Z.L., 2004. Zinc oxide nanostructures: growth, properties and applications. Journal of Physics: condensed Matter, 16 (25), R829.
  • Wiesner, M.R., et al., 2006. Assessing the risks of manufactured nanomaterials. Environmental Science Technology, 40 (14), 4336–4345.
  • Williams, D., et al., 2005., The appropriateness of existing methodologies to assess the potential risks associated with engineered and adventitious products of nanotechnologies. Report for the European Commission Health and Consumer Protection Directorate General by the Scientific Committee on Emerging and Newly Identified Health Risks. Brussels.
  • www.eng.mst.dk/
  • Xia, T., et al., 2008. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano, 2 (10), 2121–2134.
  • Yan, G., et al., 2012. Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats. Journal of Environmental Science and Health, Part A, 47 (4), 577–588.
  • Yin, Y., et al., 2012. Cytotoxic effects of ZnO hierarchical architectures on RSC96 Schwann cells. Nanoscale Research Letters, 7 (1), 439.
  • Yoshida, T., et al., 2012. Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells. Biochemical and Biophysical Research Communications, 427 (4), 748–752.
  • Zhang, X.Q., et al., 2011. ZnO, TiO2, SiO2, and Al2O3 nanoparticles-induced toxic effects on human fetal lung fibroblasts. Biomedical and Environmental Sciences, 24 (6), 661–669.

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