147
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

The mutagenic effect of psychostimulant modafinil in Wistar rats in vivo

, ORCID Icon &
Pages 373-377 | Received 02 Sep 2017, Accepted 29 Jun 2018, Published online: 08 Oct 2018

References

  • Adler, C.H., et al., 2003. Randomized trial of Modafinil for treating subjective daytime sleepiness in patients with Parkinson’s disease. Movement Disorders, 18 (3), 287–293.
  • Alden, C. J., 1995. Toxicology and Carcinogenesis studies of methylphenidate hydrocholoride (CAS NO. 298-59-9) in F344/N rats and B6C3Fl mice (Feed Studies). National Toxicology Program: Technical Report Series, NTP TR 439.
  • Andreazza, A.C., et al., 2007. DNA damage in rats after treatment with methylphenidate. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31 (6), 1282–1288.
  • ANVISA – Agência Nacional de Vigilância Sanitária. Resolução n. 63, de 27 de setembro de 2007 [online]. Avaliable from: http://www.anvisa.gov.br/hotsite/sngpc_visa/legis/resol63.pdf. [Accessed 22 August 2017].
  • Berkeley, M.B., et al., 1994. In vitro and in vivo cocaine-induced inhibition of lymphocyte proliferation. Immunopharmacology and Immunotoxicology, 16 (2), 165–178.
  • Brambilla, G. and Martelli, A., 2009. Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals. Mutation Research, 681 (2–3), 209–229.
  • Brambilla, G., et al., 2010. Genotoxicity and carcinogenicity testing of pharmaceuticals: Correlations between induction of DNA lesions and carcinogenic activity. Mutation Research, 705 (1), 20–39.
  • Broughton, R.J., et al., 1997. Randomized, double-blind, placebo-controlled crossover trial of Modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology, 49 (2), 444–451.
  • Choudhury, R.C. and Palo, A.K., 2004. Modulatory effects of caffeine on methotrexate-induced cytogenotoxicity in mouse bone marrow. Environmental Toxicology and Pharmacology, 15 (2–3), 79–85.
  • Cunha-Oliveira, T., et al., 2006. Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide. Toxicology, 217 (1), 54–62.
  • Czeisler, C.A., et al., 2005. Modafinil for excessive sleepiness associated with shift-work sleep disorder. The New England Journal of Medicine, 353 (5), 476–486.
  • Dishotsky, N.I., et al., 1971. LSD and genetic damage. Science (New York, N.Y.), 172 (3982), 431–440.
  • Düsman, E., et al., 2014. Cytotoxicity and mutagenicity of fluoxetine hydrochloride (Prozac), with or without vitamins A and C, in plant and animal model systems. Genetics and Molecular Research, 13 (1), 578–589.
  • El-Zein, R.A., et al., 2005. Cytogenetic effects in children treated with methylphenidate. Cancer Letters, 230, 284–291.
  • European Medicines Agency, 2018. Lista de nomes, formas farmacêuticas, dosagens dos medicamentos, via de administração, titulares das autorizações de introdução no mercado nos estados membros [online]. Avaliable from: https://ec.europa.eu/health/documents/community-register/2015/20150716132227/anx_132227_pt.pdf. [Accessed 12 April 2018].
  • FDA - U.S. Food and Drug Administration. FDA approved drug products [online] Avaliable from: 2017. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=search.drugdetails. [Accessed 22 August].
  • Fernández-Espejo, E., 2006. Neurobiología de la adicción a psicoestimulantes. Revista de Neurología, 43 (3), 147–154.
  • Fischman, H.K., et al., 1983. Clastogenic effects of heroin in pregnant monkeys and their offspring. Mutation Research, 118 (1–2), 77–89.
  • Fonseca, C.A.S., et al., 1994. Genotoxic and mutagenic effects of guaraná (Paullinia cupana) in prokaryotic organisms. Mutation Research, 321 (3), 165–173.
  • Ford, C.E. and Hamerton, J.L., 1956. A colchicine, hypotonic citrate, squash sequence for mammalian chromosome. Stain Technology, 31 (6), 247–251.
  • Kampman, K.M., et al., 2015. A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence. Drug and Alcohol Dependence, 155, 105–110.
  • Kuan, Y.C., et al., 2016. Effects of modafinil and armodafinil in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Clinical Therapeutics, 38 (4), 874–888.
  • Larez, A., et al., 1979. Mutagenicity obtained experimentally by oral administration of dextroamphetamine sulphate to the rat. Bulletin on Narcotics, 31 (1), 67–70.
  • Lima, M. S. and Novo, I. P, 2018. Uso de psicoestimulantes no Brasil: um problema ainda sem solução [online]. Avaiable from: http://www2.unifesp.br/dpsiq/polbr/ppm/atu6_02.htm. [Acessed 08 september 2018].
  • Lu, Y. and Morimoto, K., 2008. Exposure level to cigarette tar or nicotine is associated with leukocyte DNA damage in male Japanese smokers. Mutagenesis, 23 (6), 451–455.
  • Mahmoudi, J., et al., 2015. Antidepressant-like effect of modafinil in mice: evidence for the involvement of the dopaminergic neurotransmission. Pharmacological Reports, 67 (3), 478–484.
  • Menza, M.A., Kaufman, K.R., and Castellanos, A., 2000. Modafinil augmentation of antidepressant treatment in depression. The Journal of Clinical Psychiatry, 61 (5), 378–381.
  • Mitler, M.M., et al., 2000. Long-term efficacy and safety of Modafinil (PROVIGIL®) for the treatment of excessive daytime sleepiness associated with narcolepsy. Sleep Medicine, 1 (3), 231–243.
  • Natarajan, A.T., 2002. Chromosome aberrations: past, present and future. Mutation Research, 504 (1–2), 3–16.
  • Nehlig, A. and Debry, G., 1994. Potential genotoxic, mutagenic and antimutagenic effects of coffee: a review. Mutation Research, 317 (2), 145–162.
  • Novotna, A., et al., 2014. Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chemico-Biological Interactions, 208, 64–76.
  • Ott, J., 1996. Pharmacotheon: Entheogenic Drugs, their Plant Sources and History, Kennewick, WA: Natural Products Co.
  • Pack, A.I., et al., 2001. Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine, 164 (9), 1675–1681.
  • Rammohan, K.W., et al., 2002. Efficacy and safety of Modafinil (Provigil®) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study. Journal of Neurology, Neurosurgery & Psychiatry, 72 (2), 179–183.
  • Sadasivaiah, R.S., Collins, G.B., and Davis, D.L., 1973. Effect of LSD on mitotic and meiotic plant chromosomes. Chromosoma, 44 (3), 309–318.
  • Snyder, R.D. and Green, J.W., 2001. A review of the genotoxicity of marketed pharmaceuticals. Mutation Research, 488 (2), 151–169.
  • Suter, W., Martus, H.J., and Elhajouji, A., 2006. Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test. Mutation Research, 607 (2), 153–159.
  • Wang, S.M., et al., 2017. Modafinil for the treatment of attention-deficit/hyperactivity disorder: a meta-analysis. Journal of Phychiatric Research, 84, 292–300.
  • Weil, A., 2004. The Natural Mind: A Revolutionary Approach to the Drug Problem, Revised Edition. Boston: Livrary of Congress Cataloging in Publication Data.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.