Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data

References

• ACGIH. 2010. TLVs and BEIs based on the documentation of the threshold limit values for chemical substances and physical agents & biological exposure indices.
   Google Scholar
• Afrin, M., et al., 2016. Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice. Asian Journal of Medical and Biological Research, 2 (2), 229–235.
   Google Scholar
• Afrin, M., et al., 2017. Formaldehyde intoxication and open field behavior in mice. International Journal of Scientific & Engineering, 8 (8), 1665–1668.
   Google Scholar
• Albertini, R.J., and Kaden, D.A., 2017. Do chromosome changes in blood cells implicate formaldehyde as a leukemogen? Critical Reviews in Toxicology, 47 (2), 145–184.
   PubMed Web of Science ®Google Scholar
• Allegra, S., et al., 2019. Formaldehyde exposure and acute myeloid leukemia: a review of the literature. Medicina, 55 (10), 638.
   Web of Science ®Google Scholar
• Aydin, S., et al., 2015. Effect of carnosine supplementation on apoptosis and irisin, total oxidant and antioxidants levels in the serum, liver and lung tissues in rats exposed to formaldehyde inhalation. Peptides, 64, 14–23.
   PubMed Web of Science ®Google Scholar
• Bai, J., et al., 2017. Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner. Environmental Toxicology and Pharmacology, 56 (August), 15–20.
   PubMed Web of Science ®Google Scholar
• Barbosa, E., et al., 2019. Increase of global DNA methylation patterns in beauty salon workers exposed to low levels of formaldehyde. Environmental Science and Pollution Research, 26 (2), 1304–1314.
   PubMed Web of Science ®Google Scholar
• Bruno, E., et al., 2018. Nasal cytology as a screening tool in formaldehyde-exposed workers. Occupational Medicine, 68 (5), 307–313.
   PubMed Web of Science ®Google Scholar
• Checkoway, H., et al., 2015. Formaldehyde exposure and mortality risks from acute myeloid leukemia and other lymphohematopoietic malignancies in the US National Cancer Institute Cohort Study of Workers in Formaldehyde Industries. Journal of Occupational and Environmental Medicine, 57 (7), 785–794.
   PubMed Web of Science ®Google Scholar
• Chen, D., et al., 2017a. Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environmental Health Perspectives, 125 (9), 097019.
   PubMed Web of Science ®Google Scholar
• Chen, Y., et al., 2017b. Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide. Clinical and Experimental Pharmacology & Physiology, 44 (5), 595–601.
   PubMed Web of Science ®Google Scholar
• Cheng, J., et al., 2016. The toxicity of continuous long-term low-dose formaldehyde inhalation in mice. Immunopharmacology and Immunotoxicology, 38 (6), 495–501.
   PubMed Web of Science ®Google Scholar
• Coggon, D., et al., 2014. Upper airway cancer, myeloid leukemia, and other cancers in a cohort of British chemical workers exposed to formaldehyde. American Journal of Epidemiology, 179 (11), 1301–1311.
   PubMed Web of Science ®Google Scholar
• Costa, S., et al., 2015. Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde. Mutagenesis, 30 (4), 463–473.
   PubMed Web of Science ®Google Scholar
• Costa, S., et al., 2011. Occupational exposure to formaldehyde: genotoxic risk evaluation by comet assay and micronucleus test using human peripheral lymphocytes. Journal of Toxicology and Environmental Health. Part A, 74 (15–16), 1040–1051.
   PubMed Web of Science ®Google Scholar
• Dahlgren, J.G., and Talbott, P.J., 2018. Asthma from hair straightening treatment containing formaldehyde: two cases and a review of the literature. Toxicology and Industrial Health, 34 (4), 262–269.
   PubMed Web of Science ®Google Scholar
• Dezest, M., et al., 2017. Oxidative damage and impairment of protein quality control systems in keratinocytes exposed to a volatile organic compounds cocktail. Scientific Reports, 7 (1), 10707.
   PubMed Web of Science ®Google Scholar
• Dorokhov, Y.L., et al., 2018. Human endogenous formaldehyde as an anticancer metabolite: its oxidation downregulation may be a means of improving therapy. BioEssays, 40 (12), 1800136.
   PubMed Web of Science ®Google Scholar
• Duan, J., et al., 2018. Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model. Ecotoxicol. Environ. Saf, 163 (July), 356–364.
   PubMed Web of Science ®Google Scholar
• Gentry, P.R., et al., 2013. Formaldehyde exposure and leukemia: critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility. Critical Reviews in Toxicology, 43 (8), 661–670.
   PubMed Web of Science ®Google Scholar
• He, X., et al., 2016. Resveratrol attenuates formaldehyde induced hyperphosphorylation of tau protein and cytotoxicity in N2a cells. Frontiers in Neuroscience, 10 (JAN), 511–598.
   PubMed Web of Science ®Google Scholar
• Huang, J., et al., 2019. Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde. Toxicology, 412, 29–36.
   PubMed Web of Science ®Google Scholar
• IARC. 2006. Formaldehyde. IARC Monographs, 88, 39–325.
   Google Scholar
• IARC. 2012. Chemical agents and related occupations. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 100, 9–562.
   PubMedGoogle Scholar
• Jensen, R.P., et al., 2015. Hidden formaldehyde in E-cigarette aerosols. The New England Journal of Medicine, 372 (4), 392–394.
   PubMed Web of Science ®Google Scholar
• Katsnelson, B.A., et al., 2013. Attenuation of subchronic formaldehyde inhalation toxicity with oral administration of glutamate, glycine and methionine. Toxicology Letters, 220 (2), 181–186.
   PubMed Web of Science ®Google Scholar
• Ke, Y., et al., 2014. In vitro study on cytotoxicity and intracellular formaldehyde concentration changes after exposure to formaldehyde and its derivatives. Human & Experimental Toxicology, 33 (8), 822–830.
   PubMed Web of Science ®Google Scholar
• Kim, S.H., et al., 2018. Effect of formaldehyde on human middle ear epithelial cells. BioMed Research International, 2018, 6387983–6387988.
   PubMed Web of Science ®Google Scholar
• Kwon, S.-C., et al., 2018. Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia? Annals of Occupational and Environmental Medicine, 30 (1), 5.
   PubMedGoogle Scholar
• Lan, Q., et al., 2015. Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis, 36 (1), 160–167.
   PubMed Web of Science ®Google Scholar
• Lee, H.-M., et al., 2016. Three components of cigarette smoke altered the growth and apoptosis of metastatic colon cancer cells via inducing the synthesis of reactive oxygen species and endoplasmic reticulum stress. Environmental Toxicology and Pharmacology, 45, 80–89.
   PubMed Web of Science ®Google Scholar
• Lee, H.M., Kim, S.M., and Choi, K.C., 2017. Treatment of human placental choriocarcinoma cells with formaldehyde and benzene induced growth and epithelial mesenchymal transition via induction of an antioxidant effect. International Journal of Environmental Research and Public Health, 14 (8), 854.
   Web of Science ®Google Scholar
• Leng, J., et al., 2019. Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA-protein cross-links by liquid chromatography-tandem mass spectrometry. Archives of Toxicology, 93 (3), 763–773.
   PubMed Web of Science ®Google Scholar
• Lestari, K.S., Humairo, M.V., and Agustina, U., 2018. Formaldehyde vapor concentration in electronic cigarettes and health complaints of electronic cigarettes smokers in Indonesia. Journal of Environmental and Public Health, 2018, 9013430–9013436.
   PubMed Web of Science ®Google Scholar
• Li, L., et al., 2017. Differential effects of formaldehyde exposure on airway inflammation and bronchial hyperresponsiveness in BALB/c and C57BL/6 mice. PLoS One, 12 (6), e0179231.
   PubMed Web of Science ®Google Scholar
• Li, Q., et al., 2013. Effects of formaldehyde exposure on human NK cells in vitro. Environmental Toxicology and Pharmacology, 36 (3), 948–955.
   PubMed Web of Science ®Google Scholar
• Li, Y., et al., 2016. Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice. Chemosphere, 144, 2004–2012.
   PubMed Web of Science ®Google Scholar
• Liang, A., et al., 2018. Formaldehyde exposure in indoor air from public places and its associated health risks in Kunshan City, China. Asia-Pacific Journal of Public Health, 30 (6), 551–560.
   PubMed Web of Science ®Google Scholar
• Lima, L.F., et al., 2015. Short-term exposure to formaldehyde promotes oxidative damage and inflammation in the trachea and diaphragm muscle of adult rats. Annals of Anatomy = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft, 202, 45–51.
   PubMed Web of Science ®Google Scholar
• Liu, C., et al., 2018a. Accurate measurement of formaldehyde-induced DNA-protein cross-links by high-resolution orbitrap mass spectrometry. Chemical Research in Toxicology, 31 (5), 350–357.
   PubMed Web of Science ®Google Scholar
• Liu, Q., et al., 2018b. Formaldehyde inhalation triggers autophagy in rat lung tissues. Toxicology and Industrial Health, 34 (12), 834–841.
   Web of Science ®Google Scholar
• Liu, Y., Yu, D., and Xiao, S., 2017. Effects of chronic exposure to formaldehyde on micronucleus rate of bone marrow cells in male mice. Journal of the Pakistan Medical Association, 67 (6), 933–935.
   PubMed Web of Science ®Google Scholar
• Lorenzoni, D., et al., 2017. Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes? Medicina Oral, Patologia Oral y Cirugia Bucal, 22 (1), e58–e63.
   PubMed Web of Science ®Google Scholar
• Lu, J., et al., 2013. Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo. Biochimica et Biophysica Acta, 1830 (8), 4102–4116.
   PubMed Web of Science ®Google Scholar
• Luch, A., et al., 2014. Low-dose formaldehyde delays DNA damage recognition and DNA excision repair in human cells. PLoS One, 9 (4), e94149.
   PubMed Web of Science ®Google Scholar
• Mahboubi, A., et al., 2013. Assessment of the effect of occupational exposure to formaldehyde on the risk of lung cancer in two Canadian population-based case-control studies. Scandinavian Journal of Work, Environment & Health, 39 (4), 401–410.
   PubMed Web of Science ®Google Scholar
• Maiellaro, M., et al., 2014. Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. Toxicology and Applied Pharmacology, 278 (3), 266–274.
   PubMed Web of Science ®Google Scholar
• Mei, Y., et al., 2016. Reduction of endogenous melatonin accelerates cognitive decline in mice in a simulated occupational formaldehyde exposure environment. International Journal of Environmental Research and Public Health, 13 (3), 258.
   Web of Science ®Google Scholar
• Mohamed, A.M.T., et al., 2012. Anatomical and histological effects of formaldehyde inhalation on the lung of Albino Rat. Journal of American Science, 8 (9), 395–404.
   Google Scholar
• Möhner, M., Liu, Y., and Marsh, G.M., 2019. New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study. Journal of Occupational Medicine and Toxicology, 14 (1), 4.
   PubMed Web of Science ®Google Scholar
• Mueller, J.U., Bruckner, T., and Triebig, G., 2013. Exposure study to examine chemosensory effects of formaldehyde on hyposensitive and hypersensitive males. Int Arch Occup Environ Health, 86 (1), 107–117.
   PubMed Web of Science ®Google Scholar
• Mundt, K.A., et al., 2017. Does occupational exposure to formaldehyde cause hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells? Critical Reviews in Toxicology, 47 (7), 598–608.
   Web of Science ®Google Scholar
• Murta, G.L., et al., 2016. Oxidative effects on lung inflammatory response in rats exposed to different concentrations of formaldehyde. Environmental Pollution, 211, 206–213.
   PubMed Web of Science ®Google Scholar
• Nakamura, J., et al., 2017. Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes. Scientific Reports, 7 (1), 10787.
   PubMed Web of Science ®Google Scholar
• Nielsen, G.D., Larsen, S.T., and Wolkoff, P., 2013. Recent trend in risk assessment of formaldehyde exposures from indoor air. Archives of Toxicology, 87 (1), 73–98.
   PubMed Web of Science ®Google Scholar
• NIOSH. 2003. Formaldehyde: Method 2016. Manual of Analitical Methods, 2003(2), 1–7.
   Google Scholar
• Occupational Safety and Health Administration (OSHA). 2011. Formaldehyde. Osha-Factsheet.
   Google Scholar
• Peteffi, G.P., et al., 2016. Environmental and biological monitoring of occupational formaldehyde exposure resulting from the use of products for hair straightening. Environmental Science and Pollution Research, 23 (1), 908–917.
   PubMed Web of Science ®Google Scholar
• Pidoux, G., et al., 2015. Formaldehyde crosses the human placenta and affects human trophoblast differentiation and hormonal functions. PLoS One, 10 (7), e0133506.
   PubMed Web of Science ®Google Scholar
• Pira, E., et al., 2014. Mortality from lymphohematopoietic neoplasms and other causes in a cohort of laminated plastic workers exposed to formaldehyde. Cancer Causes Control, 25 (10), 1343–1349.
   PubMed Web of Science ®Google Scholar
• Pontel, L.B., et al., 2015. Endogenous formaldehyde is a hematopoietic stem cell genotoxin and metabolic carcinogen. Molecular Cell, 60 (1), 177–188.
   PubMed Web of Science ®Google Scholar
• Ramos, C., de, O., et al., 2017. The exposure to formaldehyde causes renal dysfunction, inflammation and redox imbalance in rats. Experimental and toxicologic pathology: Official journal of the Gesellschaft fur Toxikologische Pathologie, 69 (6), 367–372.
   PubMedGoogle Scholar
• Reingruber, H., and Pontel, L.B., 2018. Formaldehyde metabolism and its impact on human health. Current Opinion in Toxicology, 9 (2018), 28–34.
   Google Scholar
• Rizzi, M., et al., 2016. Formaldehyde solutions in simulated sweat increase human melanoma but not normal human keratinocyte cells proliferation. Toxicology in vitro: An International Journal Published in Association with Bibra, 37, 106–112.
   PubMed Web of Science ®Google Scholar
• Sapmaz, H.I., et al., 2016. Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: an experimental study. Toxicology and Industrial Health, 32 (9), 1564.
   PubMed Web of Science ®Google Scholar
• She, Y., et al., 2013. Formaldehyde induces toxic effects and regulates the expression of damage response genes in BM-MSCs. Acta Biochimica et Biophysica Sinica, 45 (12), 1011.
   PubMed Web of Science ®Google Scholar
• Shi, Y.-Q., et al., 2014. Selenium pretreatment attenuates formaldehyde-induced genotoxicity in A549 cell lines. Toxicology and Industrial Health, 30 (10), 901.
   PubMed Web of Science ®Google Scholar
• Silva Ibrahim, B., et al., 2015. Formaldehyde inhalation during pregnancy abolishes the development of acute innate inflammation in offspring. Toxicology Letters, 235 (2), 147.
   PubMed Web of Science ®Google Scholar
• Silva Macedo, R., et al., 2016. Photobiomodulation therapy decreases oxidative stress in the lung tissue after formaldehyde exposure: role of oxidant/antioxidant enzymes. Mediators of Inflammation, 2016, 9303126.
   PubMed Web of Science ®Google Scholar
• Souza, A.D., and Devi, R., 2014. Cytokinesis blocked micronucleus assay of peripheral lymphocytes revealing the genotoxic effect of formaldehyde exposure. Clinical Anatomy, 27 (3), 308–312.
   PubMed Web of Science ®Google Scholar
• Vitoux, M.-A., et al., 2018. Formaldehyde gas exposure increases inflammation in an in vitro model of dry eye. Toxicological Sciences: An Official Journal of the Society of Toxicology, 165 (1), 108–117.
   PubMed Web of Science ®Google Scholar
• Wei, C., et al., 2017. Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem/progenitor cells and enhances benzene-induced adverse effects. Archives of Toxicology, 91 (2), 921.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). 2010. WHO Guidelines for air quality: selected pollutants. WHO Office for Europe, 9:454. 
   Google Scholar
• Wu, D., et al., 2017. Vitamin E reversed apoptosis of cardiomyocytes induced by exposure to high dose formaldehyde during mice pregnancy. International Heart Journal, 58 (5), 769–777.
   PubMed Web of Science ®Google Scholar
• Xu, M., et al., 2017. The effects of formaldehyde on cytochrome P450 isoform activity in rats. BioMed Research International, 2017, 6525474.
   PubMed Web of Science ®Google Scholar
• Ye, X., et al., 2013. Inhaled formaldehyde induces DNA-protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice. Environmental and Molecular Mutagenesis, 54 (9), 705–718.
   PubMed Web of Science ®Google Scholar
• Yu, G., et al., 2014. Inhaled formaldehyde induces bone marrow toxicity via oxidative stress in exposed mice. Asian Pacific Journal of Cancer Prevention: APJCP, 15 (13), 5253–5257.
   PubMedGoogle Scholar
• Yu, G., et al., 2019. Small interfering RNA targeting of peroxiredoxinII gene enhances formaldehyde-induced toxicity in bone marrow cells isolated from BALB/c mice. Ecotoxicology and Environmental Safety, 181 (May), 89–95.
   PubMed Web of Science ®Google Scholar
• Zendehdel, R., Fazli, Z., and Mazinani, M., 2016. Neurotoxicity effect of formaldehyde on occupational exposure and influence of individual susceptibility to some metabolism parameters. Environmental Monitoring and Assessment, 188 (11), 648.
   PubMed Web of Science ®Google Scholar
• Zerin, T., et al., 2015. Effects of formaldehyde on mitochondrial dysfunction and apoptosis in SK-N-SH neuroblastoma cells. Cell Biology and Toxicology, 31 (6), 261–272.
   PubMed Web of Science ®Google Scholar
• Zhan, K., et al., 2016. Formaldehyde accelerates cellular senescence in HT22 cells: possible involvement of the leptin pathway. Acta Biochimica et Biophysica Sinica, 48 (8), 771–773.
   PubMed Web of Science ®Google Scholar
• Zhang, Q., et al., 2018a. Formaldehyde regulates vascular tensions through nitric oxide-cGMP signaling pathway and ion channels. Chemosphere, 193, 60–73.
   PubMed Web of Science ®Google Scholar
• Zhang, X., et al., 2018b. Differential health effects of constant versus intermittent exposure to formaldehyde in mice: implications for building ventilation strategies. Environmental Science & Technology, 52 (3), 1551–1560.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., et al., 2013. Bone Marrow injury induced via oxidative stress in mice by inhalation exposure to formaldehyde. PLoS One., 8 (9), e74974.
   PubMed Web of Science ®Google Scholar