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Research Articles

The evaluation of hepatoprotective effects of flavonoids from Scorzonera austriaca Wild against CCl4-induced acute liver injury in vitro and in vivo

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Pages 1284-1294 | Received 13 May 2020, Accepted 23 Aug 2020, Published online: 14 Sep 2020

References

  • Bai, F.C., et al., 2017. Trolline ameliorates liver fibrosis by inhibiting the NF-κB pathway, promoting HSC apoptosis and suppressing autophagy. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 44 (2), 436–446.
  • Cemek, M., et al., 2010. Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 48 (10), 2827–2832.
  • Chen, X., et al., 2015. Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice. Pharmaceutical Research, 32 (2), 538–548.
  • Chen, Y.S., et al., 2019. Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides against carbon tetrachloride-induced liver injury in Kunming mice. Pharmacology, 103 (3–4), 143–150.
  • Cheng, N., et al., 2013. Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 55, 234–240.
  • Chen, X.G. and Xu, C.S., 2014. Proteomic analysis of the regenerating liver following 2/3 partial hepatectomy in rats. Biological Research, 47, 59
  • Dawson, S., et al., 2012. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug Metabolism and Disposition, 40 (1), 130–138.
  • Deepha, V., et al., 2014. Experimental and theoretical investigations on the antioxidant activity of isoorientin from Crotalaria globosa. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 121, 737–745.
  • Ding, J., Cui, X., and Liu, Q., 2017. Emerging role of HMGB1 in lung diseases: friend or foe. Journal of Cellular and Molecular Medicine, 21 (6), 1046–1057.
  • Eduardo, W.I., et al., 2016. Antibiosis levels of common bean genotypes toward Zabrotes subfasciatus (Boheman) (Coleoptera: Bruchidae) and its correlation with flavonoids. Journal of Stored Products Research., 67, 63–70.
  • Esmaeili, M.A. and Alilou, M., 2014. Naringenin attenuates CCl4-induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats. Clinical and Experimental Pharmacology & Physiology, 41 (6), 416–422.
  • Ferreira, D.W., et al., 2016. Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1862 (4), 662–669.
  • Gracia-Sancho, J., et al., 2014. Modulation of autophagy for the treatment of liver diseases. Expert Opinion on Investigational Drugs, 23 (7), 965–977.
  • He, L., 2012. Studies on flavonoids of Scorzonera austriaca Wittd. Jilin University School of Pharmacy.
  • He, Y., et al., 2019. Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice. International Immunopharmacology, 68, 171–178.
  • Huang, H.L., et al., 2012. Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice. World Journal of Gastroenterology, 18 (45), 6605–6613.
  • Karkampouna, S., et al., 2016. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice . Archives of Toxicology, 90 (2), 347–357.
  • Levine, B. and Kroemer, G., 2008. Autophagy in the pathogenesis of disease. Cell, 132 (1), 27–42.
  • Li, B., et al., 2007. Two new olean-type triterpene fatty esters from Scorzonera mongolica. Chinese Chemical Letters, 18 (6), 708–710.
  • Li, J., et al., 2004. A new sesquiterpene lactone from Scorzonera austriaca. Chinese Chemical Letters, 15, 1309–1310.
  • Liu, F.Y., et al 2017. Anti-inflammatory effects of a Mytilus coruscus α-d-Glucan (MP-A) in activated macrophage cells via TLR4/NF-κB/MAPK pathway inhibition. Marine Drugs, 15 (9), 294.
  • Liu, X., et al., 2012. Isolation and structure identification of flavonoidglycosides from Scorzonera austriaca Wild. Journal of Jilin University Medicine Edition, 38, 595–597.
  • Liu, Z.G., et al., 2018. Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 103, 1262–1271.
  • Li, Q.M. and Wang, G.S., 2010. Isolation and structure identification of flavonoid glycosides from Scorzonera ruprechtiana Lipsch et Krasch. Journal of Jilin University Medicine Edition, 36, 10–13.
  • Michalopoulos, G.K., 2007. Liver regeneration. Journal of Cellular Physiology, 213 (2), 286–300.
  • Mukhopadhyay, P., et al., 2014. Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. Hepatology (Baltimore, Md.), 59 (5), 1998–2009.
  • Nadeem, M., et al., 2018. Effect of ultrasound and chemical treatment on total phenol, flavonoids and antioxidant properties on carrot-grape juice blend during storage. Ultrasonics Sonochemistry, 45, 1–6.
  • Paraschos, S., et al., 2001. Three new dihydroisocoumarins from the Greek endemic species Scorzonera cretica. Journal of Natural Products, 64 (12), 1585–1587.
  • Pelzer, L.E., et al., 1998. Acute and chronic antiinflammatory effects of plant flavonoids. Farmaco (Societa Chimica Italiana : 1989), 53 (6), 421–424.
  • Peng, W., et al., 2015. Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (Lour.) Merr. var. Tomentosa. Journal of Ethnopharmacology, 174, 317–321.
  • Qiang, L., et al., 2017. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy, 13 (12), 2086–2103.
  • Raffa, D., et al., 2017. Recent discoveries of anticancer flavonoids. European Journal of Medicinal Chemistry, 142, 213–228.
  • Recknagel, R.O., et al., 1989. Mechanisms of carbon tetrachloride toxicity. Pharmacology & Therapeutics, 43 (1), 139–154.
  • Reiter, R.J., et al., 2000. Actions of melatonin in the reduction of oxidative stress. A review. Journal of Biomedical Science, 7 (6), 444–458.
  • Ruart, M., et al., 2019. Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury. Journal of Hepatology, 70 (3), 458–469.
  • Saha, S., et al., 2018. Autophagy in health and disease: a comprehensive review. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 104, 485–495.
  • Sun, F., et al., 2001. Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver. Biochimica et Biophysica Acta, 1535 (2), 186–191.
  • Szpechcinski, A., et al., 2015. Cell-free DNA levels in plasma of patients with non-small-cell lung cancer and inflammatory lung disease. British Journal of Cancer, 113 (3), 476–483.
  • Tang, D., et al., 2017. Dicranostiga leptopodu (Maxim.) Fedde extracts attenuated CCl4-induced acute liver damage in mice through increasing anti-oxidative enzyme activity to improve mitochondrial function. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 85, 763–771.
  • The Editorial Board of Zhong Hua Ben Cao of State Administration of Traditional Chinese Medicine of the People’s Republic of China, 1999. Zhong Hua Ben Cao. 1st ed. Shanghai, China: Scientific and Technical Publishers, 939–941.
  • Wang, W.D., et al., 2018. Sesquiterpenoids from the root of Panax Ginseng protect CCl4-induced acute liver injury by anti-inflammatory and anti-oxidative capabilities in mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 102, 412–419.
  • Wang, Y., et al., 2012. Adipose derived mesenchymal stem cells transplantation via portal vein improves microcirculation and ameliorates liver fibrosis induced by CCl4 in rats. Journal of Translational Medicine, 10, 133.
  • Weber, L.W., Boll, M., and Stampfl, A., 2003. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critical Reviews in Toxicology, 33 (2), 105–136.
  • Wu, H., et al., 2016. Protective effect of Trillium tschonoskii saponin on CCl4-induced acute liver injury of rats through apoptosis inhibition. Canadian Journal of Physiology and Pharmacology, 94 (12), 1291–1297.
  • Wu, Z., et al., 2010. Acute liver failure: mechanisms of immune-mediated liver injury. Liver International : Official Journal of the International Association for the Study of the Liver, 30 (6), 782–794.
  • Xie, Y., Guo, Q.S., and Wang, G.S., 2016. Flavonoid glycosides and their derivatives from the herbs of Scorzonera austriaca Wild. Molecules, 21 (6), 803.
  • Xie, Y., Guo, Q.S., and Wang, G.S., 2016. Preparative separation and purification of the total flavonoids in Scorzonera austriaca with macroporous resins. Molecules, 21, 6.
  • Yin, H.F., et al., 2018. Baicalein improves liver inflammation in diabetic db/db mice by regulating HMGB1/TLR4/NF-κB signaling pathway. International Immunopharmacology, 55, 55–62.
  • Yoshii, S.R. and Mizushima, N., 2017. Monitoring and measuring autophagy. International Journal of Molecular Sciences, 18 (9), 1865.
  • Zhan, F., et al., 2019. Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 protects the liver from thioacetamide-induced oxidative stress, inflammation and injury by triggering hepatocyte autophagy. International Immunopharmacology, 73, 261–269.
  • Zhang, T.W., et al., 2015. Study on hepatoprotective effects of total flavonoids in Scorzonera austriaca Wild in vivo and in vitro. Chinese Journal of Biochemical and Pharmaceuticals, 5 (6-9), 13.
  • Zidorn, C., et al., 2003. Tyrolobibenzyls E and F from Scorzonera humilis and distribution of caffeic acid derivatives, lignans and tyrolobibenzyls in European taxa of the subtribe Scorzonerinae (Lactuceae, Asteraceae). Phytochemistry, 63 (1), 61–67.

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