Nebivolol alleviates liver damage caused by methotrexate via AKT1/Hif1α/eNOS signaling

References

• Abdel-Wahhab, M.A., et al., 1999. Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats. Journal of Applied Toxicology, 19 (1), 7–12.
   PubMed Web of Science ®Google Scholar
• Arab, H.H., et al., 2018. Camel milk attenuates methotrexate-induced kidney injury via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations. Food & Function, 9 (5), 2661–2672.
   PubMed Web of Science ®Google Scholar
• Asci, H., et al., 2017. The impact of gallic acid on the methotrexate-induced kidney damage in rats. Journal of Food and Drug Analysis, 25 (4), 890–897.
   PubMed Web of Science ®Google Scholar
• Bhattacharyya, A., et al., 2014. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Reviews, 94 (2), 329–354.
   PubMed Web of Science ®Google Scholar
• Celik, T., et al., 2009. The anti-inflammatory effects of nebivolol in human coronary smooth muscle cells: clinical implications. International Journal of Cardiology, 133 (3), 415–416.
   PubMed Web of Science ®Google Scholar
• Chen, L., et al., 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9 (6), 7204–7218.
   PubMedGoogle Scholar
• Cronstein, B.N., and Aune, T.M., 2020. Methotrexate and its mechanisms of action in inflammatory arthritis. Nature ReviewsRheumatology, 16 (3), 145–154.
   PubMed Web of Science ®Google Scholar
• Czarnecka-Operacz, M., and Sadowska-Przytocka, A., 2014. The possibilities and principles of methotrexate treatment of psoriasis – the updated knowledge. Postepy Dermatologii i Alergologii, 31 (6), 392–400.
   PubMed Web of Science ®Google Scholar
• Eki Nci-Akdemi, F.N., et al., 2018. The effects of casticin and myricetin on liver damage induced by methotrexate in rats. Iranian Journal of Basic Medical Sciences, 21 (12), 1281–1288.
   PubMed Web of Science ®Google Scholar
• Erdogan, M.A., and Yalcin, A., 2020. Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats. Archives of Medical Science, 16 (1), 205–211.
   PubMed Web of Science ®Google Scholar
• Erel, O., 2004. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry, 37 (4), 277–285.
   PubMed Web of Science ®Google Scholar
• Erel, O., 2005. A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38 (12), 1103–1111.
   PubMed Web of Science ®Google Scholar
• Fongemie, J., and Felix-Getzik, E.A., 2015. A review of nebivolol pharmacology and clinical evidence. Drugs, 75 (12), 1349–1371.
   PubMed Web of Science ®Google Scholar
• Gündüz, E., et al., 2015. Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats. International Journal of Clinical and Experimental Medicine, 8 (5), 7898–7905.
   PubMed Web of Science ®Google Scholar
• Guo, J.Y., et al., 2011. Ischemic postconditioning attenuates liver warm ischemia-reperfusion injury through Akt-eNOS-NO-HIF pathway. Journal of Biomedical Science, 18 (1), 79.
   PubMed Web of Science ®Google Scholar
• Howard, S.C., et al., 2016. Preventing and managing toxicities of high-dose methotrexate. The Oncologist, 21 (12), 1471–1482.
   PubMed Web of Science ®Google Scholar
• Iwakiri, Y., and Kim, M.Y., 2015. Nitric oxide in liver diseases. Trends in Pharmacological Sciences, 36 (8), 524–536.
   PubMed Web of Science ®Google Scholar
• Lehmann-Werman, R., et al., 2018. Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA. JCI Insight, 3 (12), e120687.
   PubMed Web of Science ®Google Scholar
• Ma, Q., et al., 2010. Cell density plays a critical role in ex vivo expansion of T cells for adoptive immunotherapy. Journal of Biomedicine and Biotechnology, 2010, 386545
   PubMedGoogle Scholar
• Ma, F.X., and Han, Z.C., 2005. Akt signaling and its role in postnatal neovascularization. Histol Histopathol, 20 (1), 275–281.
   PubMed Web of Science ®Google Scholar
• Mehrzadi, S., et al., 2018. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomedicine and Pharmacotherapy., 97, 233–239.
   PubMed Web of Science ®Google Scholar
• Metineren, H., et al., 2017. Effect of nebivolol on fracture healing: an experimental rat model. Advances in Clinical and Experimental Medicine, 26 (6), 919–923.
   PubMed Web of Science ®Google Scholar
• Mittal, M., et al., 2014. Reactive oxygen species in inflammation and tissue injury. Antioxidants & Redox Signaling, 20 (7), 1126–1167.
   PubMed Web of Science ®Google Scholar
• Mohamed, D.I., et al., 2019. Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat. Biomedicine and Pharmacotherapy, 109, 892–901.
   PubMed Web of Science ®Google Scholar
• Morsy, M.A., and Heeba, G.H., 2016. Nebivolol ameliorates cisplatin-induced nephrotoxicity in rats. Basic & Clinical Pharmacology & Toxicology, 118 (6), 449–455.
   PubMed Web of Science ®Google Scholar
• Rofaeil, R.R., et al., 2017. Different effects of selective β1-adrenoceptor antagonists, nebivolol or atenolol in acetaminophen-induced hepatotoxicity of rats. Fundamental and Clinical Pharmacology, 31 (2), 165–173.
   PubMed Web of Science ®Google Scholar
• Samdanci, E.T., et al., 2019. Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study. Drug Design, Development and Therapy, 13, 13–21.
   PubMed Web of Science ®Google Scholar
• Savas, H.B., et al., 2017. Positive effects of meal frequency and calorie restriction on antioxidant systems in rats. North Clin Istanb, 4 (2), 109–116.
   PubMed Web of Science ®Google Scholar
• Sripradha, R., et al., 2016. Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats. Journal of Complementary & Integrative Medicine, 13 (1), 9–16.
   PubMedGoogle Scholar
• Sumer, F., et al., 2017. Effect of nebivolol on liver regeneration in an experimental 70% partial hepatectomy model. Asian Journal of Surgery, 40 (5), 375–379.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2017. Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats. Clinical and Experimental Hypertension, 39 (7), 628–639.
   PubMed Web of Science ®Google Scholar
• Yang, H., et al., 2005. Monoclonal antibodies that identify the CD3 molecules expressed specifically at the surface of porcine gammadelta-T cells. Immunology, 115 (2), 189–196.
   PubMed Web of Science ®Google Scholar
• Yuksel, M., et al., 2017. Is oxidative stress associated with activation and pathogenesis of inflammatory bowel disease? Journal of Medical Biochemistry, 36 (4), 341–348.
   PubMed Web of Science ®Google Scholar
• Yuvanc, E., et al., 2018. Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion. Acta Cirurgica Brasileira, 33 (2), 125–133.
   PubMed Web of Science ®Google Scholar
• Zagórska, A., and Dulak, J., 2004. HIF-1: the knowns and unknowns of hypoxia sensing. Acta Biochimica Polonica, 51 (3), 563–585.
   PubMed Web of Science ®Google Scholar
• Zeng, T., et al., 2018. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. Redox Biology, 14, 295–304.
   PubMed Web of Science ®Google Scholar