529
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats

ORCID Icon, , &

References

  • Altintas, R., et al., 2012. Protective effect of dexpanthenol on ischemia-reperfusion-induced renal injury in rats. Kidney & Blood Pressure Research, 36 (1), 220–230.
  • Arora, R.B., Kumar, K., and Deshmukh, R.R., 2013. FK506 attenuates intracerebroventricular streptozotocin-induced neurotoxicity in rats. Behavioural Pharmacology, 24 (7), 580–589.
  • Assaraf, M.I., et al., 2007. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. Journal of Neuropathology and Experimental Neurology, 66 (5), 389–398.
  • Bilgic, Y., et al., 2018. Protective effect of dexpanthenol against cisplatin-induced hepatotoxicity. Experimental and Therapeutic Medicine, 16 (5), 4049–4057.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248–254.
  • Cagin, Y.F., et al., 2016. Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model. Free Radical Research, 50 (3), 354–365.
  • Clark, I., et al., 2012. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacological Reviews, 64 (4), 1004–1026.
  • Coimbra, J.R.M., et al., 2018. Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment. Frontiers in Chemistry, 6, 178.
  • Cruz-Aguado, R., et al., 2001. Behavioral and biochemical effects of glutathione depletion in the rat brain. Brain Research Bulletin, 55 (3), 327–333.
  • Daugherty, M., et al., 2002. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Journal of Biological Chemistry, 277 (24), 21431–21439.
  • Dean, O., et al., 2009. Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice. Behavioural Brain Research, 198 (1), 258–262.
  • Elmore, S., 2007. Apoptosis: a review of programmed cell death. Toxicologic Pathology, 35 (4), 495–516.
  • Emir, U.E., et al., 2011. Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain. NMR in Biomedicine, 24 (7), 888–894.
  • Erbaş, O., et al., 2018. Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study. Journal of Biochemical and Molecular Toxicology, 32 (6), e22053.
  • Ermis, H., et al., 2013. Protective effect of dexpanthenol on bleomycin-induced pulmonary fibrosis in rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 386 (12), 1103–1110.
  • Etensel, B., et al., 2007. Dexpanthenol attenuates lipid peroxidation and testicular damage at experimental ischemia and reperfusion injury. Pediatric Surgery International, 23 (2), 177–181.
  • Fan, L.L., et al., 2011. In vivo effect of 5-HT7 receptor agonist on pyramidal neurons in medial frontal cortex of normal and 6-hydroxydopamine-lesioned rats: an electrophysiological study. Neuroscience, 190, 328–338.
  • Fox, M., et al., 2013. Hygiene and the world distribution of Alzheimer's disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden. Evolution, Medicine, and Public Health, 2013 (1), 173–186.
  • Francis, P.T., et al., 1999. The cholinergic hypothesis of Alzheimer's disease: a review of progress. Journal of Neurology, Neurosurgery, and Psychiatry, 66 (2), 137–147.
  • Gominak, S.C., 2016. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity . Medical Hypotheses, 94, 103–107.
  • Grand, J.H., Caspar, S., and Macdonald, S.W., 2011. Clinical features and multidisciplinary approaches to dementia care. Journal of Multidisciplinary Healthcare, 4, 125–147.
  • Grieb, P., 2016. Intracerebroventricular streptozotocin injections as a model of Alzheimer's disease: in search of a relevant mechanism. Molecular Neurobiology, 53 (3), 1741–1752.
  • Hamidi, G., et al., 2013. Erythropoietin improves spatial learning and memory in streptozotocin model of dementia. Pathophysiology, 20 (2), 153–158.
  • Handley, R.R., Reid, S.J., et al., 2017. Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases. Proceedings of the National Academy of Sciences of the United States of America, 114 (52), E11293–E11302.
  • Kamboj, A., Kiran, R., and Sandhir, R., 2006. Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine. Experimental Brain Research, 170 (4), 567–575.
  • Karadag, A., et al., 2015. Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis. Journal of Pediatric Surgery, 50 (7), 1119–1124.
  • Karran, E., Mercken, M., and De Strooper, B., 2011. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nature Reviews. Drug Discovery, 10 (9), 698–712.
  • Kennedy, D.O., 2016. B vitamins and the brain: mechanisms, dose and Efficacy-A Review. Nutrients, 8 (2), 68.
  • Khairallah, M.I., and Kassem, L.A., 2011. Alzheimer’s disease: Current status of etiopathogenesis and therapeutic strategies. Pakistan Journal of Biological Sciences., 14, 257–272.
  • Lee, S.T., et al., 2012. Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models. Journal of Neurochemistry, 120 (1), 115–124.
  • Li-Mei, W., et al., 2016. Anti-inflammatory and anti-oxidative effects of Dexpanthenol on Lipopolysaccharide Induced Acute Lung Injury in Mice. Inflammation, 39 (5), 1757–1763.
  • Majkutewicz, I., et al., 2016. Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats. Behavioural Brain Research, 308, 24–37.
  • Mehla, J., Pahuja, M., and Gupta, Y.K., 2013. Streptozotocin-induced sporadic Alzheimer's disease: selection of appropriate dose. Journal of Alzheimer's Disease, 33 (1), 17–21.
  • Montgomery, S.L., and Bowers, W.J., 2012. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. Journal of Neuroimmune Pharmacology, 7 (1), 42–49.
  • Mucke, L., 2009. Neuroscience: Alzheimer's disease. Nature, 461 (7266), 895–897.
  • Ortman, J. M., Velkoff, V. A., and Hogan, H., 2014. An aging nation: the older population in the United States, Current Population Reports, P25-1140. U.S. Census Bureau, Washington, D.C.
  • Patassini, S., et al., 2015. Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington’s disease. Biochemical and Biophysical Research Communications., 468 (1-2), 161–166.
  • Patassini, S., et al., 2019. Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s. Metabolites, 9 (6), 113.
  • Patassini, S., et al., 2016. Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain. Biochimica et Biophysica Acta, 1862 (9), 1650–1662.
  • Paxinos, G., and Watson, C., 1998. The rat brain in stereotaxic coordinates. Spiral Bound, 4th ed. New York: Academic Press.
  • Pinton, S., et al., 2011. Sporadic dementia of Alzheimer's type induced by streptozotocin promotes anxiogenic behavior in mice. Behavioural Brain Research, 223 (1), 1–6.
  • Ravelli, K.G., et al., 2017. Intracerebroventricular streptozotocin as a model of Alzheimer's Disease: Neurochemical and Behavioral Characterization in Mice. Neurotoxicity Research, 31 (3), 327–333.
  • Rucker, R. B., and Bauerly, K., 2013. Pantothenic acid. In: Zempleni J, Suttie JW, Gregory III JF, Stover PJ, editors. Handbook of vitamins. 5th ed. Boca Raton: CRC Press.
  • Salkovic-Petrisic, M., et al., 2013. What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research. Journal of Neural Transmission, 120 (1), 233–252.
  • Salkovic-Petrisic, M., et al., 2011. Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study. Journal of Neural Transmission, 118 (5), 765–772.
  • Selkoe, D.J., 1993. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends in Neurosciences, 16 (10), 403–409.
  • Shaw, C.A., Pasqualotto, B.A., and Curry, K., 1996. Glutathione-induced sodium currents in neocortex. Neuroreport, 7 (6), 1149–1152.
  • Sm, S., et al., 2018. Curative role of pantothenic acid in brain damage of gamma irradiated rats. Indian Journal of Clinical Biochemistry, 33 (3), 314–321.
  • Slyshenkov, V.S., Dymkowska, D., and Wojtczak, L., 2004. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Letters, 569 (1-3), 169–172.
  • Slyshenkov, V.S., Moiseenok, A.G., and Wojtczak, L., 1996. Noxious effects of oxygen reactive species on energy-coupling processes in Ehrlich ascites tumor mitochondria and the protection by pantothenic acid. Free Radical Biology & Medicine, 20 (6), 793–800.
  • Slyshenkov, V.S., Rakowska, M., and Wojtczak, L., 1996. Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin. Acta Biochimica Polonica, 43 (2), 407–410.
  • Solmaz, V., et al., 2015. Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats. European Journal of Pharmacology, 765, 482–487.
  • Stepanichev, M.Y., et al., 2016. Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: the involvement of the thiol redox state and coenzyme a neurochem. Neurochemical Journal, 10 (2), 120–130.
  • Tekgul, H., et al., 2020. The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat. The International Journal of Neuroscience, 130 (2), 193–203.
  • Tonelli, L.H., et al., 2009. Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents. Brain, Behavior, and Immunity, 23 (6), 784–793.
  • Uchida, Y., et al., 2015. Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. Journal of Neurochemistry, 134 (1), 97–112.
  • Xu, J., et al., 2016. Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder. Biochimica et Biophysica Acta, 1862 (6), 1084–1092.
  • Zakaria, M.M., et al., 2011. Ameliorating effects of dexpanthenol in cerebral ischaemia reperfusion induced injury in rat brain. Journal of Pakistan Medical Association, 61 (9), 889–892.
  • Zhou, Z.H., et al., 2001. The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes. Proceedings of the National Academy of Sciences of the United States of America, 98 (26), 14802–14807.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.