Synergistic hepatoprotective effects of ω-3 and ω-6 fatty acids from Indian flax and sesame seed oils against CCl₄-induced oxidative stress-mediated liver damage in rats

References

• Ahmed, E., et al., 2011. The protective effect of flaxseed oil on lead acetate-induced renal toxicity in rats. Journal of Hazardous Materials, 194, 250–255.
   PubMed Web of Science ®Google Scholar
• Amiri, H., 2010. Antioxidant activity of the essential oil and methanolic extract of Teucrium orientale (L.) subsp. taylori (Boiss.) Rech. f. Iranian Journal of Pharmaceutical Research, 9(4), 417–423.
   PubMed Web of Science ®Google Scholar
• Arora, S., et al., 2008. Cellular responses induced by silver nanoparticles: in vitro studies. Toxicology Letters, 179(2), 93–100.
   PubMed Web of Science ®Google Scholar
• Basiricò, L., et al., 2017. Comparison between conjugated linoleic acid and essential fatty acids in preventing oxidative stress in bovine mammary epithelial cells. Journal of Dairy Science, 100(3), 2299–2309.
   PubMed Web of Science ®Google Scholar
• Baureder, M., Barane, E., and Hederstedt, L., 2014. In vitro assembly of catalase. Journal of Biological Chemistry, 289(41), 28411–28420.
   PubMed Web of Science ®Google Scholar
• Ben Hsouna, A., et al., 2019. Antioxidant and hepato-preventive effect of Citrus aurantium extract against carbon tetrachloride-induced hepatotoxicity in rats and characterisation of its bioactive compounds by HPLC-MS. Archives of Physiology and Biochemistry, 125(4), 332–343.
   PubMed Web of Science ®Google Scholar
• Benslama, A., and Harrar, A., 2016. Free radicals scavenging activity and reducing power of two Algerian Sahara medicinal plants extracts. International Journal of Herbal Medicine, 4(6c), 158–161.
   Google Scholar
• Chang, M.-L., et al., 2005. Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. World Journal of Gastroenterology, 11(27), 4167–4172.
   PubMed Web of Science ®Google Scholar
• Chidambara Murthy, K.N., Jayaprakasha, G.K., and Singh, R.P., 2002. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. Journal of Agricultural and Food Chemistry, 50(17), 4791–4795.
   PubMed Web of Science ®Google Scholar
• Draycott, S.A., et al., 2019. Maternal dietary ratio of linoleic acid to alpha-linolenic acid during pregnancy has sex-specific effects on placental and fetal weights in the rat. Nutrition & Metabolism, 16(1), 1.
   PubMed Web of Science ®Google Scholar
• Essawy, A.E., et al., 2018. Dual protective effect of ginger and rosemary extracts against CCl 4-induced hepatotoxicity in rats. Environmental Science and Pollution Research, 25(20), 19510–19517.
   PubMed Web of Science ®Google Scholar
• FadlAlla, E.A.S., et al., 2014. Hypolipidemic, antioxidant and renal protective effect of seeds mixture rich in omega-3 and omega-6 fatty acids in rats. Life Science Journal, 11(10), 866–877.
   Google Scholar
• Ferreira, E.A., et al., 2010. Potent hepatoprotective effect in CCl4-induced hepatic injury in mice of phloroacetophenone from Myrcia multiflora. Libyan Journal of Medicine, 5(1), 4891
   PubMed Web of Science ®Google Scholar
• Figueiredo, P.S., et al., 2017. Oxidative stability of sesame and flaxseed oils and their effects on morphometric and biochemical parameters in an animal model. Journal of the Science of Food and Agriculture, 97(10), 3359–3364.
   PubMed Web of Science ®Google Scholar
• Gharby, S., et al., 2017. Chemical characterization and oxidative stability of seeds and oil of sesame grown in Morocco. Journal of the Saudi Society of Agricultural Sciences, 16(2), 105–111.
   Google Scholar
• Guimarães, R.D.C.A., et al., 2013. Sesame and flaxseed oil: nutritional quality and effects on serum lipids and glucose in rats. Food Science and Technology, 33(1), 209–217.
   Web of Science ®Google Scholar
• Halliwell, B., and Gutteridge, J.M., 2015. Free radicals in biology and medicine. New York: Oxford University Press.
   Google Scholar
• Hancock, J.T., Desikan, R., and Neill, S.J., 2001. Role of reactive oxygen species in cell signalling pathways. Biochemical Society Transactions, 29, 345–350.
   PubMed Web of Science ®Google Scholar
• Hossain, M.I., et al., 2012. Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract. International Current Pharmaceutical Journal, 1(9), 250–257.
   Google Scholar
• Hsouna, A.B., et al., 2019. Essential oil from halophyte Lobularia maritima: Protective effects against CCl4-induced hepatic oxidative damage in rats and inhibition of the production of proinflammatory gene expression by lipopolysaccharide-stimulated RAW 264.7 macrophages. RSC Advances, 9(63), 36758–36770.
   PubMed Web of Science ®Google Scholar
• Jothy, S.L., et al., 2012. Antioxidant activity and hepatoprotective potential of Polyalthia longifolia and Cassia spectabilis leaves against paracetamol-induced liver injury. Evidence-Based Complementary and Alternative Medicine, 2012, 561284.
   PubMed Web of Science ®Google Scholar
• Kajla, P., Sharma, A., and Sood, D.R., 2015. Flaxseed—a potential functional food source. Journal of Food Science and Technology, 52(4), 1857–1871.
   PubMed Web of Science ®Google Scholar
• Latini, J.T.P., et al., 2018. Can the indicators of chronic ethanol consumption be minimized by a continuous flaxseed intake? International Journal of Experimental Pathology, 99(5), 218–225.
   PubMed Web of Science ®Google Scholar
• Lee, A.Y., et al., 2015. Comparative study on antioxidant activity of vegetable oils under in vitro and cellular system. Journal of Agricultural Science, 7(3), 58.
   Google Scholar
• Lee, G.H., et al., 2017. Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress. BMC Research Notes, 10(1), 77.
   PubMed Web of Science ®Google Scholar
• Lowry, O.H., et al., 1951. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193(1), 265–275.
   PubMed Web of Science ®Google Scholar
• Lu, Y., et al., 2016. Protective effect of wedelolactone against CCl4-induced acute liver injury in mice. International Immunopharmacology, 34, 44–52.
   PubMed Web of Science ®Google Scholar
• Makni, M., et al., 2008. Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in ω-3 and ω-6 fatty acids in hypercholesterolemic rats. Food and Chemical Toxicology, 46(12), 3714–3720.
   PubMed Web of Science ®Google Scholar
• Makni, M., et al., 2010. Hypolipidemic and hepatoprotective seeds mixture diet rich in ω-3 and ω-6 fatty acids. Food and Chemical Toxicology, 48(8–9), 2239–2246.
   PubMed Web of Science ®Google Scholar
• Mareai, S.S., et al., 2018. Protective Effect of secoisolariciresinol diglycoside in carbon tetrachloride induced hepatotoxicity in rats. Journal of Clinical & Cellular Immunology, 9(567), 2.
   Google Scholar
• Meganathan, M., et al., 2011. Evaluation of hepatoprotective effect of omega 3-fatty acid against paracetamol induced liver injury in albino rats. Global Journal of Pharmacology, 5(1), 50–53.
   Google Scholar
• Morrison, W.R., and Smith, L.M., 1964. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol. Journal of Lipid Research, 5(4), 600–608.
   PubMed Web of Science ®Google Scholar
• Nagy, K., and Tiuca, I.D., 2017. Importance of fatty acids in physiopathology of human body. In: A. Catala, ed. Fatty acids. IntechOpen.
   Google Scholar
• Peng, C., et al., 2019. CCl4-induced liver injury was ameliorated by Qi-Ge decoction through the antioxidant pathway. Evidence-Based Complementary and Alternative Medicine, 2019, 5941263.
   PubMed Web of Science ®Google Scholar
• Rajesha, J., et al., 2009. Effects of flaxseed and spirulina biomass in layer diet on lipid profile and quality characteristics of egg yolk. Journal of Food Science and Technology, 46(6), 509–514.
   Web of Science ®Google Scholar
• Recknagel, R.O., 1967. Carbon tetrachloride hepatotoxicity. Pharmacological Reviews, 19(2), 145–208.
   PubMed Web of Science ®Google Scholar
• Rizwan, S., et al., 2014. Protective effect of dietary flaxseed oil on arsenic-induced nephrotoxicity and oxidative damage in rat kidney. Food and Chemical Toxicology, 68, 99–107.
   PubMed Web of Science ®Google Scholar
• Scholten, D., et al., 2015. The carbon tetrachloride model in mice. Laboratory Animals, 49(1), 4–11.
   PubMed Web of Science ®Google Scholar
• Shaban, N.Z., et al., 2014. Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats. Journal of Medicinal Food, 17(3), 339–349.
   PubMed Web of Science ®Google Scholar
• Siddhuraju, P., and Becker, K., 2003. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. Journal of Agricultural and Food Chemistry, 51(8), 2144–2155.
   PubMed Web of Science ®Google Scholar
• Simopoulos, A.P., 2002. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, 56(8), 365–379.
   PubMed Web of Science ®Google Scholar
• Sy, J., and Ang, L.C., 2019. Microtomy: cutting formalin-fixed, paraffin-embedded sections. Methods of Molecular Biology, 1897, 269–278.
   PubMedGoogle Scholar
• Vozarova, B., et al., 2002. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes, 51(6), 1889–1895.
   PubMed Web of Science ®Google Scholar
• Vuda, M., et al., 2012. Hepatoprotective and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-induced liver injury in rats. Experimental and Toxicologic Pathology, 64(7–8), 855–859.
   PubMed Web of Science ®Google Scholar
• Wang, T.Y., et al., 2018. Protective effects of melatonin on CCl4-induced acute liver damage and testicular toxicity in rats. Indian Journal of Pharmaceutical Sciences, 80(6), 1100–1107.
   Web of Science ®Google Scholar
• Wells, J.C., and Stock, J.T., 2020. Life history transitions at the origins of agriculture: a model for understanding how niche construction impacts human growth, demography and health. Frontiers in Endocrinology, 11, 325.
   PubMed Web of Science ®Google Scholar
• Xu, J., et al., 2017. A combination of flaxseed oil and astaxanthin improves hepatic lipid accumulation and reduces oxidative stress in high fat-diet fed rats. Nutrients, 9(3), 271.
   PubMed Web of Science ®Google Scholar
• Yıldırım, A., Mavi, A., and Kara, A.A., 2001. Determination of antioxidant and antimicrobial activities of Rumex crispus L. extracts. Journal of Agricultural and Food Chemistry, 49(8), 4083–4089.
   PubMed Web of Science ®Google Scholar
• Zhang, X.D., et al., 2010. Toxicologic effects of gold nanoparticles in vivo by different administration routes. International Journal of Nanomedicine, 5, 771.
   PubMed Web of Science ®Google Scholar