Effects of quetiapine administration on sperm quality and testicular histology

References

• Aitken, R.J. and Roman, S.D., 2008. Antioxidant systems and oxidative stress in the testes. Oxidative Medicine and Cellular Longevity, 1 (1), 15–24.
   PubMed Web of Science ®Google Scholar
• Aragon, M.A., et al., 2005. Serotoninergic system blockage in the prepubertal rat inhibits spermatogenesis development. Reproduction, 129, 717–727.
   PubMed Web of Science ®Google Scholar
• Bancroft, J.D. and Gamble, M., 2002. Theory and practice of histological techniques. Edinburgh, UK: E.P. Churchill Livingstone, 673–674.
   Google Scholar
• Banerjee, S., et al., 2016. Drug metabolism and oxidative stress: cellular mechanism and new therapeutic insights. Biochemistry & Analytical Biochemistry, s3, 255.
   Google Scholar
• Chapin, R.E., 1997. The relationships among reproductive endpoints in Swiss mice, using the Reproductive Assessment by Continuous Breeding database. Fundamental and Applied Toxicology, 38 (2), 129–142.
   PubMedGoogle Scholar
• Correll, C.U., et al., 2015. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry, 14 (2), 119–136.
   PubMed Web of Science ®Google Scholar
• Crawford, G., et al., 2017., Pharmaceuticals and other endocrine disrupting compounds in natural water systems. Bracebridge, Canada: Muskoka Watershed Council.
   Google Scholar
• Creasy, D., 2001. Pathogenesis of male reproductive toxicity. Toxicologic Pathology, 29 (1), 64–76.
   PubMed Web of Science ®Google Scholar
• Csoka, A.B., et al., 2008. Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. The Journal of Sexual Medicine, 5 (1), 227–233.
   PubMed Web of Science ®Google Scholar
• Culpepper, L., 2003. Evidence for using atypical antipsychotics in mood and anxiety. The Journal of Clinical Psychiatry, 5 (3), 27–32.
   Google Scholar
• Dabbous, Z. and Atkin, S.L., 2018. Hyperprolactinaemia in male infertility: clinical case scenarios. Arab Journal of Urology, 16 (1), 44–52.
   PubMed Web of Science ®Google Scholar
• De Berardis, D., et al., 2018. Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of clozapine. Therapeutic Advances in Drug Safety, 9 (5), 237–256.
   PubMed Web of Science ®Google Scholar
• de Siqueira Bringel, S., et al., 2013. Endocrine and testicular changes induced by olanzapine in adult Wistar rats. Journal of Applied Toxicology, 33 (1), 24–31.
   PubMed Web of Science ®Google Scholar
• Drobnis, E. and Nangia, A.K., 2017. Psychotropics and male reproduction. Advances in Experimental Medicine and Biology, 1034, 63–101.
   PubMed Web of Science ®Google Scholar
• Duncan, D., et al., 2016. Quetiapine use in adults in the community: a population-based study in Alberta, Canada. BMJ Open, 6 (3), e010861.
   PubMed Web of Science ®Google Scholar
• Elbetieha, A., et al., 2001. Evaluation of the toxic potentials of cypermethrin pesticide on some reproductive and fertility parameters in the male rats. Archives of Environmental Contamination and Toxicology, 41 (4), 522–528.
   PubMed Web of Science ®Google Scholar
• Filler, R., 1993. Methods for evaluation of rat’s epididymal sperm morphology. In: R.E. Chapin, ed. Male reproductive toxicology. San Diego, CA: Academic Press, 334–343.
   Google Scholar
• Gao, J., et al., 2015. Effects of repeated quetiapine treatment on conditioned avoidance responding in rats. European Journal of Pharmacology, 769, 154–161.
   PubMed Web of Science ®Google Scholar
• Gao, K., et al., 2009. Atypical antipsychotics in primary generalized anxiety disorder or comorbid with mood disorders. Expert Review of Neurotherapeutics, 9 (8), 1147–1158.
   PubMed Web of Science ®Google Scholar
• Ghosh, D., et al., 2002. Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: a correlative study with testicular oxidative stress. Drug and Chemical Toxicology, 25 (3), 281–292.
   PubMed Web of Science ®Google Scholar
• Gromadzka-Ostrowska, J., et al., 2012. Silver nanoparticles effects on epididymal sperm in rats. Toxicology Letters, 214 (3), 251–258.
   PubMed Web of Science ®Google Scholar
• Guzick, D.S. 2001. Sperm morphology, motility, and concentration in fertile and infertile men. The New England Journal of Medicine, 345 (19), 1388–1393.
   PubMed Web of Science ®Google Scholar
• Hall, E. and Burt, V.K., 2012. Male fertility: psychiatric considerations. Fertility and Sterility, 97 (2), 434–439.
   PubMed Web of Science ®Google Scholar
• Hanssens, L., et al., 2008. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the schizophrenia trial of aripiprazole (STAR) study. BMC Psychiatry, 8 (1), 95.
   PubMedGoogle Scholar
• Hendrick, V., et al., 2000. Antidepressant medications, mood and male fertility. Psychoneuroendocrinology, 25 (1), 37–51.
   PubMed Web of Science ®Google Scholar
• Hyun, J.S., et al., 2002. Localization of peripheral dopamine D1 and D2 receptors in rat and human seminal vesicles. Journal of Andrology, 23 (1), 114–120.
   PubMedGoogle Scholar
• Ignacio, Z.M., et al., 2017. Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain. Metabolic Brain Disease, 32 (4), 1195–1208.
   PubMed Web of Science ®Google Scholar
• Johnsen, S.G., 1970. Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones, 1 (1), 2–25.
   PubMedGoogle Scholar
• Klett, D., et al., 2010. Effect of pharmaceutical potential endocrine disruptor compounds on protein disulfide isomerase reductase activity using di-eosin-oxidized-glutathione. PLoS One, 5 (3), e9507.
   PubMed Web of Science ®Google Scholar
• Koyuncu, H., et al., 2011. Escitalopram treatment for premature ejaculation has a negative effect on semen parameters. International Journal of Impotence Research, 23 (6), 257–261.
   PubMed Web of Science ®Google Scholar
• Kumar, N. and Singh, A.K., 2015. Trends of male factor infertility, an important cause of infertility: a review of literature. Journal of Human Reproductive Sciences, 8 (4), 191–196.
   PubMedGoogle Scholar
• Kushwaha, S. and Jena, G.B., 2013. Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms. Mutation Research, 755 (1), 11–23.
   PubMed Web of Science ®Google Scholar
• Lee, J., et al., 2018. Increasing rates of quetiapine overdose, misuse, and mortality in Victoria. Drug and Alcohol Dependence, 187, 95–99.
   PubMed Web of Science ®Google Scholar
• Li, X. and Cameron, M.D., 2012. Potential role of a quetiapine metabolite in quetiapine-induced neutropenia and agranulocytosis. Chemical Research in Toxicology, 25 (5), 1004–1011.
   PubMed Web of Science ®Google Scholar
• Lucinda, L.M., et al., 2010. Assessment of sperm production and reproductive organs of Wistar rats to long-term exposure of Caesalpinia ferrea. Anais da Academia Brasileira de Ciencias, 82 (4), 907–914.
   PubMed Web of Science ®Google Scholar
• Maan, J.S., et al., 2020. Quetiapine. In: StatPearls. Treasure Island, FL: StatPearls Publishing.
   Google Scholar
• Martin, M.V., et al., 2005. Low dose quetiapine reverses deficits in contextual and cued fear conditioning in rats with excitotoxin-induced hippocampal neuropathy. Pharmacology, Biochemistry, and Behavior, 82 (2), 263–269.
   PubMed Web of Science ®Google Scholar
• Martinez, C.S., et al., 2014. 60-Day chronic exposure to low concentrations of HgCl2 impairs sperm quality: hormonal imbalance and oxidative stress as potential routes for reproductive dysfunction in rats. PLoS One, 9 (11), e111202.
   PubMed Web of Science ®Google Scholar
• McLelland, A.E., et al., 2014. The effect of quetiapine (Seroquel™) on conditioned place preference and elevated plus maze tests in rats when administered alone and in combination with (+)-amphetamine. Psychopharmacology, 231 (22), 4349–4359.
   PubMed Web of Science ®Google Scholar
• Mdhluli, M.C. and van der Horst, G., 2002. The effect of oleanolic acid on sperm motion characteristics and fertility of male Wistar rats. Laboratory Animals, 36 (4), 432–437.
   PubMed Web of Science ®Google Scholar
• Menkveld, R., 2001. Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds. Human Reproduction, 16 (6), 1165–1171.
   PubMed Web of Science ®Google Scholar
• Mori, K., et al., 1991. Dose dependent effects of inhaled ethylene oxide on spermatogenesis in rats. British Journal of Industrial Medicine, 48 (4), 270–274.
   PubMedGoogle Scholar
• Mruk, D.D. and Cheng, C.Y., 2015. The mammalian blood-testis barrier: its biology and regulation. Endocrine Reviews, 36 (5), 564–591.
   PubMed Web of Science ®Google Scholar
• Muench, J. and Hamer, A.M., 2010. Adverse effects of antipsychotic medications. American Family Physician, 81 (5), 617–622.
   PubMed Web of Science ®Google Scholar
• Narayana, K., et al., 2002. Ribavirin-induced sperm shape abnormalities in Wistar rat. Mutation Research, 513 (1–2), 193–196.
   PubMed Web of Science ®Google Scholar
• National Research Council. 2011. Guide for the care and use of laboratory animals. 8th ed. Washington, DC: The National Academies Press.
   Google Scholar
• Opuwari, C.S. and Monsees, T.K., 2014. In vivo effects of Aspalathus linearis (rooibos) on male rat reproductive functions. Andrologia, 46 (8), 867–877.
   PubMed Web of Science ®Google Scholar
• Organization for Economic Co-operation and Development. 2008. Guidelines for the testing of chemicals. Test no. 407: repeated dose 28-day oral toxicity study in rodents. Paris, France: OECD.
   Google Scholar
• Otth, C., et al., 2007. Novel identification of peripheral dopaminergic d2 receptor in male germ cells. Journal of Cellular Biochemistry, 100 (1), 141–150.
   PubMed Web of Science ®Google Scholar
• Ozkaya, A.K., et al., 2016. Effects of chronic amiodarone treatment on rat testis. Acta Histochemica, 118, 271–277.
   PubMed Web of Science ®Google Scholar
• Ozturk, M., et al., 2012. Increased sperm DNA damage in experimental rat varicocele model and the beneficial effect of varicocelectomy. International Journal of Fertility & Sterility, 6 (2), 95–100.
   PubMed Web of Science ®Google Scholar
• Payan-Carreira, R., et al., 2013., Molecular markers in sperm analysis, success in artificial insemination - quality of semen and diagnostics employed. London, UK: IntechOpen.
   Google Scholar
• Pineda, R., et al., 2010., Physiological roles of the Kisspeptin/GPR54 system in the neuroendocrine control of reproduction. In: L. Martini, ed. Neuroendocrinology: the normal neuroendocrine system. Amsterdam, The Netherlands: Elsevier Science, 1–299.
   Google Scholar
• Pira, L., et al., 2004. The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex. European Journal of Pharmacology, 504 (1–2), 61–64.
   PubMed Web of Science ®Google Scholar
• Pringsheim, T. and Gardner, D.M., 2014. Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study. CMAJ Open, 2 (4), E225–E232.
   PubMedGoogle Scholar
• Ramirez, A.R., et al., 2009. The presence and function of dopamine type 2 receptors in boar sperm: a possible role for dopamine in viability, capacitation, and modulation of sperm motility. Biology of Reproduction, 80 (4), 753–761.
   PubMed Web of Science ®Google Scholar
• Relwani, R., et al., 2011. Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reproductive Sciences, 18 (4), 391–397.
   PubMed Web of Science ®Google Scholar
• Riggin, L. and Koren, G., 2015. Effects of selective serotonin reuptake inhibitors on sperm and male fertility. Canadian Family Physician, 61 (6), 529–530.
   Web of Science ®Google Scholar
• Sacarny, A., et al., 2018. Effect of peer comparison letters for high-volume primary care prescribers of quetiapine in older and disabled adults: a randomized clinical trial. JAMA Psychiatry, 75 (10), 1003–1011.
   PubMed Web of Science ®Google Scholar
• Safarinejad, M.R., 2008. Sperm DNA damage and semen quality impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin structure assay. The Journal of Urology, 180 (5), 2124–2128.
   PubMed Web of Science ®Google Scholar
• Samplaski, M.K. and Nangia, A.K., 2015. Adverse effects of common medications on male fertility. Nature Reviews. Urology, 12 (7), 401–413.
   PubMed Web of Science ®Google Scholar
• Sangha, G.K., et al., 2011. Toxicological effects of cypermethrin on female albino rats. Toxicology International, 18 (1), 5–8.
   PubMedGoogle Scholar
• Schug, T.T., et al., 2011. Endocrine disrupting chemicals and disease susceptibility. The Journal of Steroid Biochemistry and Molecular Biology, 127 (3–5), 204–215.
   PubMed Web of Science ®Google Scholar
• Sedha, S., et al., 2015. Role of oxidative stress in male reproductive dysfunctions with reference to phthalate compounds. Journal of Urology, 12, 2304–2316.
   Web of Science ®Google Scholar
• Semet, M., et al., 2017. The impact of drugs on male fertility: a review. Andrology, 5 (4), 640–666.
   PubMed Web of Science ®Google Scholar
• Smit, M., et al., 2010. Decreased sperm DNA fragmentation after surgical varicocelectomy is associated with increased pregnancy rate. Journal of Urology, 183 (1), 270–274.
   PubMed Web of Science ®Google Scholar
• Soeiro de Souza, M.G., et al., 2015. Role of quetiapine beyond its clinical efficacy in bipolar disorder: from neuroprotection to the treatment of psychiatric disorders (Review). Experimental and Therapeutic Medicine, 9 (3), 643–652.
   PubMed Web of Science ®Google Scholar
• Solomon, R., et al., 2019. The association between psychotropic drug use and fertility problems among male subjects. Journal of Psychiatric Practice, 25 (1), 22–33.
   PubMed Web of Science ®Google Scholar
• Spano, M., et al., 2000. Sperm chromatin damage impairs human fertility. Fertility and Sterility, 73, 4350.
   Web of Science ®Google Scholar
• Syed, V. and Hecht, N.B., 2001. Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communication during aging in the Brown Norway rat. Biology of Reproduction, 64 (1), 107–112.
   PubMed Web of Science ®Google Scholar
• Takeuchi, K., et al., 2014. Effect of rebamipide ongastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats. Journal of Gastroenterology and Hepatology, 29 (4), 37–46.
   PubMedGoogle Scholar
• Tiwari, P., et al., 2012. Evidences of possible side effects of neuroleptic drugs: a systematic review. Asian Pacific Journal of Reproduction, 1 (4), 330–336.
   Google Scholar
• Togar, B., et al., 2012. The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes. Toxicology and Industrial Health, 28 (4), 327–333.
   PubMed Web of Science ®Google Scholar
• Uhler, M.L., et al., 2003. Relationship between sperm characteristics and hormonal parameters in normal couples. Fertility and Sterility, 79 (3), 1535–1542.
   PubMedGoogle Scholar
• Urra, J.A., et al., 2014. Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. PLoS One, 9 (11), e112834.
   PubMed Web of Science ®Google Scholar
• US Food and Drug Administration. 2005. Guidance for Industry: estimating the maximum safe starting dose in adult healthy volunteer. Rockville, MD: US Food and Drug Administration.
   Google Scholar
• US Food and Drug Administration. 2009. Advisory Committee Documentation: Seroquel XR® (quetiapine fumarate) for Major Depressive Disorder (MDD) or Generalized Anxiety Disorder (GAD).
   Google Scholar
• Van der Horst, G. and Maree, L., 2009. SpermBlue: a new universal stain for human and animal sperm which is also amenable to automated sperm morphology analysis. Biotechnic & Histochemistry, 84 (6), 299–308.
   PubMed Web of Science ®Google Scholar
• Wang, F.F., et al., 2012. Chronic stress induces ageing-associated degeneration in rat Leydig cells. Asian Journal of Andrology, 14 (4), 643–648.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2019. Mental health in the workplace. Geneva, Switzerland: WHO.
   Google Scholar
• Zini, A., 2001. Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men. Fertility and Sterility, 75 (4), 674–677.
   PubMed Web of Science ®Google Scholar