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Research Articles

In silico and in vivo protective effect of Morus nigra leaves on oxidative damage induced by iron overload

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Pages 2814-2824 | Received 04 Feb 2021, Accepted 05 Oct 2021, Published online: 18 Oct 2021

References

  • Aebi, H., 1984. Catalase in vitro. Methods in Enzymology, 105, 121–126.
  • Antunes, S.A., and Canziani, M.E.F., 2016. Hepcidin: an important iron metabolism regulator in chronic kidney disease. Jornal Brasileiro de Nefrologia : 'orgao Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia, 38 (3), 351–355.
  • Badria, F.A., et al., 2015. Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats. PLOS One, 10 (7), e0134156.
  • Bhowmik, A., et al., 2017. Inositol hexa phosphoric acid (phytic acid), a nutraceuticals, attenuates iron-induced oxidative stress and alleviates liver injury in iron overloaded mice. Biomedecine & Pharmacotherapie [Biomedicine & Pharmacotherapy], 87, 443–450.
  • Brazilian Ministry of Health [Official Website of the Health Ministry of Brazil], Brazil. 2009. RENISUS – national list of medicinal interest to SUS. May 10. Available from: http://portalarquivos.saude.gov.br/images/pdf/2014/maio/07/renisus.pdf [Accessed March 2019].
  • Das, S.K., et al., 2016. Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload. Liver International, 36 (2), 246–257.
  • Drury, R. A. B., and Wallington, E. A., 1980. Carleton histological technique. 5th ed. Oxford, New York, Toronto: Oxford University Press.
  • Eid, R., Arab, N.T.T., and Greenwood, M.T., 2017. Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms. Biochimica et Biophysica Acta (Bba) – Molecular Cell Research, 1864 (2), 399–430.
  • Emad, S., et al., 2017. Attenuation of stress induced memory deficits by nonsteroidal anti-inflammatory drugs (NSAIDs) in rats: role of antioxidant enzymes. Pharmacological Reports, 69 (2), 300–305.
  • Ercisli, S., et al., 2010. Phytochemical content of some black (Morus nigra L.) and purple (Morus rubra L.) Mulberry Genotypes. Food Technology and Biotechnology, 48 (1), 102–106.
  • Faccin, H., et al., 2016. Study of ion suppression for phenolic compounds in medicinal plant extracts using liquid chromatography − electrospray tandem mass spectrometry. Journal of Chromatography A, 142 (7), 111–124.
  • Figueredo, K.C., et al., 2018. Safety assessment of Morus nigra L. leaves: acute and subacute oral toxicity studies in Wistar rats. Journal of Ethnopharmacology, 224, 290–296.
  • Fustinoni-Reis, A.M., et al., 2016. Tucum-Do-Cerrado (Bactris setosa Mart.) consumption modulates iron homeostasis and prevents iron-induced oxidative stress in the rat liver. Nutrients, 8 (2), 14–38.
  • Glück, J., et al., 2018. In silico genotoxicity and carcinogenicity prediction for food-relevant secondary plant metabolites. Food and Chemical Toxicology, 116 (Pt B), 298–306.
  • Gray, J.P., Suhali-Amacher, N., and Ray, S.D., 2017. Metals and metal antagonists. Side Effects of Drugs Annual, 39, 197–208.
  • Hafez, M.M., et al., 2015. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Biological Research, 48, 30.
  • Ige, A.O., et al., 2019. Pathophysiology of iron overload-induced renal injury and dysfunction: roles of renal oxidative stress and systemic inflammatory mediators. Pathophysiology, 26 (2), 175–180.
  • Karaman, M., et al., 2021. Polarography as a technique of choice for the evaluation of total antioxidant activity: the case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient. Natural Product Research, 35 (10), 1711–1716.
  • Kontoghiorghe, C.N., Kolnagou, A., and Kontoghiorghes, G.J., 2015. Phytochelators intended for clinical use in iron overload, other diseases of iron imbalance and free radical pathology. Molecules, 20 (11), 20841–20872.
  • Kostić, D.A., et al., 2013. A survey on macro- and micro-elements, phenolic compounds, biological activity and use of Morus spp. (Moraceae). Fruits, 68 (4), 333–347.
  • Lim, S.H., and Choi, C., 2019. Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource. Nutrients, 11 (2), 437.
  • Meerpohl, J.J., et al., 2014. Deferasirox for managing transfusional iron overload in people with sickle cell disease. Cochrane Database of Systematic Reviews, 5, 5.
  • Nairz, M., et al., 2014. Iron at the interface of immunity and infection. Frontiers in Pharmacology, 5, 152.
  • Neha, K., et al., 2019. Medicinal prospects of antioxidants: a review. European Journal of Medical Chemistry, 178, 687–704.
  • Ohkawa, H., Ohishi, H., and Yagi, K., 1979. Assay for lipid peroxide in animal tissues thiobarbituric acid reaction. Analytical Biochemistry, 95 (2), 351–358.
  • Oliveira, L.S., et al., 2016. Effects of gallic acid on delta aminolevulinic dehydratase activity and in the biochemical, histological and oxidative stress parameters in the liver and kidney of diabetic rats. Biomedicine & Pharmacotherapy, 84, 1291–1299.
  • Piloni, N.E., et al., 2016. Sub-chronic iron overload triggers oxidative stress development in rat brain: implications for cell protection. Biometals, 29 (1), 119–130.
  • Regateiro, F.S., et al., 2017. Recurrent elevated liver transaminases and acute liver failure in two siblings with novel bi-allelic mutations of NBAS. European Journal of Medical Genetics, 60 (8), 426–432.
  • Ribeiro, T.P., et al., 2015. Iron, copper, and manganese complexes with in vitro superoxide dismutase and/or catalase activities that keep Saccharomyces cerevisiae cells alive under severe oxidative stress. Free Radical Biology & Medicine, 80, 67–76.
  • Robert, C.O., and Hustead, T.R., 2011. Causes and evaluation of mildly elevated liver transaminase levels. American Family Physician, 84 (9), 1003–1008.
  • Salgueiro, A.C., et al., 2016. In vitro and in silico antioxidant and toxicological activities of Achyrocline satureioides. Journal of Ethnopharmacology, 194 (194), 6–14.
  • Sánchez-Salcedo, E.M., et al., 2017. Phytochemical properties of white (Morus alba) and black (Morus nigra) mulberry leaves, a new food supplement. Journal of Food and Nutrition Research, 5, 253–261.
  • Sarkar, R., Hazra, B., and Mandal, N., 2012. Hepatoprotective potential of Caesalpinia crista against iron-overload-induced liver toxicity in mice. Evidence-Based Complementary and Alternative Medicine, 2012, 896341.
  • Sassa, S., 1982. Delta-aminolevulinic acid dehydratase assay. Enzyme, 28 (2–3), 133–145.
  • Schwartz, A.J., et al., 2019. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. Journal of Clinical Investigation, 129 (1), 336–348.
  • Sheikh, N.A., Desai, T.R., and Tirgar, P.R., 2017. Evaluation of iron chelating and antioxidant potential of Epilobium hirsutum for the management of iron overload disease. Biomedicine & Pharmacotherapy, 89, 1353–1361.
  • Tang, Y., et al., 2014. Quercetin attenuates chronic ethanol hepatotoxicity: Implication of "free" iron uptake and release. Food and Chemical Toxicology, 67, 131–138.
  • Turan, I., et al., 2017. Antiproliferative and apoptotic effect of Morus nigra extract on human prostate cancer cells. Saudi Pharmaceutical Journal, 25 (2), 241–248.
  • Volpato, G.T., et al., 2011. Effect of Morus nigra aqueous extract treatment on the maternal-fetal outcome, oxidative stress status and lipid profile of streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 138 (3), 691–696.
  • Wichard, J.D., 2017. In silico prediction of genotoxicity. Food and Chemical Toxicology, 106 (Pt B), 595–599.
  • Winter, W.E., Bazydlo, L.A.L., and Harris, N.S., 2014. The molecular biology of human iron metabolism. Laboratory Medicine, 45 (2), 92–102.

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