References
- Al-Asmari, A.K., et al., 2016. Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: a biochemical and histological study. Human & Experimental Toxicology, 35 (1), 10–20.
- Al-Asmari, A.K., et al., 2015. Ascorbic acid attenuates antineoplastic drug 5-fluorouracil induced gastrointestinal toxicity in rats by modulating the expression of inflammatory mediators. Toxicology Reports, 2, 908–916.
- Al-Sadi, R., et al., 2016. TNF-α modulation of intestinal tight junction permeability is mediated by NIK/IKK-α axis activation of the canonical NF-κB pathway. The American Journal of Pathology, 186 (5), 1151–1165.
- Al-Sadi, R., et al., 2014. Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PloS One., 9 (3), e85345–e85345.
- Al-Sadi, R., et al., 2010. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. The American Journal of Pathology, 177 (5), 2310–2322.
- Alevizos, M., et al., 2013. Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 111 (6), 542–547.
- Andrews, C., McLean, M.H., and Durum, S.K., 2018. Cytokine tuning of intestinal epithelial function. Frontiers in Immunology, 9, 1270.
- Borthakur, A., et al., 2010. Platelet-activating factor-induced NF-kappaB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent. Inflammatory Bowel Diseases, 16 (4), 593–603.
- Buege, J.A., and Aust, S.D., 1978. Microsomal lipid peroxidation. Methods in Enzymology, 52, 302–310.
- Chang, C.T., et al., 2012. 5-Fluorouracil induced intestinal mucositis via nuclear factor-kappaB activation by transcriptomic analysis and in vivo bioluminescence imaging. PLoS One, 7 (3), e31808.
- Charalambous, M.P., et al., 2009. Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. British Journal of Cancer, 101 (1), 106–115.
- Costa, D.V.S., et al., 2019. 5-Fluorouracil induces enteric neuron death and glial activation during intestinal mucositis via a S100B-RAGE-NFκB-dependent pathway. Scientific Reports, 9 (1), 665–665.
- Falzone, L., Salomone, S., and Libra, M., 2018. Evolution of cancer pharmacological treatments at the turn of the third millennium. Frontiers in Pharmacology., 9, 1300.
- Flanagan, L., et al., 2016. Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: caspase-3 inhibition as a therapeutic approach. Cell Death & Disease, 7 (2), e2087.
- Fritz, H., and Becker, H., 1981. The suitability of carboxymethylcellulose as a vehicle in reproductive studies. Arzneimittel-Forschung, 31 (5), 813–815.
- Hafez, H.M., Abdel-Hakeem, E.A., and Hassanein, H., 2020. Rupatadine, a dual antagonist of histamine and platelet-activating factor (PAF), attenuates experimentally induced diabetic nephropathy in rats. Naunyn-Schmiedeberg's archives of pharmacology, 393 (8), 1487–1500.
- Haines, R.J., et al., 2016. TNFα/IFNγ mediated intestinal epithelial barrier dysfunction is attenuated by microRNA-93 downregulation of PTK6 in mouse colonic epithelial cells. PloS One, 11 (4), e0154351.
- Henry, M.C.W., and Lawrence Moss, R., 2010. Chapter 34 - necrotizing enterocolitis. In: G.W. Holcomb, J.P. Murphy, and D.J. Ostlie, eds. Ashcraft’s pediatric surgery. 5th ed. Philadelphia: W.B. Saunders, 439–455.
- Huang, H., et al., 2018. Molecular regulation of histamine synthesis. Frontiers in Immunology, 9, 1392.
- Jones, N.L., et al., 1998. Ketotifen therapy for acute ulcerative colitis in children: a pilot study. Digestive Diseases and Sciences, 43 (3), 609–615.
- Kim, S.H., et al., 2018. Ursodeoxycholic acid attenuates 5-fluorouracil-induced mucositis in a rat model. Oncology Letters, 16 (2), 2585–2590.
- Leitao, R.F., et al., 2007. Role of nitric oxide on pathogenesis of 5-fluorouracil induced experimental oral mucositis in hamster. Cancer Chemotherapy and Pharmacology, 59 (5), 603–612.
- Lv, X.X., et al., 2013. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One, 8 (7), e68631.
- MacPherson, B.R., and Pfeiffer, C.J., 1978. Experimental production of diffuse colitis in rats. Digestion, 17 (2), 135–150.
- Moron, M.S., Depierre, J.W., and Mannervik, B., 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et biophysica acta, 582 (1), 67–78.
- Queralt, M., et al., 2000. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflammation Research : Official Journal of the European Histamine Research Society. [et al.], 49 (7), 355–360.
- Raithel, M., et al., 2010. Plasma histamine levels (H) during adjunctive H1-receptor antagonist treatment with loratadine in patients with active inflammatory bowel disease (IBD). Inflammation research : Official journal of the European Histamine Research Society. [et al.], 59 Suppl 2, S257–S8.
- Rtibi, K., et al., 2018. Contribution of oxidative stress in acute intestinal mucositis induced by 5 fluorouracil (5-FU) and its pro-drug capecitabine in rats. Toxicology Mechanisms and Methods, 28 (4), 262–267.
- Ruder, B., Atreya, R., and Becker, C., 2019. Tumour necrosis factor alpha in intestinal homeostasis and gut related diseases. International Journal of Molecular Sciences, 20 (8), 1887.
- Sastry, K.V., et al., 2002. Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Analytical Biochemistry, 306 (1), 79–82.
- Soares, P.M., et al., 2011. Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. Cancer Chemotherapy and Pharmacology, 68 (3), 713–720.
- Song, M.-K., Park, M.-Y., and Sung, M.-K., 2013. 5-Fluorouracil-induced changes of intestinal integrity biomarkers in BALB/c mice. Journal of Cancer Prevention, 18 (4), 322–329.
- Sun, X., et al., 2008. Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition. American Journal of Physiology. Gastrointestinal and Liver Physiology, 294 (1), G139–47.
- Sun, Z., et al., 2002. Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. The Journal of Surgical Research, 105 (2), 220–233.
- Sun, Z., et al., 1999. Roles of platelet-activating factor, interleukin-1beta and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. The Journal of Surgical Research, 87 (1), 90–100.
- Vasiadi, M., et al., 2010. Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli. International Archives of Allergy and Immunology, 151 (1), 38–45.
- Yasuda, M., et al., 2013. 5-HT3 receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. British Journal of Pharmacology, 168 (6), 1388–1400.
- Yasuda, M., et al., 2012. Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology, 302 (10), G1133–42.
- Yazbeck, R., et al., 2015. Combined effects of muricid extract and 5-fluorouracil on intestinal toxicity in rats. Evidence-Based Complementary and Alternative Medicine : eCAM, 2015, 170858.
- Zaidi, D., and Wine, E., 2018. Regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ) in inflammatory bowel diseases. Frontiers in Pediatrics, 6, 317.