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Research Articles

The inhibitory effects of pimozide, an antipsychotic drug, on voltage-gated K+ channels in rabbit coronary arterial smooth muscle cells

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Pages 271-280 | Received 08 Sep 2021, Accepted 14 Dec 2021, Published online: 23 Mar 2022

References

  • Barrese, V., Stott, J.B., and Greenwood, I.A., 2018. KCNQ-encoded potassium channels as therapeutic targets. Annual Review of Pharmacology and Toxicology, 58, 625–648.
  • Chen, T.T., et al., 2006. Key role of Kv1 channels in vasoregulation. Circulation Research, 99 (1), 53–60.
  • Cheong, A., et al., 2001. K(V)alpha1 channels in murine arterioles: differential cellular expression and regulation of diameter. American Journal of Physiology. Heart and Circulatory Physiology, 281 (3), H1057–1065.
  • Cogolludo, A., et al., 2006. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Circulation Research, 98 (7), 931–938.
  • Colquhoun, D., and Hawkes, A. G., 1995. The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms. In: Sakmann, B., and Neher, E., eds. Single-Channel Recording. New York: Springer, 397–482.
  • Committee on Safety of Medicines—Medicines Control Agency, 1995. Cardiac arrhythmias with pimozide (Orap). Current Problems in Pharmacovigilance, 21, 1.
  • Dubin, A.E., et al., 2005. Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp. Journal of Biomolecular Screening, 10 (2), 168–181.
  • Enyeart, J.J., et al., 1990. Antipsychotic pimozide is a potent Ca2+ channel blocker in heart. Molecular Pharmacology, 37 (5), 752–757.
  • Glassman, A.H., and Bigger, J.T., Jr, 2001. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. The American Journal of Psychiatry, 158 (11), 1774–1782.
  • Glover, W.E., 1978. Potentiation of vasoconstrictor responses by 3- and 4-aminopyridine . British Journal of Pharmacology, 63 (4), 577–585.
  • Gomora, J.C., and Enyeart, J.J., 1999. Dual pharmacological properties of a cyclic AMP-sensitive potassium channel. Journal of Pharmacology and Experimental Therapeutics, 290, 266–275.
  • Jackson, W.F., 2018. KV channels and the regulation of vascular smooth muscle tone. Microcirculation, 25 (1), e12421.
  • Jepps, T.A., et al., 2015. Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone. The Journal of Physiology, 593 (24), 5325–5340.
  • Kang, J., Chen, X.L., and Rampe, D., 2001. The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel. Biochemical and Biophysical Research Communications, 286 (3), 499–504.
  • Kang, J., et al., 2000. High affinity blockade of the HERG cardiac K+ channel by the neuroleptic pimozide. European Journal of Pharmacology, 392 (3), 137–140.
  • Khanamiri, S., et al., 2013. Contribution of Kv7 channels to basal coronary flow and active response to ischemia. Hypertension (Dallas, Tex. : 1979), 62 (6), 1090–1097.
  • Ko, E.A., et al., 2008. Physiological roles of K+ channels in vascular smooth muscle cells. Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi, 44 (2), 65–81.
  • Kongsamut, S., et al., 2002. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. European Journal of Pharmacology, 450 (1), 37–41.
  • Li, Q., et al., 2006. The role of subtypes of voltage-gated K+ channels in pulmonary vasoconstriction induced by 15-hydroeicosatetraenoic acid. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 41 (5), 412–417.
  • Lin, Z.Y., et al., 2012. Ginsenoside Rb1 selectively inhibits the activity of L-type voltage-gated calcium channels in cultured rat hippocampal neurons. Acta Pharmacologica Sinica, 33 (4), 438–444.
  • Mothi, M., and Sampson, S., 2013. Pimozide for schizophrenia or related psychoses. Cochrane Database of Systematic Reviews, 11, CD001949.
  • Nelson, M.T., and Quayle, J.M., 1995. Physiological roles and properties of potassium channels in arterial smooth muscle. The American Journal of Physiology, 268 (4 Pt 1), C799–822.
  • Ohanyan, V., et al., 2015. Requisite role of Kv1.5 Channels in Coronary Metabolic Dilation. Circulation Research, 117 (7), 612–621.
  • Medscape 2013. Oral (pimozide) dosing, indications, interactions, adverse effects, and more. Available from: <https://reference.medscape.com/drug/orap-pimozide-342982#10>
  • Pringsheim, T., and Marras, C., 2009. Pimozide for tics in Tourette's syndrome. Cochrane Database of Systematic Reviews, 2009 (2), CD006996.
  • Quayle, J.M., Dart, C., and Standen, N.B., 1996. The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle. The Journal of Physiology, 494 (3), 715–726.
  • Richtand, N.M., et al., 2007. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology : official Publication of the American College of Neuropsychopharmacology, 32 (8), 1715–1726.
  • Roessner, V., et al.,; ESSTS Guidelines Group. 2011. European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. European Child & Adolescent Psychiatry, 20 (4), 173–196.
  • Singer, H.S., 2010. Treatment of tics and Tourette syndrome. Current Treatment Options in Neurology, 12 (6), 539–561.
  • Sung, D.J., et al., 2013. Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase . Experimental & Molecular Medicine, 45, e67.
  • Thorneloe, K.S., et al., 2001. Molecular composition of 4-aminopyridine-sensitive voltage-gated K(+) channels of vascular smooth muscle. Circulation Research, 89 (11), 1030–1037.
  • Tueth, M.J., and Cheong, J.A., 1993. Clinical uses of pimozide. Southern Medical Journal, 86 (3), 344–349.
  • Tykocki, N.R., Boerman, E.M., and Jackson, W.F., 2017. Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles. Comprehensive Physiology, 7 (2), 485–581.
  • Werner, M.E., and Ledoux, J., 2014. K+ channels in biological processes: vascular K+ channels in the regulation of blood pressure. Journal of Receptor, Ligand and Channel Research, 7, 51–60.
  • Woodhull, A.M., 1973. Ionic blockage of sodium channels in nerve. The Journal of General Physiology, 61 (6), 687–708.
  • Wu, S.N., et al., 2012. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. Evidence-Based Complementary and Alternative Medicine : eCAM, 2012, 148403.
  • Zhang, Z.H., et al., 2003. Inhibitory effects of pimozide on cloned and native voltage-gated potassium channels. Brain Research. Molecular Brain Research, 115 (1), 29–38.

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