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Drug and Chemical Toxicology Volume 46, 2023 - Issue 2
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Research Articles

28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance

Acharya Balkrishnaa Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India;b Department of Allied and Applied Sciences, University of Patanjali, Haridwar, India;c Patanjali UK Trust, Glasgow, UKView further author information
,
Sandeep Sinhaa Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, IndiaView further author information
&
Anurag Varshneya Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India;b Department of Allied and Applied Sciences, University of Patanjali, Haridwar, India;d Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8509-0882View further author information
ORCID Icon
Pages 343-356 | Received 12 Oct 2021, Accepted 25 Jan 2022, Published online: 09 Feb 2022

References

  • Agarwal, A., et al., 2002. Effect of Tinospora cordifolia on learning and memory in normal and memory deficit rats. Indian Journal of Pharmacology, 34 (5), 339–349.
  • Antony, B., et al., 2018. Acute and sub chronic toxicity studies of purified Withania Somnifera extract in rats. International Journal of Pharmacy and Pharmaceutical Sciences, 10 (12), 41.
  • Balkrishna, A., et al., 2020. Application of humanized zebrafish model in the suppression of SARS-CoV-2 spike protein induced pathology by tri-herbal medicine coronil via cytokine modulation. Molecules, 25 (21), 5091.
  • Balkrishna, A., Haldar, S., et al., 2021. Coronil, a tri-herbal formulation, attenuates spike-protein-mediated SARS-CoV-2 viral entry into human alveolar epithelial cells and pro-inflammatory cytokines production by inhibiting spike protein-ACE-2 interaction. Journal of Inflammation Research, 14, 869–884.
  • Balkrishna, A., Tomer, M., et al., 2021. Phyto‐metabolite profiling of Coronil, a herbal medicine for COVID‐19, its identification by mass‐spectroscopy and quality validation on liquid chromatographic platforms. Journal of Separation Science, 44 (22), 1–18.
  • Chandrasekaran, C.V., et al., 2013. Evaluation of the mutagenic potential and acute oral toxicity of standardized extract of Ocimum sanctum (OciBest™). Human & Experimental Toxicology, 32 (9), 992–1004.
  • CPCSEA., 2018. Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA). Compendium of CPCSEA, 2018.
  • Gautam, M.K., and Goel, R.K., 2014. Toxicological study of Ocimum sanctum Linn leaves: hematological, biochemical, and histopathological studies. Journal of Toxicology, 2014, 135654.
  • Ghatpande, N.S., et al., 2019. Tinospora cordifolia protects against inflammation associated anemia by modulating inflammatory cytokines and hepcidin expression in male Wistar rats. Scientific Reports, 9 (1), 1–11.
  • Matsuzawa, T., Nomura, M., and Unno, T., 1993. Clinical pathology reference ranges of laboratory animals. Working Group II, Nonclinical Safety Evaluation Subcommittee of the Japan Pharmaceutical Manufacturers Association. The Journal of Veterinary Medical Science, 55 (3), 351–362.
  • Organization for Economic Co‐Operation and Development (OECD). 1995. Test no. 407: repeated dose 28‐day oral toxicity study in rodents. Paris, France: OECD Guidelines for Testing of Chemicals, OECD.
  • Patel, S.B., Rao, N.J., and Hingorani, L.L., 2016. Safety assessment of Withania somnifera extract standardized for Withaferin A: acute and sub-acute toxicity study. Journal of Ayurveda and Integrative Medicine, 7 (1), 30–37.
  • Prabu, P.C., Panchapakesan, S., and Raj, C.D., 2013. Acute and sub-acute oral toxicity assessment of the hydroalcoholic extract of Withania somnifera roots in wistar rats. Phytotherapy Research, 27 (8), 1169–1178.
  • Raina, P., et al., 2015. Evaluation of subacute toxicity of methanolic/aqueous preparation of aerial parts of O. sanctum in Wistar rats: clinical, haematological, biochemical and histopathological studies. Journal of Ethnopharmacology, 175, 509–517.
  • Sharma, M., Pandey, G., and Khanna, A., 2011. Studies on phytochemistry and toxicities of Tinospora cordifolia (Giloe)#. Anusandhan, 5, 64–68.
  • Uma, K.S., et al., 2016. Evaluation of sub-acute toxicity (oral) study of Siddha medicine – Seenthil Sarkkarai in wistar albino rats. World Journal of Pharmaceutical and Life Sciences, 2 (6), 189–198.
  • Wiersinga, W.J., et al., 2020. Pathophysiology, transmission, diagnosis, and treatment of Coronavirus Disease 2019 (COVID-19): a review. JAMA - Journal of American Medical Association, 324 (8), 782.

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