In vitro cytogenotoxic evaluation of aripiprazole on human peripheral lymphocytes and computational molecular docking analysis

References

• Albertini, R.J., et al., 2000. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. Mutation Research, 463 (2), 111–172.
   PubMed Web of Science ®Google Scholar
• Baek, K.-S., et al., 2015. Immunotoxicological effects of aripiprazole: in vivo and in vitro studies. The Korean Journal of Physiology & Pharmacology, 19 (4), 365.
   PubMed Web of Science ®Google Scholar
• Biagi, E., et al., 2017. Long-acting injectable antipsychotics in schizophrenia: literature review and practical perspective, with a focus on aripiprazole once-monthly. Advances in Therapy, 34 (5), 1036–1048.
   PubMed Web of Science ®Google Scholar
• Brambilla, G., Mattioli, F., and Martelli, A., 2009. Genotoxic and carcinogenic effects of antipsychotics and antidepressants. Toxicology, 261 (3), 77–88.
   PubMed Web of Science ®Google Scholar
• Chaiyakunapruk, N., et al., 2016. Global economic burden of schizophrenia: a systematic review. Neuropsychiatric Disease and Treatment, 357.
   PubMed Web of Science ®Google Scholar
• Charlson, F.J., et al., 2018. Global epidemiology and burden of schizophrenia: findings from the global burden of disease study. Schizophrenia Bulletin, 44 (6), 1195–1203.
   PubMed Web of Science ®Google Scholar
• de Bartolomeis, A., Tomasetti, C., and Iasevoli, F., 2015. Update on the mechanism of action of aripiprazole: translational insights into antipsychotic strategies beyond dopamine receptor antagonism. CNS Drugs, 29 (9), 773–799.
   PubMed Web of Science ®Google Scholar
• Dördü, T.C., et al., 2020. In vitro genotoxicity and molecular docking study of ellagic acid. Current Bioactive Compounds, 16 (7), 1072–1082.
   Google Scholar
• Faure, C., et al., 2015. Aripiprazole-induced chorioretinopathy: multimodal imaging and electrophysiological features. Documenta Ophthalmologica, 131 (1), 35–41.
   PubMed Web of Science ®Google Scholar
• Fenech, M., 2000. The in vitro micronucleus technique. Mutation Research, 455 (1–2), 81–95.
   PubMed Web of Science ®Google Scholar
• Husunet, M.T., et al., 2021. Investigation of the genotoxic effects of patent blue V (E131) in human peripheral lymphocytes and in silico molecular docking. Drug and Chemical Toxicology, 2021, 1–7.
   Google Scholar
• Ittiyavirah, P., 2013. Insilico docking studies and evaluation of volatile oil of Zingiber officinale Rosc. and Aripiprazole for antidepressant activity. International Journal of Genetics and Molecular Biology, 5 (7), 88–98.
   Google Scholar
• Lauriello, J., et al., 2021. Real-World Outcomes and Costs Following 6 Months of Treatment with the Long-Acting Injectable (LAI) Aripiprazole Lauroxil for the Treatment of Schizophrenia. CNS Drugs, 35 (10), 1123–1135.
   PubMed Web of Science ®Google Scholar
• Loprieno, N., 1978. Handbook of mutagenicity test procedures – Kilbey, Bj, Legator, M, Nichols, W, Ramel, C. Scientia, 113 (9–12), 85–87.
   Google Scholar
• Mace, M.L., Daskal, Y., and Wray, W., 1978. Scanning-electron microscopy of chromosome aberrations. Mutation Research, 52 (2), 199–206.
   PubMedGoogle Scholar
• Meltzer, H.Y., et al., 2003. Serotonin receptors : their key role in drugs to treat schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 27 (7), 1159–1172.
   PubMed Web of Science ®Google Scholar
• Millier, A., et al., 2014. Humanistic burden in schizophrenia: a literature review. Journal of Psychiatric Research, 54, 85–93.
   PubMed Web of Science ®Google Scholar
• Mondal, S., et al., 2012. Oral aripiprazole-induced severe hypoglycemia. Therapeutic Drug Monitoring, 34 (3), 245–248.
   PubMed Web of Science ®Google Scholar
• Nasab, R.R., et al., 2017. Docking study, synthesis and antimicrobial evaluation of some novel 4-anilinoquinazoline derivatives. Research in Pharmaceutical Sciences, 12 (5), 425–433.
   PubMed Web of Science ®Google Scholar
• Ovenden, E.S., et al., 2018. DNA methylation and antipsychotic treatment mechanisms in schizophrenia: progress and future directions. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 81, 38–49.
   PubMed Web of Science ®Google Scholar
• Picada, J.N., et al., 2011. Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice. Acta Pharmacologica Sinica, 32 (10), 1225–1232.
   PubMed Web of Science ®Google Scholar
• Preda, A., and Shapiro, B.B., 2020. A safety evaluation of aripiprazole in the treatment of schizophrenia. Expert Opinion on Drug Safety, 19 (12), 1529–1538.
   PubMed Web of Science ®Google Scholar
• Ricci, C.G., and Netz, P.A., 2009. Docking studies on DNA-ligand interactions: building and application of a protocol to identify the binding mode. Journal of Chemical Information and Modeling, 49 (8), 1925–1935.
   PubMed Web of Science ®Google Scholar
• Rothfuss, A., et al., 2000. Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Research, 60 (2), 390–394.
   PubMed Web of Science ®Google Scholar
• Sanner, M.F., 1999. Python: a programming language for software integration and development. Journal of Molecular Graphics & Modelling, 17 (1), 57–61.
   PubMed Web of Science ®Google Scholar
• Sárvári, A.K., et al., 2014. Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro. Biochemical and Biophysical Research Communications, 450 (4), 1383–1389.
   PubMed Web of Science ®Google Scholar
• Shokrzadeh, M., et al., 2019. Cytotoxic effects of Aripiprazole on Mkn45 and Nih3t3 cell lines and genotoxic effects on human peripheral blood lymphocytes. Arquivos de Gastroenterologia, 56 (2), 155–159.
   PubMedGoogle Scholar
• Shulman, M., Jennifer Njoku, I., and Manu, P., 2013. Thrombotic complications of treatment with antipsychotic drugs. Minerva Medica, 104 (2), 175–184.
   PubMed Web of Science ®Google Scholar
• Singh, K.P., and Tripathi, N., 2014. Prenatal exposure of a novel antipsychotic aripiprazole: impact on maternal, fetal and postnatal body weight modulation in rats. Current Drug Safety, 9 (1), 43–48.
   PubMedGoogle Scholar
• Stahl, S. M., 2000. Essential psychopharmacology: neuroscientific basis and practical application. 2nd ed. Cambridge, UK; New York, NY, USA: Cambridge University Press.
   Google Scholar
• Travis, M.J., et al., 2005. Aripiprazole in schizophrenia: consensus guidelines. International Journal of Clinical Practice, 59 (4), 485–495.
   PubMed Web of Science ®Google Scholar
• Vergne, D., and Anton, R., 2010. Aripiprazole: a drug with a novel mechanism of action and possible efficacy for alcohol dependence. CNS & Neurological Disorders Drug Targets, 9 (1), 50–54.
   PubMed Web of Science ®Google Scholar
• Wang, M., et al., 2014. Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study. Human Psychopharmacology, 29 (2), 183–189.
   PubMed Web of Science ®Google Scholar
• Werner, F.-M., and Coveñas, R., 2014. Safety of antipsychotic drugs: focus on therapeutic and adverse effects. Expert Opinion on Drug Safety, 13 (8), 1031–1042.
   PubMed Web of Science ®Google Scholar
• Yang, A., and Tsai, S.-J., 2017. New targets for schizophrenia treatment beyond the dopamine hypothesis. International Journal of Molecular Sciences, 18 (8), 1689.
   PubMed Web of Science ®Google Scholar
• Yuksel, S., Tasdemir, S., and Korkmaz, S., 2017. Protective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytes. Bratislavske Lekarske Listy, 118 (4), 208–211.
   PubMed Web of Science ®Google Scholar