Protective efficacy of ramelteon on methotrexate-induced DNA damage

References

• Aboubakr, M., Elbadawy, M., Ibrahim, S. S., Khalil, E., et al. (2023b). Allicin and lycopene possesses a protective effect against methotrexate-induced testicular toxicity in rats. Pakistan Veterinary Journal, 43(3), 559–566.
   Web of Science ®Google Scholar
• Aboubakr, M., Farag, A., Elfadadny, A., Alkafafy, M., Soliman, A., & Elbadawy, M. (2023a). Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury in rats. Environmental Science and Pollution Research International, 30(38), 88724–88733. https://doi.org/10.1007/s11356-023-28686-4
   PubMed Web of Science ®Google Scholar
• Abraham, P., Kolli, V. K., & Rabi, S. (2010). Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats. Cell Biochemistry and Function, 28(5), 426–433. https://doi.org/10.1002/cbf.1676
   PubMed Web of Science ®Google Scholar
• Ahmad, S. B., Ali, A., Bilal, M., Rashid, S. M., Wani, A. B., Bhat, R. R., & Rehman, M. U. (2023). Melatonin and health: Insights of melatonin action, biological functions, and associated disorders. Cellular and Molecular Neurobiology, 43(6), 2437–2458. https://doi.org/10.1007/s10571-023-01324-w
   PubMed Web of Science ®Google Scholar
• Ali, N., Rashid, S., Nafees, S., Hasan, S. K., Shahid, A., Majed, F., & Sultana, S. (2017). Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chemico-Biological Interactions, 272, 80–91. https://doi.org/10.1016/j.cbi.2017.05.002
   PubMed Web of Science ®Google Scholar
• Armağan, İ., Aşcı, H., Erzurumlu, Y., Özkula, S., Hasseyid, N., Kumbul Doğuç, D., Okuyucu, G., & Varel, A. (2023). Ramelteon and mechanism of its restorative effect in an experimental lung disease model. Toxicology Mechanisms and Methods, 33(3), 239–247. https://doi.org/10.1080/15376516.2022.2156006
   PubMed Web of Science ®Google Scholar
• Aşcı Çelik, D., & Toğay, V. A. (2023). In vivo protective efficacy of astaxanthin against ionizing radiation-induced DNA damage. Chemical Biology & Drug Design, 102(4), 882–888. https://doi.org/10.1111/cbdd.14321
   PubMed Web of Science ®Google Scholar
• Aslankoc, R., Savran, M., Doğuç, D. K., Sevimli, M., Tekin, H., & Kaynak, M. (2022). Ameliorating effects of ramelteon on oxidative stress, inflammation, apoptosis, and autophagy markers in methotrexate-induced cerebral toxicity. Iranian Journal of Basic Medical Sciences, 25(10), 1183–1189. https://doi.org/10.22038/ijbms.2022.62955.13913
   PubMed Web of Science ®Google Scholar
• Aziz, D. Z., Kadhim, N. J., Majeed, A. A., & Abood, A. H. (2020). Protective effects of ginger extract against methotrexate induced cytotoxicity in mice. Paper presented at the. Journal of Physics: Conference Series, 1664(1), 012103 https://doi.org/10.1088/1742-6596/1664/1/012103
   Google Scholar
• Bedoui, Y., Guillot, X., Sélambarom, J., Guiraud, P., Giry, C., Jaffar-Bandjee, M. C., Ralandison, S., & Gasque, P. (2019). Methotrexate an old drug with new tricks. International Journal of Molecular Sciences, 20(20), 5023https://doi.org/10.3390/ijms20205023
   PubMed Web of Science ®Google Scholar
• Behairy, A., Elkomy, A., Elsayed, F., Gaballa, M. M. S., Soliman, A., & Aboubakr, M. (2024a). Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity. Naunyn-Schmiedeberg’s Archives of Pharmacology, 397(3), 1875–1888. https://doi.org/10.1007/s00210-023-02739-4
   PubMed Web of Science ®Google Scholar
• Behairy, A., Elkomy, A., Elsayed, F., Gaballa, M. M. S., Soliman, A., & Aboubakr, M. (2024b). Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats. Revista Brasileira de Farmacognosia, 34(1), 154–167. https://doi.org/10.1007/s43450-023-00470-y
   Google Scholar
• Chen, P., Liu, W., & Wei, Y. (2023). Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation. Translational Andrology and Urology, 12(12), 1859–1870. https://doi.org/10.21037/tau-23-543
   PubMed Web of Science ®Google Scholar
• Davanipour, Z., Poulsen, H. E., Weimann, A., & Sobel, E. (2009). Endogenous melatonin and oxidatively damaged guanine in DNA. BMC Endocrine Disorders, 9(1), 22https://doi.org/10.1186/1472-6823-9-22
   PubMedGoogle Scholar
• Deng, H., Zhang, M., He, J., Wu, W., Jin, L., Zheng, W., Lou, J., & Wang, B. (2005). Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points. Mutagenesis, 20(5), 351–357. https://doi.org/10.1093/mutage/gei048
   PubMed Web of Science ®Google Scholar
• El-Alfy, N. Z. I., Alqosaibi, A. I., Mahmoud, M. F., & El-Ashry, S. R. G. (2016). An analysis of micronuclei and DNA damage induced by methotrexate treatment of male albino mice. The Egyptian Journal of Hospital Medicine, 65(1), 504–514. https://doi.org/10.12816/0033759
   Google Scholar
• Fischer, T. W., Slominski, A., Zmijewski, M. A., Reiter, R. J., & Paus, R. (2008). Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Experimental Dermatology, 17(9), 713–730. https://doi.org/10.1111/j.1600-0625.2008.00767.x
   PubMed Web of Science ®Google Scholar
• Galano, A., Tan, D.-X., & Reiter, R. J. (2018). Melatonin: A versatile protector against oxidative DNA damage. Molecules (Basel, Switzerland), 23(3), 530https://doi.org/10.3390/molecules23030530
   PubMed Web of Science ®Google Scholar
• García-Sánchez, A., Miranda-Díaz, A. G., & Cardona-Muñoz, E. G. (2020). The role of oxidative stress in physiopathology and pharmacological treatment with pro-and antioxidant properties in chronic diseases. Oxidative Medicine and Cellular Longevity, 2020, 2082145–16. https://doi.org/10.1155/2020/2082145
   PubMed Web of Science ®Google Scholar
• Gunata, M., Parlakpinar, H., & Acet, H. (2020). Melatonin: A review of its potential functions and effects on neurological diseases. Revue Neurologique, 176(3), 148–165. https://doi.org/10.1016/j.neurol.2019.07.025
   PubMed Web of Science ®Google Scholar
• Gyori, B. M., Venkatachalam, G., Thiagarajan, P., Hsu, D., & Clement, M.-V. (2014). OpenComet: An automated tool for comet assay image analysis. Redox Biology, 2, 457–465. https://doi.org/10.1016/j.redox.2013.12.020
   PubMed Web of Science ®Google Scholar
• Haghi-Aminjan, H., Asghari, M. H., Farhood, B., Rahimifard, M., Hashemi Goradel, N., & Abdollahi, M. (2018). The role of melatonin on chemotherapy-induced reproductive toxicity. The Journal of Pharmacy and Pharmacology, 70(3), 291–306. https://doi.org/10.1111/jphp.12855
   PubMed Web of Science ®Google Scholar
• Hyoun, S. C., Običan, S. G., & Scialli, A. R. (2012). Teratogen update: Methotrexate. Birth Defects Research. Part A, Clinical and Molecular Teratology, 94(4), 187–207. https://doi.org/10.1002/bdra.23003
   PubMed Web of Science ®Google Scholar
• Jahovic, N., Cevik, H., Sehirli, A. O., Yeğen, B. C., & Sener, G. (2003). Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats. Journal of Pineal Research, 34(4), 282–287. https://doi.org/10.1034/j.1600-079X.2003.00043.x
   PubMed Web of Science ®Google Scholar
• Khatab, L. A., Abdel-Raheem, I. T., & Ghoneim, A. I. (2022). Protective effects of melatonin and L-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes. Naunyn-Schmiedeberg’s Archives of Pharmacology, 395(1), 87–97. https://doi.org/10.1007/s00210-021-02176-1
   PubMed Web of Science ®Google Scholar
• Kim, C., Kim, N., Joo, H., Youm, J. B., Park, W. S., Cuong, D. V., Park, Y. S., Kim, E., Min, C.-K., & Han, J. (2005). Modulation by melatonin of the cardiotoxic and antitumor activities of adriamycin. Journal of Cardiovascular Pharmacology, 46(2), 200–210. https://doi.org/10.1097/01.fjc.0000171750.97822.a2
   PubMed Web of Science ®Google Scholar
• Kruk, J., Aboul-Enein, B. H., & Duchnik, E. (2021). Exercise-induced oxidative stress and melatonin supplementation: current evidence. The Journal of Physiological Sciences, 71(1), 1–19. https://doi.org/10.1186/s12576-021-00812-2
   PubMed Web of Science ®Google Scholar
• Kuriyama, A., Honda, M., & Hayashino, Y. (2014). Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Medicine, 15(4), 385–392. https://doi.org/10.1016/j.sleep.2013.11.788
   PubMed Web of Science ®Google Scholar
• Kurt, A. H., Bozkus, F., Uremis, N., & Uremis, M. M. (2016). The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells. Renal Failure, 38(5), 686–692. https://doi.org/10.3109/0886022X.2016.1155398
   PubMed Web of Science ®Google Scholar
• Leem, J., Bai, G. Y., Kim, J. S., & Oh, J. S. (2019). Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end‐joining repair. Journal of Pineal Research, 67(4), e12603https://doi.org/10.1111/jpi.12603
   PubMed Web of Science ®Google Scholar
• Liu, D., Gu, X., Han, F., Cai, M., Liu, W., Han, L., & Ma, Q. (2021). The protective effects of Ramelteon against 6‐OHDA‐induced cellular senescence in human SH‐SY5Y neuronal cells. Brain and Behavior, 11(8), e2278https://doi.org/10.1002/brb3.2278
   PubMed Web of Science ®Google Scholar
• Luchetti, F., Canonico, B., Betti, M., Arcangeletti, M., Pilolli, F., Piroddi, M., Canesi, L., Papa, S., & Galli, F. (2010). Melatonin signaling and cell protection function. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 24(10), 3603–3624. https://doi.org/10.1096/fj.10-154450
   PubMed Web of Science ®Google Scholar
• Mir, S. M., Aliarab, A., Goodarzi, G., Shirzad, M., Jafari, S. M., Qujeq, D., Samavarchi Tehrani, S., & Asadi, J. (2022). Melatonin: A smart molecule in the DNA repair system. Cell Biochemistry and Function, 40(1), 4–16. https://doi.org/10.1002/cbf.3672
   PubMed Web of Science ®Google Scholar
• OECD (2016). Test No. 489: In Vivo Mammalian Alkaline Comet Assay. OECD Publishing.
   Google Scholar
• Özgöçmen, M., Aşcı, H., Doğan, H. K., İlhan, İ., Pekgöz, Ş., & Mustafaoğlu, A. (2021). A study on Wistar Albino rats: investigating protective role of ramelteon on liver damage caused by methotrexate. Drug and Chemical Toxicology, 45(6), 2678–2685. https://doi.org/10.1080/01480545.2021.1982623
   PubMed Web of Science ®Google Scholar
• Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2013). Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Neurotoxicity Research, 23(3), 267–300. https://doi.org/10.1007/s12640-012-9337-4
   PubMed Web of Science ®Google Scholar
• Pandi-Perumal, S. R., Srinivasan, V., Spence, D. W., Moscovitch, A., Hardeland, R., Brown, G. M., & Cardinali, D. P. (2009). Ramelteon: a review of its therapeutic potential in sleep disorders. Advances in Therapy, 26(6), 613–626. https://doi.org/10.1007/s12325-009-0041-6
   PubMed Web of Science ®Google Scholar
• Park, J. H., Hwang, Y., Nguyen, Y. N. D., Kim, H. C., & Shin, E. J. (2024). Ramelteon attenuates hippocampal neuronal loss and memory impairment following kainate‐induced seizures. Journal of Pineal Research, 76(1), e12921https://doi.org/10.1111/jpi.12921
   PubMed Web of Science ®Google Scholar
• Salem, N. I. S., Noshy, M. M., & Said, A. A. (2017). Modulatory effect of curcumin against genotoxicity and oxidative stress induced by cisplatin and methotrexate in male mice. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 105, 370–376. https://doi.org/10.1016/j.fct.2017.04.007
   PubMed Web of Science ®Google Scholar
• Sanchez-Barcelo, E. J., Mediavilla, M. D., Alonso-Gonzalez, C., & Reiter, R. J. (2012). Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation. Expert Opinion on Investigational Drugs, 21(6), 819–831. https://doi.org/10.1517/13543784.2012.681045
   PubMed Web of Science ®Google Scholar
• Srinivasan, V., Cardinali, D. P., Srinivasan, U. S., Kaur, C., Brown, G. M., Spence, D. W., Hardeland, R., & Pandi-Perumal, S. R. (2011). Therapeutic potential of melatonin and its analogs in Parkinson’s disease: focus on sleep and neuroprotection. Therapeutic Advances in Neurological Disorders, 4(5), 297–317. https://doi.org/10.1177/1756285611406166
   PubMedGoogle Scholar
• Sun, J.-T., Yuan, J.-D., Zhang, Q., Luo, X., Qi, X.-Y., Liu, J.-H., Jiang, X.-Q., Lee, S., Taweechaipaisankul, A., Liu, Z.-H., & Jin, J.-X. (2022). Ramelteon reduces oxidative stress by maintenance of lipid homeostasis in porcine oocytes. Antioxidants (Basel, Switzerland), 11(9), 1640 https://doi.org/10.3390/antiox11091640
   PubMedGoogle Scholar
• Wang, J., Jiang, C., Zhang, K., Lan, X., Chen, X., Zang, W., Wang, Z., Guan, F., Zhu, C., Yang, X., Lu, H., & Wang, J. (2019). Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. Free Radical Biology & Medicine, 131, 345–355. https://doi.org/10.1016/j.freeradbiomed.2018.12.014
   PubMed Web of Science ®Google Scholar
• Wang, T., Li, Z., Xia, S., Xu, Z., Chen, X., & Sun, H. (2021). The protective effects of ramelteon against isoflurane-induced insults and inflammatory response in brain microvascular endothelial cells. Neurotoxicity Research, 39(3), 677–686. https://doi.org/10.1007/s12640-020-00309-7
   PubMed Web of Science ®Google Scholar
• Xie, L., Zhao, T., Cai, J., Su, Y., Wang, Z., & Dong, W. (2016). Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells. OncoTargets and Therapy, 9, 7115–7122. https://doi.org/10.2147/OTT.S116387
   PubMed Web of Science ®Google Scholar
• Yang, Z., Xie, Y., Li, M., Chen, W., Zhong, C., Ju, J., Deng, Q., Wang, H., Cheng, T., Zhang, L., Du, W., & Liang, H. (2024). Ramelteon alleviates myocardial ischemia/reperfusion injury (MIRI) through Sirt3-dependent regulation of cardiomyocyte apoptosis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 172, 116229https://doi.org/10.1016/j.biopha.2024.116229
   PubMed Web of Science ®Google Scholar
• Yuksel, Y., Yuksel, R., Yagmurca, M., Haltas, H., Erdamar, H., Toktas, M., & Ozcan, O. (2017). Effects of quercetin on methotrexate-induced nephrotoxicity in rats. Human & Experimental Toxicology, 36(1), 51–61. https://doi.org/10.1177/0960327116637414
   PubMed Web of Science ®Google Scholar
• Zhang, X., Peng, B., Zhang, S., Wang, J., Yuan, X., Peled, S., Chen, W., Ding, J., Li, W., Zhang, A., Wu, Q., Stavrovskaya, I. G., Luo, C., Sinha, B., Tu, Y., Yuan, X., Li, M., Liu, S., Fu, J., … Wang, X. (2024). The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke. Journal of Pineal Research, 76(1), e12925https://doi.org/10.1111/jpi.12925
   PubMed Web of Science ®Google Scholar
• Zhou, B., Xia, X., Wang, P., Chen, S., Yu, C., Huang, R., Zhang, R., Wang, Y., Lu, L., Yuan, F., Tian, Y., Fan, Y., Zhang, X., Shu, Y., Zhang, S., Bai, D., Wu, L., Xu, H., & Yang, L. (2018). Induction and amelioration of methotrexate-induced gastrointestinal toxicity are related to immune response and gut microbiota. EBioMedicine, 33, 122–133. https://doi.org/10.1016/j.ebiom.2018.06.029
   PubMed Web of Science ®Google Scholar