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Archives of Andrology
Journal of Reproductive Systems
Volume 49, 2003 - Issue 4
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Research Article

EFFECTS OF ETHANE DIMETHANE SULFONATE ON THE FUNCTIONAL STRUCTURE OF THE ADULT RAT TESTIS

S. ARIYARATNE Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA
,
I. KIM Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA
,
N. MILLS Department of Biology, Texas Woman's University, Denton, Texas, USA
,
I. MASON University Department of Clinical Biochemistry, Royal Infirmary of Edinburgh NHS Trust, Edinburgh, Scotland, UK
&
C. MENDIS-HANDAGAMA Department of Comparative Medicine and Department of Animal Science, University of Tennessee, Knoxville, Tennessee, USA
Pages 313-326 | Published online: 09 Jul 2009

  • Ariyaratne HBS, Mendis-Handagama SMLC (2000): Changes in structure and function of the testis interstitium in Sprague Dawley rats from birth to sexual maturity. Biol Reprod 62:680690.
  • Ariyaratne UBS, Mendis-Handagama SMLC, Hales DB, Mason JI (2000): Studies on the onset of Leydig precursor cell differentiation in the prepubertal rat testis. Biol Reprod 63:165-171.
  • Ariyaratne HBS, Mason JI, Mendis-Handagama SMLC (2000): Effects of tri-iodothyronineon testicular interstitial cells and androgen secretory capacity of the prepubertal rat. Biol Reprod 63:493-502.
  • Ariyaratne HBS, Mills N, Mason JI, Mendis-Handagama SMLC (2000): Thyroid hormone and Leydig cell regeneration in the adult rat following ethane dimethane sulphonate treatment. Biol Reprod 63:1115-1123.
  • Ariyaratne HBS, Mason JI, Mendis-Handagama SMLC (2000): Effects of thyroid and luteinizing hormones on the onset of precursor cell differentiation into Leydig cells in the prepubertal rat testis. Biol Reprod 63:898-904.
  • Benton L, Shan L-X, Hardy MP (1995): Differentiation of adult Leydig cells. J Steroid Biochem MoI Biol 53:61-68.
  • Bergh A (1987): Treatment with hCG increases the size of Leydig cells and testicular macrophages in unilaterally cryptorchid rat. Int J Androl 10:765-772.
  • Gaytan F, Bellido C, Romero JL, Morales C, Reymundo C, Aguilar E (1994): Decreased number and size and the defective function of testicular macrophages in long-term hypophysectomized rats are reversed by treatment with human gonadotropins. J Endocrinol 140: 399-407.
  • Gaytan F, Bellido C, Morales C, Reymundo C, Aguilar E, van Rooijen N (1994): Selective depletion of testicular macrophages and prevention of Leydig cell repopulation after treatment with ethylene dimethane sulphonate in rats. J Reprod Fertil 101:175-182.
  • Gaytan F, Romero JL, Morales C, Reymundo C, Bellido C, Aguilar E (1995): Response of testicular macrophages to EDS-induced Leydig cell death. Andrologia 27:259-265.
  • Gaytan F, Bellido C, Morales C, Reymundo C, Aguilar E, van Rooijen N (1995): Response to Leydig cell apoptosis in the absence of testicular macrophages. J Reprod Immunol 29:81-94.
  • Hardy MP, Zirkin BR, Ewing LL (1989): Kinetic studies on the development of the adult population of Leydig cells in testes of prepubertal rat. Endocrinology 124:762-770.
  • Hutson JC (1990): Development of testicular macrophages. Biol Reprod 43:885-890.
  • Hutson J (1998): Interactions between testicular macrophages and Leydig cells. J Androl 19: 394-398.
  • Kerr JB, Bartlett JMS, Donachie K (1987): Origin of regenerating Leydig cells in the testis of the adult rat: an ultrastructural, morphometric and hormonal assay study. Cell Tissue Res 249: 367-377.
  • Lording DW, de Kretser DM (1972): Comparative ultrastructural and histochemical studies of the interstitial cells of the rat testis during fetal and postnatal development. J Reprod Fertil 29:261-269.
  • Mendis-Handagama SMLC, Risbridger GP, de Kretser DM (1987): Morphometric analysis of the components of the neonatal and the adult rat testis interstitium. Int J Androl 10:525-534.
  • Mendis-Handagama SMLC, Ewing LL (1990): Sources of error in the estimation of Leydig cell numbers in control and atrophied mammalian testes. J Microscop (Oxford) 159:73-82.
  • Mendis-Handagama SMLC, Kerr JB, de Kretser DM (1990): Experimental cryptorchidism in the adult mouse, II: a hormonal study. J Androl 11:548-554.
  • Mendis-Handagama SMLC, Ariyaratne HBS, Teunissen van Manen KR, Haupt RL (1998): Differentiation of adult Leydig cells in the neonatal rat testis is arrested by hypothyroidism. Biol Reprod 59:351-357.
  • Mendis-Handagama SMLC, Gelber SJ (1995): Signs of aging are apparent in the testis interstitium of Sprague Dawley rats at 6 months of age. Tissue Cell 27:689-699.
  • Morris ID (1996): Leydig cell toxicity. In: The Leydig Cell. Payne AH, Hardy MP, Russell LD (Eds). Vienna, IL: Cache River Press, pp 573-596.
  • O'Leary PC, Jackson AE, de Kretser DM (1986): Evaluation of testicular hCG binding in unilaterally cryptorchid rats following administration of ethane dimethane sulphonate (EDS). MoI Cell Endocrinol 48:51-58.
  • Saez JM (1994): Leydig cells: endocrine, paracrine and autocrine regulation. Endocr Rev 15:574-626.
  • Sterio DC (1984): The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-137.
  • Sylvester SR (1996): Leydig cell Sertoli cell interaction. In: The Leydig Cell, Payne AH, Hardy MP, and Russell LD (Eds). Vienna, IL: Cache River Press, pp 467-476.
  • Teerds KJ (1996): Regeneration of Leydig cells after depletion by EDS: a model for postnatal Leydig cell renewal. In: The Leydig Cell. Payne AH, Hardy MP, Russell LD (Eds), Vienna, IL: Cache River Press, pp 203-220.
  • Teerds KJ, de Boer-Brouwer M, Dorrington JH, Balvers M, Ivell R (1999): Identification of markers for precursor and Leydig cell differentiation in the adult rat testis following ethane dimethyl sulphonate administration. Biol Reprod 60:1437-1445.
  • Tena-Sempere M, Zhang FP, Huhtaniemi I (1994): Persistent expression of a truncated from of the luteinizing hormone receptor messenger ribonucleic acid in the rat testis after selective Leydig cell destruction by ethane dimethane sulphonate. Endocrinology 135:1018-1024.
  • VanDemark NL, Ewing LL (1963): Factors affecting testicular metabolism and function, I: a simple perfusion technique for short-term maintenance of rabbit testis. J Reprod Fertil 6:1-8.
  • Vreeburg JT, Ooms MP, Rommerts FF, Teerds KJ (1988): Functional properties of developing rat Leydig cells after treatment with ethylene dimethanesulphonate (EDS). J Reprod Fertil 84:63-69.
  • Wang J, Wreford NGM, Lan HY, Atkins R, Hedger MP (1994): Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol Reprod 51:551-561.

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