Optimization of enzyme-assisted extraction of ginsenoside Rb1 from Vietnamese Panax notoginseng (BURK.) F.H. Chen roots and anticancer activity examination of the extract

References

• Chien, Y. S.; Yu, Z. R.; Koo, M.; Wang, B. J. Supercritical fluid Extractive Fractionation: Study of the Antioxidant Activities of Panax Ginseng. Sep. Sci. Technol. 2016, 51(6), 954–960. DOI: 10.1080/01496395.2016.1140202.
   Web of Science ®Google Scholar
• Phuong, N. T. X.; Thy, L. T. M.; Khang, N. L. V.; My, H. T. K.; Tam, N. L. P.; Hieu, N. H. Effect of Enzyme on Extraction of Ginsenoside Rb1 and Rg3 from Panax Notoginseng Roots. AIP. 2018, 1954(1), 1–6.
   Google Scholar
• Lau, A. J.; Woo, S. O.; Koh, H. L. Analysis of Saponins in Raw and Steamed Panax Notoginseng Using High-performance Liquid Chromatography with Diode Array Detection. J. Chromatogr. A. 2003, 1011, 77–87. DOI: 10.1016/S0021-9673(03)01135-X.
   PubMed Web of Science ®Google Scholar
• Mohanan, P.; Subramaniyam, S.; Mathiyalagan, R.; Yang, D. C. Molecular Signaling of Ginsenosides Rb1, Rg1, and Rg3 and Their Mode of Actions. JGR. 2018, 42(2), 123–132.
   Google Scholar
• Liu, L.; Xu, F. R.; Wang, Y. Z. Traditional Uses, Chemical Diversity and Biological Activities of Panax L. (Araliaceae): A Review. J. Ethnopharmacol. 2020.
   Web of Science ®Google Scholar
• Park, T. Y.; Park, M. H.; Shin, W. C.; Rhee, M. H.; Seo, D. W.; Cho, J. Y.; Kim, H. M. Anti-metastatic Potential of Ginsenoside Rp1, a Novel Ginsenoside Derivative. Biol. Pharm. Bull. 2008, 31(9), 1802–1805. DOI: 10.1248/bpb.31.1802.
   PubMed Web of Science ®Google Scholar
• Nag, S. A.; Qin, J.; Wang, W.; Wang, M. H.; Wang, H.; Zhang, R. Ginsenosides as Anticancer Agents: In Vitro and in Vivo Activities, Structure-activity Relationships, and Molecular Mechanisms of Action. Front. Pharmacol. 2012, 3.
   PubMed Web of Science ®Google Scholar
• Wang, C.; Xie, J.; Fishbein, A.; Aung, H. H.; Hui, H.; Mehendale, S. R.; Tong‐Chuan, H.; Wei, D.; Yuan, C. Antiproliferative Effects of Different Plant Parts of Panax Notoginseng on SW480 Human Colorectal Cancer Cells. Phytotherapy Res. 2009, 23(1), 6–13. DOI: 10.1002/ptr.2383.
   PubMed Web of Science ®Google Scholar
• Saw, C. L. L.; Yang, A. Y.; Cheng, D. C.; Boyanapalli, S.-S.-S.; Zheng-Yuan, S.; Khor, T. O.; Gao, S.; Wang, J.; Jiang, Z.-H.; Kong, A.-N. T. Pharmacodynamics of Ginsenosides: Antioxidant Activities, Activation of Nrf2, and Potential Synergistic Effects of Combinations. Chem. Res. Toxicol. 2012, 25(8), 1574–1580. DOI: 10.1021/tx2005025.
   PubMed Web of Science ®Google Scholar
• Uzayisenga, R.; Ayeka, P. A.; Wang, Y. Anti‐diabetic Potential of Panax Notoginseng Saponins (PNS): A Review. Phytotherapy Res. 2014, 28(4), 510–516. DOI: 10.1002/ptr.5026.
   PubMed Web of Science ®Google Scholar
• Ratan, Z. A.; Haidere, M. F.; Hong, Y. H.; Park, S. H.; Lee, J. O.; Lee, J.; Cho, J. Y. Pharmacological Potential of Ginseng and Its Major Component Ginsenosides. JGR. 2020.
   PubMed Web of Science ®Google Scholar
• Dai, C. Y.; Liu, P. F.; Liao, P. R.; Qu, Y.; Wang, C. X.; Yang, Y.; Cui, X. M. Optimization of Flavonoids Extraction Process in Panax Notoginseng Stem Leaf and a Study of Antioxidant Activity and Its Effects on Mouse Melanoma B16 Cells. Molecules. 2018, 23, 9. DOI: 10.3390/molecules23092219.
   Web of Science ®Google Scholar
• Puri, M.; Sharma, D.; Barrow, C. J. Enzyme-assisted Extraction of Bioactives from Plants. Trends Biotechol. 2012, 31(1), 37–44. DOI: 10.1016/j.tibtech.2011.06.014.
   PubMed Web of Science ®Google Scholar
• Gupta, A.; Naraniwal, M.; Kothari, V. Modern Extraction Methods for Preparation of Bioactive Plant Extracts. IJANS. 2012, 1(1), 8–26.
   Google Scholar
• Tomaz, I.; Maslov, L.; Stupić, D.; Preiner, D.; Ašperger, D.; Kontić, J. K. Recovery of Flavonoids from Grape Skins by Enzyme-assisted Extraction. Sep. Sci. Technol. 2016, 51(2), 255–268. DOI: 10.1080/01496395.2015.1085881.
   Web of Science ®Google Scholar
• Phuong, N. T. X.; My, H. T. K.; Thy, L. T. M.; Han, L. M.; Tam, N. L. P.; Nam, H. M.; Hieu, N. H. Enzyme-assisted Extraction of Ginsenoside RB1 from Panax Notoginseng (Burk.) F.H. CHEN. Vietnam J. Chem. 2018, 56, 301–305.
   Google Scholar
• Yin, X.; You, Q.; Jiang, Z. Optimization of Enzyme Assisted Extraction of Polysaccharides from Tricholoma Matsutake by Response Surface Methodology. Carbohydr. Polym. 2011, 86(3), 1358–1364. DOI: 10.1016/j.carbpol.2011.06.053.
   Web of Science ®Google Scholar
• Zhang, W.; Li, B.; Dong, X.; Wang, B.; Wu, Z. Y. Enzyme-assisted Extraction of Cordycepin and Adenosine from Cultured Cordyceps Militaris and Purification by Macroporous Resin Column Chromatography. Sep. Sci. Technol. 2017, 52(8), 1350–1358. DOI: 10.1080/01496395.2017.1287736.
   Web of Science ®Google Scholar
• Tijskens, L. M. M.; Greiner, R.; Biekman, E. S. A.; Konietzny, U. Modeling the Effect of Temperature and pH on Activity of Enzymes: The Case of Phytases. Biotechnol. Bioeng. 2001, 72(3), 323–330. DOI: 10.1002/1097-0290(20010205)72:3<323::AID-BIT9>3.0.CO;2-I.
   PubMed Web of Science ®Google Scholar
• Sowbhagya, H. B.; Chitra, V. N. Enzyme-Assisted Extraction of Flavorings and Colorants from Plant Materials. Crit. Rev. Food Sci. Nutr. 2010, 50(2), 146–161. DOI: 10.1080/10408390802248775.
   PubMed Web of Science ®Google Scholar
• Vieira, J. M.; Mantovani, R. A.; Raposo, M. F. J.; Coimbra, M. A.; Vicente, A. A.; Cunha, R. L. Effect of Extraction Temperature on Rheological Behavior and Antioxidant Capacity of Flaxseed Gum. Carbohydr. Polym. 2019, 213, 217–227. DOI: 10.1016/j.carbpol.2019.02.078.
   PubMed Web of Science ®Google Scholar
• Wang, S.; Dong, X.; Tong, J. Optimization of Enzyme-assisted Extraction of Polysaccharides from Alfalfa and Its Antioxidant Activity. Int. J. Biol. Macromol. 2013, 62, 387–396. DOI: 10.1016/j.ijbiomac.2013.09.029.
   PubMed Web of Science ®Google Scholar
• RenJie, L.;. Optimization of Extraction Process of Glycyrrhiza Glabra Polysaccharides by Response Surface Methodology. Carbohydr. Polym. 2008, 74(4), 858–861. DOI: 10.1016/j.carbpol.2008.05.005.
   Web of Science ®Google Scholar
• Nadar, S. S.; Rao, P.; Rathod, V. K. Enzyme Assisted Extraction of Biomolecules as an Approach to Novel Extraction Technology: A Review. Food Res. Int. 2018, 108, 309–330. DOI: 10.1016/j.foodres.2018.03.006.
   PubMed Web of Science ®Google Scholar
• Dinkova, R.; Heffels, P.; Shikov, V.; Weber, F.; Schieber, A.; Mihalev, K. Effect of Enzyme-assisted Extraction on the Chilled Storage Stability of Bilberry (Vaccinium Myrtillus L.) Anthocyanins in Skin Extracts and Freshly Pressed Juices. Food Res. Int. 2014, 65, 35–41. DOI: 10.1016/j.foodres.2014.05.066.
   Web of Science ®Google Scholar
• Michiels, J. A.; Kevers, C.; Pincemail, J.; Defraigne, J. O.; Dommes, J. Extraction Conditions Can Greatly Influence Antioxidant Capacity Assays in Plant Food Matrices. Food Chem. 2012, 130(4), 986–993. DOI: 10.1016/j.foodchem.2011.07.117.
   Web of Science ®Google Scholar
• Daniel, R. M.; Danson, M. J.; Eisenthal, R.; Lee, C. K.; Peterson, M. E. The Effect of Temperature on Enzyme Activity: New Insights and Their Implications. Extremophiles. 2008, 12(1), 51–59. DOI: 10.1007/s00792-007-0089-7.
   PubMed Web of Science ®Google Scholar
• Kim, S. J.; Murthy, H. N.; Hahn, E. J.; Lee, H. L.; Paek, K. Y. Parameters Affecting the Extraction of Ginsenosides from the Adventitious Roots of Ginseng (Panax Ginseng CA Meyer). Sep. Purif. Technol. 2007, 56(3), 401–406. DOI: 10.1016/j.seppur.2007.06.014.
   Web of Science ®Google Scholar
• Song, Y. R.; Sung, S. K.; Jang, M.; Lim, T. G.; Cho, C. W.; Han, C. J.; Hong, H. D. Enzyme-assisted Extraction, Chemical Characteristics, and Immunostimulatory Activity of Polysaccharides from Korean Ginseng (Panax Ginseng Meyer). Int. J. Biol. Macromol. 2018, 116, 1089–1097. DOI: 10.1016/j.ijbiomac.2018.05.132.
   PubMed Web of Science ®Google Scholar
• Chen, S.; Xing, X. H.; Huang, J. J.; Xu, M. S. Enzyme-assisted Extraction of Flavonoids from Ginkgo Biloba Leaves: Improvement Effect of Flavonol Transglycosylation Catalyzed by Penicillium Decumbens Cellulase. Enzyme Microb. Tech. 2011, 48(1), 100–105. DOI: 10.1016/j.enzmictec.2010.09.017.
   PubMed Web of Science ®Google Scholar
• Kim, T. D.; Thanh, H. N.; Thuy, D. N.; Duc, L. V.; Thi, T. V.; Manh, H. V.; Boonsiri, P.; Thanh, T. B. Anticancer Effects of Saponin and Saponin–phospholipid Complex of Panax Notoginseng Grown in Vietnam. Asian Pac. J. Trop. Biomed. 2016, 6(9), 795–800. DOI: 10.1016/j.apjtb.2016.04.013.
   Web of Science ®Google Scholar