432
Views
1
CrossRef citations to date
0
Altmetric
Adsorption

Evolution of extraction technique for the separation of bioactive compounds from Aegle marmelos

ORCID Icon & ORCID Icon
Pages 667-681 | Received 14 Mar 2022, Accepted 18 Nov 2022, Published online: 29 Nov 2022

References

  • Mosić, M.; Dramićanin, A.; Ristivojević, P.; Milojković-Opsenica, D. Extraction as a Critical Step in Phytochemical Analysis. J. AOAC Int. 2021, 103(2), 365–372. DOI: 10.5740/jaoacint.19-0251.
  • Brijesh, S.; Daswani, P.; Tetali, P.; Antia, N.; Birdi, T. Studies on the Antidiarrhoeal Activity of Aegle Marmelos Unripe Fruit: Validating Its Traditional Usage. BMC Complement. Altern. Med. 2009, 9(1), 1–12. DOI: 10.1186/1472-6882-9-47.
  • Sarkar, T.; Salauddin, M.; Chakraborty, R. In-Depth Pharmacological and Nutritional Properties of Bael (Aegle Marmelos): A Critical Review. J. Agric. Food Res. 2020, 2(October), 100081. DOI: 10.1016/j.jafr.2020.100081.
  • Rahman, S.; Parvin, R. Therapeutic Potential of Aegle Marmelos (L.)-An Overview. Asian Pacific J. Trop. Dis. 2014, 4(1), 71–77. DOI: 10.1016/S2222-1808(14)60318-2.
  • Kumar, M.; Dahuja, A.; Tiwari, S.; Punia, S.; Tak, Y.; Amarowicz, R.; Bhoite, A. G.; Singh, S.; Joshi, S.; Panesar, P. S., et al. Recent Trends in Extraction of Plant Bioactives Using Green Technologies: A Review. Food Chem. 2021, 353, 129431. DOI: 10.1016/j.foodchem.2021.129431.
  • Alara, O. R.; Abdurahman, N. H.; Ukaegbu, C. I. Extraction of Phenolic Compounds: A Review. Curr. Res. Food Sci. 2021, 4, 200–214. DOI: 10.1016/j.crfs.2021.03.011.
  • Muhamad, I. I.; Hassan, N. D.; Mamat, S. N. H.; Nawi, N. M.; Rashid, W. A.; Tan, N. A. Extraction Technologies and Solvents of Phytocompounds from Plant Materials : Physicochemical Characterization and Identification of Ingredients and Bioactive Compounds from Plant Extract Using Various Instrumentations. In Ingredients Extraction by Physicochemical Methods in Food; Elsevier: 2017; pp. 523–560. doi:10.1016/b978-0-12-811521-3.00014-4.
  • Purohit, S.; Vyas, S. Medicinal Plant Cultivation: A Scientific Approach: Including Processing and Financial Guidelines; Agrobios: India, 2004.
  • Singh, A. K.; Singh, S.; Saroj, P. L.; Krishna, H.; Singh, R. S.; Singh, R. K. Research Status of Bael (Aegle Marmelos) in India: A Review. Indian J. Agric. Sci. 2019, 89(10), 1563–1571.
  • GBIF.org. Occurrence Download: Plantae. Global Biodivers. Inf. Facility. 2016. 10.15468/DL.6CX2S3.
  • Mulyaningsih, A. P.; Yetti, R. D.; Rivai, H. Phytochemical and Pharmacological Review of Maja (Aegle Marmelos). World J. Farm. Pharm. Sci. 2020, 9(9), 19–42. DOI: 10.20959/wjpps20209-17045.
  • Anadani, S. V.; Akbari, S. H.; Ravani, A.; Nema, A. Physico-Chemical Characteristics of Bael (Aegle Marmelos) Fruit and Pulp. Chem. Sci. Rev. Lett. 2021, 10(8), 1282–1284.
  • Chouhan, A. S.; Raisinghani, R.; Khan, A.; Solanki, M.; Khan, A. Aegle Marmelos (L .) Correa (Bael): A Review on Ethnobotanical, Phytochemical and Pharmacological Profile. Int. J. All Res. Educ. Sci. Methods. 2021, 9(5), 3374–3384.
  • Panda, P.; Das, B.; Bhuyan, G. C.; Rao, M. M. Therapeutic Uses of Vilwa (Aegle Marmelos) in Ayurveda with Pharmacological Evidence. Res. J. Pharmacol. Pharmacodyn. 2021, 13(02), 51–54. DOI: 10.52711/2321-5836.2021.00011.
  • Venthodika, A.; Chhikara, N.; Mann, S.; Garg, M. K.; Sofi, S. A.; Panghal, A. Bioactive Compounds of Aegle Marmelos L., Medicinal Values and Its Food Applications: A Critical Review. Phyther. Res. 2021, 35(4), 1887–1907. DOI: 10.1002/ptr.6934.
  • Sawhney, R.; Hazarika, P.; Sawhney, A. Medicinal Plants as Antibacterial Agents: A Special Reference to Emblica Officinalis, Ocimum Sanctum, Aloe Vera and Aegle Marmelos. Adv. Pharm. J. 2021, 6(5), 121–130. DOI: 10.31024/apj.2021.6.5.1.
  • Chanda, S.; Biswas, S. M.; Sarkar, P. K. Phytochemicals and Antiviral Properties of Five Dominant Medicinal Plant Species in Bankura District, West Bengal: An Overview. Phytopathology. 2020, 9(6), 1420–1427. DOI: 10.22271/PHYTO.2020.V9.I6U.13146.
  • Hettiarachchi, H.; Gunathilake, K. Bioactives and Bioactivity of Selected Underutilized Fruits, Vegetables and Legumes Grown in Sri Lanka: A Review. J. Med. Plants Stud. 2020, 8(6), 34–44. DOI: 10.22271/plants.2020.v8.i6a.1227.
  • Pathirana, C. K.; Madhujith, T.; Eeswara, J. B. Bael (Aegle Marmelos L. Corrêa), a Medicinal Tree with Immense Economic Potentials. Adv. Agric. 2020, 2020, 2020. DOI: 10.1155/2020/8814018.
  • Choudhary, M.; Grover, K. Bael (Aegle Marmelos) Oil. Fruit Oils: Chem. Funct. 2019, 605–613. DOI: 10.1007/978-3-030-12473-1_30.
  • Singh, R.; Singh, A.; Babu, N.; Navneet. Ethno-Medicinal and Pharmacological Activities of Aegle Marmelos (Linn.) Corr: A Review. Pharma Innov. J. 2019, 8(6), 176–181.
  • Kulkarni, N. A.; Mane, J. Phytochemical Analysis of Selected Medicinal Plants of India. Plantae Sci. 2019, 2(1), 19–23. DOI: 10.32439/ps.v2i1.19-23.
  • Muley, K.D.; Lidabe, N.M.; Palekar, R.S.; Waghmare, S.N.; Kore, S.C.; Phytochemistry, M. L. Pharmacology and Ethnomedicinal Uses of Aegle Marmelos Plant: A Compendious Review. World J Pharm. Res. 2021, 10(5), 461–476. DOI: 10.20959/wjpr20215-20283.
  • Mahato, T. K. Exploring Antibacterial & Antiulcer Activity of Aegle Marmelos Linn. : A Review. Int. J. Pharm. Chem. Anal. 2020, 7(3), 107–112. DOI: 10.18231/j.ijpca.2020.017.
  • Rajan, S.; Gokila, M.; Jency, P.; Brindha, P.; Sujatha, R. K. Antioxidant and Phytochemical Properties of Aegle Marmelos Fruit Pulp. Int. J. Curr. Pharm. Res. 2011, 3(2), 65–70.
  • Vinita Bisht, N.; Johar, V. Bael (Aegle Marmelos) Extraordinary Species of India: A Review. Int. J. Curr. Microbiol. Appl. Sci. 2017, 6(3), 1870–1887. DOI: 10.20546/ijcmas.2017.603.213.
  • Radhika Samarasekera, J. K. R.; Khambay, B. P. S.; Hemalal, K. P. A New Insecticidal Protolimonoid from Aegle Marmelos. Nat. Prod. Res. 2004, 18(2), 117–122. DOI: 10.1080/1478641031000149858.
  • Dhandapani, R.; Sabna, B. Phytochemical Constituents of Some Indian Medicinal Plants. Anc. Sci. Life. 2008, 27(4), 1–8.
  • Mukherjee, P. K.; Wahile, A. Integrated Approaches Towards Drug Development from Ayurveda and Other Indian System of Medicines. J. Ethnopharmacol. 2006, 103(1), 25–35. DOI: 10.1016/j.jep.2005.09.024.
  • Wangkahart, E.; Wachiraamonloed, S.; Lee, P. T.; Subramani, P. A.; Qi, Z.; Wang, B. Impacts of Aegle Marmelos Fruit Extract as a Medicinal Herb on Growth Performance, Antioxidant and Immune Responses, Digestive Enzymes, and Disease Resistance Against Streptococcus Agalactiae in Nile Tilapia (Oreochromis Niloticus). Fish Shellfish Immunol. 2022, 120, 402–410. DOI: 10.1016/j.fsi.2021.11.015.
  • Sampath, K. P.; Umadevi, M.; Bhowmik, D.; Singh, D. M.; Dutta, A. S. Recent Trends in Medicinal Uses and Health Benefits of Indian Traditional Herbs Aegle Marmelos. Pharma Innov. 2012, 1(4), 57–65.
  • Singh, A. P.; Singh, L.; Singh, P.; Bhatti, R. Biological Evaluation of Aegle Marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and INOS. ACS Omega. 2021, 6(3), 2034–2044. DOI: 10.1021/acsomega.0c04739.
  • Gautam, M.; Ramanathan, M. Ameliorative Potential of Flavonoids of Aegle Marmelos in Vincristine-Induced Neuropathic Pain and Associated Excitotoxicity. Nutr. Neurosci. 2021, 24(4), 296–306. DOI: 10.1080/1028415X.2019.1627768.
  • Akhouri, V.; Kumari, M.; Kumar, A. Therapeutic Effect of Aegle Marmelos Fruit Extract Against DMBA Induced Breast Cancer in Rats. Sci. Rep. 2020, 10(1), 1–12. DOI: 10.1038/s41598-020-72935-2.
  • Sharma, H. K.; Khanna, N. K.; Vyas, D. S.; Singhal, B. D. Effect of Labetalol, an Alpha- & Beta-Adrenoceptor Blocking Agent on Gastric Acid Secretion & Gastric Ulcers in Pylorus-Ligated Rats. Indian J. Exp. Biol. 1978, 16(10), 1093–1094.
  • Dhankhar, S.; Ruhil, S.; Balhara, M.; Dhankhar, S.; Chhillar, A. K. Aegle Marmelos (Linn.) Correa: A Potential Source of Phytomedicine. J. Med. Plants Res. 2011, 5(9), 1497–1507.
  • Gupta, R. Ethnobotanical Studies of Bael (Aegle Marmelos): A Sacred Plant of Hindus. Int. J. Herb. Med. 2016, 4(4), 114–115.
  • Dutta, A.; Lal, N.; Naaz, M.; Ghosh, A.; Verma, R. Ethnological and Ethno-Medicinal Importance of Aegle Marmelos (L.) Corr (Bael) Among Indigenous People of India. Am. J. Ethnomedicine. 2014, 1(5), 290–312.
  • Williamson, E. M. Compendium of Indian Folk Medicine and Ethnobotany (1991-2015). Phytotherapy Res. 2017, 31(1), 164. DOI: https://doi.org/10.1002/ptr.5744.
  • Tiwari, R.; Tripathi, T.; Khan, Y. A.; Gupta, A.; Dhobi, M.; Srivastava, S.; Singh, B.; Shanker, K.; Kalaiselvan, V.; Singh, G. N. Metabolite Profiling, Isolation of Cyclic Polyols, Antioxidant and Anti-Inflammatory Activities of Aegle Marmelos: NMR and GC-MS Based Metabolomics Study. J. Herbs. Spices Med. Plants. 2020, 27(1), 1–15. DOI: 10.1080/10496475.2020.1786873.
  • Ahmad, W.; Amir, M.; Ahmad, A.; Ali, A.; Ali, A.; Wahab, S.; Barkat, H. A.; Ansari, M. A.; Sarafroz, M.; Ahmad, A., et al. Aegle Marmelos Leaf Extract Phytochemical Analysis, Cytotoxicity, in vitro Antioxidant and Antidiabetic Activities. Plants. 2021, 10 (12), 2573. DOI: 10.3390/plants10122573.
  • Kumar, P. Y.; Parimalam, M.; Kumar, D.; Joseph, E.; David, D.; Vinolia, R. S. O. P. Invitro Assessment of Antioxidant, Anti-Inflammatory, Tlc Profiling and Anticancer Activity of Aegle Marmelos (L.) Leaves. Ann. Rom. Soc. Cell Biol. 2021, 25(4), 18061–18071.
  • Andleeb, R.; Ijaz, M. U.; Rafique, A.; Ashraf, A.; Bano, N.; Zafar, N.; Tasleem, F.; Marc, R. A.; Pop, O. L.; Ahmedah, H. T. Biological Activities of Methanolic Extract of Aegle Marmelos Against Hn Protein of Newcastle Disease Virus. Agronomy. 2021, 11(9), 1784. DOI: 10.3390/agronomy11091784.
  • Seth, E.; Ahsan, A. U.; Bamrara, P.; Kaushal, S.; Sharma, V. L.; Chopra, M. Cytoprotective and Antioxidant Potential of Aegle Marmelos on Cadmium-Induced Hepato-Renal Toxicity: An in vivo Study. Biologia (Bratisl). 2021, 76(6), 1859–1872. DOI: 10.1007/s11756-021-00733-w.
  • Sonar, M. P.; Nikam, D. K. D.; Rathod, V. K. Intensification of Imperatorin Extraction from Aegle Marmelos by Ultrasound Assisted Three Phase Partitioning: Comparative Studies and Exploring Its Ethnomedicinal Uses. Chem. Eng. Process. - Process Intensif. 2021, 169, 108588. DOI: 10.1016/j.cep.2021.108588.
  • Surekha, R.; Ishwarya Kishore, R.; Srinivasamoorthy, H.; Kishore Kumar, V.; Athippathi, J. Evaluation of Relaxant Effect in Methanolic Extract of Aegle Marmelos on Isolated Sprague Dawley Bronchial Tissue. Res. J. Pharm. Technol. 2021, 14(8), 4241–4246. DOI: 10.52711/0974-360X.2021.00736.
  • Sonar, M. P.; Rathod, V. K. Microwave Assisted Extraction (MAE) Used as a Tool for Rapid Extraction of Marmelosin from Aegle Marmelos and Evaluations of Total Phenolic and Flavonoids Content, Antioxidant and Anti-Inflammatory Activity. Chem. Data Collect. 2020, 30, 100545. DOI: 10.1016/j.cdc.2020.100545.
  • Sivakumar, G.; Gopalasatheeskumar, K.; Gowtham, K.; Sindhu, E.; Akash Raj, K.; Rajaguru, B.; Sriram, K.; Kalaichelvan, V. K. Phytochemical Analysis, Antioxidant and Antiarthritic Activities of Different Solvent Extract of Aegle Marmelos L. Unripe Fruit. Res. J. Pharm. Technol. 2020, 13(6), 2759–2763. DOI: 10.5958/0974-360X.2020.00490.4.
  • Karmase, A.; Birari, R.; Bhutani, K. K. Evaluation of Anti-Obesity Effect of Aegle Marmelos Leaves. Phytomedicine. 2013, 20(10), 805–812. DOI: 10.1016/j.phymed.2013.03.014.
  • Birudu, R. B.; Pamulapati, P.; Manoharan, S. K. Effects of Aegle Marmelos (L.) Methanolic Leaf Extracts on Biochemical Parameters in Diabetic Rats. J. Rep. Pharm. Sci. 2021, 10(2), 209–215. DOI: 10.4103/jrptps.JRPTPS_12_20.
  • Mustafa, S. B.; Akram, M.; Muhammad Asif, H.; Qayyum, I.; Hashmi, A. M.; Munir, N.; Khan, F. S.; Riaz, M.; Ahmad, S. Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma Longa, Lavandula Stoechas, Aegle Marmelos, and Glycyrrhiza Glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice. Dose-Response. 2019, 17(2), 1559325819852503. DOI: 10.1177/1559325819852503.
  • Crossia, W.; Dahms, H.-U.; Muthukumar, K.; Kaviarasan, T.; Thirunalasundari, T.; James, R. A. In-Vitro Study: Immunomodulatory and Cytotoxicity Effects of Ethanolic Leave Extracts of Aegle Marmelos and Ficus Benghalensis. J. Coast. Life Med. 2016, 4(3), 217–224. DOI: 10.12980/jclm.4.2016j5-235.
  • Arumugam, S.; Kavimani, S.; Kadalmani, B.; Ahmed, A. B. A.; Akbarsha, M. A.; Rao, M. V. Antidiabetic Activity of Leaf and Callus Extracts of Aegle Marmelos in Rabbit. ScienceAsia. 2008, 34(3), 317–321. DOI: 10.2306/scienceasia1513-1874.2008.34.317.
  • Rathee, D.; Kamboj, A.; Sachdev, R. K.; Sidhu, S. Hepatoprotective Effect of Aegle Marmelos Augmented with Piperine Co-Administration in Paracetamol Model. Rev. Bras. Farmacogn. 2018, 28(1), 65–72. DOI: 10.1016/j.bjp.2017.11.003.
  • Kim, H. J.; Seo, Y. J.; Htwe, K. M.; Yoon, K. D. Chemical Constituents from Aegle Marmelos Fruits. Nat. Prod. Sci. 2021, 27(4), 240–244. DOI: 10.20307/nps.2021.27.4.240.
  • Rejiniemon, T. S.; Arasu, M. V.; Duraipandiyan, V.; Ponmurugan, K.; Al-Dhabi, N. A.; Arokiyaraj, S.; Agastian, P.; Choi, K. C. In-Vitro Antimicrobial, Antibiofilm, Cytotoxic, Antifeedant and Larvicidal Properties of Novel Quinone Isolated from Aegle Marmelos (Linn.) Correa. Ann. Clin. Microbiol. Antimicrob. 2014, 13(1), 1–9. DOI: 10.1186/s12941-014-0048-y.
  • Victoria, T. D.; Samrot, A. V. Evaluation of Bioactive Potential of Aegle Marmelos. Biosci. Biotechnol. Res. Asia. 2015, 12(2), 357–360. DOI: 10.13005/bbra/2210.
  • Bakr, R. O.; Zaghloul, S. S.; Amer, R. I.; Mostafa, D. A. E.; El Bishbishy, M. H. F. Characterization and Antimicrobial Efficacy of Aegle Marmelos Essential Oil Nanogel. Res. J. Pharm. Technol. 2021, 14(7), 3662–3668. DOI: 10.52711/0974-360X.2021.00633.
  • Devi, M.; Devi, S.; Sharma, V.; Rana, N.; Bhatia, R. K.; Bhatt, A. K. Green Synthesis of Silver Nanoparticles Using Methanolic Fruit Extract of Aegle Marmelos and Their Antimicrobial Potential Against Human Bacterial Pathogens. J. Tradit. Complement. Med. 2020, 10(2), 158–165. DOI: 10.1016/j.jtcme.2019.04.007.
  • Khanal, S. K.; Dawadi, K. K. Experimental Investigation on Phytochemical Analysis and Antibacterial Activity of Aegle Marmelos (Bael) Plants. Turkish J. Agric. Sci. Technol. 2020, 8(7), 1587–1592. DOI: 10.24925/turjaf.v8i7.1587-1592.3469.
  • Somu, C.; Karuppiah, H.; Sundaram, J. Antiviral Activity of Seselin from Aegle Marmelos Against Nuclear Polyhedrosis Virus Infection in the Larvae of Silkworm, Bombyx Mori. J. Ethnopharmacol. 2019, 245, 112155. DOI: 10.1016/j.jep.2019.112155.
  • Tripathi, M.; Shukla, P. K.; Sikarwar, R. L. S.; Tiwari, A.; Dwivedi, N.; Tripathi, S. Pharmacognostic Evaluation of Bilva [Aegle Marmelos (L.) Correa] Root Bark. Indian J. Tradit. Knowl. 2019, 18(4), 670–676.
  • Hasanthi, K. B.; Gamage, R. N. N.; Kumari, K. Anti-Microbial Activity of Different Solvent Extracts of Dried Flowers of Aegle Marmelos. J. Pharmacogn. Phytochem. 2018, 7(1), 1827–1830.
  • More, Y. D.; Gade, R. M.; Shitole, A. V. In Vitro Antifungal Activity of Aegle Marmelos, Syzygium Cumini and Pongamia Pinnata Extracts Against Fusarium Oxysporum F. Sp. Cicero. Syzygium Cumini and Pongamia Pinnata Extracts Against Fusarium Oxysporum F. Sp. Cicero. Indian J. Pharm. Sci. 2017, 79(3), 457–462. DOI: 10.4172/pharmaceutical-sciences.1000249.
  • Behera, P.; Vennel Raj, V.; Basavaraju, R. Phytochemical and Antimicrobial Activity of Fruit Pulp of Aegle Marmelos. J. Chem. Pharm. Res. 2014, 6(8), 319–326.
  • Sarraf, M.; Beig-Babaei, A.; Naji-Tabasi, S. Optimizing Extraction of Berberine and Antioxidant Compounds from Barberry by Maceration and Pulsed Electric Field-Assisted Methods. J. Berry Res. 2021, 11(1), 133–149. DOI: 10.3233/JBR-200603.
  • Sindhu, R. K.; Kaur, P.; Sanjana, M.; Kaur, P.; Goyal, A.; Bala, R.; Sandhu, A. Phytochemicals: Extraction, Isolation Methods, Identification and Therapeutic Uses: A Review. Plant Arch. 2021, 21(1), 174–184. DOI: 10.51470/PLANTARCHIVES.2021.v21.S1.032.
  • Malik, J.; Mandal, S. C. Extraction of Herbal Biomolecules. In Herbal Biomolecules in Healthcare Applications; Elsevier: 2022; pp. 21–46. doi:10.1016/b978-0-323-85852-6.00015-9.
  • Ghosh, S.; Sett, S.; Saha, R.; Roy, A.; Acharya, K. Comparative Phytochemical Screening and Antioxidant Properties of Infusion, Decoction and Hydroalcoholic Extracts of Wood Ear Mushrooms; Auricularia Delicata and Auricularia Mesenterica. Indian Phytopathol. 2021, 74(1), 113–121. DOI: 10.1007/s42360-020-00301-3.
  • Veer, B.; Singh, R. Phytochemical Screening and Antioxidant Activities of Aegle Marmelos Leaves. Anal. Chem. Lett. 2019, 9(4), 478–485. DOI: 10.1080/22297928.2019.1657946.
  • Randika, S. W.; Nilushi, N. R.; Pathmalal, M.; Lanka, U.; Dhanushka, U.; Nilmini, L. R.; Prasanna, G. Effects of Extraction Solvents on Phytochemical Screening, Cytotoxicity and Anti-Obesity Activities of Selected Sri Lankan Medicinal Plants. Pharmacognosy. res. 2021, 13(4), 246–256. DOI: 10.5530/pres.13.4.18.
  • Shakyawar, S. L.; Rahman, M. A.; Sundaram, S.; Alok, S. Preliminary Qualitative Phytochemical, Physico-Chemical and Phyto-Pharmacognostical Standardisation Evaluation of the Pulp (Without Seed), Pericarp, Leaves and Seed of Aegle Marmelos L. (Bael). Int. J. Pharm. Sci. Res. 2020, 11(7), 3489–3506. DOI: 10.13040/IJPSR.0975-8232.
  • Sharma, G. N.; Dubey, S. K.; Sati, N.; Sanadya, J. Phytochemical Screening and Estimation of Total Phenolic Content in Aegle Marmelos Seeds. Int. J. Pharm. Clin. Res. 2011, 3(2), 27–29.
  • Rajendran, V. Antimicrobial Activity of Aegle Marmelos, ruta Graveolens, Opuntia Dellini, Euphorbia Royleana and Euphorbia Antiquorum. J. Pharm. Res. 2011, 4(5), 1507.
  • Janarthanan, U. K.; Varadharajan, V.; Krishnamurthy, V. Physicochemical Evaluation, Phytochemical Screening and Chromatographic Fingerprint Profile of Aegle Marmelos (L.) Leaf Extracts. World J Pharm. Res. 2012, 1(3), 813–837.
  • Rani, P.; Vasisht, K.; Khullar, N. Bio-Autography: An Efficient Method to Check the in vitro Antimicrobial Activity of Aegle Marmelos Against Enteric Pathogens. Iioab J. 2013, 4(4), 4–9.
  • Singh, S.; Lata, S.; Nath Tiwari, K. Aegle Marmelos Leaves Protect Liver Against Toxic Effects of Cyclophosphamide in Mice. New York Sci. J. 2014, 7(9), 43–53.
  • Gade, R. B.; Deshmukh, A. A.; Patil, M. K.; Pensalwar, S. B.; Waghmare, S. J. V. D. M. D. Comparative Study of Phytochemical Analysis and Extractive Value of Aegle Marmelos, Bauhinia Racemosa and Psidium Guajava. J. Pharmacogn. Phytochem. 2018, 7(5), 2904–2907.
  • Jatav, S.; Pandey, N.; Dwivedi, P.; Bansal, R.; Ahluwalia, V.; Tiwari, V. K.; Mishra, B. B. Isolation of a New Flavonoid and Waste to Wealth Recovery of 6-O-Ascorbyl Esters from Seeds of Aegle Marmelos (Family- Rutaceae). Nat. Prod. Res. 2019, 33(15), 2236–2242. DOI: 10.1080/14786419.2018.1499630.
  • Singh, J.; Dutta, T.; Kim, K. H.; Rawat, M.; Samddar, P.; Kumar, P. “Green” Synthesis of Metals and Their Oxide Nanoparticles: Applications for Environmental Remediation. J. Nanobiotechnology. 2018, 16(1), 1–24. DOI: 10.1186/s12951-018-0408-4.
  • Samrot, A. V.; Silky, I. V.; Raji, P.; SaiPriya, C.; Selvarani, J. A. Bioactivity Studies of Datura Metel, Aegle Marmelos, Annona Reticulata and Saraca Indica and Their Green Synthesized Silver Nanoparticle. J. Pure Appl. Microbiol. 2019, 13(1), 329–338. DOI: 10.22207/JPAM.13.1.36.
  • Angel Ezhilarasi, A.; Judith Vijaya, J.; Kaviyarasu, K.; John Kennedy, L.; Ramalingam, R. J.; Al-Lohedan, H. A. Green Synthesis of NiO Nanoparticles Using Aegle Marmelos Leaf Extract for the Evaluation of in-Vitro Cytotoxicity, Antibacterial and Photocatalytic Properties. J. Photochem. Photobiol. B Biol. 2018, 180, 39–50. DOI: 10.1016/j.jphotobiol.2018.01.023.
  • Sporring, S.; Bøwadt, S.; Svensmark, B.; Björklund, E. Comprehensive Comparison of Classic Soxhlet Extraction with Soxtec Extraction, Ultrasonication Extraction, Supercritical Fluid Extraction, Microwave Assisted Extraction and Accelerated Solvent Extraction for the Determination of Polychlorinated Biphenyls. J. Chromatogr. A. 2005, 1090(1–2), 1–9. DOI: 10.1016/j.chroma.2005.07.008.
  • López-Bascón-Bascon, M. A.; Luque de Castro, M. D. Soxhlet Extraction. In Liquid-Phase Extraction; Elsevier: 2019; pp. 327–354. doi:10.1016/B978-0-12-816911-7.00011-6.
  • Kejariwal, M. Evaluation of Antioxidant Potential and Phytochemical Investigations on Aegle Marmelos (L.) Corr. Bull. Environ. Pharmacol. Life Sci. 2016, 5(2), 42–52.
  • Mohammed, M. M. D.; Ibrahim, N. A.; El-Sakhawy, F. S.; Mohamed, K. M.; Deabes, D. A. H. Two New Cytotoxic Furoquinoline Alkaloids Isolated from Aegle Marmelos (Linn.) Correa. Nat. Prod. Res. 2016, 30(22), 2559–2566. DOI: 10.1080/14786419.2015.1126262.
  • Dubey, S.; Mishra, D. K.; Acharya, A.; Dubey, S.; Bole, S. Study of Glucose Uptake Activity of Aegle Marmelos Ethanolic Extract on Liver Cell Line by Flow Cytometry. WJPPS. 2018, 7(6), 1242–1247.
  • Seth, E.; Kaushal, S.; Ahsan, A. U.; Sharma, V. L.; Chopra, M. Neuroprotective Effects of Aegle Marmelos (L.) Correa Against Cadmium Toxicity by Reducing Oxidative Stress and Maintaining the Histoarchitecture of Neural Tissue in BALB/C Mice. Indian J. Biochem. Biophys. 2018, 55(2), 95–104.
  • Pynam, H.; Dharmesh, S. M. Antioxidant and Anti-Inflammatory Properties of Marmelosin from Bael (Aegle Marmelos L.); Inhibition of TNF-α Mediated Inflammatory/Tumor Markers. Biomed. Pharmacother. 2018, 106, 98–108. DOI: 10.1016/j.biopha.2018.06.053.
  • Dhanda, T.; Kumar Beniwal, R.; Madan, V. K. Quantitative Analysis of Phenols, Flavonoids in Different Parts of Aegle Marmelos (Bael) Along with the Evaluation of Antioxidant Potential Using Different Extracts. J. Pharmacogn. Phytochem. 2020, 9(3), 1192–1198.
  • Hu, B.; Xi, X.; Li, H.; Qin, Y.; Li, C.; Zhang, Z.; Liu, Y.; Zhang, Q.; Liu, A.; Liu, S., et al. A Comparison of Extraction Yield, Quality and Thermal Properties from Sapindus Mukorossi Seed Oil Between Microwave Assisted Extraction and Soxhlet Extraction. Ind. Crops Prod. 2021, 161, 113185. DOI: 10.1016/j.indcrop.2020.113185.
  • Atienza, J. J.; Segui, D. I.; Arcigal, R.; Bracewell, J.; Dimasuay, M.; Bueno, P. R.; De Grano, R. V. Specific Analytical Methods for the Extraction of Common Phytochemical Constituents of Vitex Negundo Linn: A Mini-Review. J. Pharmacogn. Phytochem. 2021, 10(5), 95–107. DOI: 10.22271/phyto.2021.v10.i5b.14226.
  • Muchahary, S.; Deka, S. C. Impact of Supercritical Fluid Extraction, Ultrasound-Assisted Extraction, and Conventional Method on the Phytochemicals and Antioxidant Activity of Bhimkol (Musa Balbisiana) Banana Blossom. J. Food Process Preserv. 2021, 45(7), e15639. DOI: 10.1111/jfpp.15639.
  • Dhanani, T.; Shah, S.; Gajbhiye, N. A.; Kumar, S. Effect of Extraction Methods on Yield, Phytochemical Constituents and Antioxidant Activity of Withania Somnifera. Arab J. Chem. 2017, 10, S1193–1199. DOI: 10.1016/j.arabjc.2013.02.015.
  • Manda, V. K.; Avula, B.; Chittiboyina, A. G.; Khan, I. A.; Walker, L. A.; Khan, S. I. Inhibition of CYP3A4 and CYP1A2 by Aegle Marmelos and Its Constituents. Xenobiotica. 2016, 46(2), 117–125. DOI: 10.3109/00498254.2015.1053006.
  • Saha, S. K.; Dey, S.; Chakraborty, R. Effect of Choline Chloride-Oxalic Acid Based Deep Eutectic Solvent on the Ultrasonic Assisted Extraction of Polyphenols from Aegle Marmelos. J. Mol. Liq. 2019, 287, 110956. DOI: 10.1016/j.molliq.2019.110956.
  • Sonar, M. P.; Rathod, V. K. Optimization Study of Marmelosin (Imperatorin) Extraction from Aegle Marmelos Using Three Phase Partitioning. J. Biol. Act. Prod. Nat. 2020, 10(5), 418–428. DOI: 10.1080/22311866.2020.1816215.
  • Kaufmann, B.; Christen, P. Recent Extraction Techniques for Natural Products: Microwave-Assisted Extraction and Pressurised Solvent Extraction. Phytochem. Anal. 2002, 13(2), 105–113. DOI: 10.1002/pca.631.
  • Truong, D.-H.; Nguyen, D. H.; Ta, N. T. A.; Bui, A. V.; Do, T. H.; Nguyen, H. C. Evaluation of the Use of Different Solvents for Phytochemical Constituents, Antioxidants, and in vitro Anti-Inflammatory Activities of Severinia Buxifolia. J. Food Qual. 2019, 2019, 1–9. DOI: 10.1155/2019/8178294.
  • Panzella, L.; Moccia, F.; Nasti, R.; Marzorati, S.; Verotta, L.; Napolitano, A. Bioactive Phenolic Compounds from Agri-Food Wastes: An Update on Green and Sustainable Extraction Methodologies. Front. Nutrit. 2020, 7, 60. DOI: 10.3389/fnut.2020.00060.
  • Bagade, S. B.; Patil, M. Recent Advances in Microwave Assisted Extraction of Bioactive Compounds from Complex Herbal Samples: A Review. Crit. Rev. Anal. Chem. 2021, 51(2), 138–149. DOI: 10.1080/10408347.2019.1686966.
  • Goh, Y. S.; Karunakaran, T.; Murugaiyah, V.; Santhanam, R.; Abu Bakar, M. H.; Ramanathan, S. Accelerated Solvent Extractions (Ase) of Mitragyna Speciosa Korth. (Kratom) Leaves: Evaluation of Its Cytotoxicity and Antinociceptive Activity. Molecules. 2021, 26(12), 3704. DOI: 10.3390/molecules26123704.
  • Vaishnavi, A.; Arvapalli, S.; Rishika, P.; Jabeen, S.; Karunakar, B.; Sharma, J. V. C. A Review on Phytosomes : Promising Approach for Drug Delivery of Herbal a Review on Phytosomes : Promising Approach for Drug Delivery of Herbal Phytochemicals. Int. J. Pharm. Res. Appl. 2021, 6(April), 289–296. DOI: 10.35629/7781-0601289296.
  • Azwanida, N. N. A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation. Med. Aromat. Plants. 2015, 04(03), 412–2167. DOI: 10.4172/2167-0412.1000196.
  • Lefebvre, T.; Destandau, E.; Lesellier, E. Selective Extraction of Bioactive Compounds from Plants Using Recent Extraction Techniques: A Review. J. Chromatogr. A. 2021, 1635, 461770. DOI: 10.1016/j.chroma.2020.461770.
  • Hikmawanti, N. P. E.; Ramadon, D.; Jantan, I.; Mun’Im, A. Natural Deep Eutectic Solvents (Nades): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development. Plants. 2021, 10(10), 2091. DOI: 10.3390/plants10102091.
  • Boldrini, C. L.; Quivelli, A. F.; Manfredi, N.; Capriati, V.; Abbotto, A. Deep Eutectic Solvents in Solar Energy Technologies. Molecules. 2022, 27(3), 709. DOI: 10.3390/molecules27030709.
  • Dai, Y.; van Spronsen, J.; Witkamp, G. J.; Verpoorte, R.; Choi, Y. H. Natural Deep Eutectic Solvents as New Potential Media for Green Technology. Anal. Chim. Acta. 2013, 766, 61–68. DOI: 10.1016/j.aca.2012.12.019.
  • Kaushik, P.; Dowling, K.; Adhikari, R.; Barrow, C. J.; Adhikari, B. Effect of Extraction Temperature on Composition, Structure and Functional Properties of Flaxseed Gum. Food Chem. 2017, 215, 333–340. DOI: 10.1016/j.foodchem.2016.07.137.
  • Mokrani, A.; Madani, K. Effect of Solvent, Time and Temperature on the Extraction of Phenolic Compounds and Antioxidant Capacity of Peach (Prunus Persica L.) Fruit. Sep. Purif. Technol. 2016, 162, 68–76. DOI: 10.1016/j.seppur.2016.01.043.
  • Difonzo, G.; Aresta, A.; Cotugno, P.; Ragni, R.; Squeo, G.; Summo, C.; Massari, F.; Pasqualone, A.; Faccia, M.; Zambonin, C., et al. Supercritical Co2 Extraction of Phytocompounds from Olive Pomace Subjected to Different Drying Methods. Molecules. 2021, 26 (3), 598. DOI: 10.3390/molecules26030598.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.