Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 39, 2017 - Issue 4
530
Views
15
CrossRef citations to date
0
Altmetric
Original Research Paper

Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study

, , , , &
Pages 337-343 | Received 15 Mar 2016, Accepted 05 Nov 2016, Published online: 01 Feb 2017

References

  • Sabayan B, Gussekloo J, de Ruijter W, et al. Framingham stroke risk score and cognitive impairment for predicting first-time stroke in the oldest old. Stroke. 2013;44:1866–1871.10.1161/STROKEAHA.113.001460
  • Weinstein G, Beiser AS, DeCarli C, et al. Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham heart study. Stroke. 2013;44:2787–2794.10.1161/STROKEAHA.113.000947
  • Sabayan B, Jansen S, Oleksik AM, et al. Cerebrovascular hemodynamics in Alzheimer’s disease and vascular dementia: a meta-analysis of transcranial Doppler studies. Ageing Res Rev. 2012;11:271–277.10.1016/j.arr.2011.12.009
  • Leys D, Hénon H, Mackowiak-Cordoliani MA, et al. Poststroke dementia. Lancet Neurol. 2005;4:752–759.10.1016/S1474-4422(05)70221-0
  • Grupke S, Hall J, Dobbs M, et al. Understanding history, and not repeating it. Neuroprotection for acute ischemic stroke: from review to preview. Clin Neurol Neurosurg. 2015;129:1–9.10.1016/j.clineuro.2014.11.013
  • Zhang L, Lü L, Chan WM, et al. Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis. Neurochem Res. 2012;37:911–919.10.1007/s11064-011-0663-3
  • Li J, Li Y, Ogle M, et al. DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway. Brain Res. 2010;1359:216–226.10.1016/j.brainres.2010.08.061
  • Zhang T, Yan W, Li Q, et al. 3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia. Neurol Res. 2011;33:396–404.10.1179/1743132810Y.0000000006
  • Cui LY, Zhu YC, Gao S, et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 2013;126:3405–3410.
  • Yoldas T, Gonen M, Godekmerdan A, et al. The serum high-sensitive C reactive protein and homocysteine levels to evaluate the prognosis of acute ischemic stroke. Mediators Inflamm. 2007;2007: 15929.
  • Yu J, Li J, Huang X. The Beijing version of the montreal cognitive assessment as a brief screening tool for mild cognitive impairment: a community-based study. BMC Psychiatry. 2012;12(156).10.1186/1471-244X-12-156
  • Jia JP. Chinese dementia and cognitive impairment diagnosis and treatment guideline. Beijing: People’s Medical Publishing House; 2010.
  • Nasreddine ZS, Phillips NA, Bedirian V, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–699.10.1111/jgs.2005.53.issue-4
  • Hasan N, McColgan P, Bentley P, et al. Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review. Br J Clin Pharmacol. 2012;74:230–240.10.1111/j.1365-2125.2012.04212.x
  • Chaudhari TS, Verma R, Garg RK, et al. Clinico-radiological predictors of vascular cognitive impairment (VCI) in patients with stroke: a prospective observational study. J Neurol Sci. 2014;340:150–158.10.1016/j.jns.2014.03.018
  • Jiang B, Chen Y, Yao G, et al. Effects of differences in serum total homocysteine, folate, and vitamin B12 on cognitive impairment in stroke patients. BMC Neurol. 2014;14:217.10.1186/s12883-014-0217-9
  • Khedr EM, Hamed SA, El-Shereef HK, et al. Cognitive impairment after cerebrovascular stroke: relationship to vascular risk factors. Neuropsychiatr Dis Treat. 2009;5:103–116.
  • Oulhaj A, Refsum H, Beaumont H, et al. Homocysteine as a predictor of cognitive decline in Alzheimer’s disease. Int J Geriatr Psychiatry. 2010;25:82–90.
  • Almeida CC, Brentani HP, Forlenza OV, et al. Serum folic acid is reduced in patients with Alzheimer’s disease. Rev Psiquiatr Clín. 2012;39:90–93.10.1590/S0101-60832012000300004
  • Ansari R, Mahta A, Mallack E, et al. Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol. 2014;10:281–288.10.3988/jcn.2014.10.4.281
  • Troen AM, Chao WH, Crivello NA, et al. Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J Nutr. 2008;138:2502–2509.10.3945/jn.108.093641
  • Zhao W, Xu S, Peng Y, et al. Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats. Neurosci Lett. 2013;541:155–160.10.1016/j.neulet.2013.01.053
  • Wang HM, Zhang T, Huang JK, et al. 3-N-butylphthalide (NBP) attenuates the amyloid-beta-induced inflammatory responses in cultured astrocytes via the nuclear factor-kappaB signaling pathway. Cell Physiol Biochem. 2013;32:235–242.10.1159/000350139
  • Zhu YC, Cui LY, Gao S. Safety and efficacy of administration of dl-3-n-butylphthalide for acute ischemic stroke: a phase III, multicenter, randomized, double-blind, double-dummy, active controlled trial. Chin J Neurol. 2014;47:113–118.
  • Fotuhi M, Hachinski V, Whitehouse PJ. Changing perspectives regarding late-life dementia. Nat Rev Neurol. 2009;5:649–658.10.1038/nrneurol.2009.175
  • Dolan H, Crain B, Troncoso J, et al. Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort. Ann Neurol. 2010;68:231–240.
  • Schaapsmeerders P, Maaijwee NA, van Dijk EJ, et al. Long-term cognitive impairment after first-ever ischemic stroke in young adults. Stroke. 2013;44:1621–1628.10.1161/STROKEAHA.111.000792
  • Jia J, Wei C, Liang J, et al. The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: a multicentre, randomized, double-blind, placebo-controlled trial. Alzheimers Dement. 2016;12:89–99.10.1016/j.jalz.2015.04.010
  • Xue LX, Zhang T, Zhao YW, et al. Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: effects on neurological and behavioral outcomes in acute ischemic stroke. Exp Ther Med. 2016;11:2015–2020.
  • Zhao H, Yun W, Zhang Q, et al. Mobilization of circulating endothelial progenitor cells by dl-3-n-butylphthalide in acute ischemic stroke patients. J Stroke Cerebrovasc Dis. 2016;25:752–760.10.1016/j.jstrokecerebrovasdis.2015.11.018

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.