Sub-chronic oral cinnamaldehyde treatment prevents scopolamine-induced memory retrieval deficit and hippocampal Akt and MAPK dysregulation in male mice

References

• Ferreira-Vieira TH, Guimaraes IM, Silva FR, et al. Alzheimer’s disease: targeting the cholinergic system. Curr Neuropharmacol. 2016;14(1):101–115.
   PubMed Web of Science ®Google Scholar
• Isik AT, Bozoglu E, Yay A, et al. Which cholinesterase inhibitor is the safest for the heart in elderly patients with Alzheimer’s disease? American J Alzheimer’s Dis Other Dementias®. 2012;27(3):171–174.
   PubMed Web of Science ®Google Scholar
• Klinkenberg I, Blokland A. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev. 2010;34(8):1307–1350.
   PubMed Web of Science ®Google Scholar
• Weintraub S, Wicklund AH, Salmon DP. The neuropsychological profile of Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Apr;2(4):a006171.
   PubMed Web of Science ®Google Scholar
• Roy DS, Arons A, Mitchell TI, et al. Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease. Nature. 2016 Mar 24;531(7595):508–512.
   PubMed Web of Science ®Google Scholar
• Moosavi M, SoukhakLari R, Moezi L, et al. Scopolamine-induced passive avoidance memory retrieval deficit is accompanied with hippocampal MMP2, MMP-9 and MAPKs alteration. Eur J Pharmacol. 2017 Dec 7;819:248–253.
   PubMed Web of Science ®Google Scholar
• SoukhakLari R, Moezi L, Pirsalami F, et al. Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3beta. J Mol Neurosci. 2018 Dec 15;841:28–32.
   Google Scholar
• SoukhakLari R, Moezi L, Pirsalami F, et al. The effect of BSA-based curcumin nanoparticles on memory and hippocampal MMP-2, MMP-9, and MAPKs in adult mice. J Mol Neurosci. 2018 Jul;65(3):319–326.
   Google Scholar
• Xue B, Mao LM, Jin DZ, et al. Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors. J Neurosci Res. 2015 Oct;93(10):1592–1599.
   PubMed Web of Science ®Google Scholar
• Li B-S, Ma W, Zhang L, et al. Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells. J Neurosci. 2001;21(5):1569–1579.
   PubMed Web of Science ®Google Scholar
• Moosavi M, SoukhakLari R, Moezi L, et al. Scopolamine-induced passive avoidance memory retrieval deficit is accompanied with hippocampal MMP2, MMP-9 and MAPKs alteration. Eur J Pharmacol. 2018 Jan 15;819:248–253.
   PubMed Web of Science ®Google Scholar
• Momtaz S, Hassani S, Khan F, et al. Cinnamon, a promising prospect towards Alzheimer’s disease. Pharmacol Res. 2018 Apr 01;130:241–258.
   PubMed Web of Science ®Google Scholar
• Frydman-Marom A, Levin A, Farfara D, et al. Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models. PloS One. 2011;6(1):e16564.
   PubMed Web of Science ®Google Scholar
• Madhavadas S, Subramanian S. Cognition enhancing effect of the aqueous extract of Cinnamomum zeylanicum on non-transgenic Alzheimer’s disease rat model: biochemical, histological, and behavioural studies. Nutr Neurosci. 2017;20(9):526–537.
   PubMed Web of Science ®Google Scholar
• Jain S, Sangma T, Shukla SK, et al. Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats. Nutr Neurosci. 2015 Jul;18(5):210–216.
   PubMed Web of Science ®Google Scholar
• Yeh HF, Luo CY, Lin CY, et al. Methods for thermal stability enhancement of leaf essential oils and their main constituents from indigenous cinnamon (Cinnamomum osmophloeum). J Agric Food Chem. 2013 Jul 3;61(26):6293–6298.
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhang Z, Fu Y, et al. Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide. Neuropharmacology. 2016 Nov;110(Pt A):503–518.
   PubMedGoogle Scholar
• Saeed M, Ghadiri A, Hadizadeh F, et al. Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex. Iran J Basic Med Sci. 2018 Dec;21(12):1316–1321.
   PubMedGoogle Scholar
• Pham HM, Xu A, Schriner SE, et al. Cinnamaldehyde improves lifespan and healthspan in drosophila melanogaster models for Alzheimer’s Disease. Biomed Res Int. 2018 Aug 29;2018:3570830.
   Google Scholar
• SoukhakLari R, Borhani-Haghighi A, Farsadrooh A, et al. The effect of cinnamaldehyde on passive avoidance memory and hippocampal Akt, ERK and GSK-3β in mice. Eur J Pharmacol. 2019 Sep 15;859:172530.
   PubMed Web of Science ®Google Scholar
• Milad MR, Igoe SA, Lebron-Milad K, et al. Estrous cycle phase and gonadal hormones influence conditioned fear extinction. Neuroscience. 2009 Dec 15;164(3):887–895.
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhang Z, Fu Y, et al. Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide. Neuropharmacology. 2016 Nov 01;110:503–518.
   PubMed Web of Science ®Google Scholar
• Izquierdo I, Bevilaqua LR, Rossato JI, et al. Different molecular cascades in different sites of the brain control memory consolidation. Trends Neurosci. 2006;29(9):496–505.
   PubMed Web of Science ®Google Scholar
• Amiri E, Ghasemi R, Moosavi M. Agmatine protects against 6-OHDA-induced apoptosis, and ERK and Akt/GSK disruption in SH-SY5Y cells. Cell Mol Neurobiol. 2016 Aug;36(6):829–838.
   PubMed Web of Science ®Google Scholar
• Moosavi M, Abbasi L, Zarifkar A, et al. The role of nitric oxide in spatial memory stages, hippocampal ERK and CaMKII phosphorylation. Pharmacol Biochem Behav. 2014;122:164–172.
   PubMed Web of Science ®Google Scholar
• Bisaz R, Travaglia A, Alberini CM. The neurobiological bases of memory formation: from physiological conditions to psychopathology. Psychopathology. 2014;47(6):347–356.
   PubMed Web of Science ®Google Scholar
• Moosavi M, Khales GY, Abbasi L, et al. Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivation. Neuropharmacology. 2012 Apr;62(5–6):2018–2023.
   PubMed Web of Science ®Google Scholar
• Pepeu G, Giovannini MG. Cholinesterase inhibitors and memory. Chem Biol Interact. 2010 Sep 06;187(1–3):403–408.
   PubMed Web of Science ®Google Scholar
• Levenga J, Wong H, Milstead RA. AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. Elife. 2017 Nov 27;6. pii: e30640.
   Google Scholar
• Yi JH, Baek SJ, Heo S, et al. Direct pharmacological Akt activation rescues Alzheimer’s disease like memory impairments and aberrant synaptic plasticity. Neuropharmacology. 2018 Jan 01;128:282–292.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu F, Grundke-Iqbal I, et al. Deficient brain insulin signalling pathway in Alzheimer’s disease and diabetes. J Pathol. 2011;225(1):54–62.
   PubMed Web of Science ®Google Scholar
• Das TK, Chakrabarti SK, Zulkipli IN, et al. Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer’s Disease in Rats. J Alzheimer’s Dis Rep. 2019 Mar 6;3(1):59–70.
   PubMedGoogle Scholar
• Gratuze M, Planel E. Regulation of brain insulin signaling: A new function for tau. J Exp Med. 2017;214(8):2171–2173.
   PubMed Web of Science ®Google Scholar
• Kandimalla R, Thirumala V, Reddy PH. Is Alzheimer’s disease a type 3 diabetes? A critical appraisal. Biochimica et biophysica acta Mol basis dis. 2017;1863(5):1078–1089.
   PubMed Web of Science ®Google Scholar
• Ferreira LSS, Fernandes CS, Vieira MNN, et al. Insulin resistance in Alzheimer’s Disease. Front Neurosci. 2018;12:830.
   PubMed Web of Science ®Google Scholar
• Kroner Z. The relationship between alzheimer’s disease and diabetes: type 3 diabetes. Altern Med Rev. 2009;14(4):373–379.
   PubMedGoogle Scholar
• Bahramian A, Rastegar K, Namavar MR, et al. Insulin potentiates the therapeutic effect of memantine against central STZ-induced spatial learning and memory deficit. Behav Brain Res. 2016 Sep 15;311:247–254.
   PubMed Web of Science ®Google Scholar
• Ghasemi R, Zarifkar A, Rastegar K, et al. Insulin protects against Abeta-induced spatial memory impairment, hippocampal apoptosis and MAPKs signaling disruption. Neuropharmacology. 2014;85:113–120.
   PubMed Web of Science ®Google Scholar
• Yu Y, Li X, Blanchard J, et al. Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice. J Neural Transm (Vienna, Austria: 1996). 2015 Apr;122(4):593–606.
   PubMed Web of Science ®Google Scholar
• Qin B, Panickar KS, Anderson RA. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 2010;4(3):685–693.
   PubMedGoogle Scholar
• Babu PS, Prabuseenivasan S, Ignacimuthu S. Cinnamaldehyde—a potential antidiabetic agent. Phytomedicine. 2007;14(1):15–22.
   PubMed Web of Science ®Google Scholar
• Zhu R, Liu H, Liu C, et al. Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacol Res. 2017;122:78–89.
   PubMed Web of Science ®Google Scholar
• Li JE, Futawaka K, Yamamoto H, et al. Cinnamaldehyde contributes to insulin sensitivity by activating PPARdelta, PPARgamma, and RXR. Am J Chin Med. 2015;43(5):879–892.
   PubMed Web of Science ®Google Scholar
• Abdelmageed ME, Shehatou GS, Abdelsalam RA, et al. Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. Naunyn-Schmiedeberg’s Arch Pharmacol. 2019 Feb;392(2):243–258.
   Google Scholar
• Pei -J-J, Braak H, An W-L, et al. Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease. Mol Brain Res. 2002;109(1–2):45–55.
   PubMedGoogle Scholar
• Mao LM, Wang HH, Wang JQ. Antagonism of muscarinic acetylcholine receptors alters synaptic ERK phosphorylation in the rat forebrain. Neurochem Res. 2017 Apr;42(4):1202–1210.
   PubMed Web of Science ®Google Scholar
• Ribeiro PR, Neto MFDC, Chagas EA, et al. Acetylcolonesterase inhibitor potential in cinnamon seed oil (cinnamomum Zeylanicum Nees) Lauraceae in Roraima, Brazil. Chem Eng Trans. 2019;75:361–366.
   Google Scholar
• Dalai MK, Bhadra S, Chaudhary SK, et al. Anticholinesterase activity of Cinnamomum zeylanicum L. leaf extract. Tang. 2014;4(2):21–26.
   Google Scholar
• Ghasemi R, Moosavi M, Zarifkar A, et al. The interplay of Akt and ERK in abeta toxicity and insulin-mediated protection in primary hippocampal cell culture. J Mol Neurosci. 2015 Nov;57(3):325–334.
   PubMed Web of Science ®Google Scholar
• Zhou J, Du T, Li B, et al. Crosstalk between MAPK/ERK and PI3K/Akt signal pathways during brain ischemia/reperfusion. ASN Neuro. 2015;7(5):1759091415602463.
   Web of Science ®Google Scholar