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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 43, 2021 - Issue 9
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Original Research Paper

Long noncoding RNA ANRIL knockdown attenuates neuroinflammation following ischemic stroke via suppressing the expression of NF-κB in vitro and in vivo

, , , , , , , & ORCID Icon show all
Pages 767-777 | Received 08 Jan 2021, Accepted 20 May 2021, Published online: 03 Jun 2021

References

  • Hankey GJ. Stroke. Lancet. 2017;389(10069):641–654.
  • Ekker MS, Boot EM, Singhal AB, et al. Epidemiology, aetiology, and management of ischaemic stroke in young adults. Lancet Neurol. 2018;17(9):790–801.
  • Yang Q, Huang Q, Hu Z, et al. Potential neuroprotective treatment of stroke: targeting excitotoxicity, oxidative stress, and inflammation. Front Neurosci. 2019;13:1036.
  • Chamorro A, Dirnagl U, Urra X, et al. Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol. 2016;15(8):869–881.
  • Jayaraj RL, Azimullah S, Beiram R, et al. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142.
  • Bonaventura A, Liberale L, Vecchié A, et al. Update on inflammatory biomarkers and treatments in ischemic stroke. Int J Mol Sci. 2016;17(12):1967.
  • Shi K, Tian DC, Li ZG, et al. Global brain inflammation in stroke. Lancet Neurol. 2019;18(11):1058–1066.
  • Qiao C, Yang L, Wan J, et al. Long noncoding RNA ANRIL contributes to the development of ulcerative colitis by miR-323b-5p/TLR4/MyD88/NF-kappaB pathway. Biochem Biophys Res Commun. 2019;508(1):217–224.
  • Clark BS, Blackshaw S. Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Front Genet. 2014;5:5164.
  • Deng QW, Li S, Wang H, et al. Differential long noncoding RNA expressions in peripheral blood mononuclear cells for detection of acute ischemic stroke. Clin sci. 2018;132(14):1597–1614.
  • Dharap A, Nakka VP, Vemuganti R. Effect of focal ischemia on long noncoding RNAs. Stroke. 2012;43(10):2800–2802.
  • Congrains A, Kamide K, Ohishi M, et al. ANRIL: molecular mechanisms and implications in human health. Int J Mol Sci. 2013;14(1):1278–1292.
  • Kong Y, Hsieh CH, Alonso LC. ANRIL: a lncRNA at the CDKN2A/B locus with roles in cancer and metabolic disease. Front Endocrinol (Lausanne). 2018;9:9405.
  • Aguilo F, Di Cecilia S, Walsh MJ. Long Non-coding RNA ANRIL and polycomb in human cancers and cardiovascular disease. Curr Top Microbiol Immunol. 2016; 394: 29–39.
  • Chen LL. Linking long noncoding RNA localization and function. Trends Biochem Sci. 2016;41(9):761–772.
  • Guo F, Tang C, Li Y, et al. The interplay of LncRNA ANRIL and miR-181b on the inflammation-relevant coronary artery disease through mediating NF-κB signalling pathway. J Cell Mol Med. 2018;22(10):5062–5075.
  • Shu L, Zhang W, Huang C, et al. lncRNA ANRIL protects H9c2 cells against hypoxia-induced injury through targeting the miR-7-5p/SIRT1 axis. J Cell Physiol. 2020;235(2):1175–1183.
  • Tan C, Liu J, Wei J, et al. Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis. Biosci Rep. 2019;39(5). DOI:10.1042/BSR20182127.
  • Yang J, Gu L, Guo X, et al. LncRNA ANRIL expression and ANRIL gene polymorphisms contribute to the risk of ischemic stroke in the Chinese Han population. Cell Mol Neurobiol. 2018;38(6):1253–1269.
  • Feng L, Guo J. Circulating long noncoding RNA ANRIL downregulation correlates with increased risk, higher disease severity and elevated pro-inflammatory cytokines in patients with acute ischemic stroke. J Clin Lab Anal. 2019;33(1):e22629.
  • Liu H, Liu S, Tian X, et al. Bexarotene attenuates focal cerebral ischemia-reperfusion injury via the suppression of JNK/Caspase-3 signaling pathway. Neurochem Res. 2019;44(12):2809–2820.
  • Hayashi K, Hasegawa Y, Takemoto Y, et al. Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease. Exp Gerontol. 2019; 120: 1–5.
  • Xue J, Zhang X, Zhang C, et al. Protective effect of Naoxintong against cerebral ischemia reperfusion injury in mice. J Ethnopharmacol. 2016; 182: 181–189.
  • Chen YA, Tsai YC, Chen YD, et al. Intraventricular medium B treatment benefits an ischemic stroke rodent model via enhancement of neurogenesis and anti-apoptosis. Sci Rep. 2020;10(1):6596.
  • Zhao P, Zhou R, Zhu XY, et al. Neuroprotective effects of lycium barbarum polysaccharide on focal cerebral ischemic injury in mice. Neurochem Res. 2017;42(10):2798–2813.
  • Zhang W, Chen Y, Liu P, et al. Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population. Stroke. 2012;43(1):14–21.
  • Jiang S, Zhao G, Lu J, et al. Silencing of circular RNA ANRIL attenuates oxygen-glucose deprivation and reoxygenation-induced injury in human brain microvascular endothelial cells by sponging miR-622. Biol Res. 2020;53(1):27.
  • Liu B, Cao W, Xue J. LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke. Artif Cells Nanomed Biotechnol. 2019;47(1):1384–1395.
  • Anrather J, Iadecola C. Inflammation and stroke: an overview. Neurotherapeutics. 2016;13(4):661–670.
  • Du S, Deng Y, Yuan H, et al. Safflower Yellow B Protects Brain against Cerebral Ischemia Reperfusion Injury through AMPK/NF-kB Pathway. Evid Based Complementary Alternat Med.eCAM 2019; 2019: 7219740.
  • Liang W, Lin C, Yuan L, et al. Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway. J Neuroinflammation. 2019;16(1):181.
  • Simmons LJ, Surles-Zeigler MC, Li Y, et al. Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation. 2016;13(1):237.
  • Cheng M, Yang L, Dong Z, et al. Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells. J Cell Mol Med. 2019;23(7):4795–4807.
  • Zhang B, Zhang HX, Shi ST, et al. Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury. Biomed Pharmacotherapy. 2019; 115: 108816.
  • Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172(3):393–407.

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