Enhanced Cerebral Microbleeds by Long-Term Air Pollution Exposure in Spontaneously Hypertensive Rats

References

• Koennecke HC. Cerebral microbleeds on mri: prevalence, associations, and potential clinical implications. Neurology. 2006;66:165–171.
   PubMed Web of Science ®Google Scholar
• Wang P, Sun Y, Yi D, et al. Clinical features of chinese patients in different age groups with spontaneous intracerebral hemorrhage based on multicenter inpatient information. Neurol Res. 2020;42:657–664.
   PubMed Web of Science ®Google Scholar
• Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS. Clinical significance of magnetic resonance imaging markers of vascular brain injury: a systematic review and meta-analysis. JAMA Neurol. 2019;76:81–94.
   PubMed Web of Science ®Google Scholar
• Bokura H, Saika R, Yamaguchi T, et al. Microbleeds are associated with subsequent hemorrhagic and ischemic stroke in healthy elderly individuals. Stroke. 2011;(42):1867–1871
   Google Scholar
• Altmann-Schneider I, Trompet S, de Craen AJ, et al. Cerebral microbleeds are predictive of mortality in the elderly. Stroke. 2011;42:638–644.
   PubMed Web of Science ®Google Scholar
• Yates PA, Villemagne VL, Ellis KA, et al. Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Front Neurol. 2014;4:205.
   PubMed Web of Science ®Google Scholar
• Li W, Yang S. Targeting oxidative stress for the treatment of ischemic stroke: upstream and downstream therapeutic strategies. Brain Circ. 2016;2:153–163.
   PubMedGoogle Scholar
• Yakushiji Y, Wilson D, Ambler G, et al. Distribution of cerebral microbleeds in the east and west: individual participant meta-analysis. Neurology. 2019;92:e1086–e1097.
   PubMed Web of Science ®Google Scholar
• Ungvari Z, Tarantini S, Kirkpatrick AC, et al. Cerebral microhemorrhages: mechanisms, consequences, and prevention. Am J Physiol Heart Circulatory Physiol. 2017;312:H1128–h1143.
   PubMed Web of Science ®Google Scholar
• Lee J, Sohn EH, Oh E, et al. Characteristics of cerebral microbleeds. Dementia Neurocognitive Disord. 2018;17:73–82.
   PubMedGoogle Scholar
• Shoamanesh A, Preis SR, Beiser AS, et al. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: framingham heart study. Neurology. 2015;84:825–832.
   PubMed Web of Science ®Google Scholar
• Zhao W, Wu C, Dornbos D 3rd, et al. Multiphase adjuvant neuroprotection: a novel paradigm for improving acute ischemic stroke outcomes. Brain Circ. 2020;6:11–18.
   PubMedGoogle Scholar
• Liu C, Chen R, Sera F, et al. Ambient particulate air pollution and daily mortality in 652 cities. N Engl J Med. 2019;381:705–715.
   PubMed Web of Science ®Google Scholar
• Shah AS, Lee KK, McAllister DA, et al. Short term exposure to air pollution and stroke: systematic review and meta-analysis. Bmj. 2015;350:h1295.
   PubMed Web of Science ®Google Scholar
• Chen G, Wang A, Li S, et al. Long-term exposure to air pollution and survival after ischemic stroke. Stroke. 2019;50:563–570.
   PubMed Web of Science ®Google Scholar
• Ji Y, Stone C, Guan L, et al. Is air pollution a potential cause of neuronal injury? Neurol Res. 2019;41:742–748.
   PubMed Web of Science ®Google Scholar
• Tian Y, Liu H, Xiang X, et al. Ambient coarse particulate matter and hospital admissions for ischemic stroke. Stroke. 2019;50:813–819.
   PubMed Web of Science ®Google Scholar
• Lin H, Tao J, Du Y, et al. Differentiating the effects of characteristics of pm pollution on mortality from ischemic and hemorrhagic strokes. Int J Hyg Environ Health. 2016;219:204–211.
   PubMed Web of Science ®Google Scholar
• Hayes RB, Lim C, Zhang Y, et al. Pm2.5 air pollution and cause-specific cardiovascular disease mortality. Int J Epidemiol. 2020;49:25–35.
   PubMed Web of Science ®Google Scholar
• Lipsett MJ, Ostro BD, Reynolds P, et al. Long-term exposure to air pollution and cardiorespiratory disease in the california teachers study cohort. Am J Respir Crit Care Med. 2011;184:828–835.
   PubMed Web of Science ®Google Scholar
• Noh J, Sohn J, Han M, et al. Long-term effects of cumulative average pm2.5 exposure on the risk of hemorrhagic stroke. Epidemiology. 2019;30(Suppl 1):S90–s98.
   PubMed Web of Science ®Google Scholar
• Lee FY, Lee MS, Wallace CG, et al. Short-interval exposure to ambient fine particulate matter (pm2.5) exacerbates the susceptibility of pulmonary damage in setting of lung ischemia-reperfusion injury in rodent: pharmacomodulation of melatonin. Biomed Pharmacothe. 2019;113:108737.
   PubMed Web of Science ®Google Scholar
• Sun Q, Wang A, Jin X, et al. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. Jama. 2005;294:3003–3010.
   PubMed Web of Science ®Google Scholar
• Zhu X, Zhao P, Lu Y, et al. Potential injurious effects of the fine particulate pm2.5 on the progression of atherosclerosis in apoe-deficient mice by activating platelets and leukocytes. Arch Med Sci. 2019;15:250–261.
   PubMed Web of Science ®Google Scholar
• Rui W, Guan L, Zhang F, et al. Pm2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through the erk/akt/nf-κb-dependent pathway. J Appl Toxicol. 2016;36:48–59.
   PubMed Web of Science ®Google Scholar
• Tayebati SK, Tomassoni D, Amenta F. Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior. J Neurol Sci. 2012;322:241–249.
   PubMed Web of Science ®Google Scholar
• Sepehrdad R, Chander PN, Oruene A, et al. Amiloride reduces stroke and renalinjury in stroke-prone hypertensive rats. Am J Hypertens. 2003;16:312–318.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Sasatani M, Doi T, et al. Protective effects of japanese soybean paste (miso) on stroke in stroke-prone spontaneously hypertensive rats (shrsp). Am J Hypertens. 2017;31:43–47.
   PubMed Web of Science ®Google Scholar
• Hem NA, Phie J, Chilton L, et al. A volume-pressure tail cuff method for hemodynamic parameters: comparison of restraint and light isoflurane anesthesia in normotensive male lewis rats. J Pharmacol Toxicol Methods. 2019;100:106601.
   PubMed Web of Science ®Google Scholar
• Guan L, Geng X, Shen J, et al. Pm2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids. Oncotarget. 2018;9:3765–3778.
   PubMedGoogle Scholar
• Guan L, Geng X, Stone C, et al. Pm2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model. Environ Toxicol. 2019;34:530–538.
   PubMed Web of Science ®Google Scholar
• Geng X, Fu P, Ji X, et al. Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism. Stroke. 2013;44:1418–1425.
   PubMed Web of Science ®Google Scholar
• Cai L, Stevenson J, Geng X, et al. Combining normobaric oxygen with ethanol or hypothermia prevents brain damage from thromboembolic stroke via pkc-akt-nox modulation. Mol Neurobiol. 2017;54:1263–1277.
   PubMed Web of Science ®Google Scholar
• Wright J, Ji Z, Geng X, et al. Ongoing progress in cleaning china′s air: a novel outlook into pollution. Environmental Dis.2016;2:43-50.
   Google Scholar
• Knecht T, Borlongan C, Dela Peña I. Combination therapy for ischemic stroke: novel approaches to lengthen therapeutic window of tissue plasminogen activator. Brain Circ. 2018;4:99–108.
   PubMedGoogle Scholar
• Suwa T, Hogg JC, Quinlan KB, et al. Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol. 2002;39:935–942.
   PubMed Web of Science ®Google Scholar
• Rao X, Zhong J, Maiseyeu A, et al. Cd36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. Circ Res. 2014;115:770–780.
   PubMed Web of Science ®Google Scholar
• Romero JR, Preis SR, Beiser A, et al. Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the framingham heart study. Stroke. 2014;45:1492–1494.
   PubMed Web of Science ®Google Scholar
• Chen H, Burnett RT, Kwong JC, et al. Spatial association between ambient fine particulate matter and incident hypertension. Circulation. 2014;129:562–569.
   PubMed Web of Science ®Google Scholar
• Sughis M, Nawrot TS, Ihsan-ul-Haque S, et al. Blood pressure and particulate air pollution in schoolchildren of lahore, pakistan. BMC Public Health. 2012;12:378.
   PubMed Web of Science ®Google Scholar
• Vinikoor-Imler LC, Gray SC, Edwards SE, et al. The effects of exposure to particulate matter and neighbourhood deprivation on gestational hypertension. Paediatr Perinat Epidemiol. 2012;26:91–100.
   PubMed Web of Science ®Google Scholar
• Widdicombe J, Lee LY. Airway reflexes, autonomic function, and cardiovascular responses. Environ Health Perspect. 2001;109(Suppl 4):579–584.
   PubMed Web of Science ®Google Scholar
• Liang R, Zhang B, Zhao X, et al. Effect of exposure to pm2.5 on blood pressure: a systematic review and meta-analysis. J Hypertens. 2014;32:2130–2140. [ discussion 2141].
   PubMed Web of Science ®Google Scholar
• Brook RD, Urch B, Dvonch JT, et al. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension. 2009;54:659–667.
   PubMed Web of Science ®Google Scholar
• Wang X, Chen M, Zhong M, et al. Exposure to concentrated ambient pm2.5 shortens lifespan and induces inflammation-associated signaling and oxidative stress in drosophila. Toxicol Sci. 2017;156:199–207.
   PubMed Web of Science ®Google Scholar
• Liu C, Xu X, Bai Y, et al. Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of ccr2 pathways in mice. Environ Health Perspect. 2014;122:17–26.
   PubMed Web of Science ®Google Scholar
• Bhatnagar A. Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res. 2006;99:692–705.
   PubMed Web of Science ®Google Scholar
• Brook RD. Cardiovascular effects of air pollution. Clin sci. 2008;115:175–187.
   PubMed Web of Science ®Google Scholar
• Ryu YS, Kang KA, Piao MJ, et al. Particulate matter induces inflammatory cytokine production via activation of nfkappab by tlr5-nox4-ros signaling in human skin keratinocyte and mouse skin. Redox Biol. 2019;21:101080.
   PubMed Web of Science ®Google Scholar
• Kampfrath T, Maiseyeu A, Ying Z, et al. Chronic fine particulate matter exposure induces systemic vascular dysfunction via nadph oxidase and tlr4 pathways. Circ Res. 2011;108:716–726.
   PubMed Web of Science ®Google Scholar
• Long YM, Yang XZ, Yang QQ, et al. Pm2.5 induces vascular permeability increase through activating mapk/erk signaling pathway and ros generation. J Hazard Mater. 2020;386:121659.
   PubMed Web of Science ®Google Scholar
• Liu B, Shen LJ, Zhao TX, et al. Automobile exhaust-derived pm2.5 induces blood-testis barrier damage through ros-mapk-nrf2 pathway in sertoli cells of rats. Ecotoxicol Environ Saf. 2020;189:110053.
   PubMed Web of Science ®Google Scholar
• Jan R, Roy R, Bhor R, et al. Toxicological screening of airborne particulate matter in atmosphere of pune: reactive oxygen species and cellular toxicity. Environ Pollut. 2019;261:113724.
   PubMed Web of Science ®Google Scholar
• Pope CA 3rd, Bhatnagar A, McCracken JP, et al. Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation. Circ Res. 2016;119:1204–1214.
   PubMed Web of Science ®Google Scholar
• Michael S, Montag M, Dott W. Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter. Environ Pollut. 2013;183:19–29.
   PubMed Web of Science ®Google Scholar