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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 44, 2022 - Issue 6
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Original Research Paper

Pathogenic cis p-tau levels in CSF reflects severity of traumatic brain injury

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Pages 496-502 | Received 10 Jul 2021, Accepted 20 Dec 2021, Published online: 03 Jan 2022

References

  • Faul M, Wald MM, Xu L, et al. Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths, 2002-2006. 2010.
  • Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21(5):375–378.
  • Ladak AA, Enam SA, Ibrahim MT. A review of the molecular mechanisms of traumatic brain injury. World Neurosurg. 2019;131:126–132.
  • McKee AC, Stein TD, Nowinski CJ, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013;136(1):43–64.
  • Smith DH, Johnson VE, Stewart W. Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nat Rev Neurol. 2013;9(4):211.
  • DeKosky ST, Blennow K, Ikonomovic MD, et al. Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers. Nat Rev Neurol. 2013;9(4):192.
  • Blennow K, Hardy J, Zetterberg H. The neuropathology and neurobiology of traumatic brain injury. Neuron. 2012;76(5):886–899.
  • Gardner RC, Burke JF, Nettiksimmons J, et al. Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity. JAMA Neurol. 2014;71(12):1490–1497.
  • Nordström P, Michaëlsson K, Gustafson Y, et al. Traumatic brain injury and young onset dementia: a nationwide cohort study. Ann Neurol. 2014;75(3):374–381.
  • Guo Z, Cupples L, Kurz A, et al. Head injury and the risk of AD in the MIRAGE study. Neurology. 2000;54(6):1316–1323.
  • Gardner RC, Burke JF, Nettiksimmons J, et al. Traumatic brain injury in later life increases risk for Parkinson disease. Ann Neurol. 2015;77(6):987–995.
  • Abu Hamdeh S, Waara ER, Möller C, et al. Rapid amyloid‐β oligomer and protofibril accumulation in traumatic brain injury. Brain Pathol. 2018;28(4):451–462.
  • Mannix RC, Whalen MJ. Traumatic brain injury, microglia, and beta amyloid. Int J Alzheimer’s Dis. 2012;2012:608732.
  • Johnson VE, Stewart W, Smith DH. Traumatic brain injury and amyloid-β pathology: a link to Alzheimer’s disease? Nat Rev Neurosci. 2010;11(5):361–370.
  • Albayram O, Kondo A, Mannix R, et al. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat Commun. 2017;8(1):1–17.
  • Marklund N, Blennow K, Zetterberg H, et al. Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury: clinical article. J Neurosurg. 2009;110(6):1227–1237.
  • Kondo A, Shahpasand K, Mannix R, et al. Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 2015;523(7561):431–436.
  • Khatoon S, Grundke-Iqbal I, Iqbal K. Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett. 1994;351(1):80–84.
  • Iqbal K, Grundke-Iqbal I. Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer’s disease. Mol Neurobiol. 1991;5(2):399–410.
  • Stein TD, Alvarez VE, McKee AC. Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel. Alzheimer’s Res Ther. 2014;6(1):1–11.
  • Hinrichs MH, Jalal A, Brenner B, et al. Tau protein diffuses along the microtubule lattice. J Biol Chem. 2012;287(46):38559–38568.
  • Vos PE, Alekseenko Y, Battistin L, et al. Mild traumatic brain injury. Eur J Neurol. 2012;19(2):191–198.
  • Wang KK, Moghieb A, Yang Z, et al. Systems biomarkers as acute diagnostics and chronic monitoring tools for traumatic brain injury: SPIE. 2013.
  • Banoei MM, Casault C, Metwaly SM, et al. Metabolomics and biomarker discovery in traumatic brain injury. J Neurotrauma. 2018;35(16):1831–1848.
  • Ma J, Zhang K, Wang Z, et al. Progress of research on diffuse axonal injury after traumatic brain injury. Neural Plast. 2016;2016:1–7.
  • Selvakumar GP, Ahmed ME, Iyer SS, et al. Absence of glia maturation factor protects from axonal injury and motor behavioral impairments after traumatic brain injury. Exp Neurobiol. 2020;29(3):230.
  • Metting Z, Wilczak N, Rodiger L, et al. GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology. 2012;78(18):1428–1433.
  • Shahim P, Gren M, Liman V, et al. Serum neurofilament light protein predicts clinical outcome in traumatic brain injury. Sci Rep. 2016;6(1):1–9.
  • Bazarian JJ, Zemlan FP, Mookerjee S, et al. Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury. Brain Inj. 2006;20(7):759–765.
  • Smith DH, Stewart W. Traumatic brain injury: a platform for studies in Aβ processing: commentary on: “Rapid Aβ oligomer and protofibril accumulation in traumatic brain injury. Brain Pathol. 2018;28(4):463–465.
  • Mannix R, Meehan WP, Pascual-Leone A. Sports-related concussions — media, science and policy. Nat Rev Neurol. 2016;12(8):486–490.
  • Kochanek PM, Jackson TC, Ferguson NM, et al. Emerging therapies in traumatic brain injury. Semin Neurol. 2015;35(1):83–100.
  • Lu J, Gary KW, Copolillo A, et al. Randomized controlled trials in adult traumatic brain injury: a review of compliance to CONSORT statement. Arch Phys Med Rehabil. 2015;96(4):702–714.
  • Lu KP, Kondo A, Albayram O, et al. Potential of the antibody against cis–phosphorylated tau in the early diagnosis, treatment, and prevention of alzheimer disease and brain injury. JAMA Neurol. 2016;73(11):1356–1362.
  • Cruz-Haces M, Tang J, Acosta G, et al. Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases. Transl Neurodegener. 2017;6(1):20.
  • Albayram O, Angeli P, Bernstein E, et al. Targeting Prion-like Cis phosphorylated tau pathology in neurodegenerative diseases. J Alzheimer’s Dis Parkinsonism. 2018;8(3). DOI:https://doi.org/10.4172/2161-0460.1000443
  • Katsumoto A, Takeuchi H, Tanaka F. Tau pathology in chronic traumatic encephalopathy and Alzheimer’s disease: similarities and differences. Front Neurol. 2019;10(980). DOI:https://doi.org/10.3389/fneur.2019.00980
  • McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement. 2014;10(3S):S242–S53.
  • Daneshvar DH, Goldstein LE, Kiernan PT, et al. Post-traumatic neurodegeneration and chronic traumatic encephalopathy. Mol Cell Neurosci. 2015;66:81–90.
  • DeKosky ST, Asken BM. Injury cascades in TBI-related neurodegeneration. Brain Inj. 2017;31(9):1177–1182.
  • Qiu C, Albayram O, Kondo A, et al. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Sci Transl Med. 2021;13(596):eaaz7615.
  • Albayram O, MacIver B, Mathai J, et al. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Sci Rep. 2019;9(1):1–12.
  • Kim N, Wang B, Koikawa K, et al. Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury. Prog Neurobiol. 2021;203:102072.

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