Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 45, 2023 - Issue 1
214
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Serum Bilirubin Associated with Stroke Severity and Prognosis: Preliminary Findings on Liver Function after Acute Ischemic Stroke

, , , , , , & show all
Pages 62-69 | Received 29 Jan 2022, Accepted 28 Aug 2022, Published online: 27 Sep 2022

References

  • Balch MHH, Nimjee SM, Rink C, et al. Beyond the brain: the systemic pathophysiological response to acute ischemic stroke. J Stroke. 2020;22(2):159–172.
  • Ma S, Zhao H, Ji X, et al. Peripheral to central: organ interactions in stroke pathophysiology. Exp Neurol. 2015;272:41–49.
  • Zera KA, Buckwalter MS. The local and peripheral immune responses to stroke: implications for therapeutic development. Neurotherapeutics. 2020;17(2):414–435.
  • Anthony DC, Couch Y, Losey P, et al. The systemic response to brain injury and disease. Brain Behav Immun. 2012;26(4):534–540.
  • Muscari A, Collini A, Fabbri E, et al. Changes of liver enzymes and bilirubin during ischemic stroke: mechanisms and possible significance. BMC Neurol. 2014;14(1):122.
  • Sheng X, Du H, Tang Y. Decreased Serum Total Bilirubin Level Predicts Early Neurological Deterioration in Patients with Acute Ischemic Stroke. Neuropsychiatr Dis Treat. 2021;7:1977–1982.
  • Kim DY, Cho KC. Extremely low serum alanine transaminase level is associated with all-cause mortality in the elderly after intracranial hemorrhage. J Korean Neurosurg Soc. 2021;64(3):460–468.
  • An SJ, Yang Y-J, Jeon N-M, et al. Significantly reduced alanine aminotransferase level increases all-cause mortality rate in the elderly after ischemic stroke. Int J Environ Res Public Health. 2021;18(9):4915.
  • Wang X, Wu D, Zhong P. Serum bilirubin and ischaemic stroke: a review of literature. Stroke Vasc Neurol. 2020;5(2):198–204.
  • Wang J, Zhang X, Zhang Z, et al. Baseline serum bilirubin and risk of first stroke in hypertensive patients. J Am Heart Assoc. 2020;9(12):e015799.
  • Choi Y, Lee SJ, Spiller W, et al. Causal associations between serum bilirubin levels and decreased stroke risk: a two-sample Mendelian randomization study. Arterioscler Thromb Vasc Biol. 2020;40(2):437–445.
  • Kimm H, Yun JE, Jo J, et al. Low serum bilirubin level as an independent predictor of stroke incidence: a prospective study in Korean men and women. Stroke. 2009;40(11):3422–3427.
  • Pineda S, Bang OY, Saver JL, et al. Association of serum bilirubin with ischemic stroke outcomes. J Stroke Cerebrovasc Dis. 2008;17(3):147–152.
  • Luo Y, Li J-W, Lu Z-J, et al. Serum bilirubin after acute ischemic stroke is associated with stroke severity. Curr Neurovasc Res. 2012;9(2):128–132.
  • Luo Y, Li J, Zhang J, et al. Elevated bilirubin after acute ischemic stroke linked to the stroke severity. Int J Dev Neurosci. 2013;31(7):634–638.
  • Wang Y, Xu S, Pan S, et al. Association of serum neuron-specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large-artery atherosclerotic strokes. J Cell Biochem. 2018;119(12):9685–9693.
  • Kurzepa J, Bielewicz J, Stelmasiak Z, et al. Serum bilirubin and uric acid levels as the bad prognostic factors in the ischemic stroke. Int J Neurosci. 2009;119(12):2243–2249.
  • Zhang MM, Gao Y, Zheng -Y-Y, et al. Association of fasting serum bilirubin levels with clinical outcomes after percutaneous coronary intervention: a prospective study. Cardiovasc Toxicol. 2017;17(4):471–477.
  • Huang FY, Peng Y, Huang B-T, et al. The correlation between serum total bilirubin and outcomes in patients with different subtypes of coronary artery disease. Clin Chim Acta. 2017;465:101–105.
  • Xu C, Dong M, Deng Y, et al. Relation of direct, indirect, and total bilirubin to adverse long-term outcomes among patients with acute coronary syndrome. Am J Cardiol. 2019;123(8):1244–1248.
  • Choi JC, Jang, MU, Kang, K, et al. Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke. J Am Heart Assoc. 2015;4(1):e001306.
  • Khatri P, Kleindorfer, DO, Devlin, T, et al. Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits: the prisms randomized clinical trial. JAMA. 2018;320(2):156–166.
  • Kishimoto Y, Niki H, Saita E, et al. Blood levels of heme oxygenase-1 versus bilirubin in patients with coronary artery disease. Clin Chim Acta. 2020;504:30–35.
  • Thakkar M, Edelenbos J, Doré S. Bilirubin and Ischemic Stroke: rendering the Current Paradigm to Better Understand the Protective Effects of Bilirubin. Mol Neurobiol. 2019;56(8):5483–5496.
  • Fevery J. Bilirubin in clinical practice: a review. Liver Int. 2008;28(5):592–605.
  • Rudilosso S, Rodríguez-Vázquez A, Urra X, et al. The potential impact of neuroimaging and translational research on the clinical management of lacunar stroke. Int J Mol Sci. 2022;23(3):1497.
  • Alhazzani A, Kumar A, Algahtany M, et al. Role of troponin as a biomarker for predicting outcome after ischemic stroke. Brain Circ. 2021;7(2):77–84.
  • Lin SP, Lin P-Y, Jiang H-L, et al. Is serum total bilirubin useful to differentiate cardioembolic stroke from other stroke subtypes? Neurol Res. 2015;37(8):727–731.
  • Okuhara K, Kisaka T, Ozono R, et al. Change in bilirubin level following acute myocardial infarction is an index for heme oxygenase activation. South Med J. 2010;103(9):876–881.
  • Herishanu Y, Abramsky O, Lavy S. Hyperbilirubinaemia in acute ischaemic stroke. J Neurol Sci. 1971;14(4):417–420.
  • Bhatia RS, Garg RK, Gaur SPS, et al. Predictive value of routine hematological and biochemical parameters on 30-day fatality in acute stroke. Neurol India. 2004;52(2):220–223.
  • Perlstein TS, Pande RL, Creager MA, et al. Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004. Am J Med. 2008;121(9):781–788 e1.
  • Xu T, Zhang J, Xu T, et al. Association of serum bilirubin with stroke severity and clinical outcomes. Can J Neurol Sci. 2013;40(1):80–84.
  • Jian Y, zhao L, Wang H, et al. Bilirubin: a novel predictor of hemorrhagic transformation and symptomatic intracranial hemorrhage after mechanical thrombectomy. Neurol Sci. 2020;41(4):903–909.
  • Iadecola C, Buckwalter MS, Anrather J. Immune responses to stroke: mechanisms, modulation, and therapeutic potential. J Clin Invest. 2020;130(6):2777–2788.
  • Meisel C, Schwab JM, Prass K, et al. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005;6(10):775–786.
  • Xue Y, Nie D, Wang L-J, et al. Microglial polarization: novel therapeutic strategy against ischemic stroke. Aging Dis. 2021;12(2):466–479.
  • Yao Y, Li Y, Ni W, et al. Systematic study of immune cell diversity in ischemic postconditioning using high-dimensional single-cell analysis with mass cytometry. Aging Dis. 2021;12(3):812–825.
  • Fink JN, Selim MH, Kumar S, et al. Insular cortex infarction in acute middle cerebral artery territory stroke: predictor of stroke severity and vascular lesion. Arch Neurol. 2005;62(7):1081–1085.
  • Krause T, Werner K, Fiebach JB, et al. Stroke in right dorsal anterior insular cortex Is related to myocardial injury. Ann Neurol. 2017;81(4):502–511.
  • Mo J, Huang L, Peng J, et al. Autonomic disturbances in acute cerebrovascular disease. Neurosci Bull. 2019;35(1):133–144.
  • Wang YY, Lin S-Y, Chuang Y-H, et al. Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model. Am J Physiol Endocrinol Metab. 2011;300(1):E155–63.
  • Wang YY, Lin S-Y, Chuang Y-H, et al. Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats. Endocrinology. 2014;155(4):1235–1246.
  • Uyama N, Geerts A, Reynaert H. Neural connections between the hypothalamus and the liver. Anat Rec A Discov Mol Cell Evol Biol. 2004;280(1):808–820.
  • Ottani A, Giuliani D, Mioni C, et al. Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke. J Cereb Blood Flow Metab. 2009;29(3):512–523.
  • Khanna S, Briggs Z, Rink C. Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke. Antioxid Redox Signal. 2015;22(2):175–186.
  • Kalirawna TR, Rohilla J, Bairwa S, et al. Increased concentration of serum gamma-glutamyl transferase in ischemic stroke patients. Brain Circ. 2021;7(2):71–76.
  • Campos F, Rodríguez-Yáñez M, Castellanos M, et al. Blood levels of glutamate oxaloacetate transaminase are more strongly associated with good outcome in acute ischaemic stroke than glutamate pyruvate transaminase levels. Clin Sci (Lond). 2011;121(1):11–17.
  • Campos F, Sobrino T, Ramos-Cabrer P, et al. High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke. J Cereb Blood Flow Metab. 2011;31(6):1387–1393.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.