Elevated levels of total homocysteine after ischemic stroke: a potential marker for in-hospital outcomes

References

• GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol. 2021;20(10):795–820.
   PubMed Web of Science ®Google Scholar
• Wang W, Jiang B, Sun H, et al. Prevalence, incidence, and mortality of stroke in china: results from a nationwide population-based survey of 480 687 adults. Circulation. 2017;135(8):759–771. DOI:10.1161/CIRCULATIONAHA.116.025250
   PubMed Web of Science ®Google Scholar
• Yu F, Liu X, Yang Q, et al. In-hospital recurrence in a Chinese large cohort with acute ischemic stroke. Sci Rep. 2019;9(1):14945.
   PubMedGoogle Scholar
• Wang F, Wang L, Du H, et al. Elevated total homocysteine predicts in-hospital pneumonia and poor functional outcomes in acute ischemic stroke. Curr Neurovasc Res. 2020;17(5):745–753. DOI:10.2174/1567202617666201214111244
   PubMed Web of Science ®Google Scholar
• Li J, Wang Y, Li H, et al. Homocysteine level predicts response to dual antiplatelet in women with minor stroke or transient ischemic attack: subanalysis of the chance trial. Arteriosclerosis Thrombosis Vasc Biol. 2020;40(3):839–846. DOI:10.1161/ATVBAHA.119.313741
   PubMed Web of Science ®Google Scholar
• Sacco R, Anand K, Lee H, et al. Homocysteine and the risk of ischemic stroke in a triethnic cohort: The northern manhattan study. Stroke. 2004; 35(10): 2263–2269.
   PubMed Web of Science ®Google Scholar
• Kumral E, Saruhan G, Aktert D, et al. Association of hyperhomocysteinemia with stroke recurrence after initial stroke. J Stroke Cerebrovasc Dis. 2016;25(8):2047–2054.
   PubMed Web of Science ®Google Scholar
• Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (visp) randomized controlled trial. JAMA. 2004;291(5):565–575. DOI:10.1001/jama.291.5.565
   PubMed Web of Science ®Google Scholar
• Group TVTS. B vitamins in patients with recent transient ischaemic attack or stroke in the vitamins to prevent stroke (vitatops) trial: a randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol. 2010;9(9):855–865. doi: 10.1016/S1474-4422(10)70187-3.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li Z, Wang Y, et al. Chinese stroke center alliance: a national effort to improve healthcare quality for acute stroke and transient ischaemic attack: rationale, design and preliminary findings. Stroke Vasc Neurol. 2018;3(4):256–262. DOI:10.1136/svn-2018-000154
   PubMedGoogle Scholar
• Malinow M, Bostom A, Krauss R. Homocyst(e)ine, diet, and cardiovascular diseases: a statement for healthcare professionals from the nutrition committee, American heart association. Circulation. 1999;99(1):178–182.
   PubMed Web of Science ®Google Scholar
• WGo. 2018 Chinese guidelines for the management of hypertension. Chin j cardiovasc med. 2019;24:24–56.
   Google Scholar
• Teo B, Xu H, Wang D, et al. Gfr estimating equations in a multiethnic asian population. Am J Kidney Dis. 2011;58(1):56–63. DOI:10.1053/j.ajkd.2011.02.393
   PubMed Web of Science ®Google Scholar
• MR M. Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis. Circulation. 1990;81(6):2004–2006.
   PubMed Web of Science ®Google Scholar
• Liaugaudas G, Jacques PF, Selhub J, et al. Renal insufficiency, vitamin B12 status, and population attributable risk for mild hyperhomocysteinemia among coronary artery disease patients in the era of folic acid–fortified cereal grain flour. Arteriosclerosis Thrombosis Vasc Biol. 2001;21(5):849–851.
   PubMed Web of Science ®Google Scholar
• Hickling S, Hung J, Knuiman M, et al. Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: a population based cohort study. J Epidemiol Community Health. 2005;59(5):371–376. DOI:10.1136/jech.2004.027078
   PubMed Web of Science ®Google Scholar
• Yang B, Fan S, Zhi X, et al. Prevalence of hyperhomocysteinemia in china: a systematic review and meta-analysis. Nutrients. 2014;7(1):74–90. DOI:10.3390/nu7010074
   PubMed Web of Science ®Google Scholar
• Moll S, Varga EA. Homocysteine and MTHFR mutations. Circulation. 2015;132(1):e6–9.
   PubMed Web of Science ®Google Scholar
• Svardal A, Refsum H, Ueland PM. Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat. J Biol Chem. 1986;261(7):3156–3163.
   PubMed Web of Science ®Google Scholar
• Wang IK, Lien LM, Lee JT, et al. Renal dysfunction increases the risk of recurrent stroke in patients with acute ischemic stroke. Atherosclerosis. 2018;277:15–20.
   PubMed Web of Science ®Google Scholar
• Khanevski AN, Bjerkreim AT, Novotny V, et al. Recurrent ischemic stroke: incidence, predictors, and impact on mortality. Acta neurol Scand. 2019;140(1):3–8. DOI:10.1111/ane.13093
   PubMed Web of Science ®Google Scholar
• Zhang G, Yang Q, Zhang H, et al. The clinical features of in-hospital recurrence in acute ischaemic stroke patients over time: a real-world observation at a single center. Brain Sci. 2022;12(2):123.
   PubMed Web of Science ®Google Scholar
• Boysen G, Brander T, Christensen H, et al. Homocysteine and risk of recurrent stroke. Stroke. 2003;34(5):1258–1261.
   PubMed Web of Science ®Google Scholar
• Zhang W, Sun K, Chen J, et al. High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population. In: Ryan M, editor. Clinical science. London, England: Portland Press; 2009. p. 187–194.
   Google Scholar
• Shi Z, Guan Y, Huo Y, et al. Elevated total homocysteine levels in acute ischemic stroke are associated with long-term mortality. Stroke. 2015;46(9):2419–2425. DOI:10.1161/STROKEAHA.115.009136
   PubMed Web of Science ®Google Scholar
• Holmes MV, Newcombe P, Hubacek JA, et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet (London, England). 2011;378(9791):584–594. DOI:10.1016/S0140-6736(11)60872-6
   PubMed Web of Science ®Google Scholar
• Huang J, Zhang X, Li J, et al. Impact of glucose fluctuation on acute cerebral infarction in type 2 diabetes. Can J Neurol Sci. 2014;41(4):486–492.
   PubMed Web of Science ®Google Scholar
• Spence J. Homocysteine and stroke prevention: have the trials settled the issue? Int J Stroke. 2006;1(4):242–244.
   PubMed Web of Science ®Google Scholar
• Brea D, Roquer J, Serena J, et al. Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins. BMC neurol. 2012;12(1):65.
   PubMedGoogle Scholar
• Sposato L, Lam M, Allen B, et al. First-ever ischemic stroke and increased risk of incident heart disease in older adults. Neurology. 2020;94(15):e1559–1570.
   PubMed Web of Science ®Google Scholar