A cross-sectional study on restless legs syndrome (RLS) in polycythemia vera (PV): is iron deficiency the only culprit?

References

• Finazzi G, Barbui T. How I treat patients with polycythemia vera. Blood. 2007;109(12):5104–5111. doi: 10.1182/blood-2006-12-038968
   PubMed Web of Science ®Google Scholar
• Ginzburg YZ, Feola M, Zimran E, et al. Dysregulated iron metabolism in polycythemia vera: etiology and consequences. Leukemia. 2018;32(10):2105–2116. doi: 10.1038/s41375-018-0207-9
   PubMed Web of Science ®Google Scholar
• Allen RPI. Iron, RLS and blood donations. Sleep Med. 2004;5(2):113–114. doi: 10.1016/j.sleep.2003.12.005
   PubMed Web of Science ®Google Scholar
• Tobiasson M, Alyass B, Söderlund S, et al. High prevalence of restless legs syndrome among patients with polycytemia vera treated with venesectio. Med Oncol. 2010;27(1):105–107. doi: 10.1007/s12032-009-9180-5
   PubMed Web of Science ®Google Scholar
• Piccolo J, Kolesar JM. Prevention and treatment of chemotherapy-induced peripheral neuropathy. Am J Heal Pharm. 2014;71(1):19–25. doi: 10.2146/ajhp130126
   PubMed Web of Science ®Google Scholar
• Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol. 2012;105(3):273–282. doi: 10.1016/j.radonc.2012.10.012
   PubMed Web of Science ®Google Scholar
• Matsuzaki T, Ichikawa T, Kondo H, et al. Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. Hepatol Res. 2012;42(12):1221–1226. doi: 10.1111/j.1872-034X.2012.01043.x
   PubMed Web of Science ®Google Scholar
• Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis–ekbom disease diagnostic criteria: updated International restless legs syndrome study group (IRLSSG) consensus criteria – history, rationale, description, and significance. Sleep Med. 2014;15(8):860–873. doi: 10.1016/j.sleep.2014.03.025
   PubMed Web of Science ®Google Scholar
• Ay E, Helvacı Yılmaz N, Arıcı Düz Ö, et al. Validity and Reliability of the Turkish Version of The International Restless Legs Syndrome Study Group Rating Scale. Acta Medica Alanya. 2019;3(2):105–110. doi: 10.30565/medalanya.453150
   Google Scholar
• Walters AS, LeBrocq C, Dhar A, et al. Validation of the International restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003; 4:121–132.
   PubMed Web of Science ®Google Scholar
• Yucel A, Senocak M, Orhan EK, et al. Results of the Leeds assessment of neuropathic symptoms and signs pain scale in Turkey: a validation study. J Pain. 2004;5(8):427–432. doi: 10.1016/j.jpain.2004.07.001
   PubMed Web of Science ®Google Scholar
• Bennett M. The LANSS pain scale: the Leeds assessment of neuropathic symptoms and signs. Pain. 2001;92(1):147–157. doi: 10.1016/S0304-3959(00)00482-6
   PubMed Web of Science ®Google Scholar
• Buysse DJ, Reynolds CF, Monk TH, et al. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(1989):193–213. doi: 10.1016/0165-1781(89)90047-4
   PubMedGoogle Scholar
• Chokroverty S. Editor’s corner: restless legs syndrome, a common disease uncommonly diagnosed. Sleep Medicine. 2003;4:91–93. doi:10.1016/S1389-9457(03)00008-X 2
   PubMed Web of Science ®Google Scholar
• Sevim S, Dogu O, Camdeviren H, et al. Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey. Neurology. 2003;61(11):1562–1569. doi: 10.1212/01.WNL.0000096173.91554.B7
   PubMed Web of Science ®Google Scholar
• Demir AU, Ardic S, Firat H, et al. Prevalence of sleep disorders in the Turkish adult population epidemiology of sleep study. Sleep Biol Rhythms. 2015;13(4):298–308. doi: 10.1111/sbr.12118
   Web of Science ®Google Scholar
• Poza JJ, Cobo AM, Martí-Massó JF. Peripheral neuropathy associated with polycythemia vera. Neurologia. 1996;11(8):276–279.
   PubMedGoogle Scholar
• Wollina U. Burning feet in polycythemia vera – peripheral sensorimotor axonal neuropathy with erythromelalgia. Int J Gen Med. 2015;8:69–71. doi:10.2147/IJGM.S78848
   PubMedGoogle Scholar
• Bittencourt RI, Vassallo J, Chauffaille MDLLF, et al. Philadelphia-negative chronic myeloproliferative neoplasms. Rev Bras Hematol Hemoter. 2012;34(2):140–149. doi: 10.5581/1516-8484.20120034
   PubMedGoogle Scholar
• Chia YC, Siti Asmaa MJ, Ramli M, et al. Molecular genetics of thrombotic myeloproliferative neoplasms: implications in precision oncology. Diagnostics. 2023;13(1):1–29. doi: 10.3390/diagnostics13010163
   Web of Science ®Google Scholar
• Ermens AAM, Vlasveld LT, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003;36(8):585–590. doi: 10.1016/j.clinbiochem.2003.08.004
   PubMed Web of Science ®Google Scholar
• McCarthy WF, Gable J, Lawrence J, et al. A retrospective study to determine if hydroxyurea augmentation of antiretroviral drug regimens that contain ddI and/or d4T increases the risk of developing peripheral neuropathy in HIV-1 infected individuals. Pharmacoepidemiol Drug Saf. 2000;9(1):49–53. doi: 10.1002/(SICI)1099-1557(200001/02)9:1<49:AID-PDS465>3.0.CO;2-C
   PubMed Web of Science ®Google Scholar
• Lisziewicz J, Foli A, Wainberg M, et al. Hydroxyurea in the treatment of HIV infection: clinical efficacy and safety concerns. Drug Saf. 2003;26(9):605–624. doi: 10.2165/00002018-200326090-00002
   PubMed Web of Science ®Google Scholar
• Visovsky C. Chemotherapy-induced peripheral neuropathy. Cancer Invest. 2003;21(3):439–451. doi: 10.1081/CNV-120018236
   PubMed Web of Science ®Google Scholar
• Komatsu N, Hashimoto Y, Baba T, et al. Safety and efficacy of anagrelide in Japanese post-marketing surveillance, with subgroup analyses on the effect of previous cytoreductive therapies, age, and starting dose. Int J Hematol. 2022;116(4):570–578. doi: 10.1007/s12185-022-03380-2
   PubMed Web of Science ®Google Scholar
• Earley CJ, Silber MH. Restless legs syndrome: understanding its consequences and the need for better treatment. Sleep Med. 2010;11(9):807–815. doi: 10.1016/j.sleep.2010.07.007
   PubMed Web of Science ®Google Scholar
• Lahuerta-Palacios JJ, Gutierrez-Rivas E, Calandre L, et al. Controlled and uncontrolled thrombocytosis. Its clinical role in essential thrombocythemia. Cancer. 1988;61(6):1207–1212. doi: 10.1002/1097-0142(19880315)61:6<1207:aid-cncr2820610625>3.0.co;2-4
   PubMed Web of Science ®Google Scholar
• Walters AS, Elin RJ, Cohen B, et al. Magnesium not likely to play a major role in the pathogenesis of restless legs syndrome: serum and cerebrospinal fluid studies. Sleep Med. 2007;8(2):186–187. doi: 10.1016/j.sleep.2006.07.001
   PubMed Web of Science ®Google Scholar
• Yıldırım E, Apaydın H. Zinc and magnesium levels of pregnant women with restless leg syndrome and their relationship with anxiety: a case-control study. Biol Trace Elem Res. 2021;199(5):1674–1685. doi: 10.1007/s12011-020-02287-5
   PubMed Web of Science ®Google Scholar
• Marshall NS, Serinel Y, Killick R, et al. Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: a systematic review. Sleep Med Rev. 2019;48:101218. doi: 10.1016/j.smrv.2019.101218
   PubMed Web of Science ®Google Scholar
• Jadidi A, Rezaei Ashtiani A, Khanmohamadi Hezaveh A, et al. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2023;23(1):1–6. doi: 10.1186/s12906-022-03814-8
   Google Scholar
• Anguelova GV, Vlak MHM, Kurvers AGY, et al. Pharmacologic and nonpharmacologic treatment of restless legs syndrome. Sleep Med Clin. 2020;15(2):277–288. doi: 10.1016/j.jsmc.2020.02.013
   PubMed Web of Science ®Google Scholar
• Trenkwalder C, Allen R, Högl B, et al. Comorbidities, treatment, and pathophysiology in restless legs syndrome. Lancet Neurol. 2018;17(11):994–1005. doi: 10.1016/S1474-4422(18)30311-9
   PubMed Web of Science ®Google Scholar
• Hornyak M, Voderholzer U, Hohagen F, et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998;21(5):501–505. doi: 10.1093/sleep/21.5.501
   PubMed Web of Science ®Google Scholar