Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Latest Articles
68
Views
0
CrossRef citations to date
0
Altmetric
Research Article

High-intensity interval training stimulates remyelination via the Wnt/β-catenin pathway in cuprizone-induced demyelination mouse model

, , , , , , , & ORCID Icon show all
Received 17 Mar 2024, Accepted 26 Jun 2024, Published online: 09 Jul 2024

References

  • Miller RH, Mi S. Dissecting demyelination. Nat Neurosci. 2007;10(11):1351–1354. doi: 10.1038/nn1995
  • Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med. 1998;338(5):278–285. doi: 10.1056/NEJM199801293380502
  • Kirby L, Jin J, Cardona JG, et al. Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination. Nat Commun. 2019;10(1):3887. doi: 10.1038/s41467-019-11638-3
  • Xing YL, Roth PT, Stratton JA, et al. Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination. J Neurosci. 2014;34(42):14128–14146. doi: 10.1523/JNEUROSCI.3491-13.2014
  • Hu D, Qi GJ, Liu KX, et al. Clinical application of GFAP,MBP and S100β protein in early identification and severity evaluation of sepsis associated encephalopathy. J Xuzhou Med Univ. 2020;40:691–694.
  • Sherafat A, Pfeiffer F, Reiss AM, et al. Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor. Nat Commun. 2021;12(1):2265. doi: 10.1038/s41467-021-22532-2
  • Huang P, Yan R, Zhang X, et al. Activating WNT/beta-catenin signaling pathway for disease therapy: challenges and opportunities. Pharmacol Ther. 2019;196:79–90. doi: 10.1016/j.pharmthera.2018.11.008
  • An Y, Zhou XL, Hu ZL, et al. SIRT1 regulates the proliferation and differentiation of neural stem cells through β-catenin nuclear translocation. J Xuzhou Med Univ. 2021;41:797–804.
  • Shackleford G, Makoukji J, Grenier J, et al. Differential regulation of WNT/beta-catenin signaling by liver X receptors in Schwann cells and oligodendrocytes. Biochem Pharmacol. 2013;86(1):106–114. doi: 10.1016/j.bcp.2013.02.036
  • Gaesser JM, Fyffe-Maricich SL. Intracellular signaling pathway regulation of myelination and remyelination in the CNS. Exp Neurol. 2016;283:501–511. doi: 10.1016/j.expneurol.2016.03.008
  • Vallee A, Lecarpentier Y, Vallee JN. Cannabidiol and the canonical WNT/β-catenin pathway in Glaucoma. IJMS. 2021;22(7):3798. doi: 10.3390/ijms22073798
  • Cadigan KM, Liu YI. Wnt signaling: complexity at the surface. J Cell Sci. 2006;119(3):395–402. doi: 10.1242/jcs.02826
  • Naghibzadeh M, Ranjbar R, Tabandeh MR, et al. Effects of two training programs on transcriptional levels of neurotrophins and glial cells population in hippocampus of experimental multiple sclerosis. Int J Sports Med. 2018;39(8):604–612. doi: 10.1055/a-0608-4635
  • Houdebine L, Gallelli CA, Rastelli M, et al. Effect of physical exercise on brain and lipid metabolism in mouse models of multiple sclerosis. Chem Phys Lipids. 2017;207:127–134. doi: 10.1016/j.chemphyslip.2017.06.002
  • Tollar J, Nagy F, Toth BE, et al. Exercise effects on multiple sclerosis quality of life and clinical–motor symptoms. Med Sci Sports Exerc. 2020;52(5):1007–1014. doi: 10.1249/MSS.0000000000002228
  • Huang HL, Tang GD, Liang ZH, et al. Role of Wnt/β-catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis. Can J Physiol Pharmacol. 2019;97(1):15–22. doi: 10.1139/cjpp-2018-0226
  • Sun YP, Ding L, Liu L. Scutellarin improves the learning and memory ability of Alzheimer′s rats by stimulating the Sirtuin1/Nrf2/HO-1 signaling pathway. J Xuzhou Med Univ. 2023;43:20–26.
  • Liu Y, Dong F, Guo R, et al. Hydrogen-rich saline ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice via the Nrf2-ARE signaling pathway. Inflammation. 2019;42(2):586–597. doi: 10.1007/s10753-018-0915-3
  • Mandolesi G, Bullitta S, Fresegna D, et al. Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination. Neurobiol Dis. 2019;129:102–117. doi: 10.1016/j.nbd.2019.05.010
  • Bao C, He C, Shu B, et al. Aerobic exercise training decreases cognitive impairment caused by demyelination by regulating ROCK signaling pathway in aging mice. Brain Res Bull. 2021;168:52–62. doi: 10.1016/j.brainresbull.2020.12.010
  • Yang L, Wu C, Li Y, et al. Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease. Geroscience. 2022;44(3):1457–1477. doi: 10.1007/s11357-022-00534-2
  • Karussis D. The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review. J Autoimmun. 2014;48-49:134–142. doi: 10.1016/j.jaut.2014.01.022
  • McKenzie IA, Ohayon D, Li H, et al. Motor skill learning requires active central myelination. Science. 2014;346(6207):318–322. doi: 10.1126/science.1254960
  • Honke K. Biological functions of sulfoglycolipids and the EMARS method for identification of co-clustered molecules in the membrane microdomains. J Biochem. 2018;163(4):253–263. doi: 10.1093/jb/mvx078
  • Jensen SK, Yong VW. Activity-dependent and experience-driven myelination provide new directions for the management of multiple sclerosis. Trends Neurosci. 2016;39(6):356–365. doi: 10.1016/j.tins.2016.04.003
  • Di Liegro CM, Schiera G, Proia P, et al. Physical activity and brain health. Genes (Basel). 2019;10(9):720. doi: 10.3390/genes10090720
  • Fancy SP, Baranzini SE, Zhao C, et al. Dysregulation of the WNT pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 2009;23:1571–1585. doi: 10.1101/gad.1806309
  • Adachi K, Mirzadeh Z, Sakaguchi M, et al. β-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone. Stem Cells. 2007;25(11):2827–2836. doi: 10.1634/stemcells.2007-0177
  • Marinaro C, Pannese M, Weinandy F, et al. Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1. Cereb Cortex. 2012;22(10):2415–2427. doi: 10.1093/cercor/bhr320
  • Azim K, Butt AM. GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo. Glia. 2011;59(4):540–553. doi: 10.1002/glia.21122
  • Cheng J, Shen W, Jin L, et al. Treadmill exercise promotes neurogenesis and myelin repair via upregulating WNT/beta‑catenin signaling pathways in the juvenile brain following focal cerebral ischemia/reperfusion. Int J Mol Med. 2020;45:1447–1463. doi: 10.3892/ijmm.2020.4515
  • Garcia-Velazquez L, Arias C. The emerging role of WNT signaling dysregulation in the understanding and modification of age-associated diseases. Ageing Res Rev. 2017;37:135–145. doi: 10.1016/j.arr.2017.06.001

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.