Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21

References

• Wu , A H , Ziegler , R G , Horn-Ross , P L , Nomura , A M West , D W . 1996 . Tofu and risk of breast cancer in Asian-Americans . Cancer Epidemiol Biomarkers Prev , 5 : 901 – 906 .
   PubMed Web of Science ®Google Scholar
• Middleton , E Jr. , Kandaswami , C and Theoharides , T C . 2000 . The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer . Pharmacol Rev , 52 : 673 – 751 .
   PubMed Web of Science ®Google Scholar
• Folts , J D . 2002 . Potential health benefits from the flavonoids in grape products on vascular disease . Adv Exp Med Biol , 505 : 95 – 111 .
   PubMed Web of Science ®Google Scholar
• Zheng , Q , Hirose , Y , Yoshimi , N , Murakami , A Koshimizu , K . 2002 . Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells . J Cancer Res Clin Oncol , 128 : 539 – 546 .
   PubMed Web of Science ®Google Scholar
• Binnerup , S J and Sorensen , J . 1992 . Nitrate and nitrite microgradients in barley rhizosphere as detected by a highly sensitive denitrification bioassay . Appl Environ Microbiol , 58 : 2375 – 2380 .
   PubMed Web of Science ®Google Scholar
• Tsuda , H , Ohshima , Y , Nomoto , H , Fujita , K Matsuda , E . 2004 . Cancer prevention by natural compounds . Drug Metab Pharmacokinet , 19 : 245 – 263 .
   PubMedGoogle Scholar
• Kanadaswami , C , Lee , L T , Lee , P P , Hwang , J J Ke , F C . 2005 . The antitumor activities of flavonoids . In Vivo , 19 : 895 – 909 .
   PubMed Web of Science ®Google Scholar
• Singh , R P and Agarwal , R . 2006 . Natural flavonoids targeting deregulated cell cycle progression in cancer cells . Curr Drug Targets , 7 : 345 – 354 .
   PubMed Web of Science ®Google Scholar
• Nichenametla , S N , Taruscio , T G , Barney , D L and Exon , J H . 2006 . A review of the effects and mechanisms of polyphenolics in cancer . Crit Rev Food Sci Nutr , 46 : 161 – 183 .
   PubMed Web of Science ®Google Scholar
• Casagrande , F and Darbon , J M . 2001 . Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1 . Biochem Pharmacol , 61 : 1205 – 1215 .
   PubMed Web of Science ®Google Scholar
• Garg , A , Garg , S , Zaneveld , L J and Singla , A K . 2001 . Chemistry and pharmacology of the Citrus bioflavonoid hesperidin . Phytother Res , 15 : 655 – 669 .
   PubMed Web of Science ®Google Scholar
• Ameer , B , Weintraub , R A , Johnson , J V , Yost , R A and Rouseff , R L . 1996 . Flavanone absorption after naringin, hesperidin, and citrus administration . Clin Pharmacol Ther , 60 : 34 – 40 .
   PubMed Web of Science ®Google Scholar
• Lee , N K , Choi , S H , Park , S H , Park , E K and Kim , D H . 2004 . Antiallergic activity of hesperidin is activated by intestinal microflora . Pharmacology , 71 : 174 – 180 .
   PubMed Web of Science ®Google Scholar
• Matsumoto , H , Ikoma , Y , Sugiura , M , Yano , M and Hasegawa , Y . 2004 . Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma . J Agric Food Chem , 52 : 6653 – 6659 .
   PubMed Web of Science ®Google Scholar
• Booth , A N , Jones , F T and DeEds , F . 1958 . Metabolic fate of hesperidin, eriodictyol, homoeriodictyol, and diosmin . J Biol Chem , 230 : 661 – 668 .
   PubMed Web of Science ®Google Scholar
• Hackett , A M , Marsh , I , Barrow , A and Griffiths , L A . 1979 . The biliary excretion of flavanones in the rat . Xenobiotica , 9 : 491 – 502 .
   PubMed Web of Science ®Google Scholar
• Kim , J Y , Jung , K J , Choi , J S and Chung , H Y . 2004 . Hesperetin: a potent antioxidant against peroxynitrite . Free Radic Res , 38 : 761 – 769 .
   PubMed Web of Science ®Google Scholar
• Pollard , S E , Whiteman , M and Spencer , J P . 2006 . Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling . Biochem Biophys Res Commun , 347 : 916 – 923 .
   PubMed Web of Science ®Google Scholar
• Choi , E J , Kim , G D , Chee , K M and Kim , G H . 2006 . The effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells . Nutrition , in press
   Web of Science ®Google Scholar
• Singh , R P and Agarwal , R . 2006 . Natural flavonoids targeting deregulated cell cycle progression in cancer cells . Curr Drug Targets , 7 : 345 – 354 .
   PubMed Web of Science ®Google Scholar
• So , F V , Guthrie , N , Chambers , A F and Carroll , K K . 1997 . Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen . Cancer Lett , 112 : 127 – 133 .
   PubMed Web of Science ®Google Scholar
• Guthrie , N and Carroll , K K . 1998 . Inhibition of mammary cancer by citrus flavonoids . Adv Exp Med Biol , 439 : 227 – 236 .
   PubMed Web of Science ®Google Scholar
• Grana , X and Reddy , E P . 1995 . Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs) . Oncogene , 11 : 211 – 219 .
   PubMed Web of Science ®Google Scholar
• Mantena , S K , Sharma , S D and Katiyar , S K . 2006 . Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells . Mol Cancer Ther , 5 : 296 – 308 .
   PubMed Web of Science ®Google Scholar
• Deng , C , Zhang , P , Harper , J W , Elledge , S J and Leder , P . 1995 . Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control . Cell , 82 : 675 – 684 .
   PubMed Web of Science ®Google Scholar
• Sherr , C J and Roberts , J M . 1999 . CDK inhibitors: positive and negative regulators of G1-phase progression . Genes Dev , 13 : 1501 – 1512 .
   PubMed Web of Science ®Google Scholar
• Suzuki , K , Kazui , T , Yoshida , M , Uno , T Kobayashi , T . 1999 . Drug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro . Jpn J Clin Oncol , 29 : 323 – 331 .
   PubMed Web of Science ®Google Scholar
• Szostak , M J , Kaur , P , Amin , P , Jacobs , S C and Kyprianou , N . 2001 . Apoptosis and bcl-2 expression in prostate cancer: significance in clinical outcome after brachytherapy . J Urol , 165 : 2126 – 2130 .
   PubMed Web of Science ®Google Scholar
• Gazzaniga , P , Gradilone , A , Vercillo , R , Gandini , O Silvestri , I . 1996 . Bcl-2/bax mRNA expression ratio as prognostic factor in low-grade urinary bladder cancer . Int J Cancer , 22 : 100 – 104 .
   Web of Science ®Google Scholar