Involvement of KLF4 in Sulforaphane- and Iberin-Mediated Induction of p21^waf1/cip1

REFERENCES

• Fung , T , Hu , F B , Fuchs , C , Giovannucci , E Hunter , D J . 2003 . Major dietary patterns and the risk of colorectal cancer in women . Arch Intern Med , 163 : 309 – 314 .
   PubMed Web of Science ®Google Scholar
• Johnson , I T . 2005 . Cancers of the gut and Western ills . Science , 307 : 1839
   Google Scholar
• Lin , H J , Probst-Hensch , N M , Louie , A D , Kau , I H Witte , J S . 1998 . Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas . Cancer Epidemiol Biomarkers Prev , 7 : 647 – 652 .
   PubMed Web of Science ®Google Scholar
• van Poppel , G , Verhoeven , D T , Verhagen , H and Goldbohm , R A . 1999 . Brassica vegetables and cancer prevention. Epidemiology and mechanisms . Adv Exp Med Biol , 472 : 159 – 168 .
   PubMed Web of Science ®Google Scholar
• Juge , N , Mithen , R F and Traka , M . 2007 . Molecular basis for chemoprevention by sulforaphane: a comprehensive review . Cell Mol Life Sci , 64 : 1105 – 1127 .
   PubMed Web of Science ®Google Scholar
• Jakubikova , J , Bao , Y , Bodo , J and Sedlak , J . 2006 . Isothiocyanate iberin modulates phase II enzymes, posttranslational modification of histones and inhibits growth of Caco-2 cells by inducing apoptosis . Neoplasma , 53 : 463 – 470 .
   Google Scholar
• Jadhav , U , Ezhilarasan , R , Vaughn , S F , Berhow , M A and Mohanam , S . 2007 . Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells . Int J Mol Med , 19 : 353 – 361 .
   PubMed Web of Science ®Google Scholar
• Jakubikova , J , Sedlak , J , Bod'o , J and Bao , Y . 2006 . Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells . J Agric Food Chem , 54 : 1656 – 1662 .
   PubMed Web of Science ®Google Scholar
• Wang , W , Wang , S , Howie , A F , Beckett , G J Mithen , R . 2005 . Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells . J Agric Food Chem , 53 : 1417 – 1421 .
   PubMed Web of Science ®Google Scholar
• Shen , G , Xu , C , Chen , C , Hebbar , V and Kong , A N . 2006 . p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1 . Cancer Chemother Pharmacol , 57 : 317 – 327 .
   PubMed Web of Science ®Google Scholar
• Parnaud , G , Li , P , Cassar , G , Rouimi , P Tulliez , J . 2004 . Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells . Nutr Cancer , 48 : 198 – 206 .
   PubMed Web of Science ®Google Scholar
• Jakubikova , J , Sedlak , J , Mithen , R and Bao , Y . 2005 . Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells . Biochem Pharmacol , 69 : 1543 – 1552 .
   PubMed Web of Science ®Google Scholar
• Traka , M , Gasper , A V , Smith , J A , Hawkey , C J Bao , Y . 2005 . Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane . J Nutr , 135 : 1865 – 1872 .
   PubMed Web of Science ®Google Scholar
• Chen , X , Johns , D C , Geiman , D E , Marban , E Dang , D T . 2001 . Kruppel-like factor 4 (gut-enriched Kruppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle . J Biol Chem , 276 : 30423 – 30428 .
   PubMed Web of Science ®Google Scholar
• Zhang , W , Geiman , D E , Shields , J M , Dang , D T Mahatan , C S . 2000 . The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter . J Biol Chem , 275 : 18391 – 18398 .
   PubMed Web of Science ®Google Scholar
• Jenkins , T D , Opitz , O G , Okano , J and Rustgi , A K . 1998 . Transactivation of the human keratin 4 and Epstein-Barr virus ED-L2 promoters by gut-enriched Kruppel-like factor . J Biol Chem , 273 : 10747 – 10754 .
   PubMed Web of Science ®Google Scholar
• Shields , J M , Christy , R J and Yang , V W . 1996 . Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest . J Biol Chem , 271 : 20009 – 20017 .
   PubMed Web of Science ®Google Scholar
• Segre , J A , Bauer , C and Fuchs , E . 1999 . Klf4 is a transcription factor required for establishing the barrier function of the skin . Nat Genet , 22 : 356 – 360 .
   PubMed Web of Science ®Google Scholar
• Yet , S F , McA'Nulty , M M , Folta , S C , Yen , H W Yoshizumi , M . 1998 . Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains . J Biol Chem , 273 : 1026 – 1031 .
   PubMedGoogle Scholar
• Shie , J L , Chen , Z Y , O'Brien , M J , Pestell , R G Lee , M E . 2000 . Role of gut-enriched Kruppel-like factor in colonic cell growth and differentiation . Am J Physiol Gastrointest Liver Physiol , 279 : G806 – G814 .
   PubMedGoogle Scholar
• Zhao , W , Hisamuddin , I M , Nandan , M O , Babbin , B A Lamb , N E . 2004 . Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer . Oncogene , 23 : 395 – 402 .
   PubMed Web of Science ®Google Scholar
• Dahlqvist , A . 1964 . Method for assay of intestinal disaccharidases . Anal Biochem , 57 : 18 – 25 .
   Google Scholar
• Dang , D T , Mahatan , C S , Dang , L H , Agboola , I A and Yang , V W . 2001 . Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2 . Oncogene , 20 : 4884 – 4890 .
   PubMed Web of Science ®Google Scholar
• Pinto , M , Robineleon , S , Appay , M D , Kedinger , M Triadou , N . 1983 . Enterocyte-like differentiation and polarization of the human-colon carcinoma cell-line Caco-2 in culture . Biol Cell , 47 : 323 – 330 .
   Web of Science ®Google Scholar
• Grasset , E , Pinto , M , Dussaulx , E , Zweibaum , A and Desjeux , J F . 1984 . Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters . Am J Physiol , 247 : C260 – C267 .
   PubMed Web of Science ®Google Scholar
• Costa , d e , Beauregard , M A , Pringault , E , Robine , S and Louvard , D . 1995 . Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells . Embo J , 14 : 409 – 421 .
   Google Scholar
• Traber , P G , Yu , L , Wu , G D and Judge , T A . 1992 . Sucrase-isomaltase gene expression along crypt-villus axis of human small intestine is regulated at level of mRNA abundance . Am J Physiol , 262 : G123 – G130 .
   PubMedGoogle Scholar
• Hu , R , Hebbar , V , Kim , B R , Chen , C Winnik , B . 2004 . In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat . J Pharmacol Exp Ther , 310 : 263 – 271 .
   PubMed Web of Science ®Google Scholar
• Yoon , H S and Yang , V W . 2004 . Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage . J Biol Chem , 279 : 5035 – 5041 .
   PubMed Web of Science ®Google Scholar
• Yoon , H S , Chen , X and Yang , V W . 2003 . Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage . J Biol Chem , 278 : 2101 – 2105 .
   PubMed Web of Science ®Google Scholar
• Chen , Z Y , Rex , S and Tseng , C C . 2004 . Kruppel-like factor 4 is transactivated by butyrate in colon cancer cells . J Nutr , 134 : 792 – 798 .
   PubMed Web of Science ®Google Scholar
• Myzak , M C , Karplus , P A , Chung , F L and Dashwood , R H . 2004 . A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase . Cancer Res , 64 : 5767 – 5774 .
   PubMed Web of Science ®Google Scholar
• Specian , R D and Oliver , M G . 1991 . Functional biology of intestinal goblet cells . Am J Physiol , 260 : C183 – C193 .
   PubMed Web of Science ®Google Scholar
• Velcich , A , Yang , W , Heyer , J , Fragale , A Nicholas , C . 2002 . Colorectal cancer in mice genetically deficient in the mucin Muc2 . Science , 295 : 1726 – 1729 .
   PubMed Web of Science ®Google Scholar
• Katz , J P , Perreault , N , Goldstein , B G , Lee , C S Labosky , P A . 2002 . The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon . Development , 129 : 2619 – 2628 .
   PubMed Web of Science ®Google Scholar
• Shibayama , T , Carboni , J M and Mooseker , M S . 1987 . Assembly of the intestinal brush border: appearance and redistribution of microvillar core proteins in developing chick enterocytes . J Cell Biol , 105 : 335 – 344 .
   Google Scholar
• Nagase , H and Nakamura , Y . 1993 . Mutations of the APC (adenomatous polyposis coli) gene . Hum Mutat , 2 : 425 – 434 .
   PubMed Web of Science ®Google Scholar
• Miyoshi , Y , Nagase , H , Ando , H , Horii , A Ichii , S . 1992 . Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene . Hum Mol Genet , 1 : 229 – 233 .
   PubMedGoogle Scholar
• Morin , P J , Sparks , A B , Korinek , V , Barker , N Clevers , H . 1997 . Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC . Science , 275 : 1787 – 1790 .
   PubMed Web of Science ®Google Scholar
• Korinek , V , Barker , N , Morin , P J , van Wichen , D de Weger , R . 1997 . Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma . Science , 275 : 1784 – 1787 .
   PubMed Web of Science ®Google Scholar
• Stone , C D , Chen , Z Y and Tseng , C C . 2002 . Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway . FEBS Lett , 530 : 147 – 152 .
   PubMedGoogle Scholar
• Mahatan , C S , Kaestner , K H , Geiman , D E and Yang , V W . 1999 . Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4) . Nucleic Acids Res , 27 : 4562 – 4569 .
   PubMedGoogle Scholar
• Dang , D T , Bachman , K E , Mahatan , C S , Dang , L H Giardiello , F M . 2000 . Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients . FEBS Lett , 476 : 203 – 207 .
   PubMed Web of Science ®Google Scholar
• Hu , R , Khor , T O , Shen , G , Jeong , W S Hebbar , V . 2006 . Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable . Carcinogenesis , 27 : 2038 – 2046 .
   PubMed Web of Science ®Google Scholar
• Myzak , M C , Dashwood , W M , Orner , G A , Ho , E and Dashwood , R H . 2006 . Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice . FASEB J , 20 : 506 – 508 .
   PubMed Web of Science ®Google Scholar
• Zhang , Y , Li , J and Tang , L . 2005 . Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress . Free Radic Biol Med , 38 : 70 – 77 .
   PubMed Web of Science ®Google Scholar
• Khor , T O , Hu , R , Shen , G , Jeong , W S Hebbar , V . 2006 . Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice . Biopharm Drug Dispos , 27 : 407 – 420 .
   Google Scholar
• Shen , G , Khor , T O , Hu , R , Yu , S Nair , S . 2007 . Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in Apcmin/+ mouse . Cancer Res , 67 : 9937 – 9944 .
   PubMed Web of Science ®Google Scholar
• Gasper , A V , Al-Janobi , A , Smith , J A , Bacon , J R Fortun , P . 2005 . Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli . Am J Clin Nutr , 82 : 1283 – 1291 .
   PubMed Web of Science ®Google Scholar
• Hedlund , T E , Maroni , P D , Ferucci , P G , Dayton , R Barnes , S . 2005 . Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in Caucasian men . J Nutr , 135 : 1400 – 1406 .
   PubMed Web of Science ®Google Scholar