114
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

NSAIDs Downregulate Bcl-XL and Dissociate BAX and Bcl-XL to Induce Apoptosis in Colon Cancer Cells

, &
Pages 98-103 | Received 14 Jul 2008, Accepted 22 Jul 2008, Published online: 10 Nov 2008

REFERENCES

  • Kune , G A , Kune , S and Watson , L F . 1988 . Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study . Cancer Res , 48 : 4399 – 4404 .
  • Thun , M J , Namboodiri , M M and Heath , C W Jr . 1991 . Aspirin use and reduced risk of fatal colon cancer . N Engl J Med , 325 : 1593 – 1596 .
  • Herendeen , J M and Lindley , C . 2003 . Use of NSAIDs for the chemoprevention of colorectal cancer . Ann Pharmacother , 37 : 1664 – 1674 .
  • Shaheen , N J , Straus , W L and Sandler , R S . 2002 . Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugs . Cancer , 94 : 950 – 963 .
  • Rao , C V , Rivenson , A , Simi , B , Zang , E Kelloff , G . 1995 . Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent . Cancer Res , 55 : 1464 – 1472 .
  • Reddy , B S , Hirose , Y , Lubet , R , Steele , V Kelloff , G . 2000 . Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis . Cancer Res , 60 : 293 – 297 .
  • Gupta , R A and Dubois , R N . 2001 . Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 . Natl Rev Cancer , 1 : 11 – 21 .
  • Keller , J J and Giardiello , F M . 2003 . Chemoprevention strategies using NSAIDs and COX-2 inhibitors . Cancer Biol Ther , 2 : S140 – S149 .
  • Sun , S Y , Hail , N Jr and Lotan , R . 2004 . Apoptosis as a novel target for cancer chemoprevention . J Natl Cancer Inst , 96 : 662 – 672 .
  • Hall , P A , Coates , P J , Ansari , B and Hopwood , D . 1994 . Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis . J Cell Sci , 107 : 3569 – 3577 . (Pt 12)
  • Hanahan , D and Weinberg , R A . 2000 . The hallmarks of cancer . Cell , 100 : 57 – 70 .
  • Mahmoud , N N , Boolbol , S K , Bilinski , R T , Martucci , C Chadburn , A . 1997 . Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration . Cancer Res , 57 : 5045 – 5050 .
  • Brown , W A , Skinner , S A , Malcontenti-Wilson , C , Vogiagis , D and O'Brien , P E . 2001 . Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation . Gut , 48 : 660 – 666 .
  • Keller , J J , Offerhaus , G J , Polak , M , Goodman , S N Zahurak , M L . 1999 . Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac . Gut , 45 : 822 – 828 .
  • Pasricha , P J , Bedi , A , O'Connor , K , Rashid , A Akhtar , A J . 1995 . The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis . Gastroenterology , 109 : 994 – 998 .
  • Samaha , H S , Kelloff , G J , Steele , V , Rao , C V and Reddy , B S . 1997 . Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion . Cancer Res , 57 : 1301 – 1305 .
  • Adams , J M and Cory , S . 2007 . The Bcl-2 apoptotic switch in cancer development and therapy . Oncogene , 26 : 1324 – 1337 .
  • Yu , J and Zhang , L . 2004 . Apoptosis in human cancer cells . Curr Opin Oncol , 16 : 19 – 24 .
  • Zhang , L , Yu , J , Park , B H , Kinzler , K W and Vogelstein , B . 2000 . Role of BAX in the apoptotic response to anticancer agents . Science , 290 : 989 – 992 .
  • Bank , A , Wang , P , Du , C , Yu , J and Zhang , L . 2008 . SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release . Cancer Res , 68 : 276 – 284 .
  • Wang , P , Yu , J and Zhang , L . 2007 . The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage . Proc Natl Acad Sci USA , 104 : 4054 – 4059 .
  • Yu , J , Wang , P , Ming , L , Wood , M A and Zhang , L . 2007 . SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events . Oncogene , 26 : 4189 – 4198 .
  • Hershko , A and Ciechanover , A . 1998 . The ubiquitin system . Annu Rev Biochem , 67 : 425 – 479 .
  • Yu , J , Tiwari , S , Steiner , P and Zhang , L . 2003 . Differential apoptotic response to the proteasome inhibitor bortezomib [VELCADE(TM), PS-341] in bax-deficient and p21-deficient colon cancer cells . Cancer Biol Ther , 2 : 694 – 699 .
  • Ming , L , Wang , P , Bank , A , Yu , J and Zhang , L . 2006 . PUMA dissociates Bax and BCL-XL to induce apoptosis in colon cancer cells . J Biol Chem , 281 : 16034 – 16042 .
  • Yu , J , Wang , Z , Kinzler , K W , Vogelstein , B and Zhang , L . 2003 . PUMA mediates the apoptotic response to p53 in colorectal cancer cells . Proc Natl Acad Sci USA , 100 : 1931 – 1936 .
  • Wang , K , Gross , A , Waksman , G and Korsmeyer , S J . 1998 . Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing . Mol Cell Biol , 18 : 6083 – 6089 .
  • Nechushtan , A , Smith , C L , Hsu , Y T and Youle , R J . 1999 . Conformation of the Bax C-terminus regulates subcellular location and cell death . Embo J , 18 : 2330 – 2341 .
  • Huang , D C and Strasser , A . 2000 . BH3-Only proteins-essential initiators of apoptotic cell death . Cell , 103 : 839 – 842 .
  • He , Q , Montalbano , J , Corcoran , C , Jin , W Huang , Y . 2003 . Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis . Oncogene , 22 : 2674 – 2679 .
  • Yin , X M . 2006 . Bid, a BH3-only multi-functional molecule, is at the cross road of life and death . Gene , 369 : 7 – 19 .
  • Yu , J , Yue , W , Wu , B and Zhang , L . 2006 . PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation . Clin Cancer Res , 12 : 2928 – 2936 .
  • Ishihara , T , Hoshino , T , Namba , T , Tanaka , K and Mizushima , T . 2007 . Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis . Biochem Biophys Res Commun , 356 : 711 – 717 .
  • Nouraini , S , Six , E , Matsuyama , S , Krajewski , S and Reed , J C . 2000 . The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L) . Mol Cell Biol , 20 : 1604 – 1615 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.