Effects of Nutrition Relevant Mixtures of Phytoestrogens on Steroidogenesis, Aromatase, Estrogen, and Androgen Activity

REFERENCES

• Setchell , K D . 2001 . Soy isoflavones—benefits and risks from nature's selective estrogen receptor modulators (SERMs) . J Am Coll Nutr , 20 : 354S – 362S . 381S – 383S .
   PubMed Web of Science ®Google Scholar
• Ibarreta , D , Daxenberger , A and Meyer , H H . 2001 . Possible health impact of phytoestrogens and xenoestrogens in food . Apmis , 109 : 161 – 184 .
   PubMed Web of Science ®Google Scholar
• Magee , P J and Rowland , I R . 2004 . Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer . Br J Nutr , 91 : 513 – 531 .
   PubMed Web of Science ®Google Scholar
• Le Bail , J C , Champavier , Y , Chulia , A J and Habrioux , G . 2000 . Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells . Life Sci , 66 : 1281 – 1291 .
   PubMed Web of Science ®Google Scholar
• Power , K A , Saarinen , N M , Chen , J M and Thompson , L U . 2006 . Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice . Int J Cancer , 118 : 1316 – 1320 .
   PubMed Web of Science ®Google Scholar
• Krista , A and Power , L UT . 2007 . Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer? . Mol Nutr Food Res , 51 : 845 – 856 .
   Google Scholar
• Tham , D M , Gardner , C D and Haskell , W L . 1998 . Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence . J Clin Endocrinol Metab , 83 : 2223 – 2235 .
   PubMed Web of Science ®Google Scholar
• Yang , J , Nakagawa , H , Tsuta , K and Tsubura , A . 2000 . Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats . Cancer Lett , 149 : 171 – 179 .
   Google Scholar
• Hilakivi-Clarke , L , Cho , E , Onojafe , I , Raygada , M and Clarke , R . 1999 . Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring . Oncol Rep , 6 : 1089 – 1095 .
   PubMed Web of Science ®Google Scholar
• Allred , C D , Ju , Y H , Allred , K F , Chang , J and Helferich , W G . 2001 . Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein . Carcinogenesis , 22 : 1667 – 1673 .
   PubMed Web of Science ®Google Scholar
• De Lemos , M L . 2001 . Effects of soy phytoestrogens genistein and daidzein on breast cancer growth . Ann Pharmacother , 35 : 1118 – 1121 .
   PubMed Web of Science ®Google Scholar
• Hedelin , M , Klint , A , Chang , E T , Bellocco , R Johansson , J E . 2006 . Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden) . Cancer Causes Control , 17 : 169 – 180 .
   PubMed Web of Science ®Google Scholar
• Adlercreutz , H , Mazur , W , Bartels , P , Elomaa , V V Watanabe , S . 2000 . Phytoestrogens and Prostate Disease . J. Nutr , 130 : 658S – 658S .
   PubMed Web of Science ®Google Scholar
• Jian-Ping Yuan , J-HWXL . 2007 . Metabolism of dietary soy isoflavones to equol by human intestinal microflora—implications for health . Mol Nutr Food Res , 51 : 765 – 781 .
   Google Scholar
• Almstrup , K , Fernandez , M F , Petersen , J H , Olea , N Skakkebaek , N E . 2002 . Dual effects of phytoestrogens result in u-shaped dose-response curves . Environ Health Perspect , 110 : 743 – 748 .
   PubMed Web of Science ®Google Scholar
• Simpson , E R and Davis , S R . 2001 . Minireview: aromatase and the regulation of estrogen biosynthesis—some new perspectives . Endocrinology , 142 : 4589 – 4594 .
   PubMed Web of Science ®Google Scholar
• Rice , S , Mason , H D and Whitehead , S A . 2006 . Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells . J Steroid Biochem Mol Biol , 101 : 216 – 225 .
   PubMed Web of Science ®Google Scholar
• Adlercreutz , H . 2002 . Phyto-oestrogens and cancer . Lancet Oncol , 3 : 364 – 373 .
   PubMed Web of Science ®Google Scholar
• Benassayag , C , Perrot-Applanat , M and Ferre , F . 2002 . Phytoestrogens as modulators of steroid action in target cells . J Chromatogr B Analyt Technol Biomed Life Sci , 777 : 233 – 248 .
   PubMed Web of Science ®Google Scholar
• Kinoshita , Y and Chen , S . 2003 . Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor {alpha} . Cancer Res , 63 : 3546 – 3555 .
   PubMed Web of Science ®Google Scholar
• Sanderson , J T , Hordijk , J , Denison , M S , Springsteel , M F Nantz , M H . 2004 . Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells . Toxicol Sci , 82 : 70 – 79 .
   PubMed Web of Science ®Google Scholar
• Edmunds , K M , Holloway , A C , Crankshaw , D J , Agarwal , S K and Foster , W G . 2005 . The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells . Reprod Nutr Dev , 45 : 709 – 720 .
   Google Scholar
• Horwitz , K B and McGuire , W L . 1978 . Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor . J Biol Chem , 253 : 2223 – 2228 .
   PubMed Web of Science ®Google Scholar
• Lundholt , B K , Briand , P and Lykkesfeldt , A E . 2001 . Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways . Breast Cancer Res Treat , 67 : 199 – 214 .
   Google Scholar
• Rasmussen , L M , Zaveri , N T , Stenvang , J , Peters , R H and Lykkesfeldt , A E . 2007 . A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer . Breast Cancer Res Treat , 106 : 191 – 203 .
   PubMed Web of Science ®Google Scholar
• Bonefeld-Jorgensen , E C , Long , M , Hofmeister , M V and Vinggaard , A M . 2007 . Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review . Environ Health Perspect , 115 ( 1 Suppl ) : 69 – 76 .
   Google Scholar
• Bonefeld-Jorgensen , E C , Grunfeld , H T and Gjermandsen , I M . 2005 . Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells . Mol Cell Endocrinol , 244 : 20 – 30 .
   PubMed Web of Science ®Google Scholar
• Vinggaard , A M , Joergensen , E C and Larsen , J C . 1999 . Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals . Toxicol Appl Pharmacol , 155 : 150 – 160 .
   PubMedGoogle Scholar
• Kastner , P , Krust , A , Turcotte , B , Stropp , U Tora , L . 1990 . Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B . Embo J , 9 : 1603 – 1614 .
   PubMed Web of Science ®Google Scholar
• Grünfeld , H T and Bonefeld-Jorgensen , E C . 2004 . Effect of in vitro estrogenic pesticides on human estrogen receptor alpha and beta mRNA levels . Toxicol Lett , 151 : 467 – 480 .
   PubMed Web of Science ®Google Scholar
• Jensen , B L , Skouv , J , Lundholt , B K and Lykkesfeldt , A E . 1999 . Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6 . Br J Cancer , 79 : 386 – 392 .
   Google Scholar
• Ohno , S , Shinoda , S , Toyoshima , S , Nakazawa , H Makino , T . 2002 . Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells . J Steroid Biochem Mol Biol , 80 : 355 – 363 .
   PubMed Web of Science ®Google Scholar
• van Meeuwen , J A , Ter Burg , W , Piersma , A H , van den Berg , M and Sanderson , J T . 2007 . Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells . Food Chem Toxicol , 45 : 2319 – 2330 .
   PubMed Web of Science ®Google Scholar
• Ying , C , Hsu , J-T , Yang , C-D , Hsung , S-J Wang , L-K . 2005 . The combination effects of phytoestrogens on cell proliferation, cell cycle progression and estrogen receptor alpha . J Food Drug Anal , 13 : 30 – 37 .
   Google Scholar