345
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

The Flavonoid Quercetin Transiently Inhibits the Activity of Taxol and Nocodazole Through Interference With the Cell Cycle

, , &
Pages 1025-1035 | Received 17 Jun 2009, Accepted 23 Feb 2010, Published online: 06 Nov 2010

REFERENCES

  • Kirsh , V A Peters , U . 2007 . Prospective study of fruit and vegetable intake and risk of prostate cancer . J Natl Cancer Inst , 99 : 1200 – 1209 .
  • Lunet , N Valbuena , C . 2007 . Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis . Eur J Cancer Prev , 16 : 312 – 327 .
  • Gonzalez , C A Pera , G . 2006 . Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) . Int J Cancer , 118 : 2559 – 2566 .
  • Millen , A E Subar , A F . 2007 . Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial . Am J Clin Nutr , 86 : 1754 – 1764 .
  • He , X and Liu , R H . 2008 . Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities . J Agric Food Chem , 56 : 9905 – 9910 .
  • Harnly , J M Doherty , R F . 2006 . Flavonoid content of U.S. fruits, vegetables, and nuts . J Agric Food Chem , 54 : 9966 – 9977 .
  • Huang , Z Wang , B . 2007 . Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for Cardiovascular Equality Project . Int J Food Sci Nutr , 60 : 100 – 108 .
  • Mertens-Talcott , S U and Percival , S S . 2005 . Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells . Cancer Lett , 218 : 141 – 151 .
  • Nguyen , T T Tran , E . 2004 . The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells . Carcinogenesis , 25 : 647 – 659 .
  • Huynh , H Nguyen , T T . 2003 . Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation . Int J Oncol , 23 : 821 – 829 .
  • Ong , C S Tran , E . 2004 . Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions . Oncol Rep , 11 : 727 – 733 .
  • Granado-Serrano , A B Angeles Martin , M . 2008 . Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells . Mol Nutr Food Res , 52 : 457 – 464 .
  • Kim , W K Bang , M H . 2005 . Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells . J Nutr Biochem , 16 : 155 – 162 .
  • Zhang , X M Huang , S P . 2004 . Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathway . Cancer Chemother Pharmacol , 53 : 82 – 88 .
  • Gee , J M Hara , H . 2002 . Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats . Nutr Cancer , 43 : 193 – 201 .
  • Ramos , S . 2008 . Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways . Mol Nutr Food Res , 52 : 507 – 526 .
  • Block , K I , Mark , A CK , Mead , N , Tothy , P K Newman , R A . 2008 . Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials . Int J Cancer , 123 : 1227 – 1239 .
  • Bairati , I , Meyer , F , Gelinas , M , Fortin , A Nabid , A . 2005 . A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients . J Natl Cancer Inst , 97 : 481 – 488 .
  • Block , K I Koch , A C . 2007 . Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials . Cancer Treat Rev , 33 : 407 – 418 .
  • Lawenda , B D Kelly , K M . 2008 . Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? . J Natl Cancer Inst , 100 : 773 – 783 .
  • Franken , N A Rodermond , H M . 2006 . Clonogenic assay of cells in vitro . Nat Protoc , 1 : 2315 – 2319 .
  • Samuel , T Okada , K . 2005 . cIAP1 Localizes to the nuclear compartment and modulates the cell cycle . Cancer Res , 65 : 210 – 218 .
  • Murtaza , I Marra , G . 2006 . A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray . Biotechnol Appl Biochem , 45 ( Pt 1 ) : 29 – 36 .
  • Jackman , M Lindon , C . 2003 . Active cyclin B1-Cdk1 first appears on centrosomes in prophase . Nat Cell Biol , 5 : 143 – 148 .
  • Béroud , C and Soussi , T . 2003 . The UMD-p53 database: new mutations and analysis tools . Hum Mutat , 21 : 176 – 181 .
  • Magali Olivier , R E , Hollstein , M , Khan , M A , Harris , C C and Hainaut , P . 2002 . The IARC TP53 database: new online mutation analysis and recommendations to users . Hum Mutat , 19 : 607 – 614 .
  • Valko , M Rhodes , C J . 2006 . Free radicals, metals, and antioxidants in oxidative stress-induced cancer . Chem Biol Interact , 160 : 1 – 40 .
  • Liu , F T Agrawal , S G . 2008 . Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib . Blood , 112 : 3835 – 3846 .
  • Golden , E B Lam , P Y . 2009 . Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors . Blood , : 5927 – 5937 .
  • Heaney , M L Gardner , J R . 2008 . Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs . Cancer Res , 68 : 8031 – 8038 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.