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Original Articles

Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs

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Pages 919-930 | Received 27 Feb 2010, Accepted 16 Jul 2010, Published online: 04 Oct 2010

REFERENCES

  • Rahman , I , Biswas , S K and Kirkham , P A . 2006 . Regulation of inflammation and redox signaling by dietary polyphenols . Biochem Pharmacol , 72 : 1439 – 1452 .
  • Tirkey , N , Kaur , G , Vij , G and Chopra , K . 2005 . Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys . BMC Pharmacol , 5 : 15
  • Brouet , I and Ohshima , H . 1995 . Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages . Biochem Biophys Res Commun , 206 : 533 – 540 .
  • Dikshit , M , Rastogi , L , Shukla , R and Srimal , R C . 1995 . Prevention of ischaemia-induced biochemical changes by curcumin and quinidine in the cat heart . Indian J Med Res , 101 : 31 – 35 .
  • Sreejayan , xx and Rao , M N . 1997 . Nitric oxide scavenging by curcuminoids . J Pharm Pharmacol , 49 : 105 – 107 .
  • Chen , J , Bai , H , Wang , C and Kang , J . 2006 . Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells . Pharmazie , 61 : 710 – 716 .
  • Chen , J , Tang , X Q , Zhi , J L , Cui , Y Yu , H M . 2006 . Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway . Apoptosis , 11 : 943 – 953 .
  • Divya , C S and Pillai , M R . 2006 . Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis . Mol Carcinog , 45 : 320 – 332 .
  • Kiso , Y , Suzuki , Y , Watanabe , N , Oshima , Y and Hikino , H . 1983 . Antihepatotoxic principles of Curcuma longa rhizomes . Planta Med , 49 : 185 – 187 .
  • Srivastava , R , Dikshit , M , Srimal , R C and Dhawan , B N . 1985 . Anti-thrombotic effect of curcumin . Thromb Res , 40 : 413 – 417 .
  • Venkatesan , N . 1998 . Curcumin attenuation of acute adriamycin myocardial toxicity in rats . Br J Pharmacol , 124 : 425 – 427 .
  • Deodhar , S D , Sethi , R and Srimal , R C . 1980 . Preliminary study on antirheumatic activity of curcumin (diferuloyl methane) . Indian J Med Res , 71 : 632 – 634 .
  • Chan , M M , Adapala , N S and Fong , D . 2005 . Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania . Parasitol Res , 96 : 49 – 56 .
  • Singh , S and Khar , A . 2006 . Biological effects of curcumin and its role in cancer chemoprevention and therapy . Anticancer Agents Med Chem , 6 : 259 – 270 .
  • Goel , A , Kunnumakkara , A B and Aggarwal , B B . Curcumin as “curecumin”: from kitchen to clinic . Biochem Pharmacol , 75 787 – 809 .
  • Gottesman , M M , Ludwig , J , Xia , D and Szakacs , G . 2006 . Defeating drug resistance in cancer . Discov Med , 6 : 18 – 23 .
  • Theodoulou , M , Batist , G , Campos , S , Winer , E Welles , L . 2009 . Phase I study of nonpegylated liposomal doxorubicin plus trastuzumab in patients with HER2-positive breast cancer . Clin Breast Cancer , 9 : 101 – 107 .
  • Ali , S and Coombes , R C . 2002 . Endocrine-responsive breast cancer and strategies for combating resistance . Nat Rev Cancer , 2 : 101 – 112 .
  • Davies , A , Cifaldi , M A , Segurado , O G and Weisman , M H . 2009 . Cost-effectiveness of sequential therapy with tumor necrosis factor antagonists in early rheumatoid arthritis . J Rheumatol , 36 : 16 – 26 .
  • Thayu , M , Leonard , M B , Hyams , J S , Crandall , W V Kugathasan , S . 2008 . Improvement in biomarkers of bone formation during infliximab therapy in pediatric Crohn's disease: results of the REACH study . Clin Gastroenterol Hepatol , 6 : 1378 – 1384 .
  • Weisberg , E , Manley , P W , Cowan-Jacob , S W , Hochhaus , A and Griffin , J D . 2007 . Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia . Nat Rev Cancer , 7 : 345 – 356 .
  • Engelman , J A , Zejnullahu , K , Mitsudomi , T , Song , Y Hyland , C . 2007 . MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling . Science , 316 : 1039 – 1043 .
  • Gottesman , M M , Fojo , T and Bates , S E . 2002 . Multidrug resistance in cancer: role of ATP-dependent transporters . Nat Rev Cancer , 2 : 48 – 58 .
  • Raguz , S and Yague , E . 2008 . Resistance to chemotherapy: new treatments and novel insights into an old problem . Br J Cancer , 99 : 387 – 391 .
  • Al-Hajj , M and Clarke , M F . 2004 . Self-renewal and solid tumor stem cells . Oncogene , 23 : 7274 – 7282 .
  • Singh , S K , Clarke , I D , Terasaki , M , Bonn , V E Hawkins , C . 2003 . Identification of a cancer stem cell in human brain tumors . Cancer Res , 63 : 5821 – 5828 .
  • Jiang , X , Zhao , Y , Smith , C , Gasparetto , M Turhan , A . 2007 . Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies . Leukemia , 21 : 926 – 935 .
  • Jemal , A , Siegel , R , Ward , E , Hao , Y Xu , J . 2009 . Cancer statistics, 2009 . CA Cancer J Clin ,
  • Howells , L M , Mitra , A and Manson , M M . 2007 . Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines . Int J Cancer ,
  • Li , L , Ahmed , B , Mehta , K and Kurzrock , R . 2007 . Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer . Mol Cancer Ther , 6 : 1276 – 1282 .
  • Patel , B B , Sengupta , R , Qazi , S , Vachhani , H Yu , Y . 2008 . Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R . Int J Cancer , 122 : 267 – 273 .
  • Du , B , Jiang , L , Xia , Q and Zhong , L . 2006 . Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29 . Chemotherapy , 52 : 23 – 28 .
  • Lev-Ari , S , Strier , L , Kazanov , D , Madar-Shapiro , L Dvory-Sobol , H . 2005 . Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells . Clin Cancer Res , 11 : 6738 – 6744 .
  • Shpitz , B , Giladi , N , Sagiv , E , Lev-Ari , S Liberman , E . 2006 . Celecoxib and curcumin additively inhibit the growth of colorectal cancer in a rat model . Digestion , 74 : 140 – 144 .
  • Koo , J Y , Kim , H J , Jung , K O and Park , K Y . 2004 . Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil . J Med Food , 7 : 117 – 121 .
  • Lev-Ari , S , Zinger , H , Kazanov , D , Yona , D Ben-Yosef , R . 2005 . Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells . Biomed Pharmacother , 59 ( 2 Suppl ) : S276 – S280 .
  • Lev-Ari , S , Vexler , A , Starr , A , Ashkenazy-Voghera , M Greif , J . 2007 . Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines . Cancer Invest , 25 : 411 – 418 .
  • Kunnumakkara , A B , Guha , S , Krishnan , S , Diagaradjane , P Gelovani , J . 2007 . Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products . Cancer Res , 67 : 3853 – 3861 .
  • Notarbartolo , M , Poma , P , Perri , D , Dusonchet , L Cervello , M . 2005 . Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells: analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression . Cancer Lett , 224 : 53 – 65 .
  • Holcomb , B , Yip-Schneider , M T , Matos , J M , Dixon , J Kennard , J . 2008 . Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies . J Gastrointest Surg , 12 : 288 – 296 .
  • Hour , T C , Chen , J , Huang , C Y , Guan , J Y Lu , S H . 2002 . Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation . Prostate , 51 : 211 – 218 .
  • Li , M , Zhang , Z , Hill , D L , Wang , H and Zhang , R . 2007 . Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway . Cancer Res , 67 : 1988 – 1996 .
  • Aggarwal , B B , Shishodia , S , Takada , Y , Banerjee , S Newman , R A . 2005 . Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice . Clin Cancer Res , 11 : 7490 – 7498 .
  • Chirnomas , D , Taniguchi , T , de , l V , Vaidya , A P Vasserman , M . 2006 . Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway . Mol Cancer Ther , 5 : 952 – 961 .
  • Somasundaram , S , Edmund , N A , Moore , D T , Small , G W Shi , Y Y . 2002 . Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer . Cancer Res , 62 : 3868 – 3875 .
  • Chan , M M , Fong , D , Soprano , K J , Holmes , W F and Heverling , H . 2003 . Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents . J Cell Physiol , 194 : 63 – 70 .
  • Lin , Y G , Kunnumakkara , A B , Nair , A , Merritt , W M Han , L Y . 2007 . Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway . Clin Cancer Res , 13 : 3423 – 3430 .
  • Venkatraman , M , Anto , R J , Nair , A , Varghese , M and Karunagaran , D . 2005 . Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis . Mol Carcinog , 44 : 51 – 59 .
  • Bava , S V , Puliappadamba , V T , Deepti , A , Nair , A Karunagaran , D . 2005 . Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization . J Biol Chem , 280 : 6301 – 6308 .
  • Sen , S , Sharma , H and Singh , N . 2005 . Curcumin enhances Vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathway . Biochem Biophys Res Commun , 331 : 1245 – 1252 .
  • Andjelkovic , T , Pesic , M , Bankovic , J , Tanic , N Markovic , I D . 2008 . Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R) . Cancer Biol Ther , 7 : 1024 – 1032 .
  • Chanvorachote , P , Pongrakhananon , V , Wannachaiyasit , S , Luanpitpong , S Rojanasakul , Y . 2009 . Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation . Cancer Invest , 27 : 624 – 635 .
  • Kamat , A M , Sethi , G and Aggarwal , B B . 2007 . Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells . Mol Cancer Ther , 6 : 1022 – 1030 .
  • Dhandapani , K M , Mahesh , V B and Brann , D W . 2007 . Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors . J Neurochem , 102 : 522 – 538 .
  • Bharti , A C , Donato , N , Singh , S and Aggarwal , B B . 2003 . Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis . Blood , 101 : 1053 – 1062 .
  • Sung , B , Kunnumakkara , A B , Sethi , G , Anand , P Guha , S . 2009 . Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model . Mol Cancer Ther , 8 : 959 – 970 .
  • Indap , M A and Barkume , M S . 2003 . Efficacies of plant phenolic compounds on sodium butyrate induced anti-tumour activity . Indian J Exp Biol , 41 : 861 – 864 .
  • Everett , P C , Meyers , J A , Makkinje , A , Rabbi , M and Lerner , A . 2007 . Preclinical assessment of curcumin as a potential therapy for B-CLL . Am J Hematol , 82 : 23 – 30 .
  • Kuhad , A , Pilkhwal , S , Sharma , S , Tirkey , N and Chopra , K . 2007 . Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity . J Agric Food Chem , 55 : 10150 – 10155 .
  • Kunnumakkara , A B , Diagaradjane , P , Guha , S , Deorukhkar , A Shentu , S . 2008 . Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products . Clin Cancer Res , 14 : 2128 – 2136 .
  • Chendil , D , Ranga , R S , Meigooni , D , Sathishkumar , S and Ahmed , M M . 2004 . Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3 . Oncogene , 23 : 1599 – 1607 .
  • Javvadi , P , Segan , A T , Tuttle , S W and Koumenis , C . 2008 . The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway . Mol Pharmacol , 73 : 1491 – 1501 .
  • Aravindan , N , Madhusoodhanan , R , Ahmad , S , Johnson , D and Herman , T S . 2008 . Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells . Cancer Biol Ther , 7 : 569 – 576 .
  • Chan , W H , Wu , C C and Yu , J S . 2003 . Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells . J Cell Biochem , 90 : 327 – 338 .
  • Chan , W H and Wu , H J . 2004 . Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells . J Cell Biochem , 92 : 200 – 212 .
  • Dujic , J , Kippenberger , S , Hoffmann , S , Ramirez-Bosca , A Miquel , J . 2007 . Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light . J Invest Dermatol ,
  • Dujic , J , Kippenberger , S , Ramirez-Bosca , A , Diaz-Alperi , J Bereiter-Hahn , J . 2009 . Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model . Int J Cancer , 124 : 1422 – 1428 .
  • Park , K and Lee , J H . 2007 . Photosensitizer effect of curcumin on UVB-irradiated HaCaT cells through activation of caspase pathways . Oncol Rep , 17 : 537 – 540 .
  • Khafif , A , Hurst , R , Kyker , K , Fliss , D M Gil , Z . 2005 . Curcumin: a new radio-sensitizer of squamous cell carcinoma cells . Otolaryngol Head Neck Surg , 132 : 317 – 321 .
  • van’t , L B , Blijlevens , N M , Marteijn , J , Timal , S Donnelly , J P . 2004 . Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury . Leukemia , 18 : 276 – 284 .
  • Venkatesan , N , Punithavathi , D and Arumugam , V . 2000 . Curcumin prevents adriamycin nephrotoxicity in rats . Br J Pharmacol , 129 : 231 – 234 .
  • Punithavathi , D , Venkatesan , N and Babu , M . 2000 . Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats . Br J Pharmacol , 131 : 169 – 172 .
  • Parshad , R , Sanford , K K , Price , F M , Steele , V E Tarone , R E . 1998 . Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells . Anticancer Res , 18 : 3263 – 3266 .
  • Srinivasan , M , Rajendra , P N and Menon , V P . 2006 . Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes . Mutat Res , 611 : 96 – 103 .
  • Kunwar , A , Narang , H , Priyadarsini , K I , Krishna , M Pandey , R . 2007 . Delayed activation of PKCdelta and NFkappaB and higher radioprotection in splenic lymphocytes by copper (II)-Curcumin (1:1) complex as compared to curcumin . J Cell Biochem ,
  • Abraham , S K , Sarma , L and Kesavan , P C . 1993 . Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage . Mutat Res , 303 : 109 – 112 .
  • Thresiamma , K C , George , J and Kuttan , R . 1998 . Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity . J Exp Clin Cancer Res , 17 : 431 – 434 .
  • Thresiamma , K C , George , J and Kuttan , R . 1996 . Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity . Indian J Exp Biol , 34 : 845 – 847 .
  • Inano , H and Onoda , M . 2002 . Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2′-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation . Int J Radiat Oncol Biol Phys , 53 : 735 – 743 .
  • Rezvani , M and Ross , G A . 2004 . Modification of radiation-induced acute oral mucositis in the rat . Int J Radiat Biol , 80 : 177 – 182 .
  • Jagetia , G C and Rajanikant , G K . 2004 . Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation . J Surg Res , 120 : 127 – 138 .
  • Jagetia , G C and Rajanikant , G K . 2004 . Effect of curcumin on radiation-impaired healing of excisional wounds in mice . J Wound Care , 13 : 107 – 109 .
  • Jagetia , G C and Rajanikant , G K . 2005 . Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation . Plast Reconstr Surg , 115 : 515 – 528 .
  • Okunieff , P , Xu , J , Hu , D , Liu , W Zhang , L . 2006 . Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines . Int J Radiat Oncol Biol Phys , 65 : 890 – 898 .

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