305
Views
30
CrossRef citations to date
0
Altmetric
Original Articles

Chlorella vulgaris Modulates Immunomyelopoietic Activity and Enhances the Resistance of Tumor-Bearing Mice

, &
Pages 1170-1180 | Received 31 Mar 2009, Accepted 13 Jul 2010, Published online: 06 Nov 2010

REFERENCES

  • Ibusuki , K and Minamishima , Y . 1990 . Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections . Natl Immun Cell Growth Regul , 9 : 121 – 128 .
  • Souza-Queiroz , J , Torello , C O , Palermo-Neto , J , Valadares , M C and Queiroz , M L . 2008 . Hematopoietic response of rats exposed to the impact of an acute psychophysiological stressor on responsiveness to an in vivo challenge with Listeria monocytogenes: modulation by Chlorella vulgaris prophylactic treatment . Brain Beh Imm , 22 : 1056 – 1065 .
  • Hasegawa , T , Matsuguchi , T , Noda , K , Tanaka , K Kumamoto , S . 2002 . Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris . Int Immunopharmacol , 2 : 579 – 589 .
  • Noda , K , Tanaka , K , Yamada , A , Ogata , J Tanaka , H . 2002 . Simple assay for antitumour immunoactive glycoprotein derived from Chlorella vulgaris strain CK22 using ELISA . Phytother Res , 16 : 581 – 585 .
  • Wu , L C , Ho , J A , Shieh , M C and Lu , I W . 2005 . Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts . J Agric Food Chem , 53 : 4207 – 4212 .
  • Cha , K H , Koo , S Y and Lee , D U . 2008 . Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells . J Agric Food Chem , 56 : 10521 – 10526 .
  • Tanaka , K , Tomita , Y , Tsuruta , M , Konishi , F Okuda , M . 1990 . Oral administration of Chlorella vulgaris augments concomitant antitumor immunity . Immunopharmacol Immunotoxicol , 12 : 277 – 291 .
  • Merchant , R E , Rice , C D and Young , H F . 1990 . Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects on immunocompetence, quality of life, and survival . Phytother Res , 4 : 220 – 231 .
  • Fecchio , D , Sirois , P , Russo , M and Jancar , S . 1990 . Studies on inflammatory response induced by Ehrlich tumor in mice peritoneal cavity . Inflammation , 14 : 125 – 132 .
  • Valadares , M C , Ramos , L R , Rehmann , F JK , Sweeney , N J Strohfeldt , K . 2006 . Antitumor activity of [1,2-di(cyclopentadienyl)-1,2-di(p-N,N-dimethylaminophenyl)-ethanediyl] titanium dichloride in xerografted Ehrlich's ascites tumor . Eur J Pharmacol , 534 : 264 – 270 .
  • Valadares , M C , Carrucha , S G , Accorsi , W and Queiroz , M L . 2006 . Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumor-bearing mice . Int Immunopharmacol , 6 : 294 – 299 .
  • Queiroz , M LS , Valadares , M C , Torello , C O , Ramos , A L Oliveira , A B . 2008 . Comparative studies of the effects of Tabebuia avellanedae bark extract and β-lapachone on the hematopoietic response of tumour-bearing mice . J Ethnopharmacol , 117 : 228 – 235 .
  • Queiroz , M LS , Torello , C O , Perhs , S MC , Rocha , M C Bechara , E JH . 2008 . Chlorella vulgaris up-modulation of myelossupression induced by lead: the role of stromal cells . Food Chem Toxicol , 46 : 3147 – 3154 .
  • Daniel , C P , Ponting , I L and Dexter , T M . 1989 . Growth and development of haemopoietic cells: a deterministic process? . Haematol Blood Transf , 32 : 172 – 177 .
  • Eaves , C J , Cashman , J D , Kay , R J , Dougherty , G J Otsuka , T . 1991 . Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer . Blood , 78 : 110 – 117 .
  • Herman , P , Ferrant , A , De Bruyere , M and Straetmans , N . 1998 . Stromal factors support the expansion of the whole hemopoietic spectrum from bone marrow CD34+DR– cells and of some hemopoietic subset from CD34+ and CD34+DR+ cells . Leukemia , 12 : 735 – 745 .
  • Olfert , E D , Cross , B M and McWilliam , A A . 1993 . Guide to the Care and Use of Experimental Animals , Vol. 1 , Ottawa, , Ontario, Canada : Canadian Council on Animal Care .
  • Tanaka , K , Koga , T , Konishi , F , Nakamura , M Mitsuyama , M . 1986 . Augmentation of host defense by a unicellular green alga, Chlorella vulgaris, to Escherichia coli infection . Infec Immun , 53 : 267 – 271 .
  • Metcalf , D . 1984 . “ The bioassay of colony-stimulating factors ” . In The Hematopoetic Colony-Stimulating Factors , 187 – 212 . Amsterdam : Elsevier .
  • Mosmann , T . 1983 . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays . J Immunol Methods , 65 : 55 – 63 .
  • Van Den Engh , G and Bol , S . 1975 . The presence of a CSF enhancing activity in the serum of endotoxin-treated mice . Cell Tiss Kinet , 8 : 579 – 587 .
  • Hauser , S P , Kajkenova , O and Lipschitz , D A . 1997 . The pivotal role of interleukin 6 in formation and function of hematopoietically active murine long-term bone marrow cultures . Stem Cells , 15 : 125 – 132 .
  • Bernad , A , Kopf , M , Kulbacki , R , Weich , N Koehler , G . 1994 . Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system . Immunity , 1 : 725 – 731 .
  • Muench , M O , Schneider , J G and Moore , M A . 1992 . Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells . Exp Hematol , 20 : 339 – 349 .
  • Kovacs , C J , Evans , M J , Daly , B M , Thomas-Patterson , D Johnke , R M . 1997 . Secondary cytokines interact in sequence with interleukin-1alpha (IL-1alpha) with or without macrophage colony-stimulating factor (M-CSF) to further accelerate granulopoietic recovery in myelosuppressed animals . J Interf Cytok Res , 17 : 453 – 460 .
  • Dinarello , C A . 1996 . Biologic basis for interleukin-1 in disease . Blood , 87 : 2095 – 2147 .
  • Lopez , D M , Lopez-Cepero , M , Watson , G A , Ganju , A Sotomayor , E M . 1991 . Modulation of the immune system by mammary tumor-derived factors . Cancer Invest , 9 : 643 – 653 .
  • Segura , J A , Barbero , L G and Márquez , J . 2000 . Ehrlich ascites tumor unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation . Immunol Lett , 74 : 111 – 115 .
  • Justo , G Z , Duran , N and Queiroz , M LS . 2000 . Myelopoietic response in tumor-bearing mice by an aggregated polymer isolated from Aspergillus oryzae . Eur J Pharmacol , 388 : 219 – 226 .
  • Donkor , M K , Lahue , E , Hoke , T A , Shafer , L R Coskun , U . 2009 . Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells . Int Immunopharmacol , 9 : 937 – 948 .
  • Oghiso , Y , Yamada , Y , Ando , K , Ishihara , H and Shibata , Y . 1993 . Differential induction of prostaglandin E2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSF . J Leukoc Biol , 53 : 86 – 92 .
  • Pessina , A , Brambilla , P , Villa , S , Marocchi , A and Mocarelli , P . 1982 . Factors produced by macrophages and tumor cells: Influence on the granulocytic precursors cells (CFU-C) in normal and tumor-bearing mice . J Cancer Res Oncol , 102 : 235 – 244 .
  • Subiza , J L , Vinuela , J E , Rodriguez , R , Gil , J Figueredo , M A . 1989 . Development of splenic natural suppressor (NS) cells in Ehrlich tumor-bearing mice . Int J Cancer , 44 : 307 – 314 .
  • Ruiz de Morales , J , Vélez , D and Subiza , J L . 1999 . Ehrlich tumor stimulates extramedullar hematopoiesis in mice without secreting identifiable colony-stimulating factors and without engagement of host T cells . Exp Hematol , 27 : 1757 – 1767 .
  • Turner , A M , Zsebo , K M , Martin , F , Jakobsen , F W Bennet , L G . 1992 . Non-hematopoietic tumor cell lines express stem cell factor and display c-kit receptors . Blood , 80 : 374 – 381 .
  • Staszewski , H . 1997 . Hematological paraneoplastic syndromes . Sem Oncol , 24 : 329 – 333 .
  • Scott , P and Trinchieri , G . 1995 . The role of natural killer cells in host-parasite interactions . Curr Opin Immunol , 7 : 34 – 40 .
  • Yamamoto , N , Zou , J P , Li , X F , Takenaka , H Noda , S . 1995 . Regulatory mechanisms for production of IFN-γ and TNF by antitumor T cells or macrophages in the tumor-bearing state . J Immunol , 154 : 2281 – 2290 .
  • Kuribayashi , K , Gillis , S , Kern , D E and Henney , C S . 1981 . Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity . J Immunol , 126 : 2321 – 2327 .
  • Misawa , E , Sakurai , T , Yamada , M , Hayasawa , H and Motoyoshi , K . 2000 . Effects of macrophage colony-stimulating factor and interleukin-2 administration on NK1.1(+) cells in mice . Int J Immunopharmacol , 22 : 967 – 977 .
  • Sayers , T J and Wiltrout , T A . 1989 . “ Differing roles for interleukin 2 and interferon γ in the augmentation of mouse peritoneal natural killer cell activity in vivo ” . In Natural Killer Cells and Host Defenses , Edited by: Ades , E W and Lopez , C . 88 – 91 . Basel .
  • Allavena , P , Scala , G , Djeu , J Y , Procopio , A D Oppenheim , J S . 1985 . Production of multiple cytokines by clones of human large granular lymphocytes . Cancer Immunol Immunother , 19 : 121 – 126 .
  • Svedersky , L P , Nedwin , G E , Goeddel , D V and Palladino , M A Jr. 1985 . Interferon-γ enhances induction of lymphotoxin in recombinant interleukin 2-stimulated peripheral blood mononuclear cells . J Immunol , 134 : 1604 – 1608 .
  • Ehrhardt , R O , Ludviksson , B R , Gray , B , Neurath , M and Strober , W . 1997 . Induction and prevention of chronic inflammation in IL-2-deficient mice . J Immunol , 158 : 566 – 573 .
  • Taniguchi , T , Matsui , H , Fujita , T , Takaoka , C Kashima , N . 1983 . Structure and expression of cloned cDNA for human interleukin-2 . Nature , 302 : 305 – 310 .
  • Licastro , F , Davis , L J and Morini , M C . 1993 . Lectins and superantigens: membrane interactions of these compounds with T lymphocytes affect immune responses . Int J Biochem , 25 : 845 – 852 .
  • Valadares , M C , Klein , S I and Queiroz , M LS . 2004 . Titanocene modulation of cytokine imbalance induced by Ehrlich ascites tumor progression . Eur J Pharmacol , 503 : 203 – 208 .
  • Parhar , R S and Lala , P K . 1985 . Changes in the host natural killer cell population in mice during tumor development. 1. Kinetics and in vivo significance . Cell Immunol , 93 : 250 – 264 .
  • Parhar , R S and Lala , P K . 1985 . Changes in the host natural killer cell population in mice during tumor development: 2. the mechanism of suppression of NK activity . Cell Immunol , 93 : 265 – 279 .
  • Yssel , H , De Wall Malefyt , R , Roncarolo , M , Abrams , J S Lahesmaa , R . 1992 . IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells . J Immunol , 149 : 2378 – 2384 .
  • Parhar , R S and Lala , P K . 1988 . Prostaglandin E2-mediated inactivation of various killer lineage cells by tumor-bearing host macrophages . J Leukoc Biol , 44 : 474 – 484 .
  • Seo , N , Hayakawa , S , Takigawa , M and Tokura , Y . 2001 . Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4+ T-regulatory cells and systemic collapse of antitumour immunity . Immunology , 103 : 449 – 457 .
  • Elexpuru , A , Martin-Nieto , J , Jimenez , A , Gomez , C and Villalobo , A . 1997 . Ehrlich ascites tumor cells produce a transforming growth factor-beta (TGF-β)-like activity but lack receptors with TGF-β-binding capacity . Mol Cell Biochem , 170 : 153 – 162 .
  • Young , M R , Wright , M A and Pandit , R . 1997 . Myeloid differentiation treatment to diminish the presence of immune-suppressive CD34+ cells within human head and neck squamous cell carcinomas . J Immunol , 159 : 990 – 996 .
  • Fung , K P , Lam , W P , Choy , Y M and Lee , C Y . 1995 . Human tumour necrosis factor-alpha inhibits glucose transport in cultured Ehrlich ascites tumour cells . Life Sci , 57 : PL1 – PL6 .
  • Obrador , E , Navarro , J , Mompo , J , Asensi , M Pellicer , J A . 1998 . Regulation of tumour cell sensitivity to TNF-induced oxidative stress and cytotoxicity: role of glutathione . Biofactors , 8 : 23 – 26 .
  • Sugarman , B J , Aggarwal , B B and Figari , I S . 1985 . Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro . Science , 230 : 943 – 945 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.