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Original Articles

Studies on the Chemopreventive Effect of Carnitine on Tumorigenesis In Vivo, Using Two Experimental Murine Models of Colon Cancer

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Pages 1279-1287 | Received 12 Apr 2011, Accepted 09 Jul 2012, Published online: 19 Nov 2012

REFERENCES

  • Marshall , J R . 2008 . Prevention of colorectal cancer: Diet, chemoprevention, and lifestyle . Gastro Clin N Am , 37 : 73 – 82 .
  • Frezza , E E , Wachtel , M S and Chiriva-Internati , M . 2006 . Influence of obesity on the risk of developing colon cancer . Gut , 55 : 285 – 291 .
  • Norat , T , Chan , D , Lau , R , Aune , D and Vieira , R . The associations between food, nutrition and physical activity and the risk of colorectal cancer . WCRF/AICR Systematic Literature Review Continuous Update Project Report , http://www.wcrf.org/PDFs/Colorectal-cancer-CUP-report-2010
  • Calle , E E and Kaaks , R . 2004 . Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms . Nat Rev Cancer , 4 : 579 – 591 .
  • Sedjo , R L , Byers , T , Barrera , E , Cohen , C Fontham , E TH . 2007 . A midpoint assessment of the American Cancer Society Challenge goal to decrease cancer incidence by 25% between 1992 and 2015 . CA Cancer J Clin , 57 : 326 – 340 .
  • Escrich , E , Moral , R , Grau , L , Costa , I and Solanas , M . 2007 . Molecular mechanisms of the effect of olive oil and other dietary lipids on cancer . Mol Nutr Food Res , 51 : 1279 – 1292 .
  • Weijenberg , M P , Luchtenborg , M , de Goeij , A F , Brink , M van Muijen , G N . 2007 . Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes . Cancer Cause Control , 18 : 865 – 879 .
  • Corpet , D E and Pierre , F . 2003 . Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in Min mice and choice of the model system . Cancer Epidemiol Biomarkers & Prev , 12 : 391 – 400 .
  • Rosenberg , D W , Giardina , C and Tanaka , T . 2009 . Mouse models for the study of colon carcinogenesis . Carcinogenesis , 30 : 183 – 196 .
  • Taketo , M M and Edelmann , W . 2009 . Mouse models of colon cancer . Gastroenterology , 136 : 780 – 796 .
  • Wasan , H S , Novelli , M and Bodmer , W F . 1997 . Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice . Proc Natl Acad Sci USA , 94 : 3308 – 3313 .
  • Yu , C F , Whiteley , L , Carryl , O and Basson , M D . 2001 . Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice . Dig Dis Sci , 46 : 1367 – 1380 .
  • Yang , K , Kurihara , N , Fan , K , Newmark , H Rigas , B . 2008 . Dietary induction of colonic tumors in a mouse model of sporadic colon cancer . Cancer Res , 68 : 7803 – 7810 .
  • Fujise , T , Iwakiri , R , Kakimoto , T , Shiraishi , R Sakata , Y . 2007 . Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats . Am J Physiol , 292 : G1150 – G1156 .
  • Larsson , S C , Kumlin , M , Ingelman-Sundberg and Wolk , A . 2004 . Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms . Am J Clin Nutr 79 , : 935 – 945 .
  • Mai , V , Colbert , L H , Berrigan , D , Perkins , S N Pfeiffer , R . 2003 . Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in APC (Min) mice through different mechanisms . Cancer Research , 63 : 1752 – 1755 .
  • Tein , I . 2003 . Carnitine transport: pathophysiology and metabolism of known molecular defects . J Inherit Metab Dis , 26 : 147 – 169 .
  • Lahjouji , K , Mitchell , G A and Qureshi , I A . 2001 . Carnitine transport by organic cation transporters and systemic carnitine deficiency . Mol Genet Metab , 73 : 287 – 297 .
  • Penn , D , Dolderer , M and Schmidt-Sommerfeld , E . 1987 . Carnitine concentrations in the milk of different species and infant formulas . Biol Neonate , 52 : 70 – 79 .
  • Gülçin , I . 2006 . Antioxidant and antiradical activities of L-carnitine . Life Sci , 78 : 803 – 811 .
  • Flanagan , J L , Simmons , P A , Vehige , J , Willcox , M DP and Garrett , Q . 2010 . Role of carnitine in disease . Nutr Metab , 7 : 30
  • Peluso , G , Nicolai , R , Reda , E , Benatti , P , Barbarisi , A and Calvani , M . 2000 . Cancer and anticancer therapy–induced modifications on metabolism mediated by carnitine system . J Cell Physiol , 182 : 339 – 350 .
  • Roy , M J , Dionne , S , Marx , G , Qureshi , I Sarma , D . 2009 . In vitro studies on the inhibition of colon cancer by butyrate and carnitine . Nutrition , 25 : 1193 – 1201 .
  • Moser , A R , Pitot , H C and Dove , W F . 1990 . A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse . Science , 247 : 322 – 324 .
  • Bird , R P . 1987 . Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary finding . Cancer Lett , 37 : 147 – 151 .
  • Paulsen , J E , Namork , E , Steffensen , I L , Eide , T J and Alexander , J . 2000 . Identification and quantification of aberrant crypt foci in the colon of Min mice: a murine model of familial adenomatous polyposis . Scand J Gastroenterol , 35 : 534 – 539 .
  • Ward , J M . 1974 . Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats . Laboratory Investigation , 30 : 505 – 513 .
  • Hoppel , C L . 1991 . “ Determination of free carnitine ” . In Techniques in Diagnostic Human Biochimical Genetics , Edited by: Hommes , F A . 309 – 326 . New York : Wiley-Liss .
  • Qureshi , I A , Ratnakumari , L , Michalak , A , Giguère , A , Cyr , D and Butterworth , R F . 1993 . A profiles of cerebral and hepatic carnitine, ammonia and energy metabolism in a model of organic aciduria: BALB/cByJ mouse with short-chain Acyl-CoA dehydrogenase deficiency . Bioch Med Met Biol , 50 : 145 – 158 .
  • Lowry , O , Rosenrough , N J , Farr , A L and Randall , R J . 1951 . Protein measurement with the folin phenol reagent . J Biol Chem , 193 : 265 – 274 .
  • Kalaria , R N and Harik , S I . 1992 . Carnitine acetyltransferase activity in the human brain and its microvessels is decrease in Alzheimer's disease . Ann Neurol , 32 : 583 – 586 .
  • Takahashi , M and Wakabayashi , K . 2004 . Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents . Cancer Sci , 95 : 475 – 780 .
  • Chen , J and Huang , X F . 2009 . The signal pathways in azoxymethane-induced colon cancer and preventive implications . Cancer Biol Ther , 8 : 1313 – 1317 .
  • Tucker , J M , Davis , C , Kitchens , M E , Bunni , M A Priest , D G . 2002 . Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice . Cancer Lett , 187 : 153 – 162 .
  • Hinoi , T , Akyol , A , Theisen , B K , Ferguson , D O Greenson , J K . 2007 . Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation . Cancer Res , 67 : 9721 – 9730 .
  • Wenzel , U , Nickel , A and Daniel , H . 2005 . Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induce apoptosis . J Nutr , 135 : 1510 – 1514 .
  • Takeshita , M , Ueda , H , Shirabe , K , Higuchi , Y and Yoshida , S . 1997 . Lack of promotion of colon carcinogenesis by high-oleic safflower oil . Cancer , 79 : 1487 – 1493 .
  • Murphy , E A , Davis , J M , McLellan , J L , Gordon , B T and Carmichael , M D . 2011 . Curcumin's effect on intestinal inflammation and tumorigenesis in the ApcMin/+ mouse . J Interferon Cytokine Res , 31 : 219 – 226 .
  • Roy , H K , Gulizia , J M , Karolski , W J , Ratashak , A , Sorrell , M F and Tuma , D . 2002 . Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia . Cancer Epidemiol Biomark Prev , 11 : 1499 – 1502 .
  • Huerta , S , Irwin , R W , Heber , D , Go , V LW Koeffler , H P . 2002 . 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse . Cancer Res , 62 : 741 – 746 .
  • Li , Y , Kundu , P , Seow , S W , Teixera de Matos , C Aronsson , L . 2012 . Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice . Carcinogenesis , Mar 29 [Epub ahead of print]
  • Colnot , S , Niwa-Kawakita , M , Hamard , G , Godard , C Le Plenier , S . 2004 . Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers . Lab Invest , 84 : 1619 – 1630 .
  • D’Argenio , G , Calvani , M , Casamassimi , A , Petillo , O Margarucci , S . 2006 . Experimental colitis: decreased Octn2 and Atb0 + expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes . FASEB J , 20 : E1878 – E1989 .
  • Fortin , G , Yurchenko , K , Collette , C , Rubio , M Villani , A-C . 2009 . L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation . Clin Exp Immunol , 156 : 161 – 171 .
  • Shekhawat , P S , Srinivas , S R , Matern , D , Bennett , M J Boriack , R . 2007 . Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient JVS (OCTN2-/-) mice . Mol Genet Metab , 92 : 315 – 324 .
  • Chang , B , Nishikawa , M , Nishiguchi , S and Inoue , M . 2005 . L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria . Int J Cancer , 113 : 719 – 729 .
  • Ashokkumar , P and Sudhandiran , G . 2008 . Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis . Biomed Pharmacother , 62 : 590 – 597 .
  • Seifert , E L , Estey , C , Xuan , J Y and Harper , M E . 2010 . Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long chain fatty acids oxidation . J Biol Chem , 285 : 5748 – 5758 .
  • Hwang , B , Jeoung , N H and Harris , R A . 2009 . Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet . Biochem J , 423 : 243 – 252 .
  • Koves , T R , Ussher , J R , Noland , R C , Slentz , S Mosedale , M . 2008 . Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance . Cell Metabolism , 7 : 45 – 56 .
  • St-Pierre , J , Drori , S , Uldry , M , Silvaggi , J M Rhee , J . 2006 . Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators . Cell , 127 : 397 – 408 .
  • Noland , R C , Koves , T R , Seiler , S E , Lum , H Lust , R M . 2009 . Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control . J Biol Chem , 284 : 22840 – 22852 .
  • Zhang , J , Wu , G , Chapkin , R S and Lupton , J R . 1998 . Energy metabolism of rat colonocytes changes during the tumorigenic process and is dependent on diet and carcinogen . J Nutr , 128 : 1262 – 1269 .
  • Hamer , H M , Jonkers , D , Venema , K , Vanhoutin , S Troost , F J . 2008 . Review article: The role of butyrate on colonic function . Aliment Pharmacol Ther , 27 : 104 – 119 .
  • Sengupta , S , Muir , J G and Gibson , P R . 2006 . Does butyrate protect from colorectal cancer? . J Gastroenterol Hepatol , 21 : 209 – 218 .
  • Fan , J P , Kim , H S and Han , G D . 2009 . “ Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells ” . In Amino Acids Vol. 36 , 365 – 372 .
  • Giugliano , D , Ceriello , A and Esposito , K . 2006 . The effects of diet on inflammation: Emphasis on the metabolic syndrome . J Am Coll Cardiol , 48 : 677 – 685 .
  • Pisano , C , Vesci , L , Milazzo , F M , Guglielmi , M B Foderà , R . 2010 . Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine . Clin Cancer Res , 16 : 3944 – 3953 .
  • Al-Rejaie , S S , Aleisa , A M , Al-Yahya , A and Alsheikh Bakheet , S A . 2009 . Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats . World J Gastroenterol , 15 : 1373 – 1380 .
  • Makowski , L , Noland , R C , Koves , T R , Xing , W Ilkayeva , O R . 2009 . Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation . FASEB J , 23 : 586 – 604 .
  • Sanders , L M , Henderson , C E , Hong , M Y Burghardt Barhoumi , R . 2004 . Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility . Cancer Letters , 208 : 155 – 161 .
  • Hong , M Y , Turner , N D , Carroll , R J , Chapkin , R S and Lupton , J R . 2005 . Differential response to DNA damage may explain cancer susceptibility between small and large intestine . Exp Biol Med , 230 : 464 – 471 .
  • Maccari , F , Arseni , A , Chiodi , P , Ramacci , M T and Angelucci , L . 1990 . Levels of carnitines in brain and other tissues of rats of different ages: effect of acetyl-L-carnitine administration . Exp Gerontol , 25 : 127 – 134 .
  • Karlic , H , Lohninger , S , Koeck , T and Lohninger , A . 2002 . Dietary L-carnitine stimulates carnitine acyltransferases in the liver of aged rats . J Histochem Cytochem , 50 : 205 – 212 .

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