Selective Cytotoxicity and Combined Effects of Camptothecin or Paclitaxel with Sodium-R-Alpha Lipoate on A549 Human Non-Small Cell Lung Cancer Cells

REFERENCES

• Ferlay , J , Shin , H R , Bray , F , Forman , D Mathers , C . 2010 . Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 . Int J Cancer , 127 : 2893 – 2917 .
   PubMed Web of Science ®Google Scholar
• Dempke , W C , Suto , T and Reck , M . 2010 . Targeted therapies for non-small cell lung cancer . Lung Cancer , 67 : 257 – 274 .
   PubMed Web of Science ®Google Scholar
• Links , M and Lewis , C . 1999 . Chemoprotectants, a review of their clinical pharmacology and therapeutic efficacy . Drugs , 57 : 293 – 308 .
   PubMed Web of Science ®Google Scholar
• Ghibu , S , Richard , C , Vergely , C , Zeller , M Cottin , Y . 2009 . Antioxidant properties of an endogenous thiol, Alpha-lipoic acid, useful in the prevention of cardiovascular diseases . J Cardiovasc Pharmacol , 54 : 391 – 398 .
   PubMed Web of Science ®Google Scholar
• Biewenga , G P , Haenen , G R and Bast , A . 1997 . The pharmacology of the antioxidant lipoic acid . Gen Pharmacol , 29 : 315 – 331 .
   PubMedGoogle Scholar
• Vallianou , N , Evangelopoulos , A and Koutalas , P . 2009 . Alpha-lipoic Acid and diabetic neuropathy . Rev Diabet Stud , 6 : 230 – 236 .
   PubMedGoogle Scholar
• Bustamante , J , Lodge , J K , Marcocci , L , Tritschler , H J Packer , L . 1998 . Alpha-lipoic acid in liver metabolism and disease . Free Radic Biol Med , 24 : 1023 – 1039 .
   PubMed Web of Science ®Google Scholar
• Suzuki , Y J , Aggarwal , B B and Packer , L . 1992 . Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells . Biochem Biophys Res Commun , 189 : 1709 – 1715 .
   PubMed Web of Science ®Google Scholar
• Wenzel , U , Nickel , A and Daniel , H . 2005 . alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation . Apoptosis , 10 : 359 – 368 .
   PubMed Web of Science ®Google Scholar
• Na , M H , Seo , E Y and Kim , W K . 2009 . Effects of alpha-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells . Nutr Res Pract , 3 : 265 – 271 .
   PubMed Web of Science ®Google Scholar
• Dozio , E , Ruscica , M , Passafaro , L , Dogliotti , G Steffani , L . 2010 . The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells . Eur J Pharmacol , 641 : 29 – 34 .
   PubMed Web of Science ®Google Scholar
• Choi , S Y , Yu , J H and Kim , H . 2009 . Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells . Ann NY Acad Sci , 1171 : 149 – 155 .
   PubMed Web of Science ®Google Scholar
• Abolhassani , M , Guais , A , Sanders , E , Campion , F Fichtner , I . 2011 . Screening of well-established drugs targeting cancer metabolism, reproducibility of the efficacy of a highly effective drug combination in mice . Invest New Drugs , 30 : 1331 – 1342 .
   PubMed Web of Science ®Google Scholar
• Guais , A , Baronzio , G , Sanders , E , Campion , F Mainini , C . 2012 . Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development, experimental results and case report . Invest New Drugs , 30 : 200 – 211 .
   PubMed Web of Science ®Google Scholar
• Isidoro , A , Martinez , M , Fernandez , P L , Ortega , A D Santamaria , G . 2004 . Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer . Biochem J , 378 : 17 – 20 .
   PubMed Web of Science ®Google Scholar
• Papandreou , I , Goliasova , T and Denko , N C . 2011 . Anticancer drugs that target metabolism: is dichloroacetate the new paradigm? . Int J Cancer , 128 : 1001 – 1008 .
   PubMed Web of Science ®Google Scholar
• Korotchkina , L G , Sidhu , S and Patel , M S . 2004 . R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase . Free Radic Res , 38 : 1083 – 1092 .
   PubMed Web of Science ®Google Scholar
• Michelakis , E D , Webster , L and Mackey , J R . 2008 . Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer . Br J Cancer , 99 : 989 – 994 .
   PubMed Web of Science ®Google Scholar
• Tong , J , Xie , G , He , J , Li , J Pan , F . 2011 . Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer . J Biomed Biotechnol , 2011 : 740564
   PubMed Web of Science ®Google Scholar
• Fiebiger , W , Olszewski , U , Ulsperger , E , Geissler , K and Hamilton , G . 2011 . In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines . Clin Transl Oncol , 13 : 43 – 49 .
   PubMed Web of Science ®Google Scholar
• Goraca , A , Huk-Kolega , H , Piechota , A , Kleniewska , P Ciejka , E . 2011 . Lipoic acid - biological activity and therapeutic potential . Pharmacol Rep , 63 : 849 – 858 .
   PubMed Web of Science ®Google Scholar
• Mervaala , E , Finckenberg , P , Lapatto , R , Muller , D N Park , J K . 2003 . Lipoic acid supplementation prevents angiotensin II-induced renal injury . Kidney Int , 64 : 501 – 508 .
   PubMed Web of Science ®Google Scholar
• Carlson , D A , Smith , A R , Fischer , S J , Young , K L and Packer , L . 2007 . The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects . Altern Med Rev , 12 : 343 – 351 .
   PubMed Web of Science ®Google Scholar
• Smith , J R , Thiagaraj , H V , Seaver , B and Parker , K K . 2005 . Differential activity of lipoic acid enantiomers in cell culture . J Herb Pharmacother , 5 : 43 – 54 .
   PubMedGoogle Scholar
• Loffelhardt , S , Bonaventura , C , Locher , M , Borbe , H O and Bisswanger , H . 1995 . Interaction of alpha-lipoic acid enantiomers and homologues with the enzyme components of the mammalian pyruvate dehydrogenase complex . Biochem Pharmacol , 50 : 637 – 646 .
   PubMed Web of Science ®Google Scholar
• Pizzolato , J F and Saltz , L B . 2003 . The camptothecins . Lancet , 361 : 2235 – 2242 .
   PubMed Web of Science ®Google Scholar
• O’Brien , M , Eckardt , J and Ramlau , R . 2007 . Recent advances with topotecan in the treatment of lung cancer . Oncologist , 12 : 1194 – 1204 .
   PubMed Web of Science ®Google Scholar
• Deshmukh , M , Chao , P , Kutscher , H L , Gao , D and Sinko , P J . 2010 . A series of alpha-amino acid ester prodrugs of camptothecin, in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity . J Med Chem , 53 : 1038 – 1047 .
   PubMed Web of Science ®Google Scholar
• Chao , P , Deshmukh , M , Kutscher , H L , Gao , D Rajan , S S . 2010 . Pulmonary targeting microparticulate camptothecin delivery system, anticancer evaluation in a rat orthotopic lung cancer model . Anticancer Drugs , 21 : 65 – 76 .
   PubMed Web of Science ®Google Scholar
• Lalloo , A , Chao , P , Hu , P , Stein , S and Sinko , P J . 2006 . Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins . J Control Release , 112 : 333 – 342 .
   PubMed Web of Science ®Google Scholar
• Paranjpe , P V , Stein , S and Sinko , P J . 2005 . Tumor-targeted and activated bioconjugates for improved camptothecin delivery . Anticancer Drugs , 16 : 763 – 775 .
   PubMed Web of Science ®Google Scholar
• Paranjpe , P V , Chen , Y , Kholodovych , V , Welsh , W Stein , S . 2004 . Tumor-targeted bioconjugate based delivery of camptothecin, design, synthesis and in vitro evaluation . J Control Release , 100 : 275 – 292 .
   PubMed Web of Science ®Google Scholar
• Zimmer , G , Beikler , T K , Schneider , M , Ibel , J Tritschler , H . 1995 . Dose/response curves of lipoic acid R-and S-forms in the working rat heart during reoxygenation, superiority of the R-enantiomer in enhancement of aortic flow . J Mol Cell Cardiol , 27 : 1895 – 1903 .
   PubMed Web of Science ®Google Scholar
• Chou , T C . 2010 . Drug combination studies and their synergy quantification using the Chou-Talalay method . Cancer Res , 70 : 440 – 446 .
   PubMed Web of Science ®Google Scholar
• Yoon , M J , Kim , E H , Lim , J H , Kwon , T K and Choi , K . 2010 . Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells . Free Radic Biol Med , 48 : 713 – 726 .
   PubMed Web of Science ®Google Scholar
• Das , A , Banik , N L and Ray , S K . 2010 . Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes . Cancer , 116 : 164 – 176 .
   PubMed Web of Science ®Google Scholar
• Manson , M M , Farmer , P B , Gescher , A and Steward , W P . 2005 . Innovative agents in cancer prevention . Recent Results Cancer Res , 166 : 257 – 275 .
   PubMedGoogle Scholar
• Yamasaki , M , Kawabe , A , Nishimoto , K , Madhyastha , H Sakakibara , Y . 2009 . Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid . In Vitro Cell Dev Biol Anim , 45 : 275 – 280 .
   PubMed Web of Science ®Google Scholar
• Minko , T , Paranjpe , P V , Qiu , B , Lalloo , A Won , R . 2002 . Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells . Cancer Chemother Pharmacol , 50 : 143 – 150 .
   PubMed Web of Science ®Google Scholar
• Lalloo , A K , Luo , F R , Guo , A , Paranjpe , P V Lee , S H . 2004 . Membrane transport of camptothecin, facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2) . BMC Med , 2 : 16
   PubMed Web of Science ®Google Scholar