Molecular Approaches Toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and Other Signal Pathways

REFERENCES

• Aggarwal , B B , Danda , D , Gupta , S and Gehlot , P . 2009 . Models for prevention and treatment of cancer: Problems vs promises . Biochem Pharmacol , 78 : 1083 – 1094 .
   PubMed Web of Science ®Google Scholar
• American Cancer Society . ACS statistics. Retrieved from http://www.cancer.org
   Google Scholar
• Cragg , G M , Newman , D J and Weiss , R B . 1997 . Coral reefs, forests, and thermal vents: the worldwide exploration of nature for novel antitumor agents . Semin Oncol , 24 : 156 – 163 .
   PubMed Web of Science ®Google Scholar
• Cragg , G M , Kingston , D GI and Newman , D J . 2005 . Anticancer Agents from Natural Products , Boca Raton , FL : Brunner-Routledge .
   Google Scholar
• Newman , D J and Cragg , G M . 2007 . Natural products as sources of new drugs over the last 25 years . J Nat Prod , 70 : 461 – 477 .
   PubMed Web of Science ®Google Scholar
• Milner , J A . 2004 . Molecular targets for bioactive food components . J Nutr , 134 : 2492 – 2498 .
   PubMed Web of Science ®Google Scholar
• Bhanot , A , Sharma , R and Malleshappa , N N . 2011 . Natural sources as potential anti-cancer agents: A review . International Journal of Phytomedicine , 3 : 9 – 26 .
   Google Scholar
• Ohigashi , H , Osawa , T , Terao , J , Watanable , S and Yoshikawa , T . 1997 . Food Factors for Cancer Prevention Tokyo , Japan : Springer-Verlag .
   Google Scholar
• American Inst. for Cancer Research . 1997 . Food, nutrition and the prevention of cancer: A global perspective . Menasha Wis.: BANTA Book Group
   Google Scholar
• Mathers , J C , Coxhead , J M and Tyson , J . 2007 . Nutrition and DNA repair-potential molecular mechanisms of action . Current Cancer Drug Targets , 5 : 425 – 431 .
   Google Scholar
• Martin , K R . 2007 . Using nutrigenomics to evaluate apoptosis as a preemptive target in cancer prevention . Current Cancer Drug Targets , 5 : 438 – 446 .
   Google Scholar
• Li , Y , Ahmed , F , Ali , S , Philip , P A Kucuk , O . 2005 . Inactivation of nuclear facto kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells . Cancer Res , 65 : 6934 – 6942 .
   PubMed Web of Science ®Google Scholar
• Rosin , A P , Anwar , W A and Ward , A J . 1994 . Inflammation, chromosomal instability, and cancer: the schistosomiasis model . Cancer Res , 54 : 1929 – 1933 .
   PubMed Web of Science ®Google Scholar
• Baldwin , A S . 1996 . The NF-κB and IκB proteins: new discoveries and insights . Ann Rev Immunol , 14 : 649 – 681 .
   PubMed Web of Science ®Google Scholar
• Pahl , H L . 1999 . Activators and target genes of Rel/NF-kB transcription factors . Oncogene , 18 : 6853 – 6866 .
   PubMed Web of Science ®Google Scholar
• Cal , C , Garban , H , Jazirehi , A , Yeh , C Mizutani , Y . 2003 . Resveratrol and cancer: chemoprevention, apoptosis and chemoimmunosensitizing activities . Anticancer Agents , 3 : 77 – 93 .
   PubMedGoogle Scholar
• Estrov , Z , Shishodia , S , Faderl , S , Harris , D Van , Q . 2003 . Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells . Blood , 102 : 987 – 995 .
   PubMed Web of Science ®Google Scholar
• Horton , J W , White , D J , Maass , D L , Hybki , D P Haudek , S . 2001 . Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-κB activation and cardiomyocyte cytokine secretion . J Trauma , 50 : 397 – 408 .
   PubMed Web of Science ®Google Scholar
• Bowie , A G and O’Neill , L A . 2000 . Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase . J Immunol , 165 : 7180 – 7188 .
   PubMed Web of Science ®Google Scholar
• Martin , K R , Wu , D and Meydani , M . 2000 . The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells . Atherosclerosis , 150 : 265 – 274 .
   PubMed Web of Science ®Google Scholar
• Chakraborty , D , Bishayee , K , Ghosh , S , Biswas , R Mandal , S K . 2012 . [6]-Gingerol induces caspase-3 dependent apoptosis and autophagy in cancer cells: Drug-DNA interaction and expression of certain signal genes in HeLa cells . Eur J Pharmacol , 694 : 20 – 29 .
   PubMed Web of Science ®Google Scholar
• Lee , Y R , Noh , E M , Han , J H , Kim , JM, , Hwang , B M Kim , BS, . 2013 . Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells . BMB Rep , 46 : 201 – 206 .
   PubMed Web of Science ®Google Scholar
• Bergman , M , Varshavsky , L , Gottlieb , H E and Grossman , S . 2001 . The antioxidant activity of aqueous spinach extract: chemical identification of active fractions . Phytochemistry , 58 : 143 – 152 .
   PubMed Web of Science ®Google Scholar
• Ohshima , H , Tazawa , H , Sylla , B S and Sawa , T . 2005 . Prevention of human cancer by modulation of chronic inflammatory processes . Mutat Res , 591 : 110 – 122 .
   PubMed Web of Science ®Google Scholar
• Eyfjord , J E and Bodvarsdottir , S K . 2005 . Genomic instability and cancer: networks involved in response to DNA damage . Mutat Res , 592 : 18 – 28 .
   PubMed Web of Science ®Google Scholar
• Kondo , S , Toyokuni , S , Iwasa , Y , Tanaka , T Onodera , H . 1999 . Persistent oxidative stress in human colorectal carcinoma but not in adenoma . Free Radic Biol Med , 27 : 401 – 410 .
   PubMed Web of Science ®Google Scholar
• Toyokuni , S , Okamoto , K , Yodoi , J and Hiai , H . 1995 . Persistent oxidative stress in cancer . FEBS Lett , 358 : 1 – 3 .
   PubMed Web of Science ®Google Scholar
• Huang , S C , Ho , C T , Lin-Shiau , S Y and Lin , J K . 2005 . Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kB and c-Jun . Biochem Pharmacol , 69 : 221 – 232 .
   PubMed Web of Science ®Google Scholar
• Bishayee , A , Barnes , K F , Bhatia , D , Darvesh , A S and Caroll , R T . 2010 . Resveratrol suppresses oxidative stress and inflammatory response in diethyl nitrosamine-initiated Rat hepatocarcinogenesis . Cancer Prevention Research , 3 : 753 – 763 .
   PubMed Web of Science ®Google Scholar
• Han , D H , Lee , M J and Kim , J H . 2006 . Antioxidant and apoptosis-inducing activities of ellagic acid . Anticancer Res , 26 : 3601 – 3606 .
   PubMed Web of Science ®Google Scholar
• Pham , N A , Jacobberger , J W , Schimmer , A D , Cao , P Gronda , M . 2004 . The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice . Mol Cancer Ther , 3 : 1239 – 1248 .
   PubMed Web of Science ®Google Scholar
• Lee , Y J and Lee , S H . 2011 . Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells . J Korean Med Sci , 26 : 1474 – 1482 .
   PubMed Web of Science ®Google Scholar
• Girdhani , S , Bhosle , S M , Thulsidas , S A , Kumar , A and Mishra , K P . 2005 . Potential of radiosensitizing agents in cancer chemo-radiotherapy . J Cancer Res Ther , 1 : 129 – 131 .
   PubMedGoogle Scholar
• Oliveira , P C , Kassab , P , Lopasso , F P , Souza , H P Janiszioski , M . 2003 . Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress . World J Gastroenterol , 9 : 446 – 448 .
   PubMed Web of Science ®Google Scholar
• Chapple , K S , Cartwright , E J , Hawcroft , G , Tisbury , A Bonifer , C . 2000 . Localization of cyclooxygenase-2 in human sporadic colorectal adenomas . Am J Pathol , 156 : 545 – 553 .
   PubMed Web of Science ®Google Scholar
• Wu , T . 1755, 2005 . Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma . Biochim Biophys Acta , : 135 – 150 .
   Google Scholar
• Mazhar , D , Gillmore , R and Waxman , J . 2005 . COX and cancer . Q J Med , 98 : 711 – 718 .
   Google Scholar
• Lee , Y K , Park , S Y , Kim , Y M and Park , O J . 2009 . Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells . Ann N Y Acad Sci. , 1171 : 489 – 494 .
   PubMed Web of Science ®Google Scholar
• Lomnitski , L , Foley , J , Grossman , S , Shaul , V B Maronpot , R R . 2000 . Effects of apocynin and natural antioxidant from spinach on inducible nitric oxide synthase and cyclooxygenase-2 induction in lipopolysaccharide-induced hepatic injury in rat . Pharmacol Toxicol , 87 : 18 – 25 .
   PubMedGoogle Scholar
• Edderkaoui , M , Odinokova , I , Ohno , I , Gukovsky , I Go , V L . 2008 . Ellagic acid induces apoptosis through inhibition of nuclear factor kB in pancreatic cancer cells . World J Gastroenterol , 14 : 3672 – 3680 .
   PubMed Web of Science ®Google Scholar
• Yan , X , Murphy , B T , Hammond , G B , Vinson , J A and Neto , C C . 2002 . Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon) . J Agric Food Chem , 50 : 5844 – 5849 .
   PubMed Web of Science ®Google Scholar
• Kim , E C , Min , J K , Kim , T Y , Lee , S J Yang , H O . 2005 . [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo . Biochem Biophys Res Commun , 335 : 300 – 308 .
   PubMed Web of Science ®Google Scholar
• Lang , A , Lahav , M , Sakhnini , E , Barshack , I Fidder , H H . 2004 . Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells . Clin Nutr , 23 : 1199 – 1208 .
   PubMed Web of Science ®Google Scholar
• Ademola , A O , Adebowale , B S and Odunayo , J A . 2010 . Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention . Biofactors , 201 : 169 – 178 .
   Google Scholar
• Cornelio , F D , Martins , Teixeira M , Lemos-de , A E and de-Freitas , C C . 2013 . Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice . Mediators Inflamm , 2013 : 164202 doi: 10.1155/2013/164202
   PubMed Web of Science ®Google Scholar
• Shen , F , Chen , S J , Dong , X J , Zhong , H Li , Y T . 2003 . Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells . J Asian Nat Prod Res , 5 : 151 – 157 .
   PubMed Web of Science ®Google Scholar
• Vivanco , I and Sawyers , C L . 2002 . The phosphatidylinositol 3-kinase AKT pathway in human cancer . Nat Rev Cancer , 2 : 489 – 501 .
   PubMed Web of Science ®Google Scholar
• Engelman , J A , Luo , J and Cantley , L C . 2006 . The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism . Nat Rev Genet , 7 : 606 – 619 .
   PubMed Web of Science ®Google Scholar
• Yap , T A , Garrett , M D , Walton , M I , Raynaud , F Bono , J S . 2008 . Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises . Curr Opin Pharmacol , 8 : 393 – 412 .
   PubMed Web of Science ®Google Scholar
• Ramos , S . 2007 . Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention . J Nutr Biochem , 18 : 427 – 442 .
   PubMed Web of Science ®Google Scholar
• Dhillon , A S , Hagan , S , Rath , O and Kolch , W . 2007 . MAP kinase signalling pathways in cancer . Oncogene , 26 : 3279 – 3290 .
   PubMed Web of Science ®Google Scholar
• Wang , W , Wang , X , Peng , L , Deng , Q Liang , Y . 2010 . CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation . Cancer Sci , 101 : 112 – 119 .
   PubMed Web of Science ®Google Scholar
• Roy , S K , Srivastava , R K and Shankar , S . 2010 . Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer . J Mol Signal , 5 : 10
   PubMedGoogle Scholar
• Corona , G , Spencer , J P and Dessi , M A . 2009 . Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract . Toxicol Ind Health , 25 : 285 – 293 .
   PubMed Web of Science ®Google Scholar
• Olsen , B B , Biorling-Poulsen , M and Guerra , B . 2007 . Emodin negatively affects the phosphoinositide-3-kinase/Akt signalling pathway: a study on its mechanism of action . Int J Biochem Cell Biol , 39 : 227 – 237 .
   PubMed Web of Science ®Google Scholar
• Sun , F , Zheng , X Y , Ye , J , Wu , T T Wang , J L . 2012 . Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo . Nutr Cancer , 64 : 599 – 606 .
   PubMed Web of Science ®Google Scholar
• Presta , M , Dell’Era , P , Mitola , S , Moroni , E Ronca , R . 2005 . Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis . Cytokine Growth Factor Rev , 16 : 159 – 178 .
   PubMed Web of Science ®Google Scholar
• Ii , M , Yamamoto , H , Adachi , Y , Maruyama , Y and Shinomura , Y . 2006 . Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth and angiogenesis . Exp Biol Med , 231 : 20 – 27 .
   PubMed Web of Science ®Google Scholar
• Stakleff , K S , Blanco , D , Marcanthony , S , Booth , T D and Bishayee , A . 2012 . Resveratrol exerts differential effects in vitro and in vivo against ovarian cancer cells . Asian Pacific J Cancer Prev , 13 : 1333 – 1340 .
   PubMed Web of Science ®Google Scholar
• Wang , X H , Wu , S Y and Zhen , Y S . 2004 . Inhibitory effects of emodin on angiogenesis . Yao Xue Xue Bao , 39 : 254 – 258 .
   PubMedGoogle Scholar
• Chinni SR , Li , Y , Upadhyay , S , Koppolu , P K and Sarkar , F Z . 2001 . Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells . Oncogene , 20 : 2927 – 2936 .
   PubMed Web of Science ®Google Scholar
• Sela , U , Brill , A , Kalchenko , V , Dashevsky , O and Hershkoviz , R . 2008 . Allicin inhibits blood vessel growth and downregulates Akt phosphorylation and actin polymerization . Nutrition and Cancer , 60 : 412 – 420 .
   PubMed Web of Science ®Google Scholar
• Liang , J A , Wu , S L , Lo , H Y , Hsiang , C Y and Ho , T Y . 2009 . Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-κB signaling pathway in human hepatocellular carcinoma cells . Mol Pharmacol , 75 : 151 – 157 .
   PubMed Web of Science ®Google Scholar
• Ko , Ch , Shen , S C , Lee , T J and Chen , Y C . 2005 . Myrecitin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells . Mol Cancer Ther , 4 : 281 – 290 .
   PubMed Web of Science ®Google Scholar
• Labrecque , L , Lamy , S , Chapus , A , Mihoubi , S Durocher , Y . 2005 . Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound . Carcinogenesis , 26 : 821 – 826 .
   PubMed Web of Science ®Google Scholar
• Hanahan , D and Weinberg , R A . 2000 . The hallmarks of cancer . Cell , 100 ( 18 ) : 57 – 70 .
   PubMed Web of Science ®Google Scholar
• Baldin , V , Lukas , J , Marcote , M J , Pagano , M Draetta , G . 1993 . Cyclin D1 is a nuclear protein required for cell cycle progression in G1 . Genes Dev , 7 : 812 – 821 .
   PubMed Web of Science ®Google Scholar
• Amati , B , Alevizopoulos , K and Vlach , J . 1998 . Myc and the cell cycle . Front Biosci , 3 : 250 – 268 .
   PubMed Web of Science ®Google Scholar
• Palozza , P , Serini , S , Torsello , A , Boninsegna , A Covacci , V . 2002 . Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism . Int J Cancer , 97 : 593 – 600 .
   PubMed Web of Science ®Google Scholar
• Johnson , J J , Syed , D N , Heren , C R , Suh , Y Adhami , V M . 2008 . Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5’-AMP-activated protein kinase (AMPK) pathway . Pharm Res , 25 : 2125 – 2134 .
   PubMed Web of Science ®Google Scholar
• Souza , I C , Martins , L A , Coelho , B P , Grivicich , I Guaragna , R M . 2008 . Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells . Mol Cell Biochem , 15 : 1 – 7 .
   Web of Science ®Google Scholar
• Ho , K , Yazan , L S , Ismail , N and Ismail , M . 2009 . Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin . Cancer Epidemiol , 33 : 155 – 160 .
   PubMed Web of Science ®Google Scholar
• Chen , H C , Hsieh , W T , Chanz , W C and Chung , J G . 2004 . Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells . Food Chem Toxicol , 42 : 1251 – 1257 .
   PubMed Web of Science ®Google Scholar
• Chiu , T H , Lai , W W , Hsia , T C , Yang , J S Lai , T Y . 2009 . Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells . Anticancer Res , 29 : 4503 – 4511 .
   PubMed Web of Science ®Google Scholar
• Li , T M , Chen , G W , Su , C C , Lin , J G Yeh , C C . 2005 . Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells . Anticancer Res , 25 : 971 – 979 .
   PubMed Web of Science ®Google Scholar
• Suppipat , K , Park , C S , Shen , Y , Zhu , X and Lacorazza , H D . 2012 . Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells . Plos One , 7 : e51251 doi: 10.1371/journal.pone.0051251
   PubMed Web of Science ®Google Scholar
• Nahum , A , Hirsch , K , Danilenko , M , Colin , K W Owen , W . 2001 . Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27kip1 in the cyclin E-cdk2 complexes . Oncogene , 20 : 3428 – 3436 .
   PubMed Web of Science ®Google Scholar
• Rodriguez , M and Schaper , J . 2005 . Apoptosis: measurement and technical issues . J Mol Cell Cardiol , 38 : 15 – 20 .
   PubMed Web of Science ®Google Scholar
• Nigam , N , George , J , Srivastava , S , Roy , P Bhui , K . 2012 . Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signalling pathway in B[a]-P induced mouse skin tumorigenesis . Cancer Chemother Pharmacol , 65 : 687 – 696 .
   Web of Science ®Google Scholar
• Huang , C , Ma , W Y , Goranson , A and Dong , Z . 1999 . Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway . Carcinogenesis , 20 : 237 – 242 .
   PubMed Web of Science ®Google Scholar
• Vanamala , J , Reddivari , L , Radhakrishnan , S and Tarver , C . 2010 . Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF/Wnt and activation of p53 signalling pathways . BMC Cancer , 10 : 238
   PubMed Web of Science ®Google Scholar
• Kanematsu , S , Uehara , N , Miki , H , Yoshizawa , K Kawanaka , A . 2010 . Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells . Anticancer Res , 30 : 3381 – 3390 .
   PubMed Web of Science ®Google Scholar
• Zhang , X , Ling , Y , Yu , H and Ji , Y . 2010 . Studies on mechanism of myricetin-induced apoptosis in human hepatocellular carcinoma HepG-2 cells . Zhongguo Zhong Yao Za Zhi , 35 : 1046 – 1050 .
   PubMedGoogle Scholar
• Chen , D Z , Qi , M , Auborn , K J and Carter , T H . 2001 . Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium . J Nutr , 131 : 3294 – 3302 .
   PubMed Web of Science ®Google Scholar
• Rahman , K M , Aranha , O , Glazyrin , A , Chinni , S R and Sarkar , F H . 2000 . Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells . Oncogene , 19 : 5764 – 5771 .
   PubMed Web of Science ®Google Scholar
• Choi , H S , Cho , M C , Lee , H G and Yoon , D Y . 2010 . Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells . Food and Chemical Toxicology , 48 : 883 – 890 .
   PubMed Web of Science ®Google Scholar
• Malik , A , Afaq , S , Shahid , M , Akhtar , K and Assiri , A . 2011 . Influence of ellagic acid on prostate cancer cell proliferation: A caspases dependent pathway . Asian Pac J Trop Med , 4 : 550 – 555 .
   PubMed Web of Science ®Google Scholar
• Nakamura , Y , Yogosawa , S , Izutani , Y , Watanabe , H Otsuji , E . 2009 . A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy . Mol Cancer , 8 : 100
   PubMed Web of Science ®Google Scholar
• Muller , K , Carpenter , K L , Challis , I R , Skepper , J N and Arends , M J . 2002 . Carotenoids induce apoptosis in the T-lymphoblast cell line Jurkat E6.1 . Free Radic Res , 36 : 791 – 802 .
   PubMed Web of Science ®Google Scholar
• Salman , H , Bergman , M , Djaldetti , M and Bessler , H . 2007 . Lycopene affects proliferation and apoptosis of four malignant cell lines . Biomed Pharmacother , 61 : 366 – 369 .
   PubMed Web of Science ®Google Scholar
• Dorrie , J , Sapala , K and Zunino , S J . 2001 . Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells . Cancer Lett , 170 : 33 – 39 .
   PubMed Web of Science ®Google Scholar
• Jaganathan , S K , Mazumdar , A , Mondhe , D and Mandal , M . 2011 . Apoptotic effect of eugenol in human colon cancer cell lines . Cell Biol Int , 6 : 607 – 615 .
   Web of Science ®Google Scholar
• Lirdprapamongkol , K , Sakurai , H , Suzuki , S , Koizumi , K Prangsaengtong , O . 2010 . Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation . In Vivo , 24 : 501 – 506 .
   PubMed Web of Science ®Google Scholar
• Nyska , A , Suttie , A , Bakshi , S , Lomnitski , L Grossman , S . 2003 . Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural antioxidant from spinach, NAO—a comparative study of three antioxidants . Toxicol Pathol , 31 : 39 – 51 .
   PubMed Web of Science ®Google Scholar
• Bhattacharyya , S S , Paul , S , De , A , Das , D Samadder , A . 2011 . Poly (lactide-co-glycolide) acid nanoencapsulation of a synthetic coumarin: cytotoxicity and bio-distribution in mice, in cancer cell line and interaction with calf thymus DNA as target . Toxicol Appl Pharmacol , 253 : 270 – 281 .
   PubMed Web of Science ®Google Scholar
• Das , J , Das , S , Samadder , A , Bhadra , K and Khuda-Bukhsh , A R . 2012 . Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells . Eur J Pharm Sci , 47 : 313 – 324 .
   PubMed Web of Science ®Google Scholar