Reduction of Adverse Effects by a Mushroom Product, Active Hexose Correlated Compound (AHCC) in Patients With Advanced Cancer During Chemotherapy—The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker During Chemotherapy

REFERENCES

• Ye , S F , Ichimura , K , Wakame , K and Ohe , M . 2003 . Suppressive effects of active hexose correlated compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress . Life Sci , 74 : 593 – 602 .
   PubMed Web of Science ®Google Scholar
• Daddaoua , A , Martinez-Plata , E , Lopez-Posadas , R , Vieites , J M Gonzalez , M . 2007 . Active hexose correlated compound acts as a prebiotic and is anti-inflammatory in rats with hapten-induced colitis . J Nutr , 137 : 1222 – 1228 .
   PubMed Web of Science ®Google Scholar
• Matsushita , K , Kuramitsu , Y , Ohiro , Y , Obara , M Kobayashi , M . 1998 . Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma . Anticancer Drugs , 9 : 343 – 350 .
   PubMed Web of Science ®Google Scholar
• Matsui , Y , Uhara , J , Satoi , S , Kaibori , M Yamada , H . 2002 . Improved prognosis of postoperative hepatocellular carcinoma patients treated with functional foods . J Hepatol , 37 : 78 – 86 .
   PubMed Web of Science ®Google Scholar
• Aviles , H , O’Donnell , P , Orshal , J , Fujii , H Sun , B . 2008 . Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection . Am J Surg , 195 : 537 – 545 .
   PubMed Web of Science ®Google Scholar
• Aviles , H , Belay , T , Fountain , K , Vance , M Sonnenfeld , G . 2003 . AHCC enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions . J Appl Physiol , 95 : 491 – 496 .
   PubMed Web of Science ®Google Scholar
• Yamanishi , K , Okuno , T , Shiraki , K , Takahashi , M Kondo , T . 1988 . Identification of human herpesvirus 6 as a causal agent for exanthema subitum . Lancet , 331 : 1065 – 1067 .
   Google Scholar
• Tanaka , M , Shigihara , Y , Funakura , M , Kanai , E and Watanabe , Y . 2012 . Fatigue-associated alterations of cognitive function and electroencephalographic power densities . PLoS ONE , 7 ( 4 ) : e34774 doi:10. 1371/journal
   PubMed Web of Science ®Google Scholar
• Singh , N and Carrigan , D R . 1996 . Human herpesvirus-6 in transplantation : an emerging pathogen . Ann Intern Med , 124 : 1065 – 1071 .
   PubMed Web of Science ®Google Scholar
• Zerr , D M , Boeckh , M , Delaney , C , Martin , P J Xie , Hu . 2012 . HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation . Biol Blood Marrow Transplant , 18 : 1700 – 1708 . doi: 10.1016/j.bbmt.2012.05.012
   PubMed Web of Science ®Google Scholar
• Miura , T , Kitadate , K , Nishioka , H and Wakame , K . 2010 . “ Basic and clinical studies on active hexose correlated compound ” . In Biotechnology in Functional Foods and Nutraceuticals , Edited by: Bagchi , D , Lau , F C and Ghosh , D K . 51 – 60 . New York : CRC Press .
   Google Scholar
• Fujii , H , Nishioka , N , Simon , R R , Kaur , R Lynch , B . 2011 . Genotoxicity and subchronic toxicity evaluation of active hexose correlated compound (AHCC) . Regul Toxicol Pharm , 59 : 237 – 250 . doi: 10. 1016/j.yrtph.2010.10.006
   PubMed Web of Science ®Google Scholar
• Shah , S K , Walker , P A , Moore-Olufemi , S D , Sundaresant , A Kulkami , A D . 2011 . An evidence-based review of a Lentinula edodes mushroom extract as complementary therapy in surgical oncology patient . J Parenter Enteral Nutr , 35 : 449 – 458 .
   PubMed Web of Science ®Google Scholar
• Aaronson , N K , Ahmedzai , S , Bergman , B , Bullinger , M Cull , A . 1993 . The European organization for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology . J Natl Cancer , 85 : 365 – 376 .
   PubMed Web of Science ®Google Scholar
• Eisenberg , D M , Kessler , R C , Foster , C , Norlock , F E Calkins , D R . 1993 . Unconventional medicine in the United States. Prevalence, costs, and patterns of use . N Engl J Med , 328 : 246 – 252 .
   PubMed Web of Science ®Google Scholar
• Eisenberg , D M , Davis , R B , Ettner , S L , Appel , S Wilkey , S . 1998 . Trends in alternative medicine use in the United States, 1990–1997: results of a follow-up national survey . JAMA , 280 : 1569 – 1575 .
   PubMed Web of Science ®Google Scholar
• Abrams , D I and Weil , A T , eds. 2009 . Integrative Oncology , New York : Oxford University Press .
   Google Scholar
• Hyodo , I , Amano , N , Eguchi , K , Narabayashi , M Imanishi , J . 2005 . Nationwide survey on complementary and alternative medicine in cancer patients in Japan . J Clin Oncol , 23 : 2645 – 2654 .
   PubMed Web of Science ®Google Scholar
• Mach , C M , Fujii , H , Wakame , K and Smith , J . 2008 . Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents . J Soc Integr Oncol , 6 : 105 – 109 .
   PubMedGoogle Scholar
• Kondo , K , Kondo , T , Okuno , T , Takahashi , M and Yamanishi , K . 1991 . Latent human herpes virus 6 of human monocytes/macrophages . J Gen Virol , 72 : 1401 – 1408 .
   PubMed Web of Science ®Google Scholar
• Kondo , K , Nagafuji , H , Hata , A , Tomomori , C and Yamanishi , K . 1993 . Association of human herpes virus 6 infection of the central nervous system with recurrence of febrile convulsions . J Infect Dis , 167 : 1197 – 1200 .
   PubMed Web of Science ®Google Scholar
• Okuno , T , Takahashi , K , Balachandra , K , Shiraki , K Yamanishi , K . 1989 . Seroepidemiology of human herpesvirus 6 infection in normal children and adults . Clin Microbiol , 27 : 651 – 653 .
   Web of Science ®Google Scholar
• Braun , D K , Dominguez , G and Pellett , P E . 1997 . Human herpesvirus 6 . Clin Microbiol Rev , 10 : 521 – 567 .
   PubMed Web of Science ®Google Scholar
• Cohrs , R J and Gilden , D H . 2001 . Human herpes virus latency . Brain Pathol , 11 : 465 – 474 .
   PubMed Web of Science ®Google Scholar
• Cameron , B , Flamand , L , Juwana , H , Middeldorp , J Naing , Z . 2010 . Serological and virological investigation of the role of herpes viruses EBV, CMV and HHV-6 in post-infective chronic fatigue . J Med Virol , 82 : 1684 – 1688 .
   PubMed Web of Science ®Google Scholar
• Sun , B , Wakame , K , Sato , E , Nishioka , H Aruoma , O I . 2009 . The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents . Cancer Epidemiology , 33 : 293 – 299 .
   PubMed Web of Science ®Google Scholar