162
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes

, , &
Pages 783-795 | Received 14 Jun 2013, Accepted 09 Apr 2015, Published online: 21 May 2015

REFERENCES

  • Cancer Research UK: Skin Cancer Incidence Statistics. England, 2012.
  • American Cancer Society: Melanoma Skin Cancer. United States, 2012.
  • Hew K: Prostate Cancer. Malaysian Oncological Society, 2012.
  • Bernhard EJ, Gruber SB, and Muschel RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proceedings of the National Academy of Sciences 91, 4293–4297, 1994.
  • Itoh Y and Nagase H: Matrix metalloproteinases in cancer. Essays Biochem 38, 21–36, 2002.
  • Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407, 249–257, 2000.
  • Bourboulia D and Stetler-Stevenson WG: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Academic Press: Seminars in cancer biology, 2010.
  • Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nature Reviews Cancer 2, 161–174, 2002.
  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al.: Global cancer statistics. CA: A Cancer Journal for Clinicians 61, 69–90, 2011. doi:10.3322/caac.20107
  • Jilaveanu LB, Aziz SA, and Kluger HM: Chemotherapy and biologic therapies for melanoma: Do they work? Clinics in Dermatology 27, 614–625, 2009.
  • Tang YQ, Jaganath IB, and Sekaran SD: Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PLoS One 5, e12644, 2010. doi:10.1371/journal.pone.0012644
  • Calixto JB, Santos ARS, and Yunes RA: A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology, and therapeutic potential. Medicinal Research Reviews 18, 225–258, 1998.
  • Nielsen BS, Timshel S, Kjeldsen L, Sehested M, Pyke C, et al.: 92 kDa type IV collagenase (MMP‐9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer. International Journal of Cancer 65, 57–62, 1998.
  • Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, et al.: Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. Clinical Cancer Research 10, 7621–7628, 2004.
  • Sier C, Kubben F, Ganesh S, Heerding M, Griffioen G, et al.: Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma. British Journal of Cancer 74, 413, 1996.
  • Kerbel RS: Tumor angiogenesis: Past, present and the near future. Carcinogenesis 21, 505–515, 2000.
  • Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, et al.: Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical cancer research 14, 4491–4499, 2008.
  • Nakachi K, Matsuyama S, Miyake S, Suganuma M, and Imai K: Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention. Biofactors 13, 49–54, 2008.
  • Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, et al.: Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Research 24, 2783–2840, 2004.
  • Tan G, Gyllenhaal C, and Soejarto D: Biodiversity as a source of anticancer drugs. Current Drug Targets 7, 265–277, 2006.
  • Huang ST, Yang RC, Lee PN, Yang SH, Liao SK, et al.: Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma. International Immunopharmacology 6, 870–879, 2006.
  • Stetler-Stevenson WG, Aznavoorian S, and Liotta LA: Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annual Review of Cell Biology 9, 541–573, 1993.
  • Lee S, Desai KK, Iczkowski KA, Newcomer RG, Wu KJ, et al.: Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor. Cell Research 16, 750–758, 2006.
  • Zhao YG, Xiao AZ, Newcomer RG, Park HI, Kang T, et al.: Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells. Journal of Biological Chemistry 278, 15056–15064, 2003.
  • Cai Y, Luo Q, Sun M, and Corke H: Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sciences 74, 2157–2184, 2004.
  • Saetung A, Itharat A, Dechsukum C, Wattanapiromsakul C, Keawpradub N, et al.: Cytotoxic activity of Thai medicinal plants for cancer treatment. Songklanakarin Journal of Science and Technology 27, 471–478, 2005.
  • Sun J and Hai Liu R: Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells. Cancer Letters 241, 124–134, 2006. doi:10.1016/j.canlet.2005.10.027
  • Tang Y-Q, Jaganath I, Manikam R, and Sekaran SD: Phyllanthus Suppresses prostate cancer cell, PC-3, proliferation and induces apoptosis through multiple signalling pathways (MAPKs, PI3K/Akt, NF B, and Hypoxia). Evidence-Based Complementary and Alternative Medicine 2013, 2013.
  • Lopes FC, Rocha A, Pirraco A, Regasini LO, Silva DH, et al.: Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa. BMC Complementary and Alternative Medicine 9, 15, 2009.
  • Eun JP and Koh GY: Suppression of angiogenesis by the plant alkaloid, sanguinarine. Biochemical and Biophysical Research Communications 317, 618–624, 2004.
  • Kruczynski A, Poli M, Dossi R, Chazottes E, Berrichon G, et al.: Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. European Journal of Cancer 42, 2821–2832, 2006.
  • Ho HH, Chang CS, Ho WC, Liao SY, Wu CH, et al.: Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals. Food and Chemical Toxicology 48, 2508–2516, 2010.
  • Lu Y, Jiang F, Jiang H, Wu K, Zheng X, et al.: Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. European Journal of Pharmacology 641, 102–107, 2010.
  • Liu KC, Huang AC, Wu PP, Lin HY, Chueh FS, et al.: Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and-9 signaling pathways. Oncology Reports 26, 177, 2011.
  • Tseng HH, Chen PN, Kuo WH, Wang JW, Chu SC, et al.: Antimetastatic Potentials of Phyllanthus urinaria L on A549 and Lewis Lung Carcinoma Cells via Repression of Matrix-Degrading Proteases. Integrative Cancer Therapies 11, 267–278, 2012.
  • Weng C-J, Chau C-F, Hsieh Y-S, Yang S-F, and Yen G-C: Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1. Carcinogenesis 29, 147–156, 2008.
  • Adya R, Tan BK, Punn A, Chen J, and Randeva HS: Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: Novel insights into visfatin-induced angiogenesis. Cardiovascular Research 78, 356–365, 2008.
  • Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, et al.: PTEN regulate angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Molecular and cellular biochemistry 331, 161–171, 2009.
  • Nakashio A, Fujita N, and Tsuruo T: Topotecan inhibits VEGF‐and bFGF‐induced vascular endothelial cell migration via downregulation of the PI3K‐Akt signaling pathway. International Journal of Cancer 98, 36–41, 2001.
  • Jin UH, Lee JY, Kang SK, Kim JK, Park WH, et al.: A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: Isolation and identification from methanol extract of Euonymus alatus. Life Sciences 77, 2760–2769, 2005.
  • He B, Hu M, Li S-D, Yang X-T, Lu Y-Q, et al.: Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression. Bioorganic & Medicinal Chemistry Letters, 630–634, 2012.
  • Vijayababu M, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, et al.: Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Molecular and Cellular Biochemistry 287, 109–116, 2006.
  • Kamalakkannan N and Prince P: The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney. Journal of Pharmacy and Pharmacology 58, 1091–1098, 2006.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.