218
Views
12
CrossRef citations to date
0
Altmetric
Articles

Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells

, , &
Pages 1170-1182 | Received 16 Dec 2014, Accepted 14 Jul 2015, Published online: 12 Sep 2015

REFERENCES

  • World Health Organization: Glioblastoma: Tumours of the central nervous system. Retrieved from http://www.pubcan.org/cancer/4938/glioblastoma/epidemiology
  • De Witt Hamer PC: Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro Oncol 12, 304–316, 2010.
  • De Witt Hamer PC: Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro Oncol 12, 304–316, 2010.
  • Hart MG, Garside R, Rogers G, Stein K, and Grant R: Temozolomide for high grade glioma. Cochrane Database Syst Rev 30(4), CD007415, 2013.
  • Wu W, O'Reilly MS, and Langley RR: Expression of epidermal growth factor (EGF)/transforming growth factor-A by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice. Mol Cancer Ther 6, 2652–2663, 2007.
  • Kisielewska J, Ligęza J, and Klein A. The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth of prostatecancer cells (DU145). Folia Histochem Cytobiol 46, 185–191, 2008.
  • Nicholas MK, Lukas RV, Chmura S, Yamini B, Lesniak M, et al.: Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges. Semin Oncol 38, 243–253, 2011.
  • Levitzki A: Protein tyrosine kinase inhibitors as novel therapeutic agents. Pharmacol Ther 82, 231–239, 1999.
  • Levitt ML and Koty PP: Tyrosine kinase inhibitors in preclinical development. Invest New Drugs 19, 213–226, 1999.
  • Srivastava RM, Singh S, Dubey SK, Misra K, and Khar A: Immunomodulatory and therapeutic activity of curcumin. Int Immunopharmacol 11, 331–341, 2011.
  • Silvestri GA and Rivera MP: Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists. Chest 128, 3975–3984, 2005.
  • Gillies RJ, Didier N, and Denton M: Determination of cell number in monolayer cultures. Anal Biochem 159, 109–113, 1986.
  • Givens KT, Kirada S, Chen AK, Rorhschiller J, and Lee DA: Proliferation of human ocular fibroblasts. Invest Ophthalmol Vis Sci 31, 1856–1862, 1990.
  • Bojko A, Reichert K, Adamczyk A, Ligeza J, Ligeza J et al.: The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol 5, 186–195, 2012.
  • Promega Corporation. Caspase-Glo® 3/7 Assay Technical Bulletin. Retrieved from https://pl.promega.com/resources/protocols/technical-bulletins/101/caspase-glo-37-assay-protocol/
  • Chen X, Zhong Z, Xu Z, Chen L, and Wang Y: 2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: forty years of application and controversy. Free Radic Res 44, 587–604, 2010.
  • Kapiszewska M, Cierniak A, Elas M, and Lankoff A: Lifespan of etoposide-treated human neutrophils is affected by antioxidant ability of quercetin. Toxicol In Vitro 1, 1020–1030, 2007.
  • De Witt Hamer PC: Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro Oncol 12, 304–316, 2010.
  • Berezowska S and Schlegel J: Targeting ErbB receptors in high-grade glioma. Curr Pharm Des 17, 2468–2487, 2011.
  • Gupta SC, Patchva S, and Aggarwal BB: Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 15(1), 195–218, 2013.
  • Karmakar S, Banik NL, and Ray SK: Curcumin suppressed anti-apoptotic signals and activated cysteine proteases for apoptosis in human malignant glioblastoma U87MG cells. Neurochem Res 32, 2103–2113, 2007.
  • Zanotto-Filho A, Braganhol E, Edelweiss MI, Behr GA, Zanin R, et al.: The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. J Nutr Biochem 23, 591–601, 2012.
  • Senft C, Polacin M, Priester M, Seifert V, Kögel D, et al.: The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas. BMC Cancer 14, 10, 491, 2010.
  • Huang TY, Tsai TH, Hsu CW, and Hsu YC: Curcuminoids suppress the growth and induce apoptosis through caspase-3-dependent pathways in glioblastoma multiforme (GBM) 8401 cells. J Agric Food Chem 58, 10639–10645, 2010.
  • Ellis AG, Doherty MM, Walker F, Weinstock J, Nerrie M, et al.: Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase. Biochem Pharmacol 71, 1422–1434, 2006.
  • Carrasco-García E, Saceda M, Grasso S, Rocamora-Reverte L, Conde M, et al.: Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines. Exp Cell Res 317, 1476–1489, 2011.
  • Puliyappadamba VT, Chakraborty S, Chauncey SS, Li L, Hatanpaa KJ, et al.: Opposing effect of EGFRWT on EGFRvIII-mediated NF-kB activation with RIP1 as a cell death switch. Cell Rep 9, 764–775. 2013.
  • Frederick L, Wang XY, Eley G, and James CD: Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 60, 1383–1387, 2000.
  • Dutta PR and Maity A: Cellular responses to EGFR inhibitors and their relevance to cancer therapy. Cancer Lett 254, 165–177, 2007.
  • Ono M and Kuwano M: Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. Clin Cancer Res 12, 7242–7251, 2006.
  • Wang S, Guo P, Wang X, Qingyu Zhou Q, and Gallo JM: Preclinical pharmacokinetic/pharmacodynamic models of EGFR wild-type and mutant tumor models. Mol Cancer Ther 7, 407–417, 2008.
  • Ramis G, Thomàs-Moyà E, Fernández de Mattos SF, Rodríguez J, and Villalonga P: EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth. PLoS One 7(6), e38770, 2012.
  • Liebmann JE, Cook JA, Lipschultz C, Teague D, Fisher J, et al.: Cytotoxic studies of paclitaxel (Taxol) in human tumor cell lines. Br J Cancer 68, 1104–1109, 1993.
  • Russo M, Spagnuolo C, Tedesco I, and Russo GL: Phytochemicals in cancer prevention and therapy: truth or dare? Toxins (Basel), 2, 517–551, 2010.
  • Sun B, Ross SM, Trask OJ, Carmichael PL, Dent M, et al.: Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. Toxicol In Vitro 27, 1877–1887, 2013.
  • Kumar A and Bora U: Molecular docking studies of curcumin natural derivatives with DNA topoisomerase I and II-DNA complexes. Interdiscip Sci 6, 285–291, 2014.
  • Ketron AC and Osheroff N: Phytochemicals as anticancer and chemopreventive topoisomerase II poisons. Phytochem Rev 13(1), 19–35, 2014.
  • Korwek Z, Bielak-Zmijewska A, Mosieniak G, Alster O, Moreno-Villanueva M, et al.: DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells. Mutagenesis 28, 411–416, 2013.
  • Grabowska W, Kucharewicz K, Wnuk M, Lewinska A, Suszek M, et al.: Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner. Age (Dordr) 37(1), 9744, 2015.
  • Lewinska A, Wnuk M, Grabowska W, Zabek T, Semik E, et al.: Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett 18, 233, 227–238, 2015.
  • Kumar N, Yadav A, Gulati S, Kanupriya, Aggarwal N, et al.: Antigenotoxic effect of curcumin and carvacrol against parathion induced DNA damage in cultured human peripheral blood lymphocytes and its relation to GSTM1 and GSTT1 polymorphism. J Toxicol 2014, 404236, 2014.
  • Subramanian M, Sreejayan, Rao MN, Devasagayam TP, and Singh BB: Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat Res 311, 249–255, 1994.
  • Lin HP, Kuo LK, and Chuu CP: Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells. Phytother Res 26(1), 122–126, 2012.
  • Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B, et al.: Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann N Y Acad Sci 1259, 95–103, 2012.
  • Montgomery RB: Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function. Int J Cancer 10, 111–117, 2002.
  • Kinsella P, Howley R, Doolan P, Clarke C, Madden SF, et al. Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib. Exp Cell Res 318, 641–652, 2012.
  • Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, et al.: Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21(4B), 2895–2900, 2001.
  • Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, et al.: Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol 58, 1167–1172, 1999.
  • Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, and Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64, 353–356, 1998.
  • Dey S and Sreenivasan K: Conjugation of curcumin onto alginate enhances aqueous solubility and stability of curcumin. Carbohydr Polym 99, 499–507, 2014.
  • Liu J, Liu J, Xu H, Zhang Y, Chu L, et al.: Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effective curcumin delivery. Int J Nanomedicine 9, 197–207, 2014.
  • Bentzen PJ, Lang E, and Lang F: Curcumin induced suicidal erythrocyte death. Cell Physiol Biochem 19(1–4), 153–164, 2007.
  • Lang F, Gulbins E, Lang PA, Zappulla D, and Föller M: Ceramide in suicidal death of erythrocytes. Cell Physiol Biochem 26(1), 21–28, 2010.
  • Zappulla D: Environmental stress, erythrocyte dysfunctions, inflammation, and the metabolic syndrome: adaptations to CO2 increases? J Cardiometab Syndr 3(1), 30–34, 2008.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.