REFERENCES
- Conney AH, Miller EC and Miller JA: The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res 16, 450–459, 1956.
- Conney AH: Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450. Annu Rev Pharmacol Toxicol 43, 1–30, 2003. doi:10.1146/annurev.pharmtox.43.100901.135754
- Conney AH: Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res 42, 4875–4917, 1982.
- Conney AH: Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture. Cancer Res 63, 7005–7031, 2003.
- Conney AH and Reidenberg MM: Cigarette smoking, coffee drinking, and ingestion of charcoal-broiled beef as potential modifiers of drug therapy and confounders of clinical trials. J Pharmacol Exp Ther 342, 9–14, 2012. doi:10.1124/jpet.112.193193
- Conney AH: Tailoring cancer chemoprevention regimens to the individual. J Cell Biochem 91, 277–286, 2004. doi:10.1002/jcb.20001
- Knox WE: Metabolic adaptation in animals. New York, NY: Academic Press, Inc., 1954.
- Omura T, Sato R: A new cytochrome in liver microsomes. J Biol Chem 237, 1375–1376, 1962.
- Lu AY, Kuntzman R, West S, Jacobson M and Conney AH: Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations. J Biol Chem 247, 1727–1734, 1972.
- Lu AY, Somogyi A, West S, Kuntzman R and Conney AH: Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes. Arch Biochem Biophys 152, 457–462, 1972.
- Guengerich FP: Cytochrome p450 and chemical toxicology. Chem Res Toxicol 21, 70–83, 2008. doi:10.1021/tx700079z
- Yang CS and Lu AYH. The diversity of substrates for cytochrome P-450. Boca Raton, FL: CRC Press, 1987.
- Yang CS, Brady JF and Hong JY: Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity. FASEB J 6, 737–744, 1992.
- Ernst E: Second thoughts about safety of St John's wort. Lancet 354, 2014–2016, 1999. doi:10.1016/S0140-6736(99)00418-3
- Fugh-Berman A: Herb–drug interactions. Lancet 355, 134–138, 2000. doi:10.1016/S0140-6736(99)06457-0
- Piscitelli SC, Burstein AH, Chaitt D, Alfaro RM and Falloon J: Indinavir concentrations and St John's wort. Lancet 355, 547–548, 2000. doi:10.1016/S0140-6736(99)05712-8
- Ruschitzka F, Meier PJ, Turina M, Luscher TF and Noll G: Acute heart transplant rejection due to Saint John's wort. Lancet 355, 548–549, 2000. doi:10.1016/S0140-6736(99)05467-7
- Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, et al.: St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci U S A 97, 7500–7502, 2000. doi:10.1073/pnas.130155097
- Nigam SK: What do drug transporters really do? Nat Rev Drug Discov 14, 29–44, 2015. doi: 10.1038/nrd4461
- Gamelin E, Delva R, Jacob J, Merrouche Y, Raoul JL, et al.: Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage: results of a multicenter randomized trial of patients with metastatic colorectal cancer. J Clin Oncol 26, 2099–2105, 2008. doi:10.1200/jco.2007.13.3934
- Kraiczi H, Jang T, Ludden T and Peck CC: Randomized concentration-controlled trials: motivations, use, and limitations. Clin Pharmacol Ther 74, 203–214, 2003. doi:10.1016/S0009-9236(03)00169-3
- Miller EC: Studies on the formation of protein-bound derivatives of 3,4-benzpyrene in the epidermal fraction of mouse skin. Cancer Res 11, 100–108, 1951.
- Patterson AD, Gonzalez FJ and Idle JR: Xenobiotic metabolism: a view through the metabolometer. Chem Res Toxicol 23, 851–860, 2010. doi:10.1021/tx100020p
- Wattenberg LW: An overview of chemoprevention: current status and future prospects. Proc Soc Exp Biol Med 216, 133–141, 1997.
- Talalay P, Dinkova-Kostova AT and Holtzclaw WD: Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis. Adv Enzyme Regul 43, 121–134, 2003.
- Hayes JD and Dinkova-Kostova AT: The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39, 199–218, 2014. doi:10.1016/j.tibs.2014.02.002
- Yang CS, Maliakal P and Meng X: Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42, 25–54, 2002. doi:10.1146/annurev.pharmtox.42.082101.154309
- Yang CS, Wang X, Lu G and Picinich SC: Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9, 429–439, 2009. doi:10.1038/nrc2641
- Inoue M, Sasazuki S, Wakai K, Suzuki T, Matsuo K, et al.: Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies. Gut 58, 1323–1332, 2009. doi:10.1136/gut.2008.166710
- Tsao AS, Liu D, Martin J, Tang XM, Lee JJ, et al.: Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev Res (Phila) 2, 931–941, 2009. doi:10.1158/1940-6207.CAPR-09-0121
- Shimizu M, Fukutomi Y, Ninomiya M, Nagura K, Kato T, et al.: Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev 17, 3020–3025, 2008. doi:10.1158/1055-9965.epi-08-0528
- Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, et al.: Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 66, 1234–1240, 2006. doi:10.1158/0008-5472.can-05-1145
- Kumar NB, Pow-Sang J, Egan KM, Spiess PE, Dickinson S, et al.: Randomized, placebo-controlled trial of green tea catechins for prostate cancer prevention. Cancer Prev Res (Phila), 2015. doi:10.1158/1940-6207.CAPR-14-0324
- Lu YP, Lou YR, Lin Y, Shih WJ, Huang MT, et al.: Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. Cancer Res 61, 5002–5009, 2001.
- Jacobsen BK, Bjelke E, Kvale G and Heuch I: Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst 76, 823–831, 1986.
- Hakim IA, Harris RB and Weisgerber UM: Tea intake and squamous cell carcinoma of the skin: influence of type of tea beverages. Cancer Epidemiol Biomarkers Prev 9, 727–731, 2000.
- Rees JR, Stukel TA, Perry AE, Zens MS, Spencer SK, et al.: Tea consumption and basal cell and squamous cell skin cancer: results of a case-control study. J Am Acad Dermatol 56, 781–785, 2007. doi:10.1016/j.jaad.2006.11.038
- Lu YP, Lou YR, Li XH, Xie JG, Brash D, et al.: Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. Cancer Res 60, 4785–4791, 2000.
- Lu YP, Lou YR, Xie JG, Peng QY, Liao J, et al.: Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc Natl Acad Sci U S A 99, 12455–12460, 2002. doi:10.1073/pnas.182429899
- Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, et al.: Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice. Cancer Res 68, 2523–2529, 2008. doi:10.1158/0008-5472.CAN-07-5955
- Lu YP, Lou YR, Peng QY, Nghiem P and Conney AH: Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice. Cancer Prev Res (Phila) 4, 1118–1125, 2011. doi:10.1158/1940-6207.CAPR-11-0116
- Michna L, Lu YP, Lou YR, Wagner GC and Conney AH: Stimulatory effect of oral administration of green tea and caffeine on locomotor activity in SKH-1 mice. Life Sci 73, 1383–1392, 2003.
- Michna L, Wagner GC, Lou YR, Xie JG, Peng QY, et al.: Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 27, 2108–2115, 2006. doi:10.1093/carcin/bgl057
- Lu YP, Lou YR, Bernard JJ, Peng QY, Li T, et al.: Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet. Proc Natl Acad Sci U S A 109, 9065–9070, 2012. doi:10.1073/pnas.1205810109
- Lu YP, Lou YR, Nolan B, Peng QY, Xie JG, et al.: Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice. Proc Natl Acad Sci U S A 103, 16301–16306, 2006. doi:10.1073/pnas.0607789103