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Original Articles

Quercetin Inhibits Proliferation and Drug Resistance in KB/VCR Oral Cancer Cells and Enhances Its Sensitivity to Vincristine

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Pages 126-136 | Received 07 Apr 2013, Accepted 16 Aug 2014, Published online: 16 Dec 2014

REFERENCES

  • Shen SC, Chen YC, Hsu FL, and Lee WR: Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase-3 cascade. J Cell Biochem 89, 1044–1055, 2003.
  • Lee LT, Huang YT, Hwang JJ, Lee PP, Ke FC, et al.: Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res 22, 1615–1627, 2002.
  • Choi JA, Kim JY, Lee JY, Kang CM, Kwon HJ, et al.: Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int J Oncol 19, 837–844, 2001.
  • Kawahara T, Kawaguchi-Ihara N, Okuhashi Y, Itoh M, Nara N, et al.: Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res 29, 4629–4632, 2009.
  • Chang YF, Hsu YC, Hung HF, Lee HJ, Lui WY, et al.: Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutr Cancer 61, 735–745, 2009.
  • Wang P, Zhang K, Zhang Q, Mei J, Chen CJ, et al.: Effects of quercetin on the apoptosis of the human gastric carcinoma cells. Toxicol In Vitro 26, 221–228, 2012.
  • Biazevic MG, Antunes JL, Togni J, de Andrade FP, de Carvalho MB, et al.: Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection. J Appl Oral Sci 18, 279–284, 2010.
  • Borowski E, Bontemps-Gracz MM, and Piwkowska A: Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells. Acta Biochim Pol 52, 609–627, 2005.
  • O’Connor R: The pharmacology of cancer resistance. Anticancer Res 27(3A), 1267–1272, 2007.
  • Gottesman MM: Mechanisms of cancer drug resistance. Annu Rev Med 53, 615–627, 2002.
  • Borska S, Sopel M, Chmielewska M, Zabel M, and Dziegiel P: Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules 15, 857–870, 2010.
  • Bansal T, Awasthi A, Jaggi M, Khar RK, and Talegaonkar S: Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. Life Sci 83(7–8), 250–259, 2008.
  • Lin CW, Shen SC, Hou WC, Yang LY, and Chen YC: Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9. Mol. Cancer Ther 7, 1195–1206, 2008.
  • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254, 1976.
  • Xi GM, Sun B, Jiang HH, Kong F, Yuan HQ, et al.: Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity. Bioorg Med Chem 18, 6725–6733, 2010.
  • Yan YX, Li WZ, Huang YQ, and Liao WX: The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function. Prostaglandins Other Lipid Mediat 97, 29–35, 2012.
  • Jordan RC and Daley T: Oral squamous cell carcinoma: new insights. J Can Dent Assoc 63, 517–518, 521–525, 1997.
  • Hicks WL Jr., Loree TR, Garcia RI, Maamoun S, Marshall D, et al.: Squamous cell carcinoma of the floor of mouth: a 20-year review. Head Neck 19, 400–405, 1997.
  • Priyadarsini RV, Vinothini G, Murugan RS, Manikandan P, and Nagini S. The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr Cancer 63, 218–226, 2011.
  • Souto FO, Zarpelon AC, Staurengo-Ferrari L, Fattori V, Casagrande R, et al.: Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization. J Nat Prod 74, 113–118, 2011.
  • Chan KC, Ho HH, Huang CN, Lin MC, Chen HM, et al.: Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-kappaB signals. J Agric Food Chem 57, 9147–9153, 2009.
  • Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, Motobayashi Y, Kawazoe K, et al.: Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells. J Pharmacol Sci 109, 257–264, 2009.
  • Ogasawara M, Matsunaga T, and Suzuki H: Differential effects of antioxidants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells. Biol Pharm Bull 30(1), 200–204, 2007.
  • Shan BE, Wang MX, and Li RQ: Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest 27, 604–612, 2009.
  • Yang JH, Hsia TC, Kuo HM, Chao PD, Chou CC, et al.: Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos 34, 296–304, 2006.
  • Cheong E, Ivory K, Doleman J, Parker ML, Rhodes M, et al.: Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest. Carcinogenesis 25, 1945–1952, 2004.
  • Ye B, Aponte M, Dai Y, Li L, Ho MC, et al.: Ginkgo biloba and ovarian cancer prevention:epidemiological and biological evidence. Cancer Lett 251, 43–52, 2007.
  • Zamin LL, Filippi-Chiela EC, Dillenburg-Pilla P, Horn F, Salbego C, et al.: Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells. Cancer Sci 100, 1655–1662, 2009.
  • Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322–1326, 1998.
  • Daniel PT: Dissecting the pathways to death. Leukemia 14, 2035–2044, 2000.
  • Lotem J and Sachs L: Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ 4, 41–47, 1993.
  • Miyashita T and Reed JC: Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81, 151–157, 1993.
  • Aneja R, Zhou J, Zhou B, Chandra R, and Joshi HC: Treatment of hormone-refractory breast cancer: Apoptosis and regression of human tumors implanted in mice. Mol Cancer Ther 5, 2366–2377, 2006.
  • Bargou RC, Wagener C, Bommert K, Mapara MY, Daniel PT, et al.: Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest 97, 2651–2659, 1996.
  • Radetzki S, Köhne CH, von Haefen C, Gillissen B, Sturm I, et al.: The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr1-negative and Mdr-1-overexpressing breast cancer cell lines. Oncogene 21, 227–238, 2002.
  • Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, et al.: Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39, 361–398, 1991.
  • Gottesman MM, Fojo T, and Bates SE: Multidrug resistance in cancer: role of ATPdependent transporters. Nat Rev Cancer 2(1), 48–58, 2002.
  • Gottesman MM and Ling V: The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research. FEBS Lett 580, 998–1009, 2006.
  • Leonessa F and Clarke R: ATP binding cassette transporters and drug resistance in breast cancer. Endocr Relat Cancer 10, 43–73, 2003.
  • Formica JV and Regelson W: Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol 33, 1061–1080, 1995.
  • Kioka N, Hosokawa N, Komano T, Hirayoshi K, Nagata K, et al.: Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite. FEBS Lett 301, 307–309, 1992.
  • Badhan R and Penny J: In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain. Eur J Med Chem; 41, 285–295, 2006.
  • Leslie EM, Deeley RG, and Cole SP: Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204, 216–237, 2005.
  • Di Pietro A, Conseil G, Perez-Victoria JM, Dayan G, Baubichon-Cortay H, et al.: Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. Cell Mol Life Sci 59, 307–322, 2002.
  • Debes A, Oerding M, Willers R, Göbel U, and Wessalowski R: Sensitization of human Ewing's tumor cells to chemotherapy and heat treatment by the bioflavonoid quercetin. Anticancer Res 23, 3359–3366, 2003.

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