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Review Article

The Potential Role of Probiotics in Cancer Prevention and Treatment

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Pages 535-544 | Received 20 Dec 2014, Accepted 19 Jan 2016, Published online: 04 May 2016

References

  • FAO/WHO Working Group. London, Ontario, Canada: 2002. Guidelines for the evaluation of probiotics in food. Report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. Available online: ftp://ftp.fao.org/es/esn/food/wgreport2.pdf.
  • Ritchie ML and Romanuk TN: A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One 7, e34938, 2012.
  • Zabala A, Martín MR, Haza AI, Fernández L, Rodríguez JM, et al.: Anti-proliferative effect of two lactic acid bacteria strains of human origin on the growth of a myeloma cell line. Lett Appl Microbiol 32, 287–292, 2001.
  • Thirabunyanon M, Boonprasom P, and Niamsup P: Probiotic potential of lactic acid bacteria isolated from fermented dairy milks on antiproliferation of colon cancer cells. Biotechnol Lett 31, 571–576, 2009.
  • Grimoud J, Durand H, de Souza S, Monsan P, Ouarné F, et al.: In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects. Int J Food Microbiol 144, 42–50, 2010.
  • Thirabunyanon M and Hongwittayakorn P: Potential probiotic lactic acid bacteria of human origin induce antiproliferation of colon cancer cells via synergic actions in adhesion to cancer cells and short-chain fatty acid bioproduction. Appl Biochem Biotechnol 169, 511–525, 2013.
  • Verma A and Shukla G: Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats. Nutr Cancer 65, 84–91, 2013.
  • Ouwehand AC, Salminen S, Roberts PJ, Ovaska J, and Salminen E: Disease-dependent adhesion of lactic acid bacteria to the human intestinal mucosa. Clin Diagn Lab Immunol 10, 643–646, 2003.
  • Ohkawara S, Furuya H, Nagashima K, Asanuma N, and Hino T: Oral administration of butyrivibrio fibrisolvens, a butyrate-producing bacterium, decreases the formation of aberrant crypt foci in the colon and rectum of mice. J Nutr 135, 2878–2883, 2005.
  • Seal M, Naito Y, Barreto R, Lorenzetti A, Safran P, et al.: Experimental radiotherapy-induced enteritis: a probiotic interventional study. J Dig Dis 8, 143–147, 2007.
  • Lopez M, Li N, Kataria J, Russell M, and Neu J: Live and ultraviolet-inactivated Lactobacillus rhamnosus GG decrease flagellin-induced interleukin-8 production in Caco-2 cells. J Nutr 138, 2264–2268, 2008.
  • Zhou C, Ma FZ, Deng XJ, Yuan H, and Ma HS: Lactobacilli inhibit interleukin-8 production induced by Helicobacter pylori lipopolysaccharide-activated Toll-like receptor 4. World J Gastroenterol 14, 5090–5095, 2008.
  • Rokka S, Myllykangas S, and Joutsjoki V: Effect of specific colostral antibodies and selected lactobacilli on the adhesion of Helicobacter pylori on AGS cells and the Helicobacter-induced IL-8 production. Scand J Immunol 68, 280–286, 2008.
  • Fang SB, Shih HY, Huang CH, Li LT, Chen CC, et al.: Live and heat-killed Lactobacillus rhamnosus GG upregulate gene expression of pro-inflammatory cytokines in 5-fluorouracil-pretreated Caco-2 cells. Support Care Cancer 22, 1647–1654, 2014.
  • Le Leu RK, Hu Y, Brown IL, Woodman RJ, and Young GP: Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats. Carcinogenesis 31, 246–251, 2010.
  • Oh Y, Osato MS, Han X, Bennett G, and Hong WK: Folk yoghurt kills Helicobacter pylori. J Appl Microbiol 93, 1083–1088, 2002.
  • Chen X, Liu XM, Tian F, Zhang Q, Zhang HP, et al.: Antagonistic activities of lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. J Food Sci 77, M9–14, 2012.
  • Kuo CH, Wang SS, Lu CY, Hu HM, Kuo FC, et al.: Long-term use of probiotic-containing yogurts is a safe way to prevent helicobacter pylori: Based on a Mongolian gerbil's model. Biochem Res Int 2013, 594561, 2013.
  • Verhoeven V, Renard N, Makar A, Van Royen P, Bogers JP, et al.: Probiotics enhance the clearance of human papillomavirus-related cervical lesions: a prospective controlled pilot study. Eur J Cancer Prev 22, 46–51, 2013.
  • Rowland IR, Rumney CJ, Coutts JT, and Lievense LC: Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 19, 281–285, 1998.
  • Nakanishi S, Kataoka K, Kuwahara T, and Ohnishi Y: Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon. Microbiol Immunol 47, 951–958, 2003.
  • de Moreno de LeBlanc A and Perdigón G: Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model. Biocell 29, 15–24, 2005.
  • Ohkawara S, Furuya H, Nagashima K, Asanuma N, and Hino T: Effect of oral administration of Butyrivibrio fibrisolvens MDT-1, a gastrointestinal bacterium, on 3-methylcholanthrene-induced tumor in mice. Nutr Cancer 59, 92–98, 2007.
  • Yazdi MH, Soltan Dallal MM, Hassan ZM, Holakuyee M, Agha Amiri S, et al.: Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour. Br J Nutr 104, 227–232, 2010.
  • Lee JW, Shin JG, Kim EH, Kang HE, Yim IB, et al.: Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum. J Vet Sci 5, 41–48, 2004.
  • Kosiewicz MM, Zirnheld AL, and Alard P: Gut microbiota, immunity, and disease: a complex relationship. Front Microbiol 2, 180, 2011.
  • Paolillo R, Romano Carratelli C, Sorrentino S, Mazzola N, and Rizzo A: Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells. Int Immunopharmacol 9, 1265–1271, 2009.
  • Lee JS, Paek NS, Kwon OS, and Hahm KB: Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in Helicobacter pylori infection: a novel mechanism. J Gastroenterol Hepatol 25, 194–202, 2010.
  • Ohara T, Yoshino K, and Kitajima M: Possibility of preventing colorectal carcinogenesis with probiotics. Hepatogastroenterology 57, 1411–1415, 2010.
  • Russo F, Orlando A, Linsalata M, Cavallini A, and Messa C: Effects of Lactobacillus rhamnosus GG on the cell growth and polyamine metabolism in HGC-27 human gastric cancer cells. Nutr Cancer 59, 106–114, 2007.
  • Orlando A, Messa C, Linsalata M, Cavallini A, and Russo F: Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines. Immunopharmacol Immunotoxicol 31, 108–116, 2009.
  • Orlando A, Refolo MG, Messa C, Amati L, Lavermicocca P, et al.: Antiproliferative and proapoptotic effects of viable or heat-killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 gastric and DLD-1 colon cell lines. Nutr Cancer 64, 1103–1111, 2012.
  • Kim Y, Lee D, Kim D, Cho J, Yang J, et al.: Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212. Arch Pharm Res 31, 468–473, 2008.
  • Ma EL, Choi YJ, Choi J, Pothoulakis C, Rhee SH, et al.: The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. Int J Cancer 127, 780–790, 2010.
  • Kim Y, Oh S, Yun HS, Oh S, and Kim SH: Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. Lett Appl Microbiol 51, 123–130, 2010.
  • Borowicki A, Michelmann A, Stein K, Scharlau D, Scheu K, et al.: Fermented wheat aleurone enriched with probiotic strains LGG and Bb12 modulates markers of tumor progression in human colon cells. Nutr Cancer 63, 151–160, 2011.
  • Stein K, Borowicki A, Scharlau D, Schettler A, Scheu K, et al.: Effects of synbiotic fermentation products on primary chemoprevention in human colon cells. J Nutr Biochem 23, 777–784, 2012.
  • Cousin FJ, Jouan-Lanhouet S, Dimanche-Boitrel MT, Corcos L, and Jan G: Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PLoS One 7, e31892, 2012.
  • Escamilla J, Lane MA, and Maitin V: Cell-free supernatants from probiotic Lactobacillus casei and Lactobacillus rhamnosus GG decrease colon cancer cell invasion in vitro. Nutr Cancer 64, 871–878, 2012.
  • Cha MK, Lee DK, An HM, Lee SW, Shin SH, et al.: Antiviral activity of Bifidobacterium adolescentis SPM1005-A on human papillomavirus type 16. BMC Me 10, 72, 2012.
  • Azam R, Ghafouri-Fard S, Tabrizi M, Modarressi MH, Ebrahimzadeh-Vesal R, et al.: Lactobacillus acidophilus and Lactobacillus crispatus culture supernatants downregulate expression of cancer-testis genes in the MDA-MB-231 cell line. Asian Pac J Cancer Prev 15, 4255–4259, 2014.
  • Ghoneum M and Gimzewski J: Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. Int J Oncol 44, 830–837, 2014.
  • Jan G, Belzacq AS, Haouzi D, Rouault A, Métivier D, et al.: Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. Cell Death Differ 9, 179–188, 2002.
  • Iyer C, Kosters A, Sethi G, Kunnumakkara AB, Aggarwal BB, et al.: Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. Cell Microbiol 10, 1442–1452, 2008.
  • Castro MS, Molina MA, Di Sciullo P, Azpiroz MB, Leocata Nieto F, et al.: Beneficial activity of Enterococcus faecalis CECT7121 in the anti-lymphoma protective response. J Appl Microbiol 109, 1234–1243, 2010.
  • Baldwin C, Millette M, Oth D, Ruiz MT, Luquet FM, et al.: Probiotic Lactobacillus acidophilus and L. casei mix sensitize colorectal tumoral cells to 5-fluorouracil-induced apoptosis. Nutr Cancer 62, 371–378, 2010.
  • Shinnoh M, Horinaka M, Yasuda T, Yoshikawa S, Morita M, et al.: Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8. Int J Oncol 42, 903–911, 2013.
  • McIntosh GH, Royle PJ, and Playne MJ: A probiotic strain of L. acidophilus reduces DMH-induced large intestinal tumors in male Sprague-Dawley rats. Nutr Cancer 35, 153–159, 1999.
  • Park E, Jeon GI, Park JS, and Paik HD: A probiotic strain of Bacillus polyfermenticus reduces DMH induced precancerous lesions in F344 male rat. Biol Pharm Bull 30, 569–574, 2007.
  • Lee NK, Park JS, Park E, and Paik HD: Adherence and anticarcinogenic effects of Bacillus polyfermenticus SCD in the large intestine. Lett Appl Microbiol 44, 274–278, 2007.
  • Chang JH, Shim YY, Cha SK, Reaney MJ, and Chee KM: Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon. J Med Microbiol 61, 361–368, 2012.
  • Kumar RS, Kanmani P, Yuvaraj N, Paari KA, Pattukumar V, et al.: Lactobacillus plantarum AS1 isolated from south Indian fermented food Kallappam suppress 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in male Wistar rats. Appl Biochem Biotechnol 166, 620–631, 2012.
  • Asha and Gayathri D: Synergistic impact of Lactobacillus fermentum, Lactobacillus plantarum and vincristine on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in mice. Exp Ther Med 3, 1049–1054, 2012.
  • Mohania D, Kansal VK, Kruzliak P, and Kumari A: Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin depleted foci and cell proliferation on 1, 2-dimethylhydrazine induced colorectal carcinogenesis in Wistar rats. Rejuvenation Res 7, 325–333, 2014.
  • Yamazaki K, Tsunoda A, Sibusawa M, Tsunoda Y, Kusano M, et al.: The effect of an oral administration of Lactobacillus casei strain shirota on azoxymethane-induced colonic aberrant crypt foci and colon cancer in the rat. Oncol Rep 7, 977–982, 2000.
  • Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, et al.: Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23, 1953–1960, 2002.
  • Marotta F, Naito Y, Minelli E, Tajiri H, Bertuccelli J, et al.: Chemopreventive effect of a probiotic preparation on the development of preneoplastic and neoplastic colonic lesions: an experimental study. Hepatogastroenterology 50, 1914–1918, 2003.
  • Klewicka E, Nowak A, Zduńczyk Z, Cukrowska B, and Błasiak J: Protective effect of lactofermented beetroot juice against aberrant crypt foci formation and genotoxicity of fecal water in rats. Exp Toxicol Pathol 64, 599–604, 2012.
  • Urbanska AM, Bhathena J, Martoni C, and Prakash S: Estimation of the potential antitumor activity of microencapsulated Lactobacillus acidophilus yogurt formulation in the attenuation of tumorigenesis in Apc(Min/+) mice. Dig Dis Sci 54, 264–273, 2009.
  • Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, et al.: Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology 137, 914–923, 2009.
  • Zhang HL, Yu LX, Yang W, Tang L, Lin Y, et al.: Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J Hepatol 57, 803–812, 2012.
  • Kaga C, Takagi A, Kano M, Kado S, Kato I, et al.: Lactobacillus casei Shirota enhances the preventive efficacy of soymilk in chemically induced breast cancer. Cancer Sci 104, 1508–1514, 2013.
  • Zhang M, Wang F, Jiang L, Liu R, Zhang L, et al.: Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide. Cancer Prev Res (Phila) 6, 686–694, 2013.
  • Demirer S, Aydintug S, Aslim B, Kepenekci I, Sengül N, et al.: Effects of probiotics on radiation-induced intestinal injury in rats. Nutrition 22, 179–186, 2006.
  • Prisciandaro LD, Geier MS, Butler RN, Cummins AG, and Howarth GS: Probiotic factors partially improve parameters of 5-fluorouracil-induced intestinal mucositis in rats. Cancer Biol Ther 11, 671–677, 2011.
  • Weill FS, Cela EM, Paz ML, Ferrari A, Leoni J, et al.: Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis. Br J Nutr 109, 457–466, 2013.
  • Urbancsek H, Kazar T, Mezes I, and Neumann K: Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhoea. Eur J Gastroenterol Hepatol 13, 391–396, 2001.
  • Giralt J, Regadera JP, Verges R, Romero J, de la Fuente I, et al.: Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial. Int J Radiat Oncol Biol Phys 71, 1213–1219, 2008.
  • Delia P, Sansotta G, Donato V, Messina G, Frosina P, et al.: Prophylaxis of diarrhoea in patients submitted to radiotherapeutic treatment on pelvic district: personal experience. Dig Liver Dis 34 (Suppl 2), S84–86, 2002.
  • Delia P, Sansotta G, Donato V, Frosina P, Messina G, et al.: Use of probiotics for prevention of radiation-induced diarrhea. World J Gastroenterol 13, 912–915, 2007.
  • Chitapanarux I, Chitapanarux T, Traisathit P, Kudumpee S, Tharavichitkul E, et al.: Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients. Radiat Oncol 5, 31, 2010.
  • Zwielehner J, Lassl C, Hippe B, Pointner A, Switzeny OJ, et al.: Changes in human fecal microbiota due to chemotherapy analyzed by TaqMan-PCR, 454 sequencing and PCR-DGGE fingerprinting. PLoS One 6, e28654, 2011.
  • Osterlund P, Ruotsalainen T, Korpela R, Saxelin M, Ollus A, et al.: Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer 97, 1028–1034, 2007.
  • Wada M, Nagata S, Saito M, Shimizu T, Yamashiro Y, et al.: Effects of the enteral administration of Bifidobacterium breve on patients undergoing chemotherapy for pediatric malignancies. Support Care Cancer 18, 751–759, 2010.
  • Sugawara G, Nagino M, Nishio H, Ebata T, Takagi K, et al.: Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Ann Surg 244, 706–714, 2006.
  • Nomura T, Tsuchiya Y, Nashimoto A, Yabusaki H, Takii Y, et al.: Probiotics reduce infectious complications after pancreaticoduodenectomy. Hepatogastroenterology 54, 661–663, 2007.
  • Gianotti L, Morelli L, Galbiati F, Rocchetti S, Coppola S, et al.: A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J Gastroenterol 16, 167–175, 2010.
  • Liu Z, Qin H, Yang Z, Xia Y, Liu W, et al.: Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery-a double-blind study. Aliment Pharmacol Ther 33, 50–63, 2011.
  • Ohigashi S, Hoshino Y, Ohde S, and Onodera H: Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today 41, 1200–1206, 2011.
  • Zhang JW, Du P, Gao J, Yang BR, Fang WJ, et al.: Preoperative probiotics decrease postoperative infectious complications of colorectal cancer. Am J Med Sci 343, 199–205, 2012.
  • Liu ZH, Huang MJ, Zhang XW, Wang L, Huang NQ, et al.: The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr 97, 117–126, 2013.
  • El-Nezami HS, Polychronaki NN, Ma J, Zhu H, Ling W, et al.: Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China. Am J Clin Nutr 83, 1199–1203, 2006.
  • Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, et al.: Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 85, 488–496, 2007.
  • Bonorden MJ, Greany KA, Wangen KE, Phipps WR, Feirtag J, et al.: Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women. Eur J Clin Nutr 58, 1635–1642, 2004.
  • Nettleton JA, Greany KA, Thomas W, Wangen KE, Adlercreutz H, et al.: Plasma phytoestrogens are not altered by probiotic consumption in postmenopausal women with and without a history of breast cancer. J Nutr 134, 1998–2003, 2004.
  • Ishikawa H, Akedo I, Otani T, Suzuki T, Nakamura T, et al.: Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors. Int J Cancer 116, 762–767, 2005.
  • Campbell CG, Chew BP, Luedecke LO, and Shultz TD: Yogurt consumption does not enhance immune function in healthy premenopausal women. Nutr Cancer 37, 27–35, 2000.
  • Toi M, Hirota S, Tomotaki A,Sato N, Hozumi Y, et al.: Probiotic beverage with soy isoflavone consumption for breast cancer prevention: A case-control study. Curr Nutr Food Sci 9, 194–200, 2013.
  • Reid G, Jass J, Sebulsky MT, and McCormick JK: Potential uses of probiotics in clinical practice. Clin Microbiol Rev 16, 658–672, 2003.
  • O'Mahony L, Feeney M, O'Halloran S, Murphy L, Kiely B, et al.: Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther 15, 1219–1225, 2001.
  • Eizaguirre I, Urkia NG, Asensio AB, Zubillaga I, Zubillaga P, et al.: Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome. J Pediatr Surg 37, 699–702, 2002.
  • Apás AL, Dupraz J, Ross R, González SN, and Arena ME: Probiotic administration effect on fecal mutagenicity and microflora in the goat's gut. J Biosci Bioeng 110, 537–540, 2010.
  • Hatakka K, Holma R, El-Nezami H, Suomalainen T, Kuisma M, et al.: The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon. Int J Food Microbiol 128, 406–410, 2008.
  • Brady LJ, Gallaher DD, and Busta FF: The role of probiotic cultures in the prevention of colon cancer. J Nutr 130, 410–414, 2000.
  • Odamaki T, Sugahara H, Yonezawa S, Yaeshima T, Iwatsuki K, et al.: Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. Anaerobe 18, 14–18, 2012.
  • Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, et al.: Effects of fermentation products of pro- and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer 51, 102–109, 2005.
  • Ko JS, Yang HR, Chang JY, and Seo JK: Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha. World J Gastroenterol 13, 1962–1965, 2007.
  • Jones C, Badger SA, Regan M, Clements BW, Diamond T, et al.: Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v. Eur J Gastroenterol Hepatol 25, 1424–1430, 2013.
  • Ahrne S and Hagslatt ML: Effect of lactobacilli on paracellular permeability in the gut. Nutrients 3, 104–107, 2011.
  • Horie H, Zeisig M, Hirayama K, Midtvedt T, Möller L, et al.: Probiotic mixture decreases DNA adduct formation in colonic epithelium induced by the food mutagen 2-amino-9H-pyrido[2,3-b]indole in a human-flora associated mouse model. Eur J Cancer Prev 12, 101–107, 2003.
  • Oberreuther-Moschner DL, Jahreis G, Rechkemmer G, and Pool-Zobel BL: Dietary intervention with the probiotics Lactobacillus acidophilus 145 and Bifidobacterium longum 913 modulates the potential of human faecal water to induce damage in HT29clone19A cells. Br J Nutr 91, 925–932, 2004.
  • Yeh SL, Lin MS, and Chen HL: Inhibitory effects of a soluble dietary fiber from Amorphophallus konjac on cytotoxicity and DNA damage induced by fecal water in Caco-2 cells. Planta Med 73, 1384–1388, 2007.
  • Kumar A, Singh NK, and Sinha PR: Inhibition of 1,2-dimethylhydrazine induced colon genotoxicity in rats by the administration of probiotic curd. Mol Biol Rep 37, 1373–1376, 2010.
  • Prisciandaro LD, Geier MS, Chua AE, Butler RN, Cummins AG, et al.: Probiotic factors partially prevent changes to caspases 3 and 7 activation and transepithelial electrical resistance in a model of 5-fluorouracil-induced epithelial cell damage. Support Care Cancer 20, 3205–3210, 2012.
  • Le Leu RK, Brown IL, Hu Y, Bird AR, Jackson M, et al.: A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon. J Nutr 135, 996–1001, 2005.
  • Zhang XP, Liu F, Cheng Z, and Wang W: Cell fate decision mediated by p53 pulses. Proc Natl Acad Sci USA 106, 12245–12250, 2009.
  • Takeda K and Okumura K: Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK-cell activity. J Nutr 137 (Suppl 2), 791S–793S, 2007.
  • Roller M, Clune Y, Collins K, Rechkemmer G, and Watzl B: Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients. Br J Nutr 97, 676–684, 2007.
  • Takagi A, Matsuzaki T, Sato M, Nomoto K, Morotomi M, et al.: Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism. Carcinogenesis 22, 599–605, 2001.
  • Roller M, Pietro Femia A, Caderni G, Rechkemmer G, and Watzl B: Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis. Br J Nutr 92, 931–938, 2004.
  • de Moreno de LeBlanc A, Matar C, Thériault C, and Perdigón G: Effects of milk fermented by Lactobacillus helveticus R389 on immune cells associated to mammary glands in normal and a breast cancer model. Immunobiology 210, 349–458, 2005.
  • Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, and Hontecillas R: Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One 7, e34676, 2012.
  • Maroof H, Hassan ZM, Mobarez AM, and Mohamadabadi MA: Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model. J Clin Immunol 32, 1353–1359, 2012.
  • Lakritz JR, Poutahidis T, Levkovich T, Varian BJ, Ibrahim YM, et al.: Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. Int J Cancer 135, 529–540, 2014.
  • Foo NP, Ou Yang H, Chiu HH, Chan HY, Liao CC, et al.: Probiotics prevent the development of 1,2-dimethylhydrazine (DMH)-induced colonic tumorigenesis through suppressed colonic mucosa cellular proliferation and increased stimulation of macrophages. J Agric Food Chem 59, 13337–13345, 2011.
  • Nurmi JT, Puolakkainen PA, and Rautonen NE: Bifidobacterium Lactis sp. 420 up-regulates cyclooxygenase (Cox)-1 and down-regulates Cox-2 gene expression in a Caco-2 cell culture model. Nutr Cancer 51, 83–92, 2005.
  • Ewaschuk JB, Walker JW, Diaz H, and Madsen KL: Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice. J Nutr 136, 1483–1487, 2006.
  • Matsumoto S, Hara T, Nagaoka M, Mike A, Mitsuyama K, et al.: A component of polysaccharide peptidoglycan complex on Lactobacillus induced an improvement of murine model of inflammatory bowel disease and colitis-associated cancer. Immunology 128 (Suppl 1), e170–180, 2009.
  • Appleyard CB, Cruz ML, Isidro AA, Arthur JC, Jobin C, et al.: Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer. Am J Physiol Gastrointest Liver Physiol 301, G1004–1013, 2011.
  • Kumar M, Verma V, Nagpal R, Kumar A, Behare PV, et al.: Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B1-induced liver carcinogenesis in rats. Br J Nutr 107, 1006–1016, 2012.

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